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Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta

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Mitochondrial Dysfunction and Its Relationship with mTOR Signaling and Oxidative Damage in Autism Spectrum Disorders

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Enhanced Th2 cell differentiation and function in the absence of Nox2

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Loss of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation

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A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance

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Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity

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Total Ginsenosides of Radix Ginseng Modulates Tricarboxylic Acid Cycle Protein Expression to Enhance Cardiac Energy Metabolism in Ischemic Rat Heart Tissues

Wang, J. R., Zhou, H., Yi, X. Q., Jiang, Z., & Liu, L. (2012) · Molecules · doi:10.3390/molecules171112746 · Cited by 35 · see citing works

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

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Metabolic Effects of Recurrent Genetic Aberrations in Multiple Myeloma

Bloedjes, T. A., de Wilde, G., & Guikema, J. E. J. (2021) · Cancers · doi:10.3390/cancers13030396 · Cited by 32 · see citing works

Breast adipose tissue‐derived extracellular vesicles from obese women alter tumor cell metabolism

Liu, S., Benito‐Martín, A., Vatter, F. A. P., Hanif, S. Z., Liu, C., Bhardwaj, P., Sethupathy, P., Farghli, A. R., Piloco, P., Paik, P. K., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357339 · Cited by 31 · see citing works

Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway

Li, L., Liu, L., Qu, B., Li, X., Gao, X., & Zhang, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.130 · Cited by 30 · see citing works

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

Chatterjee, N., Pazarentzos, E., Mayekar, M. K., Gui, P., Allegakoen, D. V., Hrustanovic, G., Olivas, V. R., Lin, L., Verschueren, E., Johnson, J. R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.063 · Cited by 26 · see citing works

Targeting the Metabolic Paradigms in Cancer and Diabetes

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Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

Weber, A., Klocker, H., Oberacher, H., Gnaiger, E., Neuwirt, H., Sampson, N., & Eder, I. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072129 · Cited by 26 · see citing works

Drosophila melanogaster : An emerging model of transgenerational effects of maternal obesity

Brookheart, R. T., & Duncan, J. G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.003 · Cited by 25 · see citing works

A ketogenic amino acid rich diet benefits mitochondrial homeostasis by altering the AKT/4EBP1 and autophagy signaling pathways in the gastrocnemius and soleus

Li, J., Kanasaki, M., Xu, L., Kitada, M., Nagao, K., Adachi, Y., Jinzu, H., Noguchi, Y., Kohno, M., Kanasaki, K., et al. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.03.013 · Cited by 24 · see citing works

Modulation of mitochondrial respiration underpins neuronal differentiation enhanced by lutein

Xie, K., Ngo, S., Rong, J., & Sheppard, A. M. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.243713 · Cited by 23 · see citing works

Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop

Kiselev, V. Y., Juvin, V., Malek, M., Luscombe, N. M., Hawkins, P. T., Novère, N. G. L., & Stephens, L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1015 · Cited by 23 · see citing works

PTEN promotes apoptosis of H2O2‑injured rat nasal epithelial cells through PI3K/Akt and other pathways

Jia, M., Chen, X., Jili, L., & Chen, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7912 · Cited by 23 · see citing works

miR‐21a negatively modulates tumor suppressor genes PTEN and miR‐200c and further promotes the transformation of M2 macrophages

Li, N., Qin, J., Han, X., Jin, F., Zhang, J., Lan, L., & Wang, Y. (2017) · Immunology and Cell Biology · doi:10.1111/imcb.1016 · Cited by 23 · see citing works

Larger improvements in fatigue resistance and mitochondrial function with high‐ than with low‐intensity contractions during interval training of mouse skeletal muscle

Yamada, T., Kimura, I., Ashida, Y., Tamai, K., Fusagawa, H., Tohse, N., Westerblad, H., Andersson, D. C., & Sato, T. (2021) · The FASEB Journal · doi:10.1096/fj.202101204r · Cited by 22 · see citing works

The consequences of increased 4E-BP1 in polycystic kidney disease

Holditch, S. J., Brown, C. N., Atwood, D. J., Pokhrel, D., Brown, S., Lombardi, A. M., Nguyen, K. N., Hill, R. C., Lanaspa, M. A., Hopp, K., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz244 · Cited by 21 · see citing works

PTEN: A Thrifty Gene That Causes Disease in Times of Plenty?

Venniyoor, A. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00081 · Cited by 20 · see citing works

Ethanol extract of Ligustrum lucidum Ait. leaves suppressed hepatocellular carcinoma in vitro and in vivo

Tian, G., Chen, J., Luo, Y., Yang, J., Gao, T., & Shi, J. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0960-5 · Cited by 19 · see citing works

A novel de novo MTOR gain-of-function variant in a patient with Smith-Kingsmore syndrome and Antiphospholipid syndrome

Rodríguez‐García, M. E., Cotrina‐Vinagre, F. J., Bellusci, M., de Aragón, A. M., Hernández-Sánchez, L. C., Carnicero‐Rodríguez, P., Martín‐Hernández, E., & Martínez‐Azorín, F. (2019) · European Journal of Human Genetics · doi:10.1038/s41431-019-0418-1 · Cited by 19 · see citing works

PTEN Regulates Mitochondrial Biogenesis via the AKT/GSK-3β/PGC-1α Pathway in Autism

Feng, C., Chen, Y., Zhang, Y., Yan, Y., Yang, M., Gui, H., & Wang, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.010 · Cited by 18 · see citing works

A superoxide-driven redox state promotes geroconversion and resistance to senolysis in replication-stress associated senescence

Luo, L., Pervaiz, S., & Clement, M. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102757 · Cited by 17 · see citing works

Selective elimination of neuroblastoma cells by synergistic effect of Akt kinase inhibitor and tetrathiomolybdate

Navrátilová, J., Karasová, M., Lánová, M. K., Moráňová, L., Budková, Z., Pachernı́k, J., Šmarda, J., & Beneš, P. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13106 · Cited by 17 · see citing works

Modulation of intracellular kinase signaling to improve TIL stemness and function for adoptive cell therapy

Feng, H., Qiu, L., Shi, Z., Yao, S., Zhao, P., Zhou, D., Li, F., Yu, H., You, Y., Wang, H., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.5095 · Cited by 16 · see citing works

Evaluation of differentially expressed microRNAs in vitrified oocytes by next generation sequencing

Li, J., Yang, X., Liu, F., Song, Y., & Liu, Y. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.05.006 · Cited by 16 · see citing works

Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury

zu Reckendorf, C. M., Moser, D., Blechschmidt, A., Joga, V. N., Sinske, D., Hegler, J., Deininger, S., Catanese, A., Vettorazzi, S., Antoniadis, G., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1305-21.2022 · Cited by 15 · see citing works

Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells

Faccio, A. T., Rupérez, F. J., Singh, N., Angulo, S., Tavares, M. F. M., Bernier, M., Barbas, C., & Wainer, I. W. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.03.008 · Cited by 13 · see citing works

The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity

Sardo, F. L., Turco, C., Messina, B., Sacconi, A., Auciello, F. R., Pulito, C., Strano, S., Lev, S., & Blandino, G. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02216-8 · Cited by 12 · see citing works

Activated PI3K/AKT Signaling Pathway Associates with Oxidative Stress and Impaired Developmental Potential of Vitrified-Thawed Oocytes

Li, J., Yang, X., Liu, F., Song, Y., & Liu, Y. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00036-1 · Cited by 12 · see citing works

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background

Wolf, T., Qi, W., Schindler, V., Runkel, E. D., & Baumeister, R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.04.002 · Cited by 11 · see citing works

Immune senescence in multiple myeloma—a role for mitochondrial dysfunction?

Seymour, F., Carmichael, J., Taylor, C., Parrish, C., & Cook, G. (2022) · Leukemia · doi:10.1038/s41375-022-01653-7 · Cited by 11 · see citing works

Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues

Callaghan, N. I., Durland, L. J., Ireland, R. G., Santerre, J. P., Simmons, C. A., & Huyer, L. D. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00246-3 · Cited by 10 · see citing works

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver

Spormann, L., Rennert, C., Kolbe, E., Ott, F., Lossius, C., Lehmann, R., Gebhardt, R., Berg, T., & Matz‐Soja, M. (2020) · Cells · doi:10.3390/cells9081817 · Cited by 10 · see citing works

20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells

Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works

gRASping the redox lever to modulate cancer cell fate signaling

Foo, C. H. J., & Pervaiz, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101094 · Cited by 6 · see citing works

BRUCE liver-KO enhances MASLD/MASH development in the steatotic PTEN-KO background by impairing mitochondrial metabolism and activating STAT3

Che, L., Stevenson, C., Plas, D. R., Wang, J., & Du, C. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08294-5 · Cited by 4 · see citing works

PI3K/Akt/mTOR signaling pathway mediates energy metabolic reprogramming and regulates mitochondrial homeostasis in host cells exposed to Toxoplasma gondii

Xu, K., Zhu, S., Ma, J., Zu, M., Yang, J., Xu, F., Dai, L., Liu, D., Wang, Y., Zhang, X., et al. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01385-25 · Cited by 4 · see citing works

A composite arctigenin/caffeine/glucose formulation enhances anti-fatigue effect

Zeng, W., Sun, L., Zhu, H., Wu, X., Xu, L., & Xu, L. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101878 · Cited by 4 · see citing works

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolismPreprint

Liu, S., Benito‐Martín, A., Vatter, F. A. P., Hanif, S. Z., Liu, C., Bhardwaj, P., Sethupathy, P., Farghli, A. R., Piloco, P., Paik, P. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.08.527715 · Cited by 4 · see citing works

Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial Respiration in Myeloblasts of Acute Myeloid Leukemia

Jang, Y., Koh, J. S., Park, J.-H., Choi, S., Pham, D. A. T., Heo, B., Lee, S. W., Kim, J. Y., Lee, M.-W., Kim, S.-H., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042140 · Cited by 4 · see citing works

The Mammary Tumor Microenvironment

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Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN

Hamuro, J., Yamashita, T., Otsuki, Y., Hiramoto, N., Adachi, M., Miyatani, T., Tanaka, H., Ueno, M., Kinoshita, S., & Sotozono, C. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.5.9 · Cited by 3 · see citing works

Metabolic Pathways of Eukaryotes and Connection to Cell Mechanics

Mierke, C. T. (2020) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-030-58532-7_17 · Cited by 2 · see citing works

DNAJA1 positively regulates amino acid‐stimulated milk protein and fat synthesis in bovine mammary epithelial cells

Li, Z., Yuan, X., Wang, Y., Sun, Z., & Ao, J. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3918 · Cited by 2 · see citing works

CAVPENET Peptide Inhibits Prostate Cancer Cells Proliferation and Migration through PP1γ-Dependent Inhibition of AKT Signaling

Matos, B., Gomes, A. A. S., Bernardino, R. L., Alves, M. G., Howl, J., Jerónimo, C., & Fardilha, M. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16091199 · Cited by 2 · see citing works

Flawed Phospholipid Formation or Faulty Fatty Acid Oxidation: Determining the Cause of Mitochondrial Dysfunction in Hearts Lacking ACSL1

Grevengoed, T. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/g7gj-eb34

Manipulating aktivated metabolism via mtorc1

Prestinary, I. V. H. (2013) · Journal of International Crisis and Risk Communication Research

Mechanisms governing the bioenergetics of naive and effector CD4+ T cells as a means of controlling autoimmunity

Previte, D. M. (2017) · D-Scholarship@Pitt (University of Pittsburgh)

mTOR under stress

Heberle, A. M. (2019) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Tigecycline and homoharringtonine synergistically target myeloid leukemia cells by inhibiting mitochondrial translation through mTOR/4EBP1 pathwayPreprint

Yang, H., Mei, C., Li, Y., Ren, Y., Zhang, H., Li, K., Huang, J., Huang, X., Xu, W., Zhou, X., et al. (2020) · doi:10.21203/rs.3.rs-42286/v1

MDK Promotes Lymph Node Metastasis of Cervical Squamous Cell Carcinoma by Activating the PI3K/AKT and p38 MAPK PathwayPreprint

Fei, H., Lin, Q., Wang, S., Shen, M., Yu, H., Jin, Y., Chen, T., & Jiang, H. (2022) · Research Square · doi:10.21203/rs.3.rs-2187224/v1

The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicityPreprint

Blandino, G., Sardo, F. L., Turco, C., Messina, B., Sacconi, A., Auciello, F. R., Pulito, C., Strano, S., & Lev, S. (2024) · Research Square · doi:10.21203/rs.3.rs-5032978/v1

The translational inhibitor 4EBP/Thor is required for Drosophila adaptation to hypoxia

Sorianello, E., Katz, M., Acevedo, J. M., Melani, M., Perez-Perri, J. I., & Wappner, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-94457-5 · Cited by 1 · see citing works

Proteomics reveal PTEN as a critical mediator of sustained mitochondrial dysfunction during chronic spinal cord injury

Patel, S. P., Gartner, C. A., Mudjgiwa, P., Patel, J., Slone, V. K., Capes, D. E., Iyer, K., Zapata-Jaramillo, M. F., Kota, V., Hash, M. T., et al. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115880

3D-printed MXene-incorporated scaffolds as a bioenergetic metabolism regulator for bone regeneration

Dai, H., Zhang, Y., Wu, Z. W., Wei, X., Li, X., Bian, Y., Zhang, S., Xu, Z., & Han, B. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100874

PTEN: Redefining tumor suppressor functions in cancer by regulating transcription.

Hameed, J. S. F., Chowdhury, S. G., Karmakar, P., Ganesan, T., & Mukherjee, A. (2026) · Biochimica et biophysica acta. Reviews on cancer · doi:10.1016/j.bbcan.2026.189659

Human Placental Transcriptome and fetal sex differences in SPTB

Simmons, R. (2022) · ImmPort · doi:10.21430/m3qpejcgy4

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1. PLoS One 2012

Goo, C. K., Lim, H. Y., Ho, Q. S., Too, H., Clement, M.-V., & Wong, P. (2016)

PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes

Li, C., Li, Y., He, L., Agarwal, A., Zeng, N., Cadenas, E., & Stiles, B. L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.013 · Cited by 70 · see citing works

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα)

Li, Y., He, L., Zeng, N., Sahu, D., Cadenas, E., Shearn, C., Li, W., & Stiles, B. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.450353 · Cited by 58 · see citing works

Akt3 knockdown induces mitochondrial dysfunction in human cancer cells

Kim, M., Kim, Y. Y., Jee, H. J., Bae, S. S., Jeong, N. Y., Um, J., & Yun, J. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw014 · Cited by 28 · see citing works

THE PLEIOTROPIC EFFECTS OF PTEN/AKT SIGNALING ON MITOCHONDRIAL RESPIRATORY FUNCTIONS

KIAT, G. C. (2013) · National University of Singapore