Cited by 411Cannabis and Cannabinoid ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

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Esposito, Giuseppe, Scuderi, Caterina, Valenza, Marta, Togna, Giuseppina Ines, Latina, Valentina, De Filippis, Daniele, Cipriano, Mariateresa, Carratù, Maria Rosaria, Iuvone, Teresa, Steardo, Luca·2011·PLoS ONE

DOI 10.1371/journal.pone.0028668PMC PMC3230631

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Abstract

Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at exploring whether CBD effects could be subordinate to its activity at PPARγ, which has been recently indicated as its putative binding site. CBD actions on β-amyloid-induced neurotoxicity in rat AD models, either in presence or absence of PPAR antagonists were investigated. Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage. Moreover, due to its interaction at PPARγ, CBD was observed to stimulate hippocampal neurogenesis. All these findings report the inescapable role of this receptor in mediating CBD actions, here reported.

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“In vivo, CBD has shown attenuation of Aβ-induced neuroinflammatory responses by minimizing proinflammatory gene and mediator expression, as well as minimized reactive gliosis [187,190].”
Background
CBD and THC in Special Populations: Pharmacokinetics and Drug–Drug Interactions
Qian, L., Beers, J. L., Jackson, K. D., & Zhou, Z. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040484 · Cited by 30
Cannabidiol Confers Neuroprotection in Rats in a Model of Transient Global Cerebral Ischemia: Impact of Hippocampal Synaptic Neuroplasticity
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Authors: Esposito, G., Scuderi, C., Valenza, M., Togna, G. I., Latina, V., De Filippis, D., Cipriano, M., Carratù, M. R., Iuvone, T., & Steardo, L.
Affiliations: Sapienza University of Rome (IT)
University of Bari Aldo Moro (IT)
University of Naples Federico II (IT)
Corresponding author: Steardo, Luca
ORCID: Esposito, Giuseppe
Scuderi, Caterina
Valenza, Marta
Latina, Valentina
Cipriano, Mariateresa
Carratù, Maria Rosaria
Steardo, Luca
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2011-12-05
Volume: 6
Issue: 12
Pages: e28668
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0028668
PMC: PMC3230631
OpenAlex: W2107076749
Cited by: 410
References: 41
Citations by year: 2026: 23 · 2025: 24 · 2024: 53 · 2023: 41 · 2022: 49 · 2021: 48 · 2020: 45 · 2019: 22 · 2018: 18 · 2017: 26 · 2016: 16 · 2015: 13 · 2014: 8 · 2013: 13 · 2012: 10
FWCI: 7.26
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: cannabidiol, PPARγ, Alzheimer's disease, amyloid-beta, neuroinflammation, hippocampal neurogenesis, reactive gliosis, neuroprotection, PPARγ antagonist, neurotoxicity
MeSH terms: Animals, Astrocytes, Binding Sites, Brain, Cannabidiol, Hippocampus, Inflammation, Male, Neurons, Nitric Oxide, Protein Binding, Time Factors, Amyloid beta-Peptides, Rats, Sprague-Dawley, Protein Structure, Tertiary, PPAR gamma, Rats, Neurogenesis

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Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

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