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Cited by 364

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

High Serum Uric Acid and Increased Risk of Type 2 Diabetes: A Systemic Review and Meta-Analysis of Prospective Cohort Studies

Open access
Lv, Qin, Meng, Xian-Fang, He, Fang-Fang, Chen, Shan, Su, Hua, Xiong, Jing, Gao, Pan, Tian, Xiu-Juan, Liu, Jian-She, Zhu, Zhong-Hua, Huang, Kai, Zhang, Chun·2013·PLoS ONE
DOI 10.1371/journal.pone.0056864
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Abstract

OBJECTIVE: Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. DESIGN AND METHODS: We conducted a systematic literature search of the PubMed database through April 2012. Prospective cohort studies were included in meta-analysis that reported the multivariate adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) for the association between serum uric acid and risk of type 2 diabetes. We used both fix-effects and random-effects models to calculate the overall effect estimate. The heterogeneity across studies was tested by both Q statistic and I(2) statistic. Begg's funnel plot and Egger's regression test were used to assess the potential publication bias. RESULTS: We retrieved 7 eligible articles derived from 8 prospective cohort studies, involving a total of 32016 participants and 2930 incident type 2 diabetes. The combined RR of developing type 2 diabetes for the highest category of serum uric acid level compared with the lowest was 1.56(95% CI, 1.39-1.76). Dose-response analysis showed the risk of type 2 diabetes was increased by 6% per 1 mg/dl increment in serum uric acid level (RR 1.06, 95% CI: 1.04-1.07). The result from each subgroup showed a significant association between serum uric acid and risk of type 2 diabetes. In sensitive analysis, the combined RR was consistent every time omitting any one study. Little evidence of heterogeneity and publication bias was observed. CONCLUSIONS: Our meta-analysis of prospective cohort studies provided strong evidence that high level of serum uric acid is independent of other established risk factors, especially metabolic syndrome components, for developing type 2 diabetes in middle-aged and older people.

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Metadata

Authors
Lv, Q., Meng, X.-F., He, F.-F., Chen, S., Su, H., Xiong, J., Gao, P., Tian, X.-J., Liu, J.-S., Zhu, Z.-H., Huang, K., & Zhang, C.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-02-20
Volume
8
Issue
2
Pages
e56864
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0056864
OpenAlex
W1984782606
Cited by
364
References
5
FWCI
2.88
Type
journal article
Language
en
Open access
gold

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Lv, Q., Meng, X.-F., He, F.-F., Chen, S., Su, H., Xiong, J., Gao, P., Tian, X.-J., Liu, J.-S., Zhu, Z.-H., Huang, K., & Zhang, C. (2013). High Serum Uric Acid and Increased Risk of Type 2 Diabetes: A Systemic Review and Meta-Analysis of Prospective Cohort Studies. PLoS ONE. https://doi.org/10.1371/journal.pone.0056864

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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