The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
Open accessAbstract
Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level.
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Molecular properties that influence the oral bioavailability of drug candidates
Veber, D. F., Johnson, S. R., Cheng, H.-Y., Smith, B. R., Ward, K. W., & Kopple, K. D. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020017n · Cited by 8,420
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
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Mechanisms of glucocorticoid receptor signaling during inflammation
Smoak, K. A., & Cidlowski, J. A. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.010 · Cited by 420
Cited by
Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment
Zhang, R., Zhu, X., Bai, H., & Ning, K. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00123 · Cited by 1,257
Zhou, X., Seto, S. W., Chang, D., Kiat, H., Razmovski-Naumovski, V., Chan, K., & Bensoussan, A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00201 · Cited by 538
Liu, H., Wang, J., Zhou, W., Wang, Y., & Yang, L. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.02.004 · Cited by 326
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Metadata
- Authors
- Li, X., Xu, X., Wang, J., Yu, H., Wang, X., Yang, H., Xu, H., Tang, S., Li, Y., Yang, L., Huang, L., Wang, Y., & Yang, S.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-09-04
- Volume
- 7
- Issue
- 9
- Pages
- e43918
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2064822275
- Cited by
- 189
- References
- 4
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, X., Xu, X., Wang, J., Yu, H., Wang, X., Yang, H., Xu, H., Tang, S., Li, Y., Yang, L., Huang, L., Wang, Y., & Yang, S. (2012). A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment. PLoS ONE. https://doi.org/10.1371/journal.pone.0043918
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