The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Feasibility of an Ingestible Sensor-Based System for Monitoring Adherence to Tuberculosis Therapy
Open accessAbstract
Poor adherence to tuberculosis (TB) treatment hinders the individual's recovery and threatens public health. Currently, directly observed therapy (DOT) is the standard of care; however, high sustaining costs limit its availability, creating a need for more practical adherence confirmation methods. Techniques such as video monitoring and devices to time-register the opening of pill bottles are unable to confirm actual medication ingestions. A novel approach developed by Proteus Digital Health, Inc. consists of an ingestible sensor and an on-body wearable sensor; together, they electronically confirm unique ingestions and record the date/time of the ingestion. A feasibility study using an early prototype was conducted in active TB patients to determine the system's accuracy and safety in confirming co-ingestion of TB medications with sensors. Thirty patients completed 10 DOT visits and 1,080 co-ingestion events; the system showed 95.0% (95% CI 93.5-96.2%) positive detection accuracy, defined as the number of detected sensors divided by the number of transmission capable sensors administered. The specificity was 99.7% [95% CI 99.2-99.9%] based on three false signals recorded by receivers. The system's identification accuracy, defined as the number of correctly identified ingestible sensors divided by the number of sensors detected, was 100%. Of 11 adverse events, four were deemed related or possibly related to the device; three mild skin rashes and one complaint of nausea. The system's positive detection accuracy was not affected by the subjects' Body Mass Index (p = 0.7309). Study results suggest the system is capable of correctly identifying ingestible sensors with high accuracy, poses a low risk to users, and may have high patient acceptance. The system has the potential to confirm medication specific treatment compliance on a dose-by-dose basis. When coupled with mobile technology, the system could allow wirelessly observed therapy (WOT) for monitoring TB treatment as a replacement for DOT.
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“and suggested this DMO can identify reasons for uncontrolled HTN and help patients achieve BP control [16-21].”
From Effectiveness of Digital Medicines to Improve Clinical Outcomes in Patients with Uncontrolled Hypertension and Type 2 Diabetes: Prospective, Open-Label, Cluster-Randomized Pilot Clinical Trial (2017) · cites this paper as [17]
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“Prior clinical studies demonstrated the accuracy, safety, and feasibility of using the DMO in patients across a range of medical conditions, including HTN and type 2 diabetes mellitus (T2DM)”
From Effectiveness of Digital Medicines to Improve Clinical Outcomes in Patients with Uncontrolled Hypertension and Type 2 Diabetes: Prospective, Open-Label, Cluster-Randomized Pilot Clinical Trial (2017) · cites this paper as [17]
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“Ingestible sensors combined with or embedded in tablets may accurately determine taking adherence[23,24].”
From Adherence is associated with a favorable outcome after lung transplantation (2019) · cites this paper as [24]
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Cites
McGuire, S. (2014) · Advances in Nutrition · doi:10.3945/an.114.007211 · Cited by 1,107
Gandhi, N. R., Nunn, P. P., Dheda, K. U. J., Schaaf, H. S., Zignol, M., van Soolingen, D., Jensen, P. A., & Bayona, J. N. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60410-2 · Cited by 1,042
Tuberculosis in New York City — Turning the Tide
Frieden, T. R., Fujiwara, P. I., Washko, R. M., & Hamburg, M. A. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330406 · Cited by 644
Haynes, R. B., McKibbon, K. A., & Kanani, R. S. (1996) · The Lancet · doi:10.1016/s0140-6736(96)01073-2 · Cited by 643
(1923) · Public Health · doi:10.1016/s0033-3506(23)80379-1 · Cited by 459
Chaulk, C. P. (1998) · JAMA · doi:10.1001/jama.279.12.943 · Cited by 272
The TB epidemic from 1992 to 2002
Raviglione, M. C. (2003) · Tuberculosis · doi:10.1016/s1472-9792(02)00071-9 · Cited by 267
Promoting adherence to treatment for tuberculosis: the importance of direct observation
Frieden, T. R. (2007) · Bulletin of the World Health Organization · doi:10.2471/blt.06.038927 · Cited by 145
Promoting adherence to treatment for tuberculosis: the importance of direct observation.
Frieden, T. R., & Sbarbaro, J. A. (2007) · PubMed · doi:10.2471/06.038927 · Cited by 125
Dixon, W., Stradling, P., & Wootton, I. D. P. (1957) · The Lancet · doi:10.1016/s0140-6736(57)90006-5 · Cited by 122
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Bibliometric analysis and evidence of clinical efficacy and safety of digital pills
Litvinova, O., Klager, E., Yeung, A. W. K., Tzvetkov, N. T., Kimberger, O., Kletečka-Pulker, M., Willschke, H., & Atanasov, A. G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1023250 · Cited by 12
Shafrin, J. T., Schwartz, T., Lakdawalla, D., & Forma, F. M. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2016.22.11.1285 · Cited by 10
Pharmacokinetics of Coencapsulated Antiretrovirals with Ingestible Sensors
Liu, H., Daar, E. S., Wang, Y., Siqueiros, L., Campbell, K. M., Shen, J., Guerrero, M., Ko, M.-W., Xiong, D., Dao, J., et al. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0202 · Cited by 10
Rao, J. S., Diwan, V., Kumar, A. A., Varghese, S. S., Sharma, U., Purohit, M. R., Das, A., & Rodrigues, R. (2022) · Wellcome Open Research · doi:10.12688/wellcomeopenres.17865.1 · Cited by 9
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How 5G (and concomitant technologies) will revolutionize healthcarePreprint
Latif, S., Qadir, J., Farooq, S., & Imran, M. A. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1708.08746 · Cited by 9
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Fielding, K., Subbaraman, R., Khan, A. R., Celan, C., Charalambous, S., Franke, M. F., Huddart, S., Katamba, A., Law, S. J., & Stagg, H. R. (2023) · European Respiratory Society eBooks · doi:10.1183/2312508x.10002223 · Cited by 8
Santosa, A., Juniarti, N., Pahria, T., & Susanti, R. D. (2025) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-025-00457-3 · Cited by 17
Liberman, J. N., Davis, T., Velligan, D. I., Robinson, D. G., Carpenter, W. A., Jaeger, C., Waters, H. C., Ruetsch, C. R., & Forma, F. M. (2022) · Psychiatric Research and Clinical Practice · doi:10.1176/appi.prcp.20210021 · Cited by 8
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Microdevices to successfully deliver orally administered drugs
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Valentini, L., Pacini, L., Errante, F., Morchio, C., Sanna, B., Rovero, P., & Morabito, A. (2022) · Molecules · doi:10.3390/molecules27144605 · Cited by 3
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Costello, R. W., Dima, A. L., Ryan, D. P., McIvor, A., Boycott, K., Chisholm, A., Price, D. B., & Blakey, J. (2017) · Pragmatic and Observational Research · doi:10.2147/por.s132316 · Cited by 3
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Ishii, K., Kawai, Y., Tsuruoka, N., Fuse, T., Obara, T., Matsunaga, T., Imai, Y., & Haga, Y. (2015) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.135.197 · Cited by 1
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Volpe, M., Tocci, G., & Gallo, G. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-76593-8_17
Hori, P. C. A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2018.tde-07112018-093940
Stauss, S., Miyazaki, R., & Honma, I. (2019) · IEEJ Transactions on Sensors and Micromachines · doi:10.1541/ieejsmas.139.359
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Rao, J. S., Diwan, V., Kumar, A. A., Varghese, S. S., Sharma, U., Purohit, M. R., Das, A., & Rodrigues, R. (2022) · doi:10.2196/preprints.38143
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Maro, R., Mtenga, A. E., Mtesha, B. A., Wilhelm, K., Emmanuel, N., Boer, M. S., & Ngowi, K. M. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4530064
Goodman, G. R., Carnes, C., Albrechta, H., Alpert, P. E., Hokayem, J., Lee, J. S., Boyer, E. W., Rosen, R. K., Mayer, K. H., O’Cleirigh, C., et al. (2024) · Hawaii International Conference on System Sciences (HICSS) · doi:10.24251/hicss.2024.388
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Metadata
- Authors
- Belknap, R., Weis, S., Brookens, A., Au-Yeung, K. Y., Moon, G., DiCarlo, L., & Reves, R.
- Affiliations
- Denver Public Health (US)
- University of Washington (US)
- Proteus Digital Health (US)
- Corresponding author
- Belknap, Robert
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-07
- Volume
- 8
- Issue
- 1
- Pages
- e53373
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3538759
- OpenAlex
- W1988611386
- Cited by
- 160
- References
- 18
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 6 · 2022: 20 · 2021: 12 · 2020: 22 · 2019: 16 · 2018: 11 · 2017: 19 · 2016: 18 · 2015: 11 · 2014: 1 · 2013: 2
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- tuberculosis, medication adherence, ingestible sensors, directly observed therapy, wearable sensors, detection accuracy, adverse events, body mass index
- MeSH terms
- Administration, Oral, Adult, Aged, Antitubercular Agents, Drug Administration Schedule, Feasibility Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Public Health, Sensitivity and Specificity, Tuberculosis, Pulmonary, Biosensing Techniques, Body Mass Index, Drug Monitoring, Directly Observed Therapy, Medication Adherence
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