Cited by 253Stress Responses and CortisolNerve injury and regenerationMemory and Neural Mechanisms

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Stress Leads to Contrasting Effects on the Levels of Brain Derived Neurotrophic Factor in the Hippocampus and Amygdala

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Lakshminarasimhan, Harini, Chattarji, Sumantra·2012·PLoS ONE

DOI 10.1371/journal.pone.0030481PMC PMC3260293

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Abstract

Recent findings on stress induced structural plasticity in rodents have identified important differences between the hippocampus and amygdala. The same chronic immobilization stress (CIS, 2 h/day) causes growth of dendrites and spines in the basolateral amygdala (BLA), but dendritic atrophy in hippocampal area CA3. CIS induced morphological changes also differ in their temporal longevity--BLA hypertrophy, unlike CA3 atrophy, persists even after 21 days of stress-free recovery. Furthermore, a single session of acute immobilization stress (AIS, 2 h) leads to a significant increase in spine density 10 days, but not 1 day, later in the BLA. However, little is known about the molecular correlates of the differential effects of chronic and acute stress. Because BDNF is known to be a key regulator of dendritic architecture and spines, we investigated if the levels of BDNF expression reflect the divergent effects of stress on the hippocampus and amygdala. CIS reduces BDNF in area CA3, while it increases it in the BLA of male Wistar rats. CIS-induced increase in BDNF expression lasts for at least 21 days after the end of CIS in the BLA. But CIS-induced decrease in area CA3 BDNF levels, reverses to normal levels within the same period. Finally, BDNF is up regulated in the BLA 1 day after AIS and this increase persists even 10 days later. In contrast, AIS fails to elicit any significant change in area CA3 at either time points. Together, these findings demonstrate that both acute and chronic stress trigger opposite effects on BDNF levels in the BLA versus area CA3, and these divergent changes also follow distinct temporal profiles. These results point to a role for BDNF in stress-induced structural plasticity across both hippocampus and amygdala, two brain areas that have also been implicated in the cognitive and affective symptoms of stress-related psychiatric disorders.

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Authors: Lakshminarasimhan, H., & Chattarji, S.
Affiliations: Tata Institute of Fundamental Research (IN)
Corresponding author: Chattarji, Sumantra
ORCID: Chattarji, Sumantra
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2012-01-17
Volume: 7
Issue: 1
Pages: e30481
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0030481
PMC: PMC3260293
OpenAlex: W2058006510
Cited by: 253
References: 42
Citations by year: 2026: 11 · 2025: 13 · 2024: 12 · 2023: 15 · 2022: 16 · 2021: 29 · 2020: 19 · 2019: 14 · 2018: 18 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 24 · 2013: 16 · 2012: 8
FWCI: 8.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Wellcome Trust (GR 0701339 MA)
Directorate for Biological Sciences
National Centre for Biological Sciences
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: brain-derived neurotrophic factor, restraint stress, chronic stress, acute stress, hippocampus, amygdala, basolateral amygdala, CA3, dendritic spine density, dendritic atrophy, structural plasticity, stress recovery, stress-related psychiatric disorders
MeSH terms: Amygdala, Animals, Body Weight, Hippocampus, Immunoassay, Male, Restraint, Physical, Stress, Physiological, Stress, Psychological, Time Factors, Rats, Wistar, Brain-Derived Neurotrophic Factor, Rats, CA3 Region, Hippocampal

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Stress Leads to Contrasting Effects on the Levels of Brain Derived Neurotrophic Factor in the Hippocampus and Amygdala

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