Early presymptomatic and long-term changes of rest activity cycles and cognitive behavior in a MPTP-monkey model of Parkinson’s disease
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BACKGROUND: It is increasingly recognized that non-motor symptoms are a prominent feature of Parkinson's disease and in the case of cognitive deficits can precede onset of the characteristic motor symptoms. Here, we examine in 4 monkeys chronically treated with low doses of the neurotoxin MPTP the early and long-term alterations of rest-activity rhythms in relationship to the appearance of motor and cognitive symptoms. METHODOLOGY/PRINCIPAL FINDINGS: Behavioral activity recordings as well as motor and cognitive assessments were carried out continuously and in parallel before, during and for several months following MPTP-treatment (12-56 weeks). Cognitive abilities were assessed using a task that is dependent on the functional integrity of the fronto-striatal axis. Rest-activity cycles were monitored continuously using infrared movement detectors of locomotor activity. Motor impairment was evaluated using standardized scales for primates. Results show that MPTP treatment led to an immediate alteration (within one week) of rest-activity cycles and cognitive deficits. Parkinsonian motor deficits only became apparent 3 to 5 weeks after initiating chronic MPTP administration. In three of the four animals studied, clinical scores returned to control levels 5-7 weeks following cessation of MPTP treatment. In contrast, both cognitive deficits and chronobiological alterations persisted for many months. Levodopa treatment led to an improvement of cognitive performance but did not affect rest-activity rhythms in the two cases tested. CONCLUSIONS/SIGNIFICANCE: Present results show that i) changes in the rest activity cycles constituted early detectable consequences of MPTP treatment and, along with cognitive alterations, characterize the presymptomatic stage; ii) following motor recovery there is a long-term persistence of non-motor symptoms that could reflect differential underlying compensatory mechanisms in these domains; iii) the progressive MPTP-monkey model of presymptomatic ongoing parkinsonism offers possibilities for in-depth studies of early non-motor symptoms including sleep alterations and cognitive deficits.
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MPTP-treated primates exhibit significant disruption of the sleep-wake cycle, particularly related to deregulation of REM sleep.
“MPTP-treated primates exhibit significant disruption of the sleep-wake cycle (Vezoli et al., 2011), in particular related to a deregulation of REM sleep.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Vezoli et al., 2011
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Ukraintseva, Y. V., & Kovalzon, V. M. (2016) · Human Physiology · doi:10.1134/s0362119716050170 · Cited by 7 · see citing works
Methods and Models of the Nonmotor Symptoms of Parkinson Disease
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Horloge circadienne et fonctions non visuelles : rôle de la lumière chez l’Homme
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Self-citationMarmosets in Neurologic Disease Research
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Circadian Dysfunction in Parkinson's Disease
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- Authors
- Vezoli, J., Fifel, K., Leviel, V., Dehay, C., Kennedy, H., Cooper, H. M., Gronfier, C., & Procyk, E.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Vezoli, Julien
- Cooper, Howard M.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-08-24
- Volume
- 6
- Issue
- 8
- Pages
- e23952
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3161087
- OpenAlex
- W2119379676
- Cited by
- 57
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 7 · 2012: 1
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR-09-MNPS-0040)
- Fondation de France
- Union Nationale des Aveugles et Déficients Visuels
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, MPTP, non-motor symptoms, rest-activity rhythm, circadian rhythm, cognitive impairment, presymptomatic stage, chronobiology, levodopa, sleep disorders, nonhuman primate model, motor recovery
- MeSH terms
- Activity Cycles, Animals, Haplorhini, Behavior, Animal, Cognition, Disease Models, Animal, Motor Skills, Neurotoxins, Parkinson Disease, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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