Non-Targeted Metabolomics and Associations with per- and Polyfluoroalkyl Substances (PFAS) Exposure in Humans: A Scoping Review
Open accessAbstract
OBJECTIVE: To summarize the application of non-targeted metabolomics in epidemiological studies that assessed metabolite and metabolic pathway alterations associated with per- and polyfluoroalkyl substances (PFAS) exposure. RECENT FINDINGS: Eleven human studies published before April 1st, 2021 were identified through database searches (PubMed, Dimensions, Web of Science Core Collection, Embase, Scopus), and citation chaining (Citationchaser). The sample sizes of these studies ranged from 40 to 965, involving children and adolescents (n = 3), non-pregnant adults (n = 5), or pregnant women (n = 3). High-resolution liquid chromatography-mass spectrometry was the primary analytical platform to measure both PFAS and metabolome. PFAS were measured in either plasma (n = 6) or serum (n = 5), while metabolomic profiles were assessed using plasma (n = 6), serum (n = 4), or urine (n = 1). Four types of PFAS (perfluorooctane sulfonate(n = 11), perfluorooctanoic acid (n = 10), perfluorohexane sulfonate (n = 9), perfluorononanoic acid (n = 5)) and PFAS mixtures (n = 7) were the most studied. We found that alterations to tryptophan metabolism and the urea cycle were most reported PFAS-associated metabolomic signatures. Numerous lipid metabolites were also suggested to be associated with PFAS exposure, especially key metabolites in glycerophospholipid metabolism which is critical for biological membrane functions, and fatty acids and carnitines which are relevant to the energy supply pathway of fatty acid oxidation. Other important metabolome changes reported included the tricarboxylic acid (TCA) cycle regarding energy generation, and purine and pyrimidine metabolism in cellular energy systems. CONCLUSIONS: There is growing interest in using non-targeted metabolomics to study the human physiological changes associated with PFAS exposure. Multiple PFAS were reported to be associated with alterations in amino acid and lipid metabolism, but these results are driven by one predominant type of pathway analysis thus require further confirmation. Standardizing research methods and reporting are recommended to facilitate result comparison. Future studies should consider potential differences in study methodology, use of prospective design, and influence from confounding bias and measurement errors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PFASs exposure disrupts mitochondrial function and cellular energy homeostasis, particularly among children and adolescents with chronic exposure.
“Comprehensive metabolomic investigations reveal that PFASs exposure alters key metabolic pathways, including amino acid, nucleotide, carbohydrate, and vitamin metabolism [112], disrupting mitochondrial function and cellular energy homeostasis, particularly among children and adolescents with chronic exposure [113].”
From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [113]
The Results (Metabolic pathway alterations; page unavailable) link PFAS exposure with changes in the TCA cycle and nucleotide metabolism, including in studies of children and adolescents. The Discussion (page unavailable) says these pathways are important for cellular homeostasis and energy generation, but the review does not establish mitochondrial dysfunction or show that the effects occur particularly in chronically exposed children and adolescents. It describes metabolic associations, not a demonstrated disruption of cellular energy homeostasis. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., et al. (2018) · Annals of Internal Medicine · doi:10.7326/m18-0850 · Cited by 43,565 · see citing works
ggplot2: Elegant Graphics for Data Analysis
Ginestet, C. E. (2011) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2010.00676_9.x · Cited by 14,484 · see citing works
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works
Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., Fan, T. W.-M., Fiehn, O., Goodacre, R., Griffin, J. L., et al. (2007) · Metabolomics · doi:10.1007/s11306-007-0082-2 · Cited by 5,368 · see citing works
Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence
Schymanski, E. L., Jeon, J., Gulde, R., Fenner, K., Ruff, M., Singer, H. P., & Hollender, J. (2014) · Environmental Science & Technology · doi:10.1021/es5002105 · Cited by 4,519 · see citing works
Metabolomics: beyond biomarkers and towards mechanisms
Johnson, C. H., Ivanisevic, J., & Siuzdak, G. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.25 · Cited by 2,829 · see citing works
Self-citationMitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813 · see citing works
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786 · see citing works
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750 · see citing works
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620 · see citing works
Beckonert, O. P., Keun, H. C., Ebbels, T. M. D., Bundy, J. G., Holmes, E. C., Lindon, J. C., & Nicholson, J. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.376 · Cited by 2,112 · see citing works
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works
A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?
Wang, Z., DeWitt, J. C., Higgins, C. P., & Cousins, I. T. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b04806 · Cited by 1,921 · see citing works
Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
Khatri, P., Sirota, M., & Butte, A. J. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002375 · Cited by 1,569 · see citing works
Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis
Xia, J., & Wishart, D. S. (2016) · Current Protocols in Bioinformatics · doi:10.1002/cpbi.11 · Cited by 1,537 · see citing works
Biological Monitoring of Polyfluoroalkyl Substances: A Review
Houde, M., Martin, J. W., Letcher, R. J., Solomon, K. R., & Muir, D. C. G. (2006) · Environmental Science & Technology · doi:10.1021/es052580b · Cited by 1,259 · see citing works
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works
Sud, M., Fahy, E., Cotter, D., Azam, K., Vadivelu, I., Burant, C., Edison, A. S., Fiehn, O., Higashi, R. M., Nair, K. S., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1042 · Cited by 1,008 · see citing works
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989 · see citing works
Predicting Network Activity from High Throughput Metabolomics
Li, S., Park, Y. H., Duraisingham, S., Strobel, F. H., Khan, N., Soltow, Q. A., Jones, D. P., & Pulendran, B. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003123 · Cited by 931 · see citing works
Self-citationDe Silva, A. O., Armitage, J. M., Bruton, T. A., Dassuncao, C., Heiger-Bernays, W., Hu, X. C., Kärrman, A., Kelly, B., Ng, C., Robuck, A., et al. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4935 · Cited by 835 · see citing works
Metabolic Phenotyping in Health and Disease
Holmes, E. C., Wilson, I. D., & Nicholson, J. K. (2008) · Cell · doi:10.1016/j.cell.2008.08.026 · Cited by 821 · see citing works
Endocrine-disrupting chemicals: Implications for human health
Kahn, L. G., Philippat, C., Nakayama, S. F., Slama, R., & Trasande, L. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30129-7 · Cited by 797 · see citing works
Trends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999−2008
Kato, K., Wong, L.-Y., Jia, L. T., Kuklenyik, Z., & Calafat, A. M. (2011) · Environmental Science & Technology · doi:10.1021/es1043613 · Cited by 777 · cited 1× · see citing works
“These findings are consistent with the temporal changes in perfluorinated compounds reported previously (Kato et al. 2011; Liu et al. 2021; Nyberg et al. 2018).”
Integrated omics: tools, advances and future approaches
Misra, B. B., Langefeld, C., Olivier, M., & Cox, L. A. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0055 · Cited by 686 · see citing works
Mihalik, S. J., Goodpaster, B. H., Kelley, D. E., Chace, D. H., Vockley, J., Toledo, F. G. S., & DeLany, J. P. (2010) · Obesity · doi:10.1038/oby.2009.510 · Cited by 653 · see citing works
Haddaway, N. R., Grainger, M. J., & Gray, C. T. (2022) · Research Synthesis Methods · doi:10.1002/jrsm.1563 · Cited by 604 · see citing works
Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
Cheng, S. C., Rhee, E. P., Larson, M. G., Lewis, G. D., McCabe, E. L., Shen, D., Palma, M. J., Roberts, L. D., Dejam, A., Souza, A. L., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.067827 · Cited by 588 · see citing works
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00128-6 · Cited by 555 · see citing works
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
PFAS and cancer, a scoping review of the epidemiologic evidence
Steenland, K., & Winquist, A. G. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110690 · Cited by 431 · see citing works
Mitochondrial Fatty-Acid Oxidation Disorders
Kompare, M., & Rizzo, W. B. (2008) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2008.05.008 · Cited by 429 · see citing works
Understanding the human health effects of chemical mixtures.
Carpenter, D. O., Arcaro, K. F., & Spink, D. C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s125 · Cited by 425 · see citing works
Rappazzo, K., Coffman, E., & Hines, E. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070691 · Cited by 405 · see citing works
apLCMS—adaptive processing of high-resolution LC/MS data
Yu, T., Park, Y. H., Johnson, J. M., & Jones, D. P. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp291 · Cited by 402 · see citing works
Self-citationUppal, K., Soltow, Q. A., Strobel, F. H., Pittard, W. S., Gernert, K. M., Yu, T., & Jones, D. P. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-15 · Cited by 373 · see citing works
Self-citationLv, Q., Meng, X., He, F.-F., Chen, S., Su, H., Xiong, J., Gao, P., Tian, X., Liu, J.-S., Zhu, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056864 · Cited by 363 · see citing works
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
(2015) · Molecular and Integrative Toxicology · doi:10.1007/978-3-319-15518-0 · Cited by 360 · see citing works
Ehresman, D. J., Froehlich, J. W., Olsen, G. W., Chang, S., & Butenhoff, J. L. (2006) · Environmental Research · doi:10.1016/j.envres.2006.06.008 · Cited by 344 · see citing works
Disorders of purine and pyrimidine metabolism
Nyhan, W. L. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.07.027 · Cited by 311 · see citing works
Rathmann, W., Funkhouser, E. M., Dyer, A. R., & Roseman, J. M. (1998) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00204-4 · Cited by 269 · see citing works
Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
Bjork, J. A., Butenhoff, J. L., & Wallace, K. B. (2011) · Toxicology · doi:10.1016/j.tox.2011.06.012 · Cited by 260 · see citing works
Nutritional Metabolomics: Progress in Addressing Complexity in Diet and Health
Jones, D. P., Park, Y. H., & Ziegler, T. R. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145159 · Cited by 258 · see citing works
Self-citationLiew, Z., Olsen, J., Cui, X., Ritz, B. R., & Arah, O. A. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu249 · Cited by 257 · see citing works
Self-citationOmega-3 fatty acids and neuropsychiatric disorders
Young, G. S., & Conquer, J. A. (2005) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2005001 · Cited by 252 · see citing works
Calafat, A. M., Kato, K., Hubbard, K., Jia, T., Botelho, J. C., & Wong, L.-Y. (2019) · Environment International · doi:10.1016/j.envint.2019.105048 · Cited by 245 · see citing works
Liew, Z., Goudarzi, H., & Oulhote, Y. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0173-4 · Cited by 237 · see citing works
Self-citationPerfluorinated Chemicals as Emerging Environmental Threats to Kidney Health: A Scoping Review
Stanifer, J. W., Stapleton, H. M., Souma, T., Wittmer, A., Zhao, X., & Boulware, L. E. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04670418 · Cited by 233 · see citing works
Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks.
Li, K., Gao, P., Xiang, P., Zhang, X.-X., Cui, X.-Y., & Ma, L. (2017) · Environment International · doi:10.1016/j.envint.2016.11.014 · Cited by 231 · see citing works
Mastrantonio, M., Bai, E., Uccelli, R., Cordiano, V., Screpanti, A., & Crosignani, P. (2018) · European Journal of Public Health · doi:10.1093/eurpub/ckx066 · Cited by 228 · see citing works
Jin, R., McConnell, R., Cioffi, C. E., Xu, S., Walker, D. I., Stratakis, N., Jones, D. P., Miller, G. W., Peng, C., Conti, D. V., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.105220 · Cited by 221 · see citing works
Self-citationLiu, G., Zhang, S., Yang, K., Zhu, L., & Lin, D. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.04.089 · Cited by 216 · see citing works
Identifying significantly impacted pathways: a comprehensive review and assessment
Nguyen, T., Shafi, A., Nguyen, T., & Drăghici, S. (2019) · Genome biology · doi:10.1186/s13059-019-1790-4 · Cited by 209 · see citing works
The association between PFOA, PFOS and serum lipid levels in adolescents
Geiger, S. D., Xiao, J., DUCATMAN, A. M., Frisbee, S. J., Innes, K. E., & Shankar, A. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.10.005 · Cited by 203 · see citing works
Role of carnitine and its derivatives in the development and management of type 2 diabetes
Bene, J., Hadzsiev, K., & Melegh, B. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0017-1 · Cited by 188 · see citing works
Gleason, J. A., Post, G. B., & Fagliano, J. A. (2014) · Environmental Research · doi:10.1016/j.envres.2014.10.004 · Cited by 184 · see citing works
Brunius, C. F., Shi, L. S., & Landberg, R. (2016) · Metabolomics · doi:10.1007/s11306-016-1124-4 · Cited by 184 · see citing works
Tzoulaki, I., Ebbels, T. M. D., Valdes, A. M., Elliott, P., & Ioannidis, J. P. A. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu143 · Cited by 183 · see citing works
l -Carnitine and heart disease
Wang, Z., Liu, Y., Liu, G., Lu, H., & Mao, C.-Y. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.015 · Cited by 182 · see citing works
Chadeau‐Hyam, M., Athersuch, T. J., Keun, H. C., Iorio, M. D., Ebbels, T. M. D., Jenab, M., Sacerdote, C., Bruce, S. J., Holmes, E. C., & Vineis, P. (2010) · Biomarkers · doi:10.3109/1354750x.2010.533285 · Cited by 176 · see citing works
Chen, Z., Yang, T., Walker, D. I., Thomas, D. C., Qiu, C., Chatzi, L., Alderete, T. L., Kim, J. S., Conti, D. V., Breton, C. V., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.106091 · Cited by 176 · see citing works
Liu, L., Qu, Y., Huang, J., & Weber, R. (2021) · Environmental Sciences Europe · doi:10.1186/s12302-020-00425-3 · Cited by 176 · see citing works
Soltow, Q. A., Strobel, F. H., Mansfield, K. G., Wachtman, L. M., Park, Y. H., & Jones, D. P. (2011) · Metabolomics · doi:10.1007/s11306-011-0332-1 · Cited by 174 · see citing works
Self-citationChang, E. T., Adami, H., Boffetta, P., Wedner, H. J., & Mandel, J. S. (2016) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1122573 · Cited by 174 · see citing works
Alderete, T. L., Jin, R., Walker, D. I., Valvi, D., Chen, Z., Jones, D. P., Peng, C., Gilliland, F. D., Berhane, K. T., Conti, D. V., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.02.047 · Cited by 159 · see citing works
Self-citationSeo, S.-H., Son, M.-H., Choi, S., Lee, D., & Chang, Y. (2018) · Environment International · doi:10.1016/j.envint.2018.01.025 · Cited by 153 · see citing works
Aderemi, A. V., Ayeleso, A. O., Oyedapo, O. O., & Mukwevho, E. (2021) · Metabolites · doi:10.3390/metabo11070418 · Cited by 152 · see citing works
Critical review on PFOA, kidney cancer, and testicular cancer
Bartell, S. M., & Vieira, V. M. (2021) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2021.1909668 · Cited by 151 · see citing works
Peter, K. T., Phillips, A. L., Knolhoff, A. M., Gardinali, P. R., Manzano, C. A., Miller, K. E., Pristner, M., Sabourin, L., Sumarah, M. W., Warth, B., et al. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02621 · Cited by 150 · see citing works
Lehmann, R., Zhao, X., Weigert, C., Simon, P. D., Fehrenbach, E., Fritsche, J., Machann, J., Schick, F., Wang, J., Hoene, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011519 · Cited by 149 · see citing works
Bias Amplification in Epidemiologic Analysis of Exposure to Mixtures
Weisskopf, M. G., Seals, R. M., & Webster, T. F. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2450 · Cited by 148 · see citing works
Bictash, M., Ebbels, T. M., Chan, Q., Loo, R. L., Yap, I. K. S., Brown, I. J., de Iorio, M., Daviglus, M. L., Holmes, E., Stamler, J., et al. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.10.001 · Cited by 140 · see citing works
Lü, Y., Gao, K., Li, X., Tang, Z., Xiang, L., Zhao, H., Fu, J., Wang, L., Zhu, N., Cai, Z., et al. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b01608 · Cited by 134 · see citing works
Healy-Stoffel, M., & Levant, B. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666180412153612 · Cited by 133 · see citing works
Ortiz‐Villanueva, E., Jaumot, J., Martínez, R., Navarro‐Martín, L., Piña, B., & Tauler, R. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.03.369 · Cited by 132 · see citing works
Oxidative stress from environmental exposures
Samet, J. M., & Wages, P. A. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.10.008 · Cited by 124 · see citing works
Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008–2013
Bjerregaard‐Olesen, C., Bach, C. C., Long, M., Ghisari, M., Bossi, R., Bech, B. H., Nohr, E. A., Henriksen, T. B., Olsen, J., & Bonefeld‐Jørgensen, E. C. (2016) · Environment International · doi:10.1016/j.envint.2016.02.010 · Cited by 118 · see citing works
Beyond genomics: understanding exposotypes through metabolomics
Rattray, N. J. W., Deziel, N. C., Wallach, J. D., Khan, S. A., Vasiliou, V., Ioannidis, J. P. A., & Johnson, C. H. (2018) · Human Genomics · doi:10.1186/s40246-018-0134-x · Cited by 116 · see citing works
Self-citationMETLIN: A Tandem Mass Spectral Library of Standards
Montenegro-Burke, J. R., Guijas, C., & Siuzdak, G. E. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0239-3_9 · Cited by 115 · see citing works
Inosine and hypoxanthine as novel biomarkers for cardiac ischemia: From bench to point-of-care
Farthing, D. E., Farthing, C. A., & Xi, L. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215584931 · Cited by 113 · see citing works
Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation
Brière, J.-J., Favier, J., Gimenez‐Roqueplo, A., & Rustin, P. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00216.2006 · Cited by 110 · see citing works
Donat‐Vargas, C., Bergdahl, I. A., Tornevi, A., Wennberg, M., Sommar, J. N., Koponen, J. M., Kiviranta, H., & Åkesson, A. (2019) · Environment International · doi:10.1016/j.envint.2019.01.007 · Cited by 109 · see citing works
Manzano-Salgado, C. B., Casas, M., López-Espinosa, M.-J., Ballester, F., Íñiguez, C., Martinez, D. R., Romaguera, D., Fernández‐Barrés, S., Santa‐Marina, L., Basterretxea, M., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1330 · Cited by 100 · see citing works
The Metabolome-Wide Association Study: a new look at human disease risk factors
Nicholson, J. K., Holmes, E., & Elliott, P. (2008) · Journal of Proteome Research · doi:10.1021/pr8005099 · Cited by 93 · see citing works
Metabolomics of Childhood Exposure to Perfluoroalkyl Substances: A Cross-Sectional Study
Kingsley, S. L., Walker, D. I., Calafat, A. M., Chen, A., Papandonatos, G. D., Xu, Y., Jones, D. P., Lanphear, B. P., Pennell, K. D., & Braun, J. M. (2019) · Metabolomics · doi:10.1007/s11306-019-1560-z · Cited by 90 · see citing works
Self-citationGong, X., Yang, C., Hong, Y., Chung, A. C. K., & Cai, Z. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.04.208 · Cited by 88 · see citing works
Hybrid Feature Detection and Information Accumulation Using High-Resolution LC–MS Metabolomics Data
Yu, T., Park, Y. H., Li, S., & Jones, D. P. (2013) · Journal of Proteome Research · doi:10.1021/pr301053d · Cited by 87 · see citing works
Self-citationBarnes, S., Benton, H. P., Casazza, K., Cooper, S. J., Cui, X., Du, X., Engler, J. A., Kabarowski, J. H. S., Li, S., Pathmasiri, W., et al. (2016) · Journal of Mass Spectrometry · doi:10.1002/jms.3782 · Cited by 87 · see citing works
Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances
Salihović, S., Fall, T., Ganna, A., Broeckling, C. D., Prenni, J. E., Hyötyläinen, T., Kärrman, A., Lind, P., Ingelsson, E., & Lind, L. (2018) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0060-y · Cited by 86 · see citing works
Perfluorinated Compounds: An Overview
Lau, C. S. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15518-0_1 · Cited by 86 · see citing works
Urpí-Sardà, M., Almanza‐Aguilera, E., Llorach, R., Vázquez‐Fresno, R., Estruch, R., Corella, D., Sorlí, J. V., Carmona, F., Sánchez‐Pla, Á., Salas‐Salvadó, J., et al. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.02.006 · Cited by 85 · see citing works
Nguyen, D. H., Nguyen, C. H., & Mamitsuka, H. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby066 · Cited by 84 · see citing works
Wang, X., Liu, L., Zhang, W., Zhang, J., Du, X., Huang, Q., Tian, M., & Shen, H. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.04.086 · Cited by 82 · see citing works
Compliance with minimum information guidelines in public metabolomics repositories
Spicer, R., Salek, R. M., & Steinbeck, C. (2017) · Scientific Data · doi:10.1038/sdata.2017.137 · Cited by 77 · see citing works
Dietary patterns and PFAS plasma concentrations in childhood: Project Viva, USA
Seshasayee, S. M., Rifas‐Shiman, S. L., Chavarro, J. E., Carwile, J. L., Lin, P. D., Calafat, A. M., Sagiv, S. K., Oken, E., & Fleisch, A. F. (2021) · Environment International · doi:10.1016/j.envint.2021.106415 · Cited by 75 · see citing works
Chen, Y., Zhou, L., Xu, J., Zhang, L., Li, M., Xie, X., Xie, Y., Luo, D., Zhang, D., Yu, X., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.02.010 · Cited by 74 · see citing works
Early Hepatic Insulin Resistance in Mice: A Metabolomics Analysis
Li, L. O., Hu, Y.-F., Wang, L. H.-C., Mitchell, M. W., Berger, A., & Coleman, R. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0152 · Cited by 73 · see citing works
Guelfo, J. L., Marlow, T., Klein, D. M., Savitz, D. A., Frickel, S., Crimi, M., & Suuberg, E. M. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2727 · Cited by 73 · see citing works
Wang, M., Park, J.-S., & Petreas, M. X. (2011) · Environmental Science & Technology · doi:10.1021/es2012275 · Cited by 72 · see citing works
Barnes, S., Benton, H. P., Casazza, K., Cooper, S. J., Cui, X., Du, X., Engler, J. A., Kabarowski, J. H. S., Li, S., Pathmasiri, W., et al. (2016) · Journal of Mass Spectrometry · doi:10.1002/jms.3672 · Cited by 70 · see citing works
Maître, L., Robinson, O., Martinez, D. R., Toledano, M. B., Ibarluzea, J. M., Marina, L. S., Sunyer, J., Villanueva, C. M., Keun, H. C., Vrijheid, M., et al. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b02215 · Cited by 66 · see citing works
Inoue, K., Yan, Q. J., Arah, O. A., Paul, K. C., Walker, D. I., Jones, D. P., & Ritz, B. R. (2020) · Current Environmental Health Reports · doi:10.1007/s40572-020-00284-3 · Cited by 66 · see citing works
Self-citationLarge-scale non-targeted metabolomic profiling in three human population-based studies
Ganna, A., Fall, T., Salihović, S., Lee, W., Broeckling, C. D., Kumar, J., Hägg, S., Stenemo, M., Magnusson, P. K. E., Prenni, J. E., et al. (2015) · Metabolomics · doi:10.1007/s11306-015-0893-5 · Cited by 65 · see citing works
Upham, B. L., Park, J.-S., Babica, P., Sovadinová, I., Rummel, A. M., Trosko, J. E., Hirose, A., Hasegawa, R., Kanno, J., & Sai, K. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11728 · Cited by 64 · see citing works
Barnes, S., Benton, H. P., Casazza, K., Cooper, S. J., Cui, X., Du, X., Engler, J. A., Kabarowski, J. H. S., Li, S., Pathmasiri, W., et al. (2016) · Journal of Mass Spectrometry · doi:10.1002/jms.3780 · Cited by 64 · see citing works
Cao, Y., Li, J., Zhang, Z., Liu, J., Sun, X., Feng, X., Luo, H., Yang, W., Li, S., Yang, X., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00050 · Cited by 64 · see citing works
Li, Z., Liang, D., Ye, D., Chang, H. H., Ziegler, T. R., Jones, D. P., & Ebelt, S. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110506 · Cited by 63 · see citing works
Self-citationQi, S., Xu, D., Li, Q., Xie, N., Xia, J., Huo, Q., Li, P., Chen, Q., & Huang, S. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.08.022 · Cited by 62 · see citing works
WERF, M. J. V. D., Takors, R., Smedsgaard, J., Nielsen, J., Ferenci, T., Portais, J., Wittmann, C., Hooks, M. A., Tomassini, A., Oldiges, M., et al. (2007) · Metabolomics · doi:10.1007/s11306-007-0080-4 · Cited by 61 · see citing works
Metabolomics in the developmental origins of obesity and its cardiometabolic consequences
Hivert, M., Perng, W., Watkins, S. M., Newgard, C. B., Kenny, L. C., Kristal, B. S., Patti, M., ISGANAITIS, E. M., DeMeo, D. L., Oken, E., et al. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s204017441500001x · Cited by 60 · see citing works
Neurotoxic effects of perfluoroalkyl acids: Neurobehavioral deficit and its molecular mechanism
Wang, Y., Wang, L., Chang, W., Zhang, Y., Zhang, Y., & Liu, W. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.01.012 · Cited by 60 · see citing works
Metabolomic Analysis Reveals a Unique Urinary Pattern in Normozoospermic Infertile Men
Zhang, J., Mu, X., Xia, Y., Martin, F. L., Hang, W., Liu, L., Tian, M., Huang, Q., & Shen, H. (2014) · Journal of Proteome Research · doi:10.1021/pr5003142 · Cited by 59 · see citing works
(1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80442-0 · Cited by 57 · see citing works
Schillemans, T., Shi, L. S., Donat‐Vargas, C., Hanhineva, K., Tornevi, A., Johansson, I., Koponen, J. M., Kiviranta, H., Rolandsson, O., Bergdahl, I. A., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.106180 · Cited by 56 · see citing works
Kalkman, H. O., Hersberger, M., Walitza, S., & Berger, G. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094393 · Cited by 53 · see citing works
Dietary predictors of prenatal per- and poly-fluoroalkyl substances (PFAS) exposure
Eick, S., Goin, D., Trowbridge, J., Cushing, L., Smith, S., Park, J.-S., DeMicco, E., Padula, A., Woodruff, T., & Morello-Frosch, R. (2021) · Journal of Exposure Science and Environmental Epidemiology · doi:10.1038/s41370-021-00386-6 · Cited by 53 · see citing works
Razavi, A. C., Bazzano, L., He, J., Fernandez, C., Whelton, S. P., Krousel-Wood, M. A., Li, S., Nierenberg, J. L., Shi, M., Li, C., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015118 · Cited by 51 · see citing works
Zeeshan, M., Zhang, Y.-T., Yu, S., Huang, W.-Z., Zhou, Y., Vinothkumar, R., Chu, C., Li, Q.-Q., Wu, Q.-Z., Ye, W.-L., et al. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130486 · Cited by 51 · see citing works
Nyberg, E., Awad, R., Bignert, A., Ek, C., Sallsten, G., & Benskin, J. P. (2018) · Environmental Science: Processes & Impacts · doi:10.1039/c8em00174j · Cited by 49 · see citing works
Li, N., Liu, Y., Papandonatos, G., Calafat, A., Eaton, C., Kelsey, K., Cecil, K., Kalkwarf, H., Yolton, K., Lanphear, B., et al. (2021) · Environment International · doi:10.1016/j.envint.2020.106344 · Cited by 49 · see citing works
Adverse bioeffect of perfluorooctanoic acid on liver metabolic function in mice
Wu, X., Xie, G., Xu, X., Wu, W., & Yang, B. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0872-7 · Cited by 48 · see citing works
Chen, H., Wang, Z., Qin, M., Zhang, B., Lin, L., Ma, Q., Liu, C., Chen, X., Li, H., Lai, W., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.632950 · Cited by 46 · see citing works
Zhang, R., Yao, Y., Tu, L., Luan, T., & Chen, B. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.125017 · Cited by 45 · see citing works
Metabolomics in chemical risk analysis – A review
Hernández‐Mesa, M., Bizec, B. L., & Dervilly, G. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338298 · Cited by 45 · see citing works
Valvi, D., Højlund, K., Coull, B. A., Nielsen, F., Weihe, P., & Grandjean, P. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab267 · Cited by 42 · see citing works
Hu, X. Y., Li, S., Cirillo, P. M., Krigbaum, N. Y., Tran, V., Jones, D. P., & Cohn, B. A. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.05.058 · Cited by 40 · see citing works
Self-citationUse of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin, L., Pollitt, K. J. G., Liew, Z., Vollmar, A. K. R., Vasiliou, V., Johnson, C. H., & Zhang, Y. (2021) · Current Environmental Health Reports · doi:10.1007/s40572-020-00298-x · Cited by 39 · see citing works
Self-citationLi, S., Cirillo, P. M., Hu, X. Y., Tran, V., Krigbaum, N. Y., Yu, S., Jones, D. P., & Cohn, B. A. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.06.013 · Cited by 38 · see citing works
Self-citationBiomarker identification and pathway analysis of preeclampsia based on serum metabolomics
Chen, T., He, P., Tan, Y., & Xu, D. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.032 · Cited by 34 · see citing works
Chou, J., Liu, R., Yu, J., Liu, X., Zhao, X., Li, Y., Liu, L., & Sun, C. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.09.004 · Cited by 33 · see citing works
López‐Hernández, Y., Lara-Ramirez, E. E., Salgado‐Bustamante, M., López, J. A., Oropeza-Valdez, J. J., Jaime-Sánchez, E., Castañeda‐Delgado, J. E., Magaña-Aquino, M., Murgu, M., & Enciso‐Moreno, J. A. (2019) · Archives of Medical Research · doi:10.1016/j.arcmed.2019.05.006 · Cited by 33 · see citing works
Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum
Hu, X. Y., Li, S., Cirillo, P. M., Krigbaum, N. Y., Tran, V., Ishikawa, T., Merrill, M. A. L., Jones, D. P., & Cohn, B. A. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.05.059 · Cited by 32 · see citing works
Self-citationThe problem of nitrogen disposal in the obese
Alemany, M. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422411000163 · Cited by 31 · see citing works
Shi, L. S., Brunius, C. F., Lindelöf, M., Shameh, S. A., Wu, H., Lee, I., Landberg, R., & Moazzami, A. A. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600924 · Cited by 30 · see citing works
Hu, X. Y., Li, S., Cirillo, P. M., Krigbaum, N. Y., Tran, V., Jones, D. P., & Cohn, B. A. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.01.001 · Cited by 26 · see citing works
Self-citationKovalik, J., Zhao, X., Gao, F., Leng, S., Chow, V., Chew, H., Teo, L. L., Tan, R., Ewe, S. H., Tan, H. C., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.05.009 · Cited by 22 · see citing works
Analyzing Metabolomics Data for Environmental Health and Exposome Research
Cai, Y. A., Vollmar, A. K. R., & Johnson, C. H. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0239-3_22 · Cited by 16 · see citing works
Self-citationEnvironmental Pollution and the Developmental Origins of Childhood Liver Disease
Cave, M. C. (2020) · Hepatology · doi:10.1002/hep.31549 · Cited by 15 · see citing works
Martínez, P. J., Agudiez, M., Molero, D., Martin‐Lorenzo, M., Martin, M. B., Santiago‐Hernandez, A., García-Segura, J. M., Madruga, F., Cabrera, M., Calvo, E., et al. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01976-x · Cited by 15 · see citing works
Morillon, A.-C., Leite, D. F. B., Yakkundi, S. R., Gethings, L. A., Thomas, G. R., Baker, P. N., Kenny, L. C., English, J. A., & McCarthy, F. P. (2021) · Metabolomics · doi:10.1007/s11306-020-01740-9 · Cited by 14 · see citing works
Analysis of Purine Metabolites Maternal Serum for Evaluating the Risk of Gestosis
Senyavina, N. V., Анатольевна, Х. С., Grebennik, T. K., & Pavlovich, S. V. (2013) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-013-2225-y · Cited by 6 · see citing works
Does Nutrition Matter in Liver Disease?
Ramos‐Tovar, E., & Muriel, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00053-9 · Cited by 6 · see citing works
Schillemans, T., Shi, L. S., Donat‐Vargas, C., Tornevi, A., Sommar, J. N., Johansson, I., Koponen, J. M., Kiviranta, H., Hanhineva, K., Rolandsson, O., et al. (2020) · ISEE Conference Abstracts · doi:10.1289/isee.2020.virtual.p-0883 · Cited by 2 · see citing works
Flagged first, then by citations
2 of the 145 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Brunn, H., Arnold, G., Körner, W., Rippen, G., Steinhäuser, K. G., & Valentin, I. (2023) · Environmental Sciences Europe · doi:10.1186/s12302-023-00721-8 · Cited by 504 · see citing works
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
India-Aldana, S., Yao, M., Midya, V., Colicino, E., Chatzi, L., Chu, J., Gennings, C., Jones, D. P., Loos, R. J. F., Setiawan, V. W., et al. (2023) · Current Pollution Reports · doi:10.1007/s40726-023-00269-4 · Cited by 114 · see citing works
Self-citationGoodrich, J. A., Walker, D. I., He, J., Lin, X., Baumert, B. O., Hu, X., Alderete, T. L., Chen, Z., Valvi, D., Fuentes, Z. C., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11372 · Cited by 96 · see citing works
Self-citationZheng, J., Liu, S., Yang, J., Zheng, S., & Sun, B. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176158 · Cited by 98 · see citing works
Seewoo, B. J., Goodes, L. M., Mofflin, L., Mulders, Y. R., Wong, E. V. S., Toshniwal, P., Brunner, M., Alex, J., Johnston, B., Elagali, A. E. M., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108225 · Cited by 98 · see citing works
Wu, E., Wang, K., Liu, Z., Wang, J., Yan, H., Zhu, X., Zhu, X., & Chen, B. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c07020 · Cited by 88 · see citing works
Liu, T., Hu, L., Han, Y., Dong, L.-L., Wang, Y., Zhao, J., Liu, Y., Zhao, J., & Ying, G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157021 · Cited by 81 · see citing works
Yu, G., Wang, J., Liu, Y., Luo, T., Meng, X., Zhang, R., Huang, B., Sun, Y., & Zhang, J. (2023) · Environment International · doi:10.1016/j.envint.2023.107851 · Cited by 59 · see citing works
He, Q., Yang, Q., Wu, L., He, Y., Zeng, N., & Wang, Z. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137699 · Cited by 53 · see citing works
Prince, N., Begum, S., Mínguez‐Alarcón, L., Génard-Walton, M., Huang, M., Soeteman, D. I., Wheelock, C. E., Litonjua, A. A., Weiss, S. T., Kelly, R. S., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138228 · Cited by 48 · see citing works
Per‐ and polyfluoroalkyl substances and cardiometabolic diseases: A review
Schillemans, T., Donat‐Vargas, C., & Åkesson, A. (2023) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13949 · Cited by 48 · see citing works
Simplifying Nontargeted Analysis of PFAS in Complex Food Matrixes
Kaufmann, A., Butcher, P., Maden, K., Walker, S., & Widmer, M. (2022) · Journal of AOAC International · doi:10.1093/jaoacint/qsac071 · Cited by 42 · see citing works
Exploring the Chemical Space of the Exposome: How Far Have We Gone?
Samanipour, S., Barron, L., van Herwerden, D., Praetorius, A., Thomas, K. V., & O'Brien, J. W. (2024) · JACS Au · doi:10.1021/jacsau.4c00220 · Cited by 46 · see citing works
Zheng, J., Sun, B., Berardi, D., Lu, L., Yan, H. Y., Zheng, S., Aladelokun, O. B., Xie, Y., Cai, Y., Pollitt, K. J. G., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c04844 · Cited by 42 · see citing works
Self-citationFeng, C., Lin, Y., Le, S., Ji, J., Chen, Y., Wang, G., Xiao, P., Zhao, Y., & Lu, D. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c07533 · Cited by 40 · see citing works
Prenatal PFAS exposure, gut microbiota dysbiosis, and neurobehavioral development in childhood
Zhou, Y., Zhang, L., Li, Q., Wang, H., Wang, H., Shi, H., Lu, W., & Zhang, Y. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133920 · Cited by 38 · see citing works
Pezeshki, H., Rajabi, S., Hashemi, M., Moradalizadeh, S., & Nasab, H. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42782 · Cited by 38 · see citing works
Beale, D. J., Nguyen, T. V., Shah, R., Bissett, A. B., Nahar, A., Smith, M. D., González-Astudillo, V., Braun, C., Baddiley, B., & Vardy, S. (2022) · Metabolites · doi:10.3390/metabo12080747 · Cited by 36 · see citing works
Chen, Y., Lv, J., Fu, L., Wu, Y. Q., Zhou, S., Liu, S., Zheng, L., Feng, W., & Zhang, L. (2023) · Environment International · doi:10.1016/j.envint.2023.107817 · Cited by 35 · see citing works
Beale, D. J., Bissett, A. B., Nilsson, S., Bose, U., Nelis, J. L. D., Nahar, A., Smith, M. D., González-Astudillo, V., Braun, C., Baddiley, B., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156324 · Cited by 35 · see citing works
Ji, D., Pan, Y., Qiu, X., Gong, J., Li, X., Niu, C., Yao, J., Luo, S., Zhang, Z., Wang, Q., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c09184 · Cited by 34 · see citing works
Hampson, H. E., Li, S., Walker, D. I., Wang, H., Jia, Q., Rock, S., Costello, E. J., Bjornstad, P., Pyle, L. L., Nelson, J. W., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176519 · Cited by 31 · see citing works
Rock, K. D., Polera, M. E., Guillette, T. C., Starnes, H. M., Dean, K., Watters, M., Stevens-Stewart, D., & Belcher, S. M. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c01146 · Cited by 31 · see citing works
Lettoof, D. C., Nguyen, V., Richmond, W. R., Nice, H. E., Gagnon, M. M., & Beale, D. J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165260 · Cited by 29 · see citing works
Chen, Y., Wu, Y. Q., Lv, J., Zhou, S., Lin, S., Huang, S., Zheng, L., Deng, G., Feng, Y., Zhang, G., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108405 · Cited by 28 · see citing works
Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice
Hu, J., Dai, J., & Sheng, N. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c08033 · Cited by 27 · see citing works
Wang, F., Lin, Y., Qin, L., Zeng, X., Jiang, H., Liang, Y., Wen, S., Li, X., Huang, S., Li, C., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109203 · Cited by 28 · see citing works
Conley, J. M., Lambright, C. S., Evans, N., Farraj, A. K., Smoot, J., Grindstaff, R. D., Hill, D., McCord, J. P., Medlock-Kakaley, E., Dixon, A., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164609 · Cited by 27 · see citing works
Hyötyläinen, T., McGlinchey, A. J., Salihović, S., Schubert, A., Douglas, A., Hay, D. C., O’Shaughnessy, P. J., Iredale, J. P., Shaw, S., Fowler, P., et al. (2024) · The Lancet Planetary Health · doi:10.1016/s2542-5196(23)00257-7 · Cited by 24 · see citing works
Maître, L., Jedynak, P., Gallego-Paüls, M., Ciaran, L., Audouze, K., Casas, M., & Vrijheid, M. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115788 · Cited by 24 · see citing works
Effects of Perfluorooctanoic Acid on Gut Microbiota and Microbial Metabolites in C57BL/6J Mice
Gao, B., Chen, L., Xu, W., Shan, J., Shen, W., & Gao, N. (2023) · Metabolites · doi:10.3390/metabo13060707 · Cited by 24 · see citing works
Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014
Guo, P., Jin, Z., Bellia, G., Luo, J., Inoue, K., Pollitt, K. J. G., Deziel, N. C., & Liew, Z. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117092 · Cited by 24 · see citing works
Self-citationA metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
Rhee, J., Loftfield, E., Albanes, D., Layne, T. M., Stolzenberg‐Solomon, R. Z., Liao, L. M., Playdon, M. C., Berndt, S. I., Sampson, J. N., Freedman, N. D., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108198 · Cited by 22 · see citing works
PFAS and their association with the increased risk of cardiovascular disease in postmenopausal women
Eve, A. A., Tunc, E. P., Mehta, D., Yoo, J. Y., Yılmaz, H. E., Emren, S. V., Akçay, F. A., & Madak‐Erdogan, Z. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae065 · Cited by 24 · see citing works
Hunting Metabolic Biomarkers for Exposure to Per- and Polyfluoroalkyl Substances: A Review
Ma, X., Cai, D., Chen, Q., Zhu, Z., Zhang, S., Wang, Z., Hu, Z., Shen, H., & Meng, Z. (2024) · Metabolites · doi:10.3390/metabo14070392 · Cited by 22 · see citing works
Critical role of pore size on perfluorooctanoic acid adsorption behaviors in carbonaceous sorbents
Robertson, M. A., Lamb, B., Griffin, A. S., He, L., Ma, B., & Qiang, Z. (2025) · Materials Horizons · doi:10.1039/d4mh01771d · Cited by 20 · see citing works
Kaiser, A.-M., Jeddi, M. Z., Uhl, M., Jornod, F., Fernández, M. F., & Audouze, K. (2022) · Toxics · doi:10.3390/toxics10080449 · Cited by 20 · see citing works
Ge, Y., Wang, Z., Chen, X., Wang, W., Liu, Z., Sun, H., & Zhang, L. (2023) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5774 · Cited by 20 · see citing works
Li, Z., Zhang, M., Hong, X., Wang, G., Choi, G., Nadeau, K. C., Buckley, J. P., & Wang, X. (2024) · Environment International · doi:10.1016/j.envint.2024.109144 · Cited by 20 · see citing works
Iwata, H., Kobayashi, S., Itoh, M., Itoh, S., Ketema, R. M., Tamura, N., Miyashita, C., Yamaguchi, T., Yamazaki, K., Masuda, H., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108321 · Cited by 18 · see citing works
Zhao, Z., Zhou, J., Shi, A., Wang, J., Li, H., Yin, X., Gao, J., Wu, Y., Li, J., Sun, Y. X., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136090 · Cited by 18 · see citing works
Wang, Z., Zhang, B., Zhang, J., Xu, S., Dai, Y., Ding, J., Guo, J., Qi, X., Chang, X., Wu, C., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109037 · Cited by 17 · see citing works
Thangaraj, S. V., Kachman, M. T., Halloran, K. M., Sinclair, K. D., Lea, R. G., Bellingham, M., Evans, N. P., & Padmanabhan, V. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.161054 · Cited by 17 · see citing works
Rabotnick, M. H., Ehlinger, J. V., Haidari, A., & Goodrich, J. M. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112046 · Cited by 17 · see citing works
Chang, C.-J., Young, A. S., Keil, A., Mullins, C. E., Liang, D., Zhao, S., Jones, D. P., Hu, X., Walker, D. I., & White, A. J. (2025) · Environment International · doi:10.1016/j.envint.2025.109590 · Cited by 16 · see citing works
Self-citationContaminations from Lithium-Ion Battery Fires—Per- and Polyfluoroalkyl Substances (PFAS) in Soot
Willstrand, O., Quant, M., & Hynynen, J. (2025) · Fire Technology · doi:10.1007/s10694-025-01708-y · Cited by 16 · see citing works
Yu, T., Zhang, H., Xie, J., Yan, Y., Zhang, D., Wu, Y., Sun, L., Tian, N., Zhou, Y., & Zhang, X. (2025) · Environment International · doi:10.1016/j.envint.2025.109934 · Cited by 16 · see citing works
Marín‐Sáez, J., Hernández‐Mesa, M., Cano-Sancho, G., & García-Campaña, A. M. (2024) · Talanta · doi:10.1016/j.talanta.2024.126616 · Cited by 16 · see citing works
Suthar, H., Manea, T., Pak, D., Woodbury, M., Eick, S. M., Cathey, A. L., Watkins, D. J., Strakovsky, R. S., Ryva, B. A., Pennathur, S., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c00094 · Cited by 15 · see citing works
Beale, D. J., Limpus, D. J., Sinclair, G. M., Bose, U., Bourne, N. A., Stockwell, S., Lettoof, D. C., Shah, R., Nguyen, T. V., González-Astudillo, V., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176313 · Cited by 14 · see citing works
Qiao, R., Guo, F., Ding, H., Sun, D., Hu, Q., Li, Y., Zhang, M., Zhang, Q., & Li, W. (2025) · Human Reproduction Open · doi:10.1093/hropen/hoaf044 · Cited by 14 · see citing works
Metabolic changes associated with PFAS exposure in firefighters: A pilot study
Rotander, A., Gómez, M. J., Mueller, J. F., Toms, L.-M. L., & Hyötyläinen, T. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176004 · Cited by 14 · see citing works
Briassoulis, G., Ilia, S., & Briassouli, E. (2025) · Life · doi:10.3390/life15071057 · Cited by 15 · see citing works
Sun, B., Zhao, Y., Yang, S., Li, X., Li, N., Wang, Y., Han, Q., Liu, X., Tu, Q., Zheng, J., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137613 · Cited by 13 · see citing works
Microbial and molecular approaches for PFAS transformation in soils: prospects and limitations
Shahid, M., & Shafi, Z. (2026) · RSC Advances · doi:10.1039/d5ra07508d · Cited by 15 · see citing works
Neonatal per- and polyfluoroalkyl substance exposure in relation to retinoblastoma
Chen, Y., Paul, K. C., Walker, D. I., Jones, D. P., Wang, X., Ritz, B. R., & Heck, J. E. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117435 · Cited by 13 · see citing works
Self-citationRemili, A., Morris, A. D., Muir, D. C. G., Houde, M., Brown, T. M., Ferguson, S. H., Blair, D. A. D., & Letcher, R. J. (2025) · Environmental Research · doi:10.1016/j.envres.2025.120862 · Cited by 13 · see citing works
Midya, V., Yao, M., Colicino, E., Barupal, D. K., Lin, X., Gennings, C., Chatzi, L., Setiawan, V. W., Loos, R. J. F., Walker, R. W., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105838 · Cited by 12 · see citing works
Zhang, F., Tian, Y., Pan, Y., Sheng, N., & Dai, J. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c03774 · Cited by 11 · see citing works
Shurson, G. C. (2025) · Sustainability · doi:10.3390/su17156957 · Cited by 12 · see citing works
Early pregnancy serum PFAS are associated with alterations in the maternal lipidome
Rabotnick, M. H., Haidari, A., Dolinoy, D. C., Meijer, J. L., Harris, S. M., Burant, C., Padmanabhan, V., & Goodrich, J. M. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120183 · Cited by 10 · see citing works
Chen, Z., Zhao, Y., Wei, T., & Shen, C. (2025) · Water · doi:10.3390/w17091319 · Cited by 10 · see citing works
Zeng, X., Chen, T., Cui, Y., Zhao, J., Chen, Q., Yu, Z., Zhang, Y., Han, L., Chen, Y., & Zhang, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161504 · Cited by 10 · see citing works
Zhang, T., Wen, R., Yang, Y., Yang, N., & Liu, C. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1278830 · Cited by 9 · see citing works
Yang, M., Zhao, J., An, Z., Li, H., Ma, C., Lv, J., Xiao, F., Tan, Z., Li, L., Zhang, X., et al. (2024) · Journal of Environmental Sciences · doi:10.1016/j.jes.2024.03.022 · Cited by 8 · see citing works
Min, E. K., Park, S.-Y., Liu, K., & Kim, K. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136712 · Cited by 8 · see citing works
Hossain, M. M., Nawaz, M. Z., Dar, M. A., Geng, A., Alghamdi, H. A., Han, S. Y., & Zhu, D. (2024) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2024.100579 · Cited by 9 · see citing works
Assessment of PFDA toxicity on RTgill-W1 cell line via metabolomics and lipidomics approaches.
Nguyen, T. V., Kumar, A., Taraji, M., & Lloyd, N. D. R. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107395 · Cited by 6 · see citing works
Wu, M., Wu, Y., Li, K., Guo, W., Liu, Y., Song, X., Liang, H., Zhao, H., Miao, M., Xue, J., et al. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.06.008 · Cited by 8 · see citing works
Guo, P., Luo, J., Zhang, J., Bonde, J. ., Struciński, P., Ohniev, V. A., Arah, O. A., Deziel, N. C., Warren, J. L., Toft, G. V., et al. (2025) · Environmental Health · doi:10.1186/s12940-025-01199-y · Cited by 8 · see citing works
Self-citationLi, X., Hou, S., Guo, X., Zhang, M., Alvarez, P. J. J., Chen, W., & Zhang, T. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.1567631 · Cited by 8 · see citing works
Zhang, J., Sun, P., Ren, H., Guo, X., Ding, E., Ma, X., Li, C., Li, C., Xu, Y., Cao, K., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c12999 · Cited by 7 · see citing works
Suthar, H., Tanghal, R. B., Chatzi, L., Goodrich, J. A., Morello-Frosch, R. A., & Aung, M. T. (2024) · Current Environmental Health Reports · doi:10.1007/s40572-024-00451-w · Cited by 7 · see citing works
Guo, P., Warren, J. L., Deziel, N. C., & Liew, Z. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae309 · Cited by 7 · see citing works
Self-citationLiu, J., Lu, H., Yang, N., Hua, X., Pan, W., Gu, Y., Dong, D., & Liang, D. (2022) · The Analyst · doi:10.1039/d2an00820c · Cited by 7 · see citing works
Cheng, X., Wang, F., Zhang, J., Wang, Y., Liu, L., Liu, L., Guo, H. Y., Gao, J., Tan, Y., & He, M. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.139644 · Cited by 6 · see citing works
Impact of PFAS exposure on lipid metabolic pathways: mechanisms and implications in carcinogenesis
Ferguson, E. J., Tessmann, J. W., & Zaytseva, Y. Y. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1768277 · Cited by 6 · see citing works
Guo, P.-F., Luo, J., Zhang, J., Bonde, J. P., Struciński, P., Ohniev, V. A., Arah, O., Deziel, N., Warren, J. L., Toft, G., et al. (2025) · Environmental Science and Technology · doi:10.1021/acs.est.4c13040 · Cited by 6 · see citing works
Self-citationSalihović, S., Dunder, L., Lind, M., & Lind, L. (2024) · Journal of Mass Spectrometry · doi:10.1002/jms.4999 · Cited by 6 · see citing works
Chu, S., de Solla, S. R., Smythe, T. A., Eng, M. L., Lavoie, R. A., & Letcher, R. J. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126414 · Cited by 6 · see citing works
Hu, L., Huang, Y., Shen, X., Wang, F., Yang, M., Zhu, M., Cai, X., Xiang, F., Song, L., Wang, Y., et al. (2025) · American Journal of Epidemiology · doi:10.1093/aje/kwaf033 · Cited by 5 · see citing works
Studying on genetic diversity and metabolic differences of Saccharomyces cerevisiae in Baijiu
Li, Q., Lin, B., Tang, J., An, L., Jiang, W., Li, R., Zhang, G., Yang, Q., Yang, S., & Chen, S. (2024) · European Food Research and Technology · doi:10.1007/s00217-024-04489-w · Cited by 5 · see citing works
Yang, M., Li, A., Mei, Y., Li, H., An, Z., Zhou, Q., Zhao, J., Li, Y., Li, K., Zhao, M., et al. (2024) · Journal of Environmental Sciences · doi:10.1016/j.jes.2024.12.029 · Cited by 5 · see citing works
Neurochemical mechanisms of perfluoroalkyl substances (PFAS) neurotoxic action
Brown-Leung, J. M., & Cannon, J. R. (2023) · Advances in neurotoxicology · doi:10.1016/bs.ant.2023.08.002 · Cited by 5 · see citing works
Cao, Y., Huang, Y., Ma, Y., Nie, J., Hu, C., Chen, Y., Xu, J., & Lu, L. (2025) · Environmental Research Communications · doi:10.1088/2515-7620/add0fa · Cited by 4 · see citing works
Mixture toxicity of perfluoroalkyl substances on the aquatic invertebrate Gammarus roeselii
Kalis, E. J. J., Zander, J. W., Geist, J. P., & Beggel, S. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107618 · Cited by 4 · see citing works
Yang, J., Wu, J., & Wa̅ng, Y. (2025) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.5c01048 · Cited by 4 · see citing works
Per- and polyfluoroalkyl substances: A novel risk factor for cardiovascular disease
Chen, W., Qiu, C., Yang, Z., Nash, H., Karim, R., & Chen, Z. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.119955 · Cited by 4 · see citing works
Guan, H., Chen, J., Kaur, K., Amreen, B., Lesseur, C., Dolios, G., Andra, S. S., Narasimhan, S., Pulivarthi, D., Midya, V., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179520 · Cited by 4 · see citing works
Zhu, J., Li, S., Li, X., Wang, L., & Ling-bin, D. (2025) · Environmental Technology & Innovation · doi:10.1016/j.eti.2025.104242 · Cited by 4 · see citing works
Invited Perspective: PFAS and Dyslipidemia—The Perimenopausal Period as a Critical Time Window
Chatzi, L., & Baumert, B. O. (2023) · Environmental Health Perspectives · doi:10.1289/ehp13195 · Cited by 4 · see citing works
Yu, G., Luo, T., Huo, X., Meng, X., Feng, L., Sun, Y., Liu, Y., & Zhang, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1589826 · Cited by 3 · see citing works
Leader, J. E., Robinson, J., Whitcomb, B. W., Valvi, D., Chen, C., Chong, Y. S., Tan, K. H., Ng, S., Chan, J. C. Y., Eriksson, J. G., et al. (2025) · Environment International · doi:10.1016/j.envint.2025.109865 · Cited by 3 · see citing works
Wan, N., Liu, Y., Wang, Q., Liu, S., Zhang, M., Li, M., Zhang, X., Wang, X., & Mai, B. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140209 · Cited by 3 · see citing works
Zhang, T., Liu, L., Zhang, Q., Jiang, W. H., Huang, Y., Ye, W., Zhang, N., & Zhang, J. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141652 · Cited by 3 · see citing works
Li, X., Ren, J., Li, T., Han, Y., Dong, H., Sun, H. J., Yan, G., & Wang, X. (2024) · Natural Product Communications · doi:10.1177/1934578x241259364 · Cited by 3 · see citing works
Li, L., Li, C., Zhang, G., Wang, Y., Wang, H., & Xu, B. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.06.020 · Cited by 3 · see citing works
PFBS disrupts lipid metabolism and mitochondrial function in human trophoblast cells
Happel, J., Mellouk, N., Crute, C., & Feng, L. (2025) · Toxicology · doi:10.1016/j.tox.2025.154269 · Cited by 3 · see citing works
Song, C., Dong, R., Yijing, Z., Li, X., Dong, D., Huang, Z., Song, X., & Zhou, G. (2025) · Aquaculture International · doi:10.1007/s10499-024-01821-9 · Cited by 3 · see citing works
Wang, A., Zeng, J. S., Song, X., Huang, Y., Yao, J., Zhu, L., Gao, Y., Wang, B., Wu, Y., Xu, Z., et al. (2024) · Food Frontiers · doi:10.1002/fft2.504 · Cited by 2 · see citing works
- Authors
- Guo, P., Furnary, T., Vasiliou, V., Yan, Q., Nyhan, K., Jones, D. P., Johnson, C. H., & Liew, Z.
- Affiliations
- Yale University (US)
- University of California, Los Angeles (US)
- Emory University (US)
- Corresponding author
- Liew, Zeyan
- ORCID
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 162
- Pages
- 107159
- ISSN
- 0160-4120 (ISSN-L)
- PMC
- PMC8969205
- OpenAlex
- W4214507826
- Cited by
- 145
- References
- 145
- Citations by year
- 2026: 33 · 2025: 44 · 2024: 33 · 2023: 28 · 2022: 7
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China Scholarship Council
- National Institutes of Health
- National Cancer Institute (K12CA215110)
- National Institute of Environmental Health Sciences (R00ES026729)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- per- and polyfluoroalkyl substances, PFAS exposure, untargeted metabolomics, tryptophan metabolism, urea cycle, lipid metabolism, glycerophospholipid metabolism, fatty acids, L-carnitine, TCA cycle, purine and pyrimidine metabolism, perfluorooctanoic acid, PFOS, PFHxS, perfluorononanoic acid, PFAS mixtures, children and adolescents, pregnant women
- MeSH terms
- Adolescent, Adult, Child, Environmental Pollutants, Female, Fluorocarbons, Humans, Pregnancy, Prospective Studies, Alkanesulfonic Acids, Lipid Metabolism, Metabolomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review