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Cited by 146Alzheimer's disease research and treatmentsFatty Acid Research and HealthDementia and Cognitive Impairment Research

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer’s disease

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Astarita, Giuseppe, Jung, Kwang-Mook, Vasilevko, Vitaly, DiPatrizio, Nicholas V., Martin, Sarah K., Cribbs, David H., Head, Elizabeth, Cotman, Carl W. +1 more·2011·PLoS ONE
DOI 10.1371/journal.pone.0024777PMC PMC3202527
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Abstract

The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable elevations in levels of non-esterified monounsaturated fatty acids (MUFAs) and mead acid (20:3n-9) in mid-frontal cortex, temporal cortex and hippocampus of AD patients. Further studies showed that brain mRNAs encoding for isoforms of the rate-limiting enzyme in MUFAs biosynthesis, stearoyl-CoA desaturase (SCD-1, SCD-5a and SCD-5b), were elevated in subjects with AD. The monounsaturated/saturated fatty acid ratio ('desaturation index')--displayed a strong negative correlation with measures of cognition: the Mini Mental State Examination test (r = -0.80; P = 0.0001) and the Boston Naming test (r = -0.57; P = 0.0071). Our results reveal a previously unrecognized role for the lipogenic enzyme SCD in AD.

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  • Blocking fatty acid desaturation through inhibition of stearoyl-CoA desaturase 1 or supplementing cells with choline reduces lipid droplet accumulation in APOE4 iPSCs.

    “Blocking fatty acid desaturation through inhibition of stearoyl-CoA desaturase 1, an enzyme elevated in Alzheimer's disease patient brains, or supplementing cells with choline reduced LD accumulation in APOE4 iPSCs (Astarita et al., 2011; Sienski et al., 2021).”

    From APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size (2024) · cites this paper as Astarita et al., 2011

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Authors
Astarita, G., Jung, K.-M., Vasilevko, V., DiPatrizio, N. V., Martin, S. K., Cribbs, D. H., Head, E., Cotman, C. W., & Piomelli, D.
Affiliations
  • University of California, Irvine (US)
  • University of Kentucky (US)
Corresponding author
Piomelli, Daniele
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2011-10-26
Volume
6
Issue
10
Pages
e24777
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0024777
PMC
PMC3202527
OpenAlex
W2171253460
Cited by
146
References
3
Citations by year
2026: 10 · 2025: 13 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 2
FWCI
3.92
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UKnowledge (University of Kentucky) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • Alzheimer's Association (IIRG-08-92000)
  • University of California, Irvine
  • National Institute on Drug Abuse (RC2DA028902)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, stearoyl-CoA desaturase, stearoyl-CoA desaturase 1, monounsaturated fatty acids, Mead acid, brain lipidomics, desaturation index, cognitive impairment, hippocampus, temporal cortex, frontal cortex, lipogenic enzymes
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Mapping, Cognition, Fatty Acids, Monounsaturated, Female, Humans, Male, RNA, Messenger, Stearoyl-CoA Desaturase, 8,11,14-Eicosatrienoic Acid, Case-Control Studies, Protein Isoforms, Metabolic Networks and Pathways

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