Semen Quality and Sperm Function Loss by Hypercholesterolemic Diet Was Recovered by Addition of Olive Oil to Diet in Rabbit
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Fat increment (0.05% cholesterol, chol) in standard diet promoted a significant increase in serum and sperm membrane chol, which ultimately altered membrane-coupled sperm specific functions: osmotic resistance, acrosomal reaction, and sperm capacitation in White New Zealand rabbits. These changes were also associated with a reduction in motility percentage and appearance of abnormal sperm morphology. The present study was carried out to evaluate the effect of dietary olive oil (OO, 7% v/w) administration to several male hypercholesterolemic rabbits (hypercholesterolemic rabbits, HCR) with altered fertility parameters. These HCR males were achieved by feeding normal rabbits with a high-fat diet (0.05% chol). HCR were associated with a modest non-significant increase in body weight (standard diet, 4.08±0.17 Kg, versus high-fat diet, 4.37±0.24 Kg). Hypercholesterolemic rabbits presented a marked decrease in semen volume, sperm cell count, and percentage of sperm motility, associated with a significant increase in sperm cell abnormalities. Moreover, sperm capacitation measured by the characteristic phosphorylated protein pattern in and induced acrosomal reaction were also altered suggesting sperm dysfunction. However, the administration of OO (for 16 weeks) to rabbits that were fed with 50% of the high-fat diet normalized serum chol. Curiously, OO supply succeeded to attenuate the seminal and sperm alterations observed in HCR group. Administration of OO alone did not cause any significant changes in above mentioned parameters. These data suggest that OO administration to HCR male rabbits recovers the loss of semen quality and sperm functionality.
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Olive oil supplementation significantly reverses the effects of a high cholesterol diet on sperm.
“These observations were significantly reversed after olive oil supplementation [94].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [94]
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- Authors
- Saez Lancellotti, T. E., Boarelli, P. V., Romero, A. A., Funes, A. K., Cid-Barria, M., Cabrillana, M. E., Monclus, M. A., Simón, L., Vicenti, A. E., & Fornés, M. W.
- Affiliations
- Aconcagua University (AR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Fornés, Miguel W.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-11
- Volume
- 8
- Issue
- 1
- Pages
- e52386
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3543415
- OpenAlex
- W2037475158
- Cited by
- 57
- References
- 64
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 1
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Funders
- Universidad Nacional de Cuyo
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Rabbits: Nutrition, Reproduction, Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- olive oil, hypercholesterolemia, semen quality, sperm dysfunction, cholesterol, sperm capacitation, acrosome reaction, sperm motility, sperm morphology, seminal plasma, serum cholesterol, dietary fat, male fertility, rabbits
- MeSH terms
- Olive Oil, Animals, Cholesterol, Dietary, Dietary Fats, Unsaturated, Electrophoresis, Polyacrylamide Gel, Hypercholesterolemia, Male, Phosphorylation, Plant Oils, Rabbits, Sperm Capacitation, Sperm Count, Sperm Motility, Spermatozoa, Phosphotyrosine, Acrosome Reaction, Semen Analysis, Diet, High-Fat
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