The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cryptic Distant Relatives Are Common in Both Isolated and Cosmopolitan Genetic Samples
Open accessAbstract
Although a few hundred single nucleotide polymorphisms (SNPs) suffice to infer close familial relationships, high density genome-wide SNP data make possible the inference of more distant relationships such as 2(nd) to 9(th) cousinships. In order to characterize the relationship between genetic similarity and degree of kinship given a timeframe of 100-300 years, we analyzed the sharing of DNA inferred to be identical by descent (IBD) in a subset of individuals from the 23andMe customer database (n = 22,757) and from the Human Genome Diversity Panel (HGDP-CEPH, n = 952). With data from 121 populations, we show that the average amount of DNA shared IBD in most ethnolinguistically-defined populations, for example Native American groups, Finns and Ashkenazi Jews, differs from continentally-defined populations by several orders of magnitude. Via extensive pedigree-based simulations, we determined bounds for predicted degrees of relationship given the amount of genomic IBD sharing in both endogamous and 'unrelated' population samples. Using these bounds as a guide, we detected tens of thousands of 2(nd) to 9(th) degree cousin pairs within a heterogenous set of 5,000 Europeans. The ubiquity of distant relatives, detected via IBD segments, in both ethnolinguistic populations and in large 'unrelated' populations samples has important implications for genetic genealogy, forensics and genotype/phenotype mapping studies.
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Citations
Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
A second generation human haplotype map of over 3.1 million SNPs
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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
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“[36] suggest that a large sample of individuals with European ancestry is likely to include many pairs of 2 through 9 cousins.”
InfluentialRapid, global demographic expansions after the origins of agriculture
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Cited by
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
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The genetic ancestry of African Americans, Latinos, and European Americans across the United States
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Self-citationGazal, S., Finucane, H. K., Furlotte, N. A., Loh, P.-R., Palamara, P. F., Liu, X., Schoech, A., Bulik-Sullivan, B., Neale, B. M., Gusev, A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3954 · Cited by 525
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
Moreno-Estrada, A., Gignoux, C. R., Fernández-López, J. C., Zakharia, F., Sikora, M., Contreras, A. V., Acuña-Alonzo, V., Sandoval, K., Eng, C., Romero-Hidalgo, S., et al. (2014) · Science · doi:10.1126/science.1251688 · Cited by 478
Metadata
- Authors
- Henn, B. M., Hon, L., Macpherson, J. M., Eriksson, N., Saxonov, S., Pe'er, I., & Mountain, J. L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-03
- Volume
- 7
- Issue
- 4
- Pages
- e34267
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2019512405
- Cited by
- 204
- References
- 9
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- gold
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