A Crp-Dependent Two-Component System Regulates Nitrate and Nitrite Respiration in Shewanella oneidensis
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We have previously illustrated the nitrate/nitrite respiratory pathway of Shewanella oneidensis, which is renowned for its remarkable versatility in respiration. Here we investigated the systems regulating the pathway with a reliable approach which enables characterization of mutants impaired in nitrate/nitrite respiration by guaranteeing biomass. The S. oneidensis genome encodes an Escherichia coli NarQ/NarX homolog SO3981 and two E. coli NarP/NarL homologs SO1860 and SO3982. Results of physiological characterization and mutational analyses demonstrated that S. oneidensis possesses a single two-component system (TCS) for regulation of nitrate/nitrite respiration, consisting of the sensor kinase SO3981(NarQ) and the response regulator SO3982(NarP). The TCS directly controls the transcription of nap and nrfA (genes encoding nitrate and nitrite reductases, respectively) but regulates the former less tightly than the latter. Additionally, phosphorylation at residue 57 of SO3982 is essential for its DNA-binding capacity. At the global control level, Crp is found to regulate expression of narQP as well as nap and nrfA. In contrast to NarP-NarQ, Crp is more essential for nap rather than nrfA.
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NarZYW is constitutively expressed at low levels in the aerobic setting and only up-regulated in response to high nitrate concentrations, likely aiding in the transition from aerobic to anaerobic respiration.
“Conversely, NarZYW is constitutively expressed at low levels in the aerobic setting and only up-regulated in response to high nitrate concentrations, likely aiding in the transition from aerobic to anaerobic respiration [256,259,260].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [260]
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Pterin-Containing Microbial Molybdenum Enzymes
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Bromate reduction by Shewanella oneidensis MR-1 is mediated by dimethylsulfoxide reductase
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Enzyme specific isotope effects of the Nap and Nar nitrate reductasesPreprint
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- Authors
- Dong, Y., Wang, J., Fu, H., Zhou, G., Shi, M., & Gao, H.
- Affiliations
- Zhejiang University (CN)
- Corresponding author
- Gao, Haichun
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-11
- Volume
- 7
- Issue
- 12
- Pages
- e51643
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3519889
- OpenAlex
- W2071817568
- Cited by
- 67
- References
- 45
- Citations by year
- 2025: 4 · 2024: 2 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 6
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (30870032, 973 Program)
- National Key Research and Development Program of China (2010CB833803)
- Natural Science Foundation of Zhejiang Province (R3110096)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- Shewanella oneidensis, two-component systems, C-reactive protein, transcriptional regulation, nitrate reductase, nitrite reductase, nrfA gene, sensor kinase, response regulator phosphorylation, DNA binding, global gene regulation
- MeSH terms
- Cyclic AMP Receptor Protein, DNA-Binding Proteins, Escherichia coli, Membrane Proteins, Nitrate Reductases, Nitrates, Nitrite Reductases, Nitrites, Phosphoproteins, Respiration, Sequence Homology, Shewanella, Escherichia coli Proteins
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