Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults
Open accessAbstract
Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
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Studies using multiple proteomic technologies have shown that thousands of proteins change with age in human plasma and cerebrospinal fluid.
“Studies using multiple proteomic technologies have shown that thousands of proteins change with age in human plasma91–93 and cerebrospinal fluid94, which has recently led to the development of multiple proteomic ageing clocks.”
From Measuring biological age using omics data (2022) · cites this paper as [93]
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- Authors
- Lu, J., Huang, Y., Wang, Y., Li, Y., Zhang, Y., Wu, J., Zhao, F., Meng, S., Yu, X., Ma, Q., Song, M., Chang, N., Bittles, A. H., & Wang, W.
- Affiliations
- Capital Medical University (CN)
- Beijing Haidian Hospital (CN)
- Beijing Hospital (CN)
- Edith Cowan University (AU)
- Corresponding author
- Song, Manshu
- Chang, Naibai
- Wang, Wei
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-07-03
- Volume
- 7
- Issue
- 7
- Pages
- e39726
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3389038
- OpenAlex
- W2154730276
- Cited by
- 33
- References
- 45
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 4 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Australasian Journal of Paramedicine (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (31070727, 81001281, 2011CB503806, 30901238, 2012BAI37B03)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- aging biomarkers, plasma peptides, age-related protein changes, apolipoprotein A-I, albumin degradation
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Female, Fibrinogen, Humans, Male, Middle Aged, Peptides, Serum Albumin, Biomarkers, Apolipoprotein A-I, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Transcriptome
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