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Cited by 474

The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.

Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

Open access
Shore, Susan E., Roberts, Larry E., Langguth, Berthold·2016·Nature Reviews Neurology
DOI 10.1038/nrneurol.2016.12
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Abstract

Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with hearing loss caused by ageing or noise exposure. Exposure to loud recreational sound is common among the young, and this group are at increasing risk of developing tinnitus. Head or neck injuries can also trigger the development of tinnitus, as altered somatosensory input can affect auditory pathways and lead to tinnitus or modulate its intensity. Emotional and attentional state could be involved in the development and maintenance of tinnitus via top-down mechanisms. Thus, military personnel in combat are particularly at risk owing to combined risk factors (hearing loss, somatosensory system disturbances and emotional stress). Animal model studies have identified tinnitus-associated neural changes that commence at the cochlear nucleus and extend to the auditory cortex and other brain regions. Maladaptive neural plasticity seems to underlie these changes: it results in increased spontaneous firing rates and synchrony among neurons in central auditory structures, possibly generating the phantom percept. This Review highlights the links between animal and human studies, and discusses several therapeutic approaches that have been developed to target the neuroplastic changes underlying tinnitus.

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Citations

Cites

Show all 147 references

Research works printed but not linked: 22

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Metadata

Authors
Shore, S. E., Roberts, L. E., & Langguth, B.
Venue
Nature Reviews Neurology
Publisher
Springer Science and Business Media LLC
Published
2016-02-12
Volume
12
Issue
3
Pages
150-160
ISSN
  • 1759-4758 (ISSN-L)
  • 1759-4766
DOI
10.1038/nrneurol.2016.12
OpenAlex
W2252713678
Cited by
474
References
147
FWCI
5.46
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment. https://app.cochat.ai/papers/10.1038/nrneurol.2016.12
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Shore, S. E., Roberts, L. E., & Langguth, B. (2016). Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment. Nature Reviews Neurology. https://doi.org/10.1038/nrneurol.2016.12

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