Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity

White, H. (1980) · Econometrica · doi:10.2307/1912934 · Cited by 25,861 · see citing works

Longitudinal data analysis using generalized linear models

LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550 · see citing works

Origins and evolution of the Western diet: health implications for the 21st century1,2

Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397 · see citing works

Intracellular amyloid-β in Alzheimer's disease

LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works

Alzheimer’s disease

Cummings, J. L. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040223 · Cited by 1,152 · see citing works

Conversion of <b>α</b> -linolenic acid to longer-chain polyunsaturated fatty acids in human adults

Burdge, G. C., & Calder, P. C. (2005) · Reproduction Nutrition Development · doi:10.1051/rnd:2005047 · Cited by 939 · see citing works

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · cited 1× · see citing works

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.013 · Cited by 707 · see citing works

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works

Dietary omega 3 fatty acids and the developing brain

Innis, S. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.078 · Cited by 671 · see citing works

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

Söderberg, M., Edlund, C., Kristensson, K., & Dallner, G. (1991) · Lipids · doi:10.1007/bf02536067 · Cited by 667 · see citing works

The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase.

Voss, A., Reinhart, M., Sankarappa, S. K., & Sprecher, H. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54882-1 · Cited by 665 · see citing works

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

Han, X., Holtzman, D. M., & McKeel, D. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00332.x · Cited by 562 · see citing works

Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids.

Sprecher, H. W., Luthria, D. L., Mohammed, B. S., & Baykousheva, S. P. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41084-3 · Cited by 515 · see citing works

Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.

Scott, B. L., & Bazan, N. (1989) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.86.8.2903 · Cited by 445 · see citing works

Regional Membrane Phospholipid Alterations in Alzheimer's Disease

Prasad, M. R., Lovell, M. A., Yatin, M., Dhillon, H. S., & Markesbery, W. R. (1998) · Neurochemical Research · doi:10.1023/a:1022457605436 · Cited by 440 · see citing works

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353 · see citing works

Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

Green, K. N., Martínez‐Coria, H., Khashwji, H., Hall, E. B., Yurko‐Mauro, K., Ellis, L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-07.2007 · Cited by 326 · see citing works

Fish, docosahexaenoic acid and Alzheimer’s disease

Cunnane, S. C., Plourde, M., Pifferi, F., Bégin, M. E., Féart, C., & Barberger‐Gateau, P. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.04.001 · Cited by 316 · see citing works

Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver

Rapoport, S. I., Rao, J. S., & Igarashi, M. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.023 · Cited by 295 · see citing works

DOCOSAHEXAENOIC ACID, FATTY ACID–INTERACTING PROTEINS, AND NEURONAL FUNCTION: Breastmilk and Fish Are Good for You

Marszalek, J. R., & Lodish, H. F. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120624 · Cited by 270 · see citing works

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia

Goodenowe, D. B., Cook, L. L., Liu, J., Lu, Y., Jayasinghe, D., Ahiahonu, P. W. K., Heath, D., Yamazaki, Y., Flax, J., Krenitsky, K. F., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.p700023-jlr200 · Cited by 253 · see citing works

Docosahexaenoic Acid and the Aging Brain

Lukiw, W. J., & Bazan, N. G. (2008) · Journal of Nutrition · doi:10.3945/jn.108.096016 · Cited by 247 · see citing works

Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease

Guan, Z., Wang, Y., Cairns, N. J., Lantos, P. L., Dallner, G., & Sindelar, P. J. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199907000-00008 · Cited by 236 · see citing works

Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer’s Disease

Fraser, T., Tayler, H. M., & Love, S. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0087-5 · Cited by 198 · see citing works

Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders

Martínez, M. (1992) · Brain Research · doi:10.1016/s0006-8993(10)80021-6 · Cited by 190 · see citing works

Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, S. A., Hurt, E., Yoder, E. J., Sprecher, H. W., & Spector, A. A. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39724-8 · Cited by 171 · see citing works

Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects

SKINNER, E. R., Watt, C., BESSON, J. A. O., & Best, P. V. (1993) · Brain · doi:10.1093/brain/116.3.717 · Cited by 137 · see citing works

Peroxisomal Straight-chain Acyl-CoA Oxidase and D-bifunctional Protein Are Essential for the Retroconversion Step in Docosahexaenoic Acid Synthesis

Su, H., Moser, A. B., Moser, H. W., & Watkins, P. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106326200 · Cited by 108 · see citing works

Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content.

Corrigan, F., Horrobin, D., Skinner, E., Besson, J. O., & Cooper, M. (1998) · International Journal of Biochemistry and Cell Biology · doi:10.1016/s1357-2725(97)00125-8 · Cited by 102 · see citing works

Severe deficiency of docosahexaenoic acid in peroxisomal disorders

Martínez, M. (1990) · Neurology · doi:10.1212/wnl.40.8.1292 · Cited by 102 · see citing works

Nutrition and the Brain

Morley, J. E. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.11.005 · Cited by 87 · see citing works

Physiological Role of D-3-Hydroxyacyl-CoA Dehydratase/D-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein

Jiang, L., Kurosawa, T., Sato, M., Suzuki, Y., & Hashimoto, T. (1997) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021615 · Cited by 86 · see citing works

Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in usher's syndrome

Bazan, N. G., Scott, B. L., Reddy, T. S., & Pelias, M. Z. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80215-7 · Cited by 78 · see citing works

Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis

Rapoport, S. I., Igarashi, M., & Gao, F. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.02.015 · Cited by 74 · see citing works

Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA?

Rapoport, S. I., & Igarashi, M. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.021 · Cited by 63 · see citing works

Fat Intake and CNS Functioning: Ageing and Disease

Crawford, M. A., Bazinet, R. P., & Sinclair, A. J. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000229003 · Cited by 62 · see citing works

Lipid abnormalities in the brain in adult Down’s syndrome and Alzheimer’s disease

Brooksbank, B. W. L., & Martínez, M. (1989) · Molecular and Chemical Neuropathology · doi:10.1007/bf03160049 · Cited by 55 · see citing works

Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.

Youssef, J., & Badr, M. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107791 · Cited by 41 · see citing works

Catalase turnover in rat liver and kidney as a function of age

Haining, J. L., & Legan, J. S. (1973) · Experimental Gerontology · doi:10.1016/0531-5565(73)90018-1 · Cited by 41 · see citing works

Liver disease as a risk factor for cognitive decline and dementia: An Under-recognized issue #

Yilmaz, Y. N., & Ozdogan, O. C. (2008) · Hepatology · doi:10.1002/hep.22752 · Cited by 32 · see citing works

Functions of plasmalogen lipids in health and disease

Braverman, N. E., & Moser, A. B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.05.008 · Cited by 1,082 · see citing works

Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA

Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943 · see citing works

DHA Effects in Brain Development and Function

Lauritzen, L., Brambilla, P., Mazzocchi, A., Harsløf, L. B. S., Ciappolino, V., & Agostoni, C. V. (2016) · Nutrients · doi:10.3390/nu8010006 · Cited by 566 · see citing works

Significance of long chain polyunsaturated fatty acids in human health

Zárate, R., el Jaber-Vazdekis, N., Tejera, N., Pérez, J. A., & Rodríguez, C. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0153-6 · Cited by 547 · see citing works

Homocysteine, B Vitamins, and Cognitive Impairment

Smith, A. D., & Refsum, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050947 · Cited by 526 · see citing works

Lipids and Alzheimer’s Disease

Kao, Y.-C., Ho, P.-C., Tu, Y.-K., Jou, I.-M., & Tsai, K.-J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041505 · Cited by 485 · see citing works

<scp>A</scp>rizona <scp>S</scp>tudy of <scp>A</scp>ging and <scp>N</scp>eurodegenerative <scp>D</scp>isorders and <scp>B</scp>rain and <scp>B</scp>ody <scp>D</scp>onation <scp>P</scp>rogram

Beach, T. G., Adler, C. H., Sue, L. I., Serrano, G., Shill, H. A., Walker, D. G., Lue, L., Roher, A. E., Dugger, B. N., Maarouf, C., et al. (2015) · Neuropathology · doi:10.1111/neup.12189 · Cited by 460 · see citing works

Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases

Bazan, N. G., Molina, M. F., & Gordon, W. C. (2011) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104635 · Cited by 441 · see citing works

Docosahexaenoic Acid and Cognition throughout the Lifespan

Weiser, M., Butt, C., & Mohajeri, M. (2016) · Nutrients · doi:10.3390/nu8020099 · Cited by 400 · see citing works

Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta‐analysis

da Silva, S. L., Vellas, B. J., Elemans, S., Luchsinger, J. A., Kamphuis, P. J. G. H., Yaffe, K. S., Sijben, J., Groenendijk, M., & Stijnen, T. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1771 · Cited by 313 · see citing works

A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease

Xu, M., Zhang, D., Luo, R., Wu, Y., Zhou, H., Kong, L., Bi, R., & Yao, Y. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.08.012 · Cited by 294 · see citing works

Mitochondria-associated ER membranes in Alzheimer disease

Schon, E. A., & Area-Gomez, E. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.07.011 · Cited by 261 · see citing works

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works

ER stress and impaired autophagy flux in neuronal degeneration and brain injury

Yin, Y., Sun, G., Li, E., Kiselyov, K. I., & Sun, D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.008 · Cited by 214 · see citing works

Brain docosahexaenoic acid uptake and metabolism

Lacombe, R. J. S., Chouinard‐Watkins, R., & Bazinet, R. P. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.12.004 · Cited by 205 · see citing works

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Li, R.-Y., Qin, Q., Yang, H.-C., Wang, Y.-Y., Mi, Y.-X., Yin, Y.-S., Wang, M., Yu, C.-J., & Tang, Y. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00542-y · Cited by 204 · see citing works

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

Zhu, M., Wang, X., Hjorth, E., Colas, R. A., Schroeder, L., Granholm, A.-C., Serhan, C. N., & Schultzberg, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9544-0 · Cited by 204 · see citing works

Metabolite profiling for the identification of altered metabolic pathways in Alzheimer's disease

González‐Domínguez, R., García‐Barrera, T., & Gómez‐Ariza, J. L. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.10.010 · Cited by 201 · see citing works

Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology

Naudí, A., Cabré, R., Jové, M., Ayala, V., Gonzalo‐Benito, H., Portero‐Otín, M., Ferrer, I., & Pamplona, R. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.05.008 · Cited by 199 · see citing works

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

Rojas-Gutierrez, E., Muñoz‐Arenas, G., Treviño, S., Espinosa, B., Chávez, R., Rojas, K., Flores, G., Díaz, A., & Guevara, J. (2017) · Synapse · doi:10.1002/syn.21990 · Cited by 198 · see citing works

Peroxisomes in brain development and function

Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works

Plasmalogens and Alzheimer’s disease: A review

Su, X. Q., Wang, J., & Sinclair, A. J. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1044-1 · Cited by 172 · see citing works

Lipidomics of Alzheimer's disease: current status

Wood, P. L. (2012) · Alzheimer's Research &amp; Therapy · doi:10.1186/alzrt103 · Cited by 167 · see citing works

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer’s disease

Astarita, G., Jung, K.-M., Vasilevko, V., DiPatrizio, N. V., Martin, S. K., Cribbs, D. H., Head, E., Cotman, C. W., & Piomelli, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024777 · Cited by 146 · see citing works

Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments

Bartzokis, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.015 · Cited by 142 · see citing works

Lower brain and blood nutrient status in Alzheimer's disease: Results from meta‐analyses

de Wilde, M. C., Vellas, B. J., Girault, E. M., Cetinyurek‐Yavuz, A., & Sijben, J. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.06.002 · Cited by 138 · see citing works

Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism

Paglia, G., Stocchero, M., Cacciatore, S., Lai, S., Angel, P. M., Alam, M. T., Keller, M. A., Ralser, M., & Astarita, G. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b01020 · Cited by 136 · see citing works

Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases

Jo, D. S., Park, N. Y., & Cho, D. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00503-9 · Cited by 135 · see citing works

An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease

Jung, K., Astarita, G., Yaşar, S., Vasilevko, V., Cribbs, D. H., Head, E., Cotman, C. W., & Piomelli, D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.012 · Cited by 132 · see citing works

Targeting Synaptic Dysfunction in Alzheimer’s Disease by Administering a Specific Nutrient Combination

van Wijk, N., Broersen, L. M., de Wilde, M. C., Hageman, R. J. J., Groenendijk, M., Sijben, J. W. C., & Kamphuis, P. J. G. H. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130998 · Cited by 128 · see citing works

Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer’s disease

Heras-Sandoval, D., Pedraza‐Chaverrí, J., & Pérez‐Rojas, J. M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0525-7 · Cited by 121 · see citing works

A Blood-Based, 7-Metabolite Signature for the Early Diagnosis of Alzheimer's Disease

Olazarán, J., Gil‐de‐Gómez, L., Rodríguez‐Martín, A., Valentí, M., Payo, B. F., Marín-Muñoz, J., Antúnez, C., Frank, A., Acedo, C., Gracia, L. M., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142925 · Cited by 116 · see citing works

Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention

Grimm, M. O. W., Michaelson, D. M., & Hartmann, T. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r076331 · Cited by 110 · see citing works

An Emerging Role for Metabolomics in Nutrition Science

Astarita, G., & Langridge, J. (2013) · Lifestyle Genomics · doi:10.1159/000354403 · Cited by 109 · see citing works

Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion

Kitson, A. P., Metherel, A. H., Chen, C. T., Domenichiello, A. F., Trépanier, M., Berger, A., & Bazinet, R. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.009 · Cited by 107 · see citing works

Brain peroxisomes

Trompier, D., Véjux, A., Zarrouk, A., Gondcaille, C., Geillon, F., Nury, T., Savary, S., & Lizard, G. (2013) · Biochimie · doi:10.1016/j.biochi.2013.09.009 · Cited by 99 · see citing works

Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions

Ren, F., Wei, J., Chen, Q., Hu, M., Yu, L., Mi, J., Zhou, X., Qin, D., Wu, J., & Wu, A. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.030 · Cited by 97 · see citing works

Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection

Asatryan, A., & Bazan, N. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.783076 · Cited by 95 · see citing works

Mass Spectrometry Strategies for Clinical Metabolomics and Lipidomics in Psychiatry, Neurology, and Neuro-Oncology

Wood, P. L. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.167 · Cited by 94 · see citing works

Dietary Docosahexaenoic Acid Supplementation in Children With Autism

Voigt, R. G., Mellon, M. W., Katusic, S. K., Weaver, A. L., Matern, D., Mellon, B., Jensen, C. L., & Barbaresi, W. J. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000260 · Cited by 94 · see citing works

Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?

Cunnane, S. C., Chouinard‐Watkins, R., Castellano, C., & Barberger‐Gateau, P. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.04.006 · Cited by 92 · see citing works

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Wu, A., Noble, E. E., Tyagi, E., Ying, Z., Zhuang, Y., & Gómez‐Pinilla, F. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.005 · Cited by 90 · see citing works

Nutritional approaches in the risk reduction and management of Alzheimer's disease

Mi, W., van Wijk, N., Cansev, M., Sijben, J., & Kamphuis, P. J. G. H. (2013) · Nutrition · doi:10.1016/j.nut.2013.01.024 · Cited by 88 · see citing works

Differences in Nutritional Status Between Very Mild Alzheimer's Disease Patients and Healthy Controls

Rikkert, M. G. M. O., Verhey, F. R. J., Sijben, J., Bouwman, F. H., DAUTZENBERG, P. L. J., Lansink, M., Sipers, W. M. W. H., van Asselt, D. Z. B., van Hees, A. M. J., Stevens, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131892 · Cited by 86 · see citing works

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

Bennett, S. A. L., Valenzuela, N., Xu, H., Franko, B., Fai, S., & Figeys, D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00168 · Cited by 86 · see citing works

Alzheimer’s Disease: Pathogenesis and Therapeutic Interventions

Ogbodo, J. O., Agbo, C. P., Njoku, U. O., Ogugofor, M. O., Egba, S. I., Ihim, S. A., Echezona, A. C., Brendan, K. C., Upaganlawar, A. B., & Upasani, C. D. (2021) · Current Aging Science · doi:10.2174/1874609814666210302085232 · Cited by 84 · see citing works

Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease

Cao, M., Li, H., Zhao, J., Cui, J., & Hu, G. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.05.023 · Cited by 80 · see citing works

Alteration of Metabolic Profile and Potential Biomarkers in the Plasma of Alzheimer’s Disease

Shao, Y., Ouyang, Y., Li, T., Liu, X., Xu, X., Li, S., Xu, G., & Le, W. (2020) · Aging and Disease · doi:10.14336/ad.2020.0217 · Cited by 79 · see citing works

The blood‐brain barrier fatty acid transport protein 1 ( FATP 1/ SLC 27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport

Ochiai, Y., Uchida, Y., Ohtsuki, S., Tachikawa, M., Aizawa, S., & Terasaki, T. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13943 · Cited by 74 · see citing works

Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease

Emre, C., Do, K. V., Jun, B., Hjorth, E., Alcalde, S. G., Kautzmann, M.-A. I., Gordon, W. C., Nilsson, P., Bazan, N. G., & Schultzberg, M. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01216-4 · Cited by 71 · see citing works

Roles of the Unsaturated Fatty Acid Docosahexaenoic Acid in the Central Nervous System: Molecular and Cellular Insights

Toledo, A. P., Reyna‐Jeldes, M., Ortega, L., Coddou, C., & Yévenes, G. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105390 · Cited by 71 · see citing works

DHA-PC and DHA-PS improved Aβ1–40 induced cognitive deficiency uncoupled with an increase in brain DHA in rats

Wen, M., Ding, L., Zhang, L., Zhou, M., Xu, J., Wang, J., Wang, Y., & Xue, C. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.004 · Cited by 71 · see citing works

Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids

Torres, M., Parets, S., Fernández-Díaz, J., Beteta-Göbel, R., Rodríguez-Lorca, R., Román, R., Lladó, V., Rosselló, C. A., Fernández‐García, P., & Escribá, P. V. (2021) · Membranes · doi:10.3390/membranes11120919 · Cited by 70 · see citing works

Exercise facilitates the action of dietary DHA on functional recovery after brain trauma

Wu, A. D., Ying, Z., & Gómez‐Pinilla, F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.041 · Cited by 69 · see citing works

Relationship between central and peripheral fatty acids in humans

Guest, J., Garg, M. L., BILGIN, A. A. B., & Grant, R. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-79 · Cited by 69 · see citing works

Lipidomics applications in health, disease and nutrition research

MURPHY, S. A., & Nicolaou, A. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200863 · Cited by 69 · see citing works

New Perspectives on Alzheimer’s Disease and Nutrition

Gustafson, D., Morris, M. C., Scarmeas, N., Shah, R. C., Sijben, J., Yaffe, K. S., & Zhu, X. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150084 · Cited by 69 · see citing works

A nutrient combination that can affect synapse formation

Wurtman, R. (2014) · Nutrients · doi:10.3390/nu6041701 · Cited by 68 · see citing works

Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We?

Chiurchiù, V., Tiberi, M., Matteocci, A., Fazio, F., Siffeti, H., Saracini, S., Mercuri, N. B., & Sancesario, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116235 · Cited by 68 · see citing works

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Torres, M., Price, S. L., Fiol-deRoque, M. A., Marcilla-Etxenike, A., Ahyayauch, H., Barceló‐Coblijn, G., Terés, S., Katsouri, L., Ordinas, M., López, D. J., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.12.016 · Cited by 68 · see citing works

Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?

Chouinard‐Watkins, R., & Plourde, M. (2014) · Nutrients · doi:10.3390/nu6104452 · Cited by 67 · see citing works

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

Kim, J., & Bai, H. (2022) · Antioxidants · doi:10.3390/antiox11020192 · Cited by 64 · see citing works

Peroxisomal dysfunction in neurodegenerative diseases

Jo, D. S., & Cho, D. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01131-2 · Cited by 64 · see citing works

Targeted Metabolomic Analysis in Alzheimer’s Disease Plasma and Brain Tissue in Non-Hispanic Whites

Kalecký, K., German, D. C., Montillo, A., & Bottiglieri, T. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215448 · Cited by 62 · see citing works

Brain targeting with docosahexaenoic acid as a prospective therapy for neurodegenerative diseases and its passage across blood brain barrier

Hachem, M., Belkouch, M., Van, A. L., Picq, M., Bernoud‐Hubac, N., & Lagarde, M. (2020) · Biochimie · doi:10.1016/j.biochi.2020.01.013 · Cited by 61 · see citing works

Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease

Troesch, B., Weber, P., & Mohajeri, M. H. (2016) · Nutrients · doi:10.3390/nu8120803 · Cited by 61 · see citing works

Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD)

Wood, P. L., Locke, V. A., Herling, P., Passaro, A., Vigna, G. B., Volpato, S., Valacchi, G., Cervellati, C., & Zuliani, G. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.11.004 · Cited by 60 · see citing works

Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer’s Disease: Possible Interactions between Amyloid-β and These Lipids

Yamashita, S., Kiko, T., Fujiwara, H., Hashimoto, M., Nakagawa, K., Kinoshita, M., Furukawa, K., Arai, H., & Miyazawa, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150640 · Cited by 59 · see citing works

Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet

Zhou, M., Ding, L., Wen, M., Che, H., Huang, J., Zhang, T., Xue, C., Mao, X., & Wang, Y.-M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.05.009 · Cited by 59 · see citing works

Serum Phosphatidylethanolamine and Lysophosphatidylethanolamine Levels Differentiate Alzheimer’s Disease from Controls and Predict Progression from Mild Cognitive Impairment

Llano, D. A., Initiative, A. D. N., & Devanarayan, V. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201420 · Cited by 58 · see citing works

Sex difference in CHI3L1 expression levels in human brain aging and in Alzheimer’s disease

Sanfilippo, C., Castrogiovanni, P., Imbesi, R., Kazakowa, M., Musumeci, G., Blennow, K., Zetterberg, H., & Rosa, M. D. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146305 · Cited by 56 · see citing works

Fatty Acids: From Membrane Ingredients to Signaling Molecules

Hashimoto, M., & Hossain, S. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.80430 · Cited by 51 · see citing works

Targeting Alzheimer’s Disease: The Critical Crosstalk between the Liver and Brain

Huang, Z., Lin, H. W. (., Zhang, Q., & Zong, X. (2022) · Nutrients · doi:10.3390/nu14204298 · Cited by 50 · see citing works

The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival

Bazan, N. G. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.08.008 · Cited by 50 · see citing works

Neuroprotectin D1 Induces Neuronal Survival and Downregulation of Amyloidogenic Processing in Alzheimer’s Disease Cellular Models

Stark, D. T., & Bazan, N. G. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8174-4 · Cited by 49 · see citing works

The omega-3 hydroxy fatty acid 7( S )-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology

Liu, J., Sahin, C., Ahmad, S., Magomedova, L., Zhang, M., Jia, Z., Metherel, A. H., Orellana, A. J., Poda, G. I., Bazinet, R. P., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abo1857 · Cited by 48 · see citing works

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

Pinçon, A., de Montgolfier, O., Akkoyunlu, N., Daneault, C., Pouliot, P., Villeneuve, L. R., Lesage, F., Levy, B. I., Thorin‐Trescases, N., Thorin, É., et al. (2019) · Metabolites · doi:10.3390/metabo9050104 · Cited by 47 · see citing works

Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer’s Disease Dementia

Bottero, V., & Potashkin, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215403 · Cited by 46 · see citing works

Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer’s disease

Rijpma, A., Meulenbroek, O., van Hees, A. M. J., Sijben, J., Vellas, B. J., Shah, R. C., Bennett, D. A., Scheltens, P., & Rikkert, M. G. M. O. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0134-1 · Cited by 44 · see citing works

Towards a whole-body systems [multi-organ] lipidomics in Alzheimer’s disease

Astarita, G., & Piomelli, D. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.021 · Cited by 43 · see citing works

Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition

Ooi, K.-L. M., Vacy, K., & Boon, W. C. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105143 · Cited by 41 · see citing works

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline

Hennebelle, M., Plourde, M., Chouinard‐Watkins, R., Castellano, C., Barberger‐Gateau, P., & Cunnane, S. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003625 · Cited by 40 · see citing works

Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome

Filho, A. J. M. C., Braniff, O., Angelova, A., Deng, Y., & Tremblay, M. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110702 · Cited by 39 · see citing works

The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging

Hancock, S. E., Friedrich, M. G., Mitchell, T. W., Truscott, R. J. W., & Else, P. L. (2017) · GeroScience · doi:10.1007/s11357-017-9961-2 · Cited by 39 · see citing works

Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease

Wood, P. L., Smith, T. M., Lane, N., Khan, M. A., Ehrmantraut, G., & Goodenowe, D. B. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-227 · Cited by 38 · see citing works

Lipids and brain inflammation in APOE4-associated dementia

Duro, M. V. V., Ebright, B., & Yassine, H. N. (2021) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000801 · Cited by 38 · see citing works

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau

Kling, M. A., Goodenowe, D. B., Senanayake, V. K., MahmoudianDehkordi, S., Arnold, M., Massaro, T., Baillie, R., Han, X., Leung, Y. Y., Saykin, A. J., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12110 · Cited by 36 · see citing works

The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease

Ehtezazi, T., Rahman, K., Davies, R., & Leach, A. G. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220071 · Cited by 35 · see citing works

Regioisomers of Phosphatidylcholine Containing DHA and Their Potential to Deliver DHA to the Brain: Role of Phospholipase Specificities

Chen, S., & Subbaiah, P. V. (2013) · Lipids · doi:10.1007/s11745-013-3791-5 · Cited by 35 · see citing works

Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review

Skender, B., Vaculová, A. H., & Hofmanová, J. (2012) · Biomedical Papers · doi:10.5507/bp.2012.093 · Cited by 35 · see citing works

High throughput multiorgan metabolomics in the APP/PS1 mouse model of Alzheimer's disease

González‐Domínguez, R., García‐Barrera, T., Vitórica, J., & Gómez‐Ariza, J. L. (2015) · Electrophoresis · doi:10.1002/elps.201400544 · Cited by 34 · see citing works

The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy

Torres, M., Rosselló, C. A., Fernández‐García, P., Lladó, V., Kakhlon, O., & Escribá, P. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072322 · Cited by 33 · see citing works

Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure

Warstadt, N. M., Dennis, E. L., Jahanshad, N., Omid Kohannim, A., Nir, T. M., McMahon, K. L., de Zubicaray, G. I., Montgomery, G. W., Henders, A. K., Martin, N. G., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.024 · Cited by 33 · see citing works

A blood‐based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

Bowman, G. L., Dodge, H. H., Guyonnet, S., Zhou, N., Donohue, J., Bichsel, A., Schmitt, J. A. J., Hooper, C., Bartfai, T., Andrieu, S., et al. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.11.004 · Cited by 32 · see citing works

The essential nature of dietary omega-3 fatty acids in dogs

Bauer, J. E. (2016) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.249.11.1267 · Cited by 32 · see citing works

Modulations of bioactive lipids and their receptors in postmortem Alzheimer’s disease brains

Kurano, M., Saito, Y., Uranbileg, B., Saigusa, D., Kano, K., Aoki, J., & Yatomi, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1066578 · Cited by 30 · see citing works

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Pan, Y., Omori, K., Ali, I., Tachikawa, M., Terasaki, T., Brouwer, K. L. R., & Nicolazzo, J. A. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00500 · Cited by 30 · see citing works

Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia

van Wijk, N., Slot, R. E. R., Duits, F. H., Strik, M., Biesheuvel, E., Sijben, J., Blankenstein, M. A., Bierau, J., van der Flier, W. M., Scheltens, P., et al. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.04.005 · Cited by 29 · see citing works

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Puris, E., Auriola, S. O. K., Petralla, S., Hartman, R., Gynther, M., de Lange, E. C. M., & Fricker, G. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105741 · Cited by 29 · see citing works

Healthy brain ageing and cognition: Nutritional factors

Vandewoude, M. F. J., Barberger‐Gateau, P., Cederholm, T., Mecocci, P., Salvà, A., Sergi, G., Topinková, E., & van Asselt, D. (2016) · European Geriatric Medicine · doi:10.1016/j.eurger.2015.12.005 · Cited by 28 · see citing works

Lipidomics of Alzheimer’s disease: a liver peroxisomal dysfunction in the metabolism of omega-3 fatty acids

Astarita, G., & Piomelli, D. (2011) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2011.0387 · Cited by 2 · see citing works

P3‐011: Omega‐3 fatty acid deficit in Alzheimer's disease

Astarita, G., Head, E., Cotman, C. W., & Piomelli, D. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.1188

Towards a whole-body systems [multi-organ] lipidomics in Alzheimer’s disease

Astarita, G., & Piomelli, D. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.021 · Cited by 43 · see citing works

The pivotal roles of docosahexaenoic acid in the evolution and function of the brain

Crawford, M. A. (2013) · Journal of Alzheimer’s Disease & Parkinsonism

Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended

Cunnane, S. C., Plourde, M., Vandal, M., Freemantle, E., Tremblay‐Mercier, J., & Bégin, M. E. (2007) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2007.0118 · Cited by 8 · see citing works