Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry
Abstract
It has been known for many years that the classic motor symptoms of Parkinson's disease are accompanied by deficits of executive function that resemble those seen after frontal lobe damage in humans. What is less clear is how different components of frontostriatal circuitry contribute to these impairments. Recently, improved methods of clinical assessment and classification, combined with novel technical approaches, such as functional neuroimaging, have led to great advances in our understanding of the fundamental mechanisms that drive frontostriatal circuitry. As a direct result, it has been possible to redefine impairments of executive function in Parkinson's disease more precisely in terms of the specific neuropsychological, neuroanatomical, and psychopharmacological mechanisms involved.
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Loss of dopamine in the basal ganglia impairs cognitive (executive) functions, particularly mental flexibility and set shifting related to alterations in fronto-striatal connectivity.
“The loss of DA in the basal ganglia not only impacts automatic behavior but also impairs cognitive (executive) functions55, 56, particularly mental flexibility and set shifting related to alterations in fronto-striatal connectivity 57–59.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [59]
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Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
Ekman, U., Eriksson, J., Forsgren, L., Mo, S. J., Riklund, K., & Nyberg, L. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70138-2 · Cited by 172 · see citing works
Sundaram, S., Hughes, R. L., Peterson, E., Müller-Oehring, E. M., Brontë-Stewart, H. M., Poston, K. L., Faerman, A., Bhowmick, C., & Schulte, T. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.016 · Cited by 152 · see citing works
Executive impairment in Parkinson's disease: response automaticity and task switching
Cameron, I. G. M., Watanabe, M., Pari, G., & Munoz, D. P. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.03.015 · Cited by 135 · see citing works
Birba, A., García-Cordero, I., Kozono, G., Legaz, A., Ibáñez, A., Sedeño, L., & García, A. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.011 · Cited by 128 · see citing works
Vezoli, J., Fifel, K., Leviel, V., Dehay, C., Kennedy, H., Cooper, H. M., Gronfier, C., & Procyk, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023952 · Cited by 57 · see citing works
- Authors
- Owen, A. M.
- Affiliations
- MRC Cognition and Brain Sciences Unit (GB)
- Corresponding author
- Owen, Adrian M.
- ORCID
- Owen, Adrian M.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2004-12
- Volume
- 10
- Issue
- 6
- Pages
- 525-537
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2143726556
- Cited by
- 496
- References
- 106
- Citations by year
- 2026: 15 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 19 · 2021: 14 · 2020: 17 · 2019: 17 · 2018: 17 · 2017: 26 · 2016: 33 · 2015: 33 · 2014: 23 · 2013: 43 · 2012: 28
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, cognitive impairment, executive function, frontostriatal circuits, frontal lobe damage, neuropsychological assessment, functional neuroimaging, psychopharmacology, neuroanatomy
- MeSH terms
- Animals, Cognition, Cognition Disorders, Corpus Striatum, Dopamine, Frontal Lobe, Humans, Magnetic Resonance Imaging, Memory Disorders, Neural Pathways, Neuropsychological Tests, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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