Cited by 367Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke ManagementTryptophan and brain disorders

The many faces of tumor necrosis factor in stroke

Hallenbeck, John M.·2002·Nature Medicine

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Crossref · 10.1038/nm1202-1363

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78 of 78 references verified0 citation errors · 0 not checkable

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  • Blood-derived macrophages and microglia have many functions in the dynamic process of CNS injury and repair, affecting BBB permeabilization, which in turn can aggravate stroke.

    “Blood-derived macrophages and microglia appear to have many functions in the dynamic process of CNS injury and repair, affecting BBB permeabilization, which in turn can aggravate stroke (Hallenbeck, 2002; Sandoval and Witt, 2008; Jiao et al., 2011).”

    From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Hallenbeck, 2002

  • Microglial-induced late-phase BBB disruption is due to direct effects on endothelial cells: IL-1β and TNF-α downregulate tight junction protein expression in ECs, and together with IL-6 modulate expression of adhesion molecules ICAM-1 and VCAM.

    “Apart from the effects of MMPs, microglial-induced late-phase BBB disruption is due to direct effects on ECs: IL-1β and TNF-α downregulate tight junction proteins expression in ECs (Yamagata et al., 2004; Jiao et al., 2011) and, together with IL-6, modulate the expression of adhesion molecules (ICAM-1 and VCAM; Hallenbeck, 2002).”

    From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Hallenbeck, 2002

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Authors
Hallenbeck, J. M.
Affiliations
National Institutes of Health (US)
Corresponding author
Hallenbeck, John M.
Venue
Nature Medicine
Published
2002-12-01
Volume
8
Issue
12
Pages
1363-1368
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2031236369
Cited by
367
References
78
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 19 · 2013: 18 · 2012: 26
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
TNF-α, stroke, TNF receptor signaling, cytokines, neuroinflammation, neuroprotection
MeSH terms
Animals, Arteriosclerosis, Brain Ischemia, Endothelium, Vascular, Humans, Mice, Transgenic, Tumor Necrosis Factor-alpha, Antigens, CD, Receptors, Tumor Necrosis Factor, Stroke, Receptors, Tumor Necrosis Factor, Type I, Mice

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