The many faces of tumor necrosis factor in stroke
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Blood-derived macrophages and microglia have many functions in the dynamic process of CNS injury and repair, affecting BBB permeabilization, which in turn can aggravate stroke.
“Blood-derived macrophages and microglia appear to have many functions in the dynamic process of CNS injury and repair, affecting BBB permeabilization, which in turn can aggravate stroke (Hallenbeck, 2002; Sandoval and Witt, 2008; Jiao et al., 2011).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Hallenbeck, 2002
Microglial-induced late-phase BBB disruption is due to direct effects on endothelial cells: IL-1β and TNF-α downregulate tight junction protein expression in ECs, and together with IL-6 modulate expression of adhesion molecules ICAM-1 and VCAM.
“Apart from the effects of MMPs, microglial-induced late-phase BBB disruption is due to direct effects on ECs: IL-1β and TNF-α downregulate tight junction proteins expression in ECs (Yamagata et al., 2004; Jiao et al., 2011) and, together with IL-6, modulate the expression of adhesion molecules (ICAM-1 and VCAM; Hallenbeck, 2002).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Hallenbeck, 2002
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- Authors
- Hallenbeck, J. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Hallenbeck, John M.
- Venue
- Nature Medicine
- Published
- 2002-12-01
- Volume
- 8
- Issue
- 12
- Pages
- 1363-1368
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2031236369
- Cited by
- 367
- References
- 78
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 19 · 2013: 18 · 2012: 26
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- TNF-α, stroke, TNF receptor signaling, cytokines, neuroinflammation, neuroprotection
- MeSH terms
- Animals, Arteriosclerosis, Brain Ischemia, Endothelium, Vascular, Humans, Mice, Transgenic, Tumor Necrosis Factor-alpha, Antigens, CD, Receptors, Tumor Necrosis Factor, Stroke, Receptors, Tumor Necrosis Factor, Type I, Mice
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