Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works

Statins and the risk of dementia

Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,763 · see citing works

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

Wolozin, B. L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,401 · see citing works

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies

McGeer, P. L., Schulzer, M., & McGeer, E. G. (1996) · Neurology · doi:10.1212/wnl.47.2.425 · Cited by 1,367 · see citing works

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,167 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J. J., Bryant‐Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., & Duff, K. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0304 · Cited by 1,003 · see citing works

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Yu, G., Nishimura, M., Arawaka, S., Levitan, D. J., Zhang, L., Tandon, A., Song, Y., Rogaeva, E. A., Chen, F., Kawarai, T., et al. (2000) · Nature · doi:10.1038/35024009 · Cited by 906 · see citing works

Cholesterol metabolism in the brain

Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906 · see citing works

Alzheimer's disease: the cholesterol connection

Puglielli, L., Tanzi, R. E., & Kovacs, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn0403-345 · Cited by 864 · see citing works

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works

Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

Notkola, I.-L., Sulkava, R. O., Pekkanen, J., Erkinjuntti, T., Ehnholm, C., Kivinen, P., Tuomilehto, J., & Nissinen, A. (1998) · Neuroepidemiology · doi:10.1159/000026149 · Cited by 666 · see citing works

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling

Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517 · see citing works

Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein

Bodovitz, S., & Klein, W. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4436 · Cited by 447 · see citing works

Incidence and Prevalence of Dementia in the Cardiovascular Health Study

Fitzpatrick, A. L., Kuller, L. H., Ives, D. G., Lopez, O. L., Jagust, W., Breitner, J. C. S., Jones, B., Lyketsos, C., & Dulberg, C. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52058.x · Cited by 438 · see citing works

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

Pappolla, M. A., Omar, R. A., Kim, K. S., & Robakis, N. K. R. K. (1992) · PubMed Central · Cited by 363 · see citing works

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

Pappolla, M. A., Chyan, Y., Omar, R. A., Hsiao, K., Perry, G. L., Smith, M. A., & Bozner, P. (1998) · Europe PMC (PubMed Central) · Cited by 328 · see citing works

The role of cholesterol in the biosynthesis of β-amyloid.

Frears, E. R., Stephens, D. J., Walters, C. E., Davies, H., & Austen, B. (1999) · Neuroreport · doi:10.1097/00001756-199906030-00014 · Cited by 324 · see citing works

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

Pappolla, M. A., Bryant‐Thomas, T., Herbert, D., Pacheco, J., Garcia, M. F., Manjón, M., Gironès, X., Henry, T. L., Matsubara, E., Zambón, D., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000070182.02537.84 · Cited by 308 · see citing works

β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain

Fukumoto, H., Rosene, D. L., Moss, M. B., Raju, S., Hyman, B. T., & Irizarry, M. C. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63159-8 · Cited by 294 · see citing works

Increased Brain β-Amyloid Load, Phosphorylated Tau, and Risk of Alzheimer Disease Associated With an Intronic CYP46 Polymorphism

Papassotiropoulos, A., Streffer, J. R., Tsolaki, M., Schmid, S., Thal, D. R., Nicosia, F. M., Iakovidou, V., Maddalena, A. S., Lütjohann, D., Ghebremedhin, E., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.1.29 · Cited by 208 · see citing works

Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol

Mason, R. P., Shoemaker, W. J., Shajenko, L., Chambers, T. E., & Herbette, L. G. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90116-f · Cited by 189 · see citing works

Clearance of amyloid β-peptide from brain: transport or metabolism?

Zlokovic, B. V., Yamada, S., Holtzman, D., Ghiso, J., & Frangione, B. (2000) · Nature Medicine · doi:10.1038/77397 · Cited by 186 · see citing works

Prostaglandins and other lipid mediators in Alzheimer’s disease

Bazan, N. G., Colangelo, V., & Lukiw, W. J. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00031-x · Cited by 173 · see citing works

Gene Expression Profiling in Fetal, Aged, and Alzheimer Hippocampus: A Continuum of Stress-Related Signaling

Lukiw, W. J. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023615.89699.63 · Cited by 172 · see citing works

Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials

Edwards, J. E., & Moore, R. A. (2003) · BMC Family Practice · doi:10.1186/1471-2296-4-18 · Cited by 166 · see citing works

Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease

Wood, W. G., Eckert, G. P., Igbavboa, U., & Müller, W. E. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00025-7 · Cited by 164 · see citing works

Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration

WILSON, H., Schwartz, D. M., Bhatt, H. R. F., McCulloch, C. E., & Duncan, J. L. (2004) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(03)01286-8 · Cited by 153 · see citing works

Statins as potential therapeutic agents in neuroinflammatory disorders

Stüve, O., Youssef, S., Steinman, L., & Zamvil, S. S. (2003) · Current Opinion in Neurology · doi:10.1097/01.wco.0000073942.19076.d1 · Cited by 141 · see citing works

Dietary Links to Alzheimer's Disease: 1999 Update

Grant, W. B. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-14-501 · Cited by 138 · see citing works

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease

Aliev, G. M., Smith, M. A., Obrenovich, M. E., de la Torre, J. C., & Perry, G. L. (2003) · Neurotoxicity Research · doi:10.1007/bf03033159 · Cited by 134 · see citing works

FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

Flood, D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00330-x · Cited by 131 · see citing works

Lovastatin enhances Aβ production and senile plaque deposition in female Tg2576 mice

Park, I.-H., Hwang, E. M., Hong, H., Boo, J. H., Oh, S. S., Lee, J., Jung, M. W., Bang, O. Y., Kim, S. U., & Mook‐Jung, I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00155-0 · Cited by 124 · see citing works

The role of the endosomal/ lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective

Pasternak, S., Callahan, J. W., & Mahuran, D. J. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6107 · Cited by 122 · see citing works

Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program

Weir, M. R., SPERLING, R. S., Reicin, A. S., & Gertz, B. J. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00398-3 · Cited by 122 · see citing works

Recent advances in brain cholesterol dynamics: Transport, domains, and Alzheimer's disease

Wood, W. G., Schroeder, F., Avdulov, N. A., Chochina, S. V., & Igbavboa, U. (1999) · Lipids · doi:10.1007/s11745-999-0357-9 · Cited by 111 · see citing works

Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

Qin, W., Ho, L., Pompl, P. N., Peng, Y., Zhao, Z., Xiang, Z., Robakis, N. K. R. K., Shioi, J., Suh, J., & Pasinetti, G. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307699200 · Cited by 110 · see citing works

Plasma Levels of β-Amyloid(1-40), β-Amyloid(1-42), and Total β-Amyloid Remain Unaffected in Adult Patients With Hypercholesterolemia After Treatment With Statins

Höglund, K., Wiklund, O., Vanderstichele, H., Eikenberg, O., Vanmechelen, E., & Blennow, K. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.333 · Cited by 102 · see citing works

24S-Hydroxycholesterol: a Marker of Brain Cholesterol Metabolism

Lütjohann, D., & von Bergmann, K. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-43053 · Cited by 97 · see citing works

Nonsteroidal Anti-Inflammatory Drug Use and the Risk for Alzheimer???s Disease

Launer, L. J. (2003) · Drugs · doi:10.2165/00003495-200363080-00001 · Cited by 69 · see citing works

Aging and Total Cholesterol Levels: Cohort, Period, and Survivorship Effects

Newschaffer, C. J., Bush, T. L., & Hale, W. E. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116417 · Cited by 68 · see citing works

Amyloid and lipids in the pathology of Alzheimer disease

Roher, A. E., Kuo, Y., Kokjohn, K., Emmerling, M. R., & Gracon, S. I. (1999) · Amyloid · doi:10.3109/13506129909007315 · Cited by 63 · see citing works

The Role of Cholesterol and Statins in Alzheimer's Disease

Miller, L. J., & Chacko, R. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1d104 · Cited by 63 · see citing works

Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications

Cacabelos, R., Fernández‐Novoa, L., Lombardi, V., Corzo, L., Pichel, V., & Kubota, Y. (2003) · Neurological Research · doi:10.1179/016164103101202002 · Cited by 62 · see citing works

Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol

Petanceska, S. S., DeRosa, S., Sharma, A., Diaz, N. S., Duff, K., Tint, S. G., Refolo, L. M., & Pappolla, M. A. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:395 · Cited by 50 · see citing works

Cholesterol-dependent generation of a unique amyloid β-protein from apically missorted amyloid precursor protein in MDCK cells

Mizuno, T., Haass, C., Michikawa, M., & Yanagisawa, K. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00097-2 · Cited by 47 · see citing works

Cyp46 (24S-Cholesterol Hydroxylase)

Wolozin, B. L. (2003) · Archives of Neurology · doi:10.1001/archneur.60.1.16 · Cited by 47 · see citing works

Lipid signals in pain control

Bazan, N. G., & Flower, R. (2002) · Nature · doi:10.1038/420135a · Cited by 42 · see citing works

Overexpression of nicastrin increases Aß production

Murphy, M. P., Das, P., Nyborg, A. C., Rochette, M. J., Dodson, M. W., Loosbrock, N., Souder, T., McLendon, C., Merit, S. L., Piper, S. C., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1050fje · Cited by 38 · see citing works

Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits

Zatta, P. F., Zambenedetti, P., Stella, M. P., & Licastro, F. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4101 · Cited by 35 · see citing works

The role of 24S-hydroxycholesterol in Alzheimer's disease.

Kölsch, H., Lütjohann, D., von Bergmann, K., & Heun, R. (2003) · PubMed · Cited by 33 · see citing works

Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients

Baskin, F., Rosenberg, R. N., Fang, X. T., Hynan, L. S., Moore, C. B., Weiner, M., & Vega, G. L. (2003) · Neurology · doi:10.1212/01.wnl.0000068029.56740.96 · Cited by 30 · see citing works

A partner for presenilin

Schenk, D. (2000) · Nature · doi:10.1038/35024194 · Cited by 25 · see citing works

Aβ, aging, and Alzheimer's disease: A tale, models, and hypotheses

Chaney, M. O., Baudry, J. Y., Esh, C. L., Childress, J., Luehrs, D. C., Kokjohn, T. A., & Roher, A. E. (2003) · Neurological Research · doi:10.1179/016164103101202011 · Cited by 22 · see citing works

The Role of Cardiovascular Risk Factors in Alzheimer's Disease

Ravona‐Springer, R., Davidson, M., & Noy, S. (2003) · CNS Spectrums · doi:10.1017/s109285290001926x · Cited by 20 · see citing works

Proteolytic cascade in the amyloidogenesis of Alzheimer's disease

Sidera, C., Parsons, R. B., & Austen, B. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320033 · Cited by 11 · see citing works

Untitled work

Cole (2000) · doi:10.1002/1097-0029(20000815)50:4

Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

Lukiw, W. J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280148e8b · Cited by 662 · see citing works

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

Rojas-Gutierrez, E., Muñoz‐Arenas, G., Treviño, S., Espinosa, B., Chávez, R., Rojas, K., Flores, G., Díaz, A., & Guevara, J. (2017) · Synapse · doi:10.1002/syn.21990 · Cited by 193 · see citing works

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer’s disease

Astarita, G., Jung, K.-M., Vasilevko, V., DiPatrizio, N. V., Martin, S. K., Cribbs, D. H., Head, E., Cotman, C. W., & Piomelli, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024777 · Cited by 146 · see citing works

Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers

Florent‐Béchard, S., Malaplate, C., Youssef, I., Kriem, B., Koziel, V., Escanyé, M., Fifre, A., Sponne, I., Leininger‐Muller, B., Olivier, J. L., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03541.x · Cited by 131 · see citing works

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells

Natali, F., Siculella, L., Salvati, S., & Gnoni, G. V. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700051-jlr200 · Cited by 110 · see citing works

Polyunsaturated Fatty Acids Induce α-Synuclein-Related Pathogenic Changes in Neuronal Cells

Assayag, K., Yakunin, E., Loeb, V., Selkoe, D. J., & Sharon, R. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070373 · Cited by 106 · see citing works

The effects of cholesterol on learning and memory

Schreurs, B. G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.010 · Cited by 105 · see citing works

The Novel Perspectives of Adipokines on Brain Health

Lee, T. H.-Y., Cheng, K. K. Y., Hoo, R. L. C., Siu, P. M., & Yau, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225638 · Cited by 100 · see citing works

Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions

Pattar, G. R., Tackett, L., Liu, P., & Elmendorf, J. S. (2006) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2006.06.018 · Cited by 88 · see citing works

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

Placanica, L., Zhu, L., & Li, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005088 · Cited by 88 · see citing works

Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)

Lukiw, W. J. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.672559 · Cited by 74 · see citing works

Survival signalling in Alzheimer's disease

Lukiw, W. J., & Bazan, N. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341277 · Cited by 63 · see citing works

Metal-Sulfate Induced Generation of ROS in Human Brain Cells: Detection Using an Isomeric Mixture of 5- and 6-Carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a Cell Permeant Tracer

Pogue, A. I., Jones, B. M., Bhattacharjee, S., Percy, M. E., Zhao, Y., & Lukiw, W. J. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13089615 · Cited by 52 · see citing works

Proteomic analysis of human very low‐density lipoprotein by two‐dimensional gel electrophoresis and MALDI‐TOF/TOF

Mancone, C., Amicone, L., Fimia, G. M., Bravo, E., Piacentini, M., Tripodi, M., & Alonzi, T. (2006) · PROTEOMICS · doi:10.1002/pmic.200600339 · Cited by 51 · see citing works

Potential role of hydroxytyrosol in neuroprotection

Chen, C., Ai, Q., & Wei, Y. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104506 · Cited by 46 · see citing works

Human apolipoprotein C-I expression in mice impairs learning and memory functions

Abildayeva, K., Berbée, J. F. P., Blokland, A., Jansen, P. J., Hoek, F. J., Meijer, O. C., Lütjohann, D., Gautier, T., Pillot, T., de Vente, J., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700518-jlr200 · Cited by 45 · see citing works

Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α

Sáez-Orellana, F., Octave, J., & Pierrot, N. (2020) · Cells · doi:10.3390/cells9051215 · Cited by 45 · see citing works

Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders

Harris, J. R., & Milton, N. G. N. (2010) · Subcellular Biochemistry · doi:10.1007/978-90-481-8622-8_2 · Cited by 44 · see citing works

Oxysterols in biological systems: The gastrointestinal tract, liver, vascular wall and central nervous system

Garenc, C., Julien, P., & Levy, E. H. (2009) · Free Radical Research · doi:10.3109/10715760903321804 · Cited by 43 · see citing works

Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells

Priore, P., Gnoni, A., Natali, F., Testini, M., Gnoni, G. V., Siculella, L., & Damiano, F. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9076052 · Cited by 40 · see citing works

Natural Secretory Products of Human Neural and Microvessel Endothelial Cells: Implications in Pathogenic "Spreading" and Alzheimer's Disease

Zhao, Y., Cui, J.-G., & Lukiw, W. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:3:181 · Cited by 39 · see citing works

miRNAs: From Neurogeneration to Neurodegeneration

Singh, S. K. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.8.971 · Cited by 36 · see citing works

Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)

Lukiw, W. J. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.13.2.255 · Cited by 29 · see citing works

Cardiovascular Dementia - A Different Perspective

Kumari, U., & Heese, K. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010029 · Cited by 27 · see citing works

Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain

Snigdha, S., Astarita, G., Piomelli, D., & Cotman, C. W. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.002 · Cited by 27 · see citing works

Apolipoprotein CI Knock-Out Mice Display Impaired Memory Functions

Berbée, J. F. P., Vanmierlo, T., Abildayeva, K., Blokland, A., Jansen, P. J., Lütjohann, D., Gautier, T., Sijbrands, E. J. G., Prickaerts, J., Hadfoune, M., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100576 · Cited by 23 · see citing works

Food-induced changes of lipids in rat neuronal tissue visualized by ToF-SIMS imaging

Pour, M. D., Jennische, E., Lange, S., Ewing, A. G., & Malmberg, P. (2016) · Scientific Reports · doi:10.1038/srep32797 · Cited by 21 · see citing works

Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer’s disease

Lukiw, W. J. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.5.683 · Cited by 20 · see citing works

Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01567-0 · Cited by 17 · see citing works

Lipid metabolism in Alzheimer’s and Parkinson’s disease

Xu, Q., & Huang, Y. (2006) · Future Lipidology · doi:10.2217/17460875.1.4.441 · Cited by 16 · see citing works

Minocycline Recovers MTT-Formazan Exocytosis Impaired by Amyloid Beta Peptide

Kreutzmann, P., Wolf, G. L., & Kupsch, K. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9528-6 · Cited by 12 · see citing works

Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors

Zhang, Y., Wang, T., Zhang, X., Deuther‐Conrad, W., Fu, H., Cui, M., Zhang, J., Brust, P., Huang, Y. H., & Jia, H. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.029 · Cited by 11 · see citing works

Phosphorylated Extracellular Signal-Regulated Kinase 1/2 Immunoreactivity and Its Protein Levels in the Gerbil Hippocampus during Normal Aging

Lee, C. H., Yoo, K., Park, O. K., Choi, J. H., Kang, I., Bae, E., Kim, S. K., Hwang, I. K., & Won, M. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0046-7 · Cited by 9 · see citing works

A cholesterol-centric outlook on steroidogenesis

Sidhu, S. K., & Mishra, S. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.05.006 · Cited by 8 · see citing works

Oleic acid and olive oil polyphenols downregulate fatty acid and cholesterol synthesis in brain and liver cells

Gnoni, A., Longo, S., Damiano, F., Gnoni, G. V., & Giudetti, A. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819528-4.00036-5 · Cited by 8 · see citing works

Hypercholesterolemia is associated with visual field alterations detectable with computerized perimetry

Alcalá, A., Jansen, S., Farkouh, M. E., & Morell, M. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.01.013 · Cited by 7 · see citing works

Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer's disease with hyperlipoidemia

Cai, Z., Yan, Y., Yan, L., Wang, F., Huang, H., Wang, Y.-L., & Zhao, Y. C. (2007) · 中国人民解放军军医大学学报：英文版 · doi:10.1016/s1000-1948(08)60017-9 · Cited by 7 · see citing works

Structure-based drug discovery of ApoE4 inhibitors from the plant compounds

Singh, K. D., Muthusamy, K., Kirubakaran, P., Sathya, V., & Nagamani, S. (2011) · Medicinal Chemistry Research · doi:10.1007/s00044-011-9595-3 · Cited by 5 · see citing works

Lipids of Brain Mitochondria

Corazzi, L., & Roberti, R. (2009) · Springer eBooks · doi:10.1007/978-0-387-30378-9_8 · Cited by 4 · see citing works

β- and γ-Secretases and Lipid Rafts

Araki, W. (2010) · The Open Biology Journal · doi:10.2174/18741967010030100016 · Cited by 2 · see citing works

Implication de l'acide docosanoïque (C22 0) et des acides gras à très longue chaîne (acide tétracosanoïque (C24 0), acide hexacosanoïque ( C26 0) dans la maladie d'Alzheimer : aspects biologiques et cliniques

Zarrouk, A. (2013) · doi:10.70675/0ca0afb8z8b2cz4b48zb97az382f4a6003ba · Cited by 2 · see citing works

Brain Self-protection by Bioactive Lipids

Ng, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-94431-4_11 · Cited by 1 · see citing works

Cell apoptosis in ischemic stroke: Focus on lipid metabolism

Sun, R., Yang, W., Zhao, Y., Zhang, F., Wu, G., Wang, A., & Tian, Y. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00301 · Cited by 1 · see citing works

Beyond Cholesterol: Statin Benefits in Alzheimer's Disease

Soares, H. D., & Sparks, D. L. (2007) · Springer eBooks · doi:10.1007/7355_2007_013 · Cited by 1 · see citing works

Apolipoproteins E and C1 in the brain: role in Alzheimer's disease

Abildayeva, K. (2006) · doi:10.26481/dis.20061220ka

Membrane cholesterol balance in exercise and insulin resistance

Habegger, K. M. (2010) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1850

Re-imagining the biological membrane

Castro, J. M. (2015) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814656863_0017

The Effects of Chromium on Skeletal Muscle Membrane/Cytoskeletal Parameters and Insulin Sensitivity

Hoffman, N. J. (2012) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1996

Lipid and transcriptome profile of the brain of pigs fed with different oil sources

da Silva, B. P. M. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.74.2022.tde-31012023-094032

Alcohol use as a potential moderator of risk factors for Alzheimer's disease

Stelmokas, J. (2013) · CommonKnowledge Research Repository (Pacific University Oregon)

Additional file 5 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588847

Additional file 6 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588850

Additional file 3 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588841

Additional file 1 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588829

Additional file 7 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588853

Additional file 4 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588844

Additional file 2 of Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains

Semikasev, E., Ahlemeyer, B., Acker, T., Schänzer, A., & Baumgart‐Vogt, E. (2024) · Figshare · doi:10.6084/m9.figshare.26588832

Effets des acides gras ω-3 sur l'inflammation cérébro-vasculaire associée à la maladie d'Alzheimer et aux angiopathies amyloïdes cérébrales

Hur, J. (2017) · theses.fr (ABES) · doi:10.70675/74388921za6fcz4e1ez8033z6d776311f983

Effects of brain cholesterol metabolism on Alzheimer's disease

Yi-ming, H. (2011) · Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi

Abnormality of Cholesterol Metabolism and Alzheimer′s Disease

Chen, F. (2007) · Xiandai shengwu yixue jinzhan

The Role of Cholesterol Metabolism in Alzheimer’s Disease

Sun, J.-H., Yu, J.-T., & Tan, L. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8749-y · Cited by 70 · see citing works

The Link between Cholesterol and a Brain Disease

Purushothaman, S., & Anand, A. V. (2021)

Alzheimer's disease: brain expression of a metabolic disorder?

Merlo, S., Spampinato, S. F., Canonico, P. L., Copani, A., & Sortino, M. A. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.05.005 · Cited by 47 · see citing works