The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Auditory Resting-State Network Connectivity in Tinnitus: A Functional MRI Study
Open accessAbstract
The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI "resting-state" connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress leading to disabling chronic tinnitus.
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Cites
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Consistent resting-state networks across healthy subjects
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Cited by
Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment
Shore, S. E., Roberts, L. E., & Langguth, B. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.12 · Cited by 474
Central gain control in tinnitus and hyperacusis
Auerbach, B. D., Rodrigues, P. V., & Salvi, R. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00206 · Cited by 439
De Ridder, D., Vanneste, S., Weisz, N., Londero, A., Schlee, W., Elgoyhen, A. B., & Langguth, B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.021 · Cited by 398
Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus
De Ridder, D., Vanneste, S., Langguth, B., & Llinas, R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00124 · Cited by 279
Frontostriatal Gating of Tinnitus and Chronic Pain
Rauschecker, J. P., May, E. S., Maudoux, A., & Ploner, M. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.08.002 · Cited by 253
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Metadata
- Authors
- Maudoux, A., Lefebvre, P., Cabay, J.-E., Demertzi, A., Vanhaudenhuyse, A., Laureys, S., & Soddu, A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-05-04
- Volume
- 7
- Issue
- 5
- Pages
- e36222
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2072941199
- Cited by
- 221
- References
- 10
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- gold
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