The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology
Open accessAbstract
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and physiology of zygotes formed from such oocytes, using the cow as a model. The zygotes were grown to blastocysts, which were evaluated for their quality in terms of cell number, apoptosis, expression of key genes, amino acid turnover and oxidative metabolism. Oocyte maturation under elevated NEFA concentrations resulted in blastocysts with significantly lower cell number, increased apoptotic cell ratio and altered mRNA abundance of DNMT3A, IGF2R and SLC2A1. In addition, the blastocysts displayed reduced oxygen, pyruvate and glucose consumption, up-regulated lactate consumption and higher amino acid metabolism. These data indicate that exposure of maturing oocytes to elevated NEFA concentrations has a negative impact on fertility not only through a reduction in oocyte developmental capacity but through compromised early embryo quality, viability and metabolism.
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Cites
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Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway
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Obesity and reproductive disorders in women
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Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women
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Cited by
Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation
Dunning, K. R., Russell, D. L., & Robker, R. L. (2014) · Reproduction · doi:10.1530/rep-13-0251 · Cited by 451
Metadata
- Authors
- Van Hoeck, V., Sturmey, R. G., Bermejo-Alvarez, P., Rizos, D., Gutierrez-Adan, A., Leese, H. J., Bols, P. E. J., & Leroy, J. L. M. R.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-08-17
- Volume
- 6
- Issue
- 8
- Pages
- e23183
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2017228002
- Cited by
- 272
- References
- 46
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Van Hoeck, V., Sturmey, R. G., Bermejo-Alvarez, P., Rizos, D., Gutierrez-Adan, A., Leese, H. J., Bols, P. E. J., & Leroy, J. L. M. R. (2011). Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology. PLoS ONE. https://doi.org/10.1371/journal.pone.0023183
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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