The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine
Open accessAbstract
Understanding the functions of proteins requires information about their protein-protein interactions (PPI). The collective effort of the scientific community generates far more data on any given protein than individual experimental approaches. The latter are often too limited to reveal an interactome comprehensively. We developed a workflow for parallel mining of all major PPI databases, containing data from several model organisms, and to integrate data from the literature for a protein of interest. We applied this novel approach to build the PPI network of the human Hsp90 molecular chaperone machine (Hsp90Int) for which previous efforts have yielded limited and poorly overlapping sets of interactors. We demonstrate the power of the Hsp90Int database as a discovery tool by validating the prediction that the Hsp90 co-chaperone Aha1 is involved in nucleocytoplasmic transport. Thus, we both describe how to build a custom database and introduce a powerful new resource for the scientific community.
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Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Hierarchical Organization of Modularity in Metabolic Networks
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HSP90 at the hub of protein homeostasis: emerging mechanistic insights
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Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches
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Self-citationGaligniana, M. D., Echeverría, P. C., Erlejman, A. G., & Piwien-Pilipuk, G. (2010) · Nucleus · doi:10.4161/nucl.1.4.11743 · Cited by 114
Self-citationNovel Hsp90 partners discovered using complementary proteomic approaches
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Cited by
Schopf, F. H., Biebl, M. M., & Buchner, J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.20 · Cited by 1,540
Polypharmacology: Challenges and Opportunities in Drug Discovery: Miniperspective
Anighoro, A., Bajorath, J., & Rastelli, G. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5006463 · Cited by 1,131
Regulation and function of the human HSP90AA1 gene
Zuehlke, A. D., Beebe, K., Neckers, L., & Prince, T. (2015) · Gene · doi:10.1016/j.gene.2015.06.018 · Cited by 347
Dual or multi-targeting inhibitors: The next generation anticancer agents
Raghavendra, N. M., Pingili, D., Kadasi, S., Mettu, A., & Prasad, S. V. U. M. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.021 · Cited by 333
Structure, Function, and Regulation of the Hsp90 Machinery
Biebl, M. M., & Buchner, J. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034017 · Cited by 304
Metadata
- Authors
- Echeverría, P. C., Bernthaler, A., Dupuis, P., Mayer, B., & Picard, D.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-10-11
- Volume
- 6
- Issue
- 10
- Pages
- e26044
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2030858953
- Cited by
- 251
- References
- 10
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- Echeverría, P. C., Bernthaler, A., Dupuis, P., Mayer, B., & Picard, D. (2011). An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine. PLoS ONE. https://doi.org/10.1371/journal.pone.0026044
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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