Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

Ferreira Mello, Bruna Stefânia; Monte, Aline Santos; McIntyre, Roger S.; Soczynska, Joanna K.; Custódio, Charllyany Sabino; Cordeiro, Rafaela Carneiro; Chaves, João Henrique; Mendes Vasconcelos, Silvânia Maria; Nobre Júnior, Hélio Vitoriano; Florenço de Sousa, Francisca Cléa; Hyphantis, Thomas N.; Carvalho, André Férrer; Macêdo, Danielle Silveira

doi:10.1016/j.jpsychires.2013.06.008

Cited by 195Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

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Ferreira Mello, Bruna Stefânia, Monte, Aline Santos, McIntyre, Roger S., Soczynska, Joanna K., Custódio, Charllyany Sabino, Cordeiro, Rafaela Carneiro, Chaves, João Henrique, Mendes Vasconcelos, Silvânia Maria +5 more·2013·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2013.06.008

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Abstract

Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-derived neurotrophic factor (BDNF) signaling mechanisms as important in depression pathophysiology. Tetracycline antibiotics have anti-inflammatory and antioxidant properties. Preliminary evidence indicates that minocycline has antidepressant properties. Doxycycline (DOXY) has favorable pharmacokinetic and safety profiles when compared to other tetracycline congeners. The antidepressant activity of DOXY has not been adequately investigated. This study evaluated the effects of DOXY (25 and 50 mg/kg, i.p.) on LPS-induced (0.5 mg/kg, i.p.) depressive-like behavior. Doxycycline was administered 30 min before LPS (pre-LPS) or 1.5 and 23.5 h following LPS (post-LPS) administration in mice. LPS-treated animals presented an increase in immobility time in the forced swimming test (FST) when compared to controls 24 h after endotoxin administration. Similarly to imipramine (IMI-10 mg/kg, i.p.), DOXY at both doses prevented and reversed LPS-induced alterations in the FST. IL-1β content was increased 24 h after LPS administration in striatum, hippocampus and prefrontal cortex. IMI and DOXY prevented and reversed LPS-induced increase in IL-1β. IMI and DOXY also prevented and reversed LPS-induced alterations in nitrite content and oxidative stress parameters (lipid peroxidation and reduced glutathione levels). Both DOXY and IMI prevented LPS-induced decrease in hippocampal BDNF levels. Taken together, our results demonstrate that DOXY is comparable to IMI in effectively ameliorate LPS-induced depressive-like behavior, providing a rationale for testing DOXY's antidepressant efficacy in humans.

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Certain antibiotics, such as β-lactams and tetracyclines have potential antidepressant properties in rodents and humans.
“Conversely, certain antibiotics, such as β-lactams and tetracyclines have potential antidepressant properties in rodents and humans [161,162].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [161]

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Neuroinflammation and Depression
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The Tetracyclines
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Tetraciclinas, sulfamidas y metronidazol
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Doxycycline protects against pilocarpine-induced convulsions in rats, through its antioxidant effect and modulation of brain amino acids
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Inhibition of nitric oxide synthase accentuates endotoxin-induced sickness behavior in mice
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
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Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609 · see citing works
Self-citation
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Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
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Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works
Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala
Zheng, Z.-H., Tu, J., Li, X., Hua, Q., Liu, W.-Z., Liu, Y., Pan, B., Hu, P., & Zhang, W. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.007 · Cited by 313 · see citing works
Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works
Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression
Zhao, X., Cao, F., Liu, Q., Li, X., Xu, G., Liu, G., Zhang, Y., Yang, X., Yi, S., Xu, F., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.064 · Cited by 278 · see citing works
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness
Macêdo, D. S., Filho, A. J. M. C., de Sousa, C. N. S., Quevedo, J., Barichello, T., Júnior, H. V. N., & de Lucena, D. F. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.012 · Cited by 264 · see citing works
Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation
André, C., Dinel, A.-L., Ferreira, G., Layé, S., & Castanon, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.012 · Cited by 241 · see citing works
Sodium Butyrate Abolishes Lipopolysaccharide-Induced Depression-like Behaviors and Hippocampal Microglial Activation in Mice
Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2017.12.004 · Cited by 204 · see citing works
Alzheimer’s Disease, Oligomers, and Inflammation
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Fermented foods, the gut and mental health: a mechanistic overview with implications for depression and anxiety
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Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
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Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers
Stepanichev, M. Y., Дыгало, Н. Н., Grigoryan, G. A., Shishkina, G. T., & Gulyaeva, N. V. (2014) · BioMed Research International · doi:10.1155/2014/932757 · Cited by 172 · see citing works
Inflammation Models of Depression in Rodents: Relevance to Psychotropic Drug Discovery
Remus, J. L., & Dantzer, R. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw028 · Cited by 166 · see citing works
Therapeutic Strategies for Treatment of Inflammation-related Depression
Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works
Role of neuro-immunological factors in the pathophysiology of mood disorders
Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149 · see citing works
Lipopolysaccharide induced anxiety- and depressive-like behaviour in mice are prevented by chronic pre-treatment of esculetin
Sulakhiya, K., Keshavlal, G. P., Bezbaruah, B. K., Dwivedi, S., Gurjar, S. S., Munde, N., Jangra, A., Lahkar, M., & Gogoi, R. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.11.031 · Cited by 140 · see citing works
Ketamine interactions with gut-microbiota in rats: relevance to its antidepressant and anti-inflammatory properties
Getachew, B., Aubee, J. I., Schottenfeld, R. S., Csoka, A. B., Thompson, K. M., & Tizabi, Y. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1373-7 · Cited by 137 · see citing works
Mapping inflammation onto mood: inflammatory mediators of anhedonia
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The Gut-Microglia Connection: Implications for Central Nervous System Diseases
Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 128 · see citing works
Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice
Sulakhiya, K., Kumar, P., Jangra, A., Dwivedi, S., Hazarika, N. K., Baruah, C. C., & Lahkar, M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.049 · Cited by 117 · see citing works
Lipopolysaccharide animal models of Parkinson’s disease: Recent progress and relevance to clinical disease
Deng, I. B., Corrigan, F., Zhai, G., Zhou, X., & Bobrovskaya, L. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100060 · Cited by 120 · see citing works
Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury
Khan, A., Shal, B., Naveed, M., Shah, F. A., Atiq, A., Khan, N. U., Kim, Y. S., & Khan, S. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.02.002 · Cited by 109 · see citing works
Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice
Ge, L., Liu, L., Liu, H., Liu, S., Xue, H., Wang, X., Yuan, L., Wang, Z., & Liu, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.026 · Cited by 106 · see citing works
Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice
Tomaz, V. D. S., Cordeiro, R. C., Costa, A. M. N., de Lucena, D. F., Júnior, H. V. N., de Sousa, F. C. F., Vasconcelos, S. M. M., Vale, M. L., Quevedo, J., & Macêdo, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.025 · Cited by 103 · see citing works
Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice
An, K., Xie, T., Zhu, D., Shan, J., Di, L., & Zheng, X. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02386 · Cited by 101 · see citing works
The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration
Wang, Z., Zhang, Q., Yuan, L., Wang, S., Liu, L., Yang, X., Li, G., & Liu, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.018 · Cited by 97 · see citing works
The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice
Li, R., Zhao, D., Qu, R., Fu, Q., & Ma, S. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.040 · Cited by 92 · see citing works
Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-κB regulating NLRP3 signal pathway
Li, H., Lin, S., Qin, T., Li, H., Ma, Z., & Ma, S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.10.001 · Cited by 91 · see citing works
Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression
Tomaz, V. D. S., Filho, A. J. M. C., Cordeiro, R. C., Jucá, P. M., Soares, M. V. R., Barroso, P. N., Cristino, L. M. F., Jiang, W., Teixeira, A. L., de Lucena, D. F., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.022 · Cited by 90 · see citing works
Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice
Taniguti, E. H., Ferreira, Y. S., Stupp, I. J. V., Fraga-Junior, E. B., Doneda, D. L., Lopes, L., Rios-Santos, F., Lima, E., Buss, Z. S., Viola, G. G., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.018 · Cited by 91 · see citing works
Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties
de Souza, A. G., Filho, A. J. M. C., Oliveira, J. V. S., de Souza, D. A. A., Lopes, I. S., de Carvalho, M. A. J., de Lima, K. A., de Sousa, F. C. F., Vasconcelos, S. M. M., Macêdo, D. S., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.066 · Cited by 87 · see citing works
Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway
Jiang, X., Liu, J., Lin, Q., Mao, K., Tian, F., Jing, C., Wang, C., Ding, L., & Pang, C. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.09.010 · Cited by 75 · see citing works
Antidepressant-like effect of a new selenium-containing compound is accompanied by a reduction of neuroinflammation and oxidative stress in lipopolysaccharide-challenged mice
Casaril, A. M., Domingues, M., Fronza, M. G., Vieira, B. M., Begnini, K. R., Lenardao, E. J., Seixas, F. K., Collares, T. V., Nogueira, C. W., & Savegnago, L. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117711713 · Cited by 75 · see citing works
Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review
Rosenblat, J. D., McIntyre, R. S., Alves, G. S., Fountoulakis, K. Ν., & Carvalho, A. F. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150630175044 · Cited by 71 · see citing works
Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus
Hriţcu, L., & Gorgan, L. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.016 · Cited by 70 · see citing works
Fenretinide attenuates lipopolysaccharide (LPS)-induced blood-brain barrier (BBB) and depressive-like behavior in mice by targeting Nrf-2 signaling
Li, T., Zheng, L.-N., & Han, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109680 · Cited by 64 · see citing works
Antidepressants Impact Connexin 43 Channel Functions in Astrocytes
Jeanson, T., Pondaven, A., Ezan, P., Mouthon, F., Charvériat, M., & Giaume, C. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00495 · Cited by 64 · see citing works
The Dopamine Receptor D3 Regulates Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
Wang, J., Jia, Y., Li, G., Wang, B., Zhou, T., Zhu, L., Chen, T., & Chen, Y. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy005 · Cited by 62 · see citing works
Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice
Taniguti, E. H., Ferreira, Y. S., Stupp, I. J. V., Fraga-Junior, E. B., Mendonça, C. B., Rossi, F. L., Ynoue, H. N., Doneda, D. L., Lopes, L., Lima, E., et al. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.034 · Cited by 62 · see citing works
Depression and Inflammatory Periodontal Disease Considerations—An Interdisciplinary Approach
Dumitrescu, A. L. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00347 · Cited by 63 · see citing works
Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations
Rodrigues, F. T. S., de Souza, M. R. M., Lima, C. N. D. C., da Silva, F. E. R., Costa, D. V. D. S., dos Santos, C. C., Miyajima, F., de Sousa, F. C. F., Vasconcelos, S. M. M., Barichello, T., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.10.003 · Cited by 59 · see citing works
Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice
Shal, B., Khan, A., Naveed, M., Khan, N. U., Ihsan‐ul‐Haq, AlSharari, S. D., Kim, Y. S., & Khan, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.047 · Cited by 58 · see citing works
Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells
Hongxia, L., Yuxiao, T., Zhilei, S., Yan, S., Qu, Y., Jiamin, S., Xin, X., Yang, J., Mo, F., & Shen, H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.041 · Cited by 59 · see citing works
Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice
Jiang, X., Chen, L., Shen, L., Chen, Z., Xu, L., Zhang, J., & Yu, X. (2016) · Brain Research · doi:10.1016/j.brainres.2016.08.029 · Cited by 58 · see citing works
Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors
Cordeiro, R. C., Filho, A. J. M. C., Gomes, N. S., Tomaz, V. D. S., Medeiros, C. D., Queiroz, A. I. D. G., Maes, M. H. J., Macêdo, D. S., & Carvalho, A. F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00125 · Cited by 54 · see citing works
The Microbiome in Mental Health: Potential Contribution of Gut Microbiota in Disease and Pharmacotherapy Management
Flowers, S. A., & Ellingrod, V. L. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1640 · Cited by 52 · see citing works
Doxycycline prevents and reverses schizophrenic-like behaviors induced by ketamine in mice via modulation of oxidative, nitrergic and cholinergic pathways
Ben‐Azu, B., Omogbiya, I. A., Aderibigbe, A. O., Umukoro, S., Ajayi, A. M., & Iwalewa, E. O. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.02.007 · Cited by 52 · see citing works
The microbiome and childhood diseases: Focus on brain‐gut axis
O’Mahony, S. M., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21118 · Cited by 50 · see citing works
Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice
Silva, M. C. C., de Sousa, C. N. S., Gomes, P. X. L., de Oliveira, G. V., de Araújo, F. Y. R., Ximenes, N. C., da Silva, J. C., Vasconcelos, G. S., Leal, L. K. A. M., Macêdo, D. S., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.002 · Cited by 52 · see citing works
Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression
de Sousa, C. N. S., Meneses, L. N., Vasconcelos, G. S., Silva, M. C. C., da Silva, J. C., Macêdo, D. S., de Lucena, D. F., & Vasconcelos, S. M. M. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.08.042 · Cited by 50 · see citing works
Antidepressant Activity of Astilbin: Involvement of Monoaminergic Neurotransmitters and BDNF Signal Pathway
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Determinação dos efeitos da doxiciclina em um modelo de depressão induzido por lipopolissacarídeo em camundongos
Mello, B. S. F. (2012) · Americanae (AECID Library)
Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression
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DeterminaÃÃo dos efeitos da doxiciclina em um modelo de depressÃo induzido por lipopolissacarÃdeo em camundongos
Mello, B. S. F. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex
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Study of the immunomodulatory effect of different class antidepressants and nitric oxide synthase isoform inhibitors in the lipopolysaccharide-induced depression model
Tomaz, V. D. S. (2019) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Authors: Ferreira Mello, B. S., Monte, A. S., McIntyre, R. S., Soczynska, J. K., Custódio, C. S., Cordeiro, R. C., Chaves, J. H., Mendes Vasconcelos, S. M., Nobre Júnior, H. V., Florenço de Sousa, F. C., Hyphantis, T. N., Carvalho, A. F., & Macêdo, D. S.
Affiliations: Universidade Federal do Ceará (BR)
University Health Network (CA)
University of Toronto (CA)
University of Ioannina (GR)
Corresponding author: Macêdo, Danielle Silveira
ORCID: Monte, Aline Santos
McIntyre, Roger S.
Soczynska, Joanna K.
Cordeiro, Rafaela Carneiro
Chaves, João Henrique
Hyphantis, Thomas N.
Macêdo, Danielle Silveira
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2013-10
Volume: 47
Issue: 10
Pages: 1521-1529
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2013.06.008
OpenAlex: W2081306572
Cited by: 195
References: 99
Citations by year: 2026: 6 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 22 · 2020: 20 · 2019: 20 · 2018: 19 · 2017: 18 · 2016: 13 · 2015: 15 · 2014: 15
FWCI: 4.85
Type: journal article
Language: en
Open access: green
www.repositorio.ufc.br
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: doxycycline, antidepressant effects, depression-like behavior, lipopolysaccharide, neuroinflammation, brain-derived neurotrophic factor, IL-1β, oxidative stress, lipid peroxidation, glutathione, imipramine, tetracycline antibiotics, forced swim test, hippocampus, prefrontal cortex, striatum
MeSH terms: Animals, Antidepressive Agents, Brain, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Doxycycline, Exploratory Behavior, Gene Expression Regulation, Glutathione, Lipopolysaccharides, Male, Nitrites, Swimming, Tumor Necrosis Factor-alpha, Thiobarbituric Acid Reactive Substances, Statistics, Nonparametric, Brain-Derived Neurotrophic Factor, Mice, Interleukin-1beta

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Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

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