Medication Adherence in Type 2 Diabetes: The ENTRED Study 2007, a French Population-Based Study
Open accessAbstract
BACKGROUND: Adherence to prescribed medications is a key dimension of healthcare quality. The aim of this large population-based study was to evaluate self-reported medication adherence and to identify factors linked with poor adherence in patients with type 2 diabetes in France. METHODOLOGY: The ENTRED study 2007, a French national survey of people treated for diabetes, was based on a representative sample of patients who claimed reimbursement for oral hypoglycaemic agents and/or insulin at least three times between August 2006 and July 2007, and who were randomly selected from the database of the two main National Health Insurance Systems. Medication adherence was determined using a six-item self-administered questionnaire. A multinomial polychotomous logistic regression model was used to identify factors associated with medication adherence in the 3,637 persons with type 2 diabetes. PRINCIPAL FINDINGS: Thirty nine percent of patients reported good medication adherence, 49% medium adherence and 12% poor adherence. The factors significantly associated with poor adherence in multivariate analysis were socio-demographic factors: age <45 years, non-European geographical origin, financial difficulties and being professionally active; disease and therapy-related factors: HbA(1c)>8% and existing diabetes complications; and health care-related factors: difficulties for taking medication alone, decision making by the patient only, poor acceptability of medical recommendations, lack of family or social support, need for information on treatment, reporting no confidence in the future, need for medical support and follow-up by a specialist physician. CONCLUSIONS: In a country with a high level of access to healthcare, our study demonstrated a substantial low level of medication adherence in type 2 diabetic patients. Better identification of those with poor adherence and individualised suitable recommendations remain essential for better healthcare management.
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Poor adherence to insulin administration is common in patients with diabetes, with up to half reporting poor adherence and one-third reporting insulin omission.
“Among factors that could explain the low rate of optimal response to insulin therapy, poor adherence to insulin administration has been reported in up to half of patients with diabetes,7-9 with one-third of patients reporting an average of 3 episodes of insulin omission within the previous month.8,10”
From Efficacy of a Smart Insulin Pen Cap for the Management of Patients with Uncontrolled Type 2 Diabetes: A Randomized Cross-Over Trial (2023) · cites this paper as [9]
The Results (Medication adherence; page unavailable) report that 39% of patients had good medication adherence, supporting the general point that suboptimal adherence is common. The paper does not give an insulin-administration-specific estimate of up to half. The insulin-omission figure is attached to other citations in the citing sentence, not to this paper. (LLM, conf=0.85)
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- Authors
- Tiv, M., Viel, J.-F., Mauny, F., Eschwège, E., Weill, A., Fournier, C., Fagot-Campagna, A., & Penfornis, A.
- Affiliations
- Centre Hospitalier Universitaire de Besançon (FR)
- Inserm (FR)
- l'Assurance Maladie (FR)
- Institut National de Prévention et d’Education pour la Santé (FR)
- Corresponding author
- Penfornis, Alfred
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-05
- Volume
- 7
- Issue
- 3
- Pages
- e32412
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3293796
- OpenAlex
- W2072979222
- Cited by
- 245
- References
- 43
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 17 · 2021: 20 · 2020: 20 · 2019: 20 · 2018: 23 · 2017: 20 · 2016: 24 · 2015: 23 · 2014: 20 · 2013: 15 · 2012: 6
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institut de Veille Sanitaire
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- medication adherence, type 2 diabetes, self-reported adherence, oral antidiabetic drugs, insulin, HbA1c, diabetes complications, sociodemographic factors, financial hardship, family and social support, patient decision-making, health care access
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Female, France, Humans, Male, Middle Aged, Risk Factors, Multivariate Analysis, Drug Monitoring, Young Adult, Self Report
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