Plasma uric acid and the risk of type 2 diabetes in a Chinese community
Abstract
BACKGROUND: Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals. METHODS: We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes. RESULTS: High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20-2.23; P for trend <0.001]. After additional adjustment for metabolic syndrome, the RR for comparing the participants in the fifth and first uric acid quintiles was 1.40 (95% CI, 1.02-1.92; P for trend = 0.027). In joint analyses, participants who were in the highest uric acid quintile and also had metabolic syndrome had a 3.3-fold greater risk of diabetes (95% CI, 2.27-4.94) than those in the lowest uric acid quintile and without metabolic syndrome. CONCLUSIONS: These findings suggest a modest positive association between plasma uric acid concentration and the incidence of type 2 diabetes in Chinese individuals. The association between hyperuricemia and diabetes was partly mediated through the metabolic syndrome.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
[17] used a design probe methodology and self-documentation to examine how social and environmental contexts shaped dietary behaviors in Ireland.
“For instance, [17] used a design probe methodology and self-documentation to examine how social and environmental contexts shaped dietary behaviors in Ireland.”
From Methodological Approaches in Studying Type-2 Diabetes-Related Health Behaviors—A Systematic Review (2025) · cites this paper as [17]
Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305 · see citing works
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
Johnson, R. J., Kang, D., Feig, D. I., Kivlighn, S. D., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodríguez‐Iturbe, B., Herrera-Acosta, J., & Mazzali, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000069700.62727.c5 · Cited by 1,354 · see citing works
Fossati, P., Prencipe, L., & Berti, G. (1980) · Clinical Chemistry · doi:10.1093/clinchem/26.2.227 · Cited by 965 · see citing works
Tan, C. T., Ma, S., Wai, D. C. H., Chew, S. K., & Tai, E. S. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1182 · Cited by 824 · see citing works
Fossati, P., Prencipe, L., & Berti, G. (1980) · Clinical Chemistry · doi:10.1093/clinchem/26.2.0227 · Cited by 701 · see citing works
Uric Acid Is a Risk Factor for Myocardial Infarction and Stroke
Bos, M. J., Koudstaal, P. J., Albert Hofman, D., Witteman, J. C. M., & Breteler, M. M. B. (2006) · Stroke · doi:10.1161/01.str.0000221716.55088.d4 · Cited by 616 · see citing works
Relations of Serum Uric Acid to Longitudinal Blood Pressure Tracking and Hypertension Incidence
Sundström, J., Sullivan, L., D'Agostino, R., Levy, D., Kannel, W., & Vasan, R. (2005) · HYPERTENSION · doi:10.1161/01.hyp.0000150784.92944.9a · Cited by 536 · see citing works
Enzyme immunoassay for intact human insulin in serum or plasma
Andersen, L., Dinesen, B., Jørgensen, P. N., Poulsen, F., & Røder, M. E. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.4.578 · Cited by 519 · see citing works
Hansel, B., Giral, P., Nobécourt, E., Chantepie, S., Bruckert, É., Chapman, M. J., & Kontush, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0305 · Cited by 476 · see citing works
Effect of insulin on uric acid excretion in humans
Galvan, A. Q., Natali, A., Baldi, S., Frascerra, S., Sanna, G., Ciociaro, D., & Ferrannini, E. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.1.e1 · Cited by 454 · see citing works
Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease
Kanellis, J., & Kang, D. (2005) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.09.007 · Cited by 444 · see citing works
A simple specific method for precipitation of low density lipoproteins.
Wieland, H., & Seidel, D. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37936-0 · Cited by 433 · see citing works
Relationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome
Yoo, T. W., Sung, K., Shin, H. S., Kim, B. J., Kim, B. S., Kang, J. H., Lee, M. H., Park, J. R., Kim, H. Y., Rhee, E., et al. (2005) · Circulation Journal · doi:10.1253/circj.69.928 · Cited by 412 · see citing works
Hayden, M. R., & Tyagi, S. C. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-10 · Cited by 397 · see citing works
Nakanishi, N., Okamoto, M., Yoshida, H., Matsuo, Y., Suzuki, K., & Tatara, K. (2003) · European Journal of Epidemiology · doi:10.1023/a:1024600905574 · Cited by 383 · see citing works
Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us?
Baker, J. F., Krishnan, E., Chen, L., & Schumacher, H. R. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.03.043 · Cited by 354 · see citing works
Conen, D., Wietlisbach, V., Bovet, P., Shamlaye, C. F., Riesen, W., Paccaud, F. M., & Burnier, M. (2004) · BMC Public Health · doi:10.1186/1471-2458-4-9 · Cited by 352 · see citing works
PRIMARY PREVENTION OF DIABETES: What Can Be Done and How Much Can Be Prevented?
Schulze, M. B., & Hu, F. B. (2004) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.26.021304.144532 · Cited by 330 · see citing works
Self-citationIshizaka, N., Ishizaka, Y., Toda, E.-I., Nagai, R., & Yamakado, M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000161274.87407.26 · Cited by 306 · see citing works
Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome
Krishnan, E., Kwoh, C. K., Schumacher, H. R., & Kuller, L. H. (2006) · Hypertension · doi:10.1161/01.hyp.0000254480.64564.b6 · Cited by 292 · see citing works
Role of uric acid in hypertension, renal disease, and metabolic syndrome.
Heinig, M., & Johnson, R. J. (2006) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.73.12.1059 · Cited by 291 · see citing works
Taniguchi, Y., Hayashi, T., Tsumura, K., Endo, G., Fujii, S., & Okada, K. (2001) · Journal of Hypertension · doi:10.1097/00004872-200107000-00005 · Cited by 290 · see citing works
Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-Based Study
Onat, A., Uyarel, H., Hergenç, G., Karabulut, A., Albayrak, S., Sarı, İ., Yazıcı, M., & Keleş, İ. (2006) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.02.014 · Cited by 245 · see citing works
Serum Uric Acid Predicts Incident Hypertension in a Biethnic Cohort
Mellen, P. B., Bleyer, A. J., Erlinger, T. P., Evans, G. W., Nieto, F. J., Wagenknecht, L. E., Wofford, M. R., & Herrington, D. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000249768.26560.66 · Cited by 234 · see citing works
Nakagawa, T., Kang, D., Feig, D. I., Sánchez‐Lozada, L. G., Srinivas, T. R., Sautin, Y. Y., Ejaz, A. A., Segal, M. S., & Johnson, R. J. (2006) · Kidney International · doi:10.1038/sj.ki.5000391 · Cited by 172 · see citing works
Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes
Bo, S., Cavallo‐Perin, P., Gentile, L., Repetti, E., & Pagano, G. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00812.x · Cited by 162 · see citing works
Association Between Serum Uric Acid Level and Components of the Metabolic Syndrome
Lin, S.-D., Tsai, D.-H., & Hsu, S.-R. (2006) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70320-x · Cited by 151 · see citing works
Feig, D. I., Mazzali, M., Kang, D., Nakagawa, T., Price, K. L., Kannelis, J., & Johnson, R. J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121331 · Cited by 150 · see citing works
Patterson, R. A., Horsley, E. T. M., & Leake, D. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200407-jlr200 · Cited by 142 · see citing works
Lee, Y., Lin, R. S., Sung, F. C., Yang, C.-Y., Chien, K., Chen, W., Su, T., Hsu, H.-C., & Huang, Y.-C. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00198-0 · Cited by 113 · see citing works
Self-citationChien, K., Hsu, H., Sung, F., Su, T., Chen, M.-F., & Lee, Y. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.07.033 · Cited by 88 · see citing works
Self-citationHormonal and cytokine effects of uric acid
Sánchez‐Lozada, L. G., Nakagawa, T., Kang, D., Feig, D. I., Franco, M., Johnson, R. J., & Herrera-Acosta, J. (2005) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000199010.33929.7f · Cited by 67 · see citing works
Apolipoprotein A-I and B and Stroke Events in a Community-Based Cohort in Taiwan
Chien, K., Sung, F., Hsu, H., Su, T., Lin, R. S., & Lee, Y. (2002) · Stroke · doi:10.1161/hs0102.101626 · Cited by 63 · see citing works
Self-citationLi, Y., Stamler, J., Xiao, Z., Folsom, A. R., Tao, S., & Zhang, H. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.2.288 · Cited by 61 · see citing works
Chien, K., Lee, Y., Sung, F., Hsu, H., Su, T., & Lin, R. S. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.6.838 · Cited by 47 · see citing works
Self-citationUric acid and the immune response
Gersch, M. S., & Johnson, R. J. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl226 · Cited by 22 · see citing works
Relative importance of atherosclerotic risk factors for coronary heart disease in Taiwan
Chien, K., Sung, F. C., Hsu, H. C., Su, T., Chang, W.-D., & Lee, Y.-T. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000161443.88679.8f · Cited by 21 · see citing works
Self-citationPeripheral blood cells among community residents living near nuclear power plants
Lee, Y. L., Sung, F. C., LIN, R., Hsu, H., Chien, K., Yang, C., & Chen, W. (2001) · The Science of The Total Environment · doi:10.1016/s0048-9697(01)00823-3 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Uric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,443 · see citing works
Association Between Serum Uric Acid and Development of Type 2 Diabetes
Kodama, S., Saito, K., Yachi, Y., Asumi, M., Sugawara, A., Totsuka, K., Saito, A., & Sone, H. (2009) · Diabetes Care · doi:10.2337/dc09-0288 · Cited by 548 · see citing works
Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?
Johnson, R. J., Perez-Pozo, S. E., Sautin, Y. Y., Manitius, J., Sánchez‐Lozada, L. G., Feig, D. I., Shafiu, M., Segal, M. S., Glassock, R. J., Shimada, M., et al. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0033 · Cited by 500 · see citing works
Metabolic syndrome, diabetes, and hyperuricemia
Li, C., Hsieh, M., & Chang, S. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32835d951e · Cited by 468 · see citing works
SLC2A9 Is a High-Capacity Urate Transporter in Humans
Caulfield, M. J., Munroe, P. B., O’Neill, D., Witkowska, K., Charchar, F. J., Doblado, M., Evans, S., Eyheramendy, S., Onipinla, A. K., Howard, P., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050197 · Cited by 375 · see citing works
Association of risk factors with type 2 diabetes: A systematic review
Ismail, L., Materwala, H., & Alkaabi, J. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.03.003 · Cited by 366 · see citing works
Lv, Q., Meng, X., He, F.-F., Chen, S., Su, H., Xiong, J., Gao, P., Tian, X., Liu, J.-S., Zhu, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056864 · Cited by 363 · see citing works
Two Risk-Scoring Systems for Predicting Incident Diabetes Mellitus in U.S. Adults Age 45 to 64 Years
Kahn, H. S., Cheng, Y. J., Thompson, T. J., Imperatore, G., & Gregg, E. W. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-11-200906020-00002 · Cited by 204 · see citing works
Villegas, R., Xiang, Y., Elasy, T. A., Xu, W., Cai, H., Cai, Q., Linton, M. F., Fazio, S., Zheng, W., & Shu, X. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.07.012 · Cited by 197 · see citing works
Uric Acid as a Cause of the Metabolic Syndrome
King, C., Lanaspa, M. A., Jensen, T., Tolan, D. R., Sánchez‐Lozada, L. G., & Johnson, R. J. (2018) · Contributions to nephrology · doi:10.1159/000484283 · Cited by 190 · see citing works
Shi, Y., & Williamson, G. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005310 · Cited by 157 · see citing works
A prediction model for type 2 diabetes risk among Chinese people
Chien, K., Cai, T., Hsu, H., Su, T., Chang, W., Chen, M., Lee, Y.-C., & Hu, F. B. (2008) · Diabetologia · doi:10.1007/s00125-008-1232-4 · Cited by 157 · see citing works
Self-citationOxidative stress, antioxidant status and lipid profile in the saliva of type 2 diabetics
Al-Rawi, N. H. (2011) · Diabetes and Vascular Disease Research · doi:10.1177/1479164110390243 · Cited by 148 · see citing works
Is there anything good in uric acid?
Alvarez‐Lario, B., & Macarrón‐Vicente, J. (2011) · QJM · doi:10.1093/qjmed/hcr159 · Cited by 137 · see citing works
Chen, P., Sung, F. C., Chien, K., Hsu, H. C., Su, T., & Lee, Y.-T. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp360 · Cited by 127 · see citing works
Self-citationAssociation between Serum Uric Acid Levels and Diabetes Mellitus
Bandaru, P., & Shankar, A. (2011) · International Journal of Endocrinology · doi:10.1155/2011/604715 · Cited by 120 · see citing works
Haque, M. T., Rahman, S., Islam, S., Molla, N. H., & Ali, N. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0446-6 · Cited by 109 · see citing works
Ito, H., Abe, M., Mifune, M., Oshikiri, K., Antoku, S., Takeuchi, Y., & Togane, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027817 · Cited by 106 · see citing works
Pfister, R., Barnes, D. R., Luben, R., Forouhi, N. G., Bochud, M., Khaw, K., Wareham, N. J., & Langenberg, C. (2011) · Diabetologia · doi:10.1007/s00125-011-2235-0 · Cited by 103 · see citing works
Kramer, C. K., von Mühlen, D. G., Jassal, S. K., & Barrett-Connor, E. L. (2009) · Diabetes Care · doi:10.2337/dc09-0275 · Cited by 99 · see citing works
Jia, Z., Zhang, X., Kang, S., & Wu, Y. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.03.026 · Cited by 98 · see citing works
Zuo, Y., Yang, Y., Zhuo, Z., He, W., & Aydın, Z. (2010) · Talanta · doi:10.1016/j.talanta.2010.11.073 · Cited by 97 · see citing works
Lack of association between dietary fructose and hyperuricemia risk in adults
Sun, S. Z., Flickinger, B. D., Williamson-Hughes, P. S., & Empie, M. W. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-16 · Cited by 96 · see citing works
Oda, E., Kawai, R., Sukumaran, V., & Watanabe, K. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.2426 · Cited by 90 · see citing works
Muir, S. W., Harrow, C., Dawson, J., Lees, K. R., Weir, C. J., Sattar, N. A., & Walters, M. R. (2008) · Stroke · doi:10.1161/strokeaha.108.519793 · Cited by 90 · see citing works
Lippi, G., Montagnana, M., Salvagno, G. L., Targher, G., & Guidi, G. C. (2009) · Clinical Cardiology · doi:10.1002/clc.20511 · Cited by 81 · see citing works
Han, T., Meng, X., Shan, R., Zi, T., Li, Y., Ma, H., Zhao, Y., Shi, D., Qu, R., Guo, X., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0074-5 · Cited by 80 · see citing works
Bombelli, M., Quarti‐Trevano, F., Tadic, M. V., Facchetti, R., Cuspidi, C., Mancia, G., & Grassi, G. M. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001721 · Cited by 80 · see citing works
2011 Recommendations for the Diagnosis and Management of Gout and Hyperuricemia
Hamburger, M. I., Baraf, H. S. B., Adamson, T. C., Basile, J., Bass, L., Cole, B., Doghramji, P. P., Guadagnoli, G. A., Hamburger, F., Harford, R., et al. (2011) · The Physician and Sportsmedicine · doi:10.3810/psm.2011.11.1946 · Cited by 76 · see citing works
At the interface of antioxidant signalling and cellular function: Key polyphenol effects
Kerimi, A., & Williamson, G. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500940 · Cited by 71 · see citing works
Wei, C., Sun, C.-C., Wei, J. C., Tai, H.-C., Sun, C., Chung, C.-F., Chou, Y., Lin, P., & Yang, T. (2015) · BioMed Research International · doi:10.1155/2015/369179 · Cited by 66 · see citing works
The Impact of Education and Age on Metabolic Disorders
Stephens, C. R., Easton, J. F., Robles-Cabrera, A., Fossión, R., de la Cruz, L., Tapia, R., Barajas‐Martínez, A., Hernández-Chávez, A. A., López-Rivera, J. A., & Rivera, A. L. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00180 · Cited by 65 · see citing works
The Association between Serum Uric Acid and Residualβ-Cell Function in Type 2 Diabetes
Tang, W., Fu, Q., Zhang, Q., Sun, M., Gao, Y. J., Liu, X., Li, Q., Shan, S., & Yang, T. (2014) · Journal of Diabetes Research · doi:10.1155/2014/709691 · Cited by 62 · see citing works
Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan
Chien, K., Hsu, H.-C., Su, T., Chang, W.-T., Sung, F.-C., Chen, M.-F., & Lee, Y.-T. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2010.63 · Cited by 61 · see citing works
Self-citationShani, M., Vinker, S., Dinour, D., Leiba, M., Twig, G., Holtzman, E. J., & Leiba, A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2107 · Cited by 59 · see citing works
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
Krishnan, E., Akhras, K. S., Sharma, H., Marynchenko, M. B., Wu, E. Q., Tawk, R. H., Liu, J., & Shi, L. (2013) · QJM · doi:10.1093/qjmed/hct093 · Cited by 57 · see citing works
Interaction between serum uric acid and triglycerides in relation to blood pressure
Teng, F., Zhu, R., Zou, C., Xue, Y., Yang, M., Song, H., & Liang, J. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2010.112 · Cited by 54 · see citing works
Visceral fat mass: is it the link between uric acid and diabetes risk?
Seyedsadjadi, N., Berg, J., BILGIN, A. A. B., & Grant, R. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0532-4 · Cited by 54 · see citing works
Comparison of Nutrient Intake and Diet Quality Between Hyperuricemia Subjects and Controls in Korea
Ryu, K.-A., Kang, H. H., Kim, S. Y., Yoo, M.-K., Kim, J. S., Lee, C. H., & Wie, G.-A. (2014) · Clinical Nutrition Research · doi:10.7762/cnr.2014.3.1.56 · Cited by 52 · see citing works
Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
Pan, A., Teng, G. G., Yuan, J., & Koh, W. (2016) · Scientific Reports · doi:10.1038/srep25766 · Cited by 50 · see citing works
Elevation of serum uric acid and incidence of type 2 diabetes: A systematic review and meta‐analysis
Xu, Y., Xu, K., Bai, J., Liu, Y., Yu, R., Liu, C., Shen, C., & Wu, X. (2016) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2016.09.003 · Cited by 49 · see citing works
Uric Acid, Type 2 Diabetes, and Cardiovascular Diseases: Fueling the Common Soil Hypothesis?
Köenig, W., & Meisinger, C. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.099705 · Cited by 49 · see citing works
Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men
Villegas, R., Xiang, Y.-B., Cai, Q., Fazio, S., Linton, M. F., Li, H., Elasy, T. A., Zheng, W., & Shu, X. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2009.0084 · Cited by 48 · see citing works
Yamada, T., Fukatsu, M., Suzuki, S., Wada, T., & Joh, T. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.10.009 · Cited by 48 · see citing works
Comorbidities in Patients with Crystal Diseases and Hyperuricemia
Sattui, S. E., Singh, J. A., & Gaffo, A. (2014) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2014.01.005 · Cited by 47 · see citing works
Chuengsamarn, S., Rattanamongkolgul, S., & Jirawatnotai, S. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.12.002 · Cited by 46 · see citing works
Hyperuricemia and metabolic syndrome in children with overweight and obesity
Modino, S. C., de Armas, M. G. G., Mejías, S. M., Martínez, J. M. M., Bolaños, P. I., Viveros, M. M., & Quesada, J. M. L. (2012) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2012.06.010 · Cited by 45 · see citing works
Sun, Y., Chien, K., Hsu, H., Su, T., Chen, M.-F., & Lee, Y. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1077 · Cited by 45 · see citing works
Self-citationZhang, L., Wang, F., Wang, X., Liu, L., & Wang, H. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr597 · Cited by 43 · see citing works
Relevance of Uric Acid in Progression of Type 2 Diabetes Mellitus
Čaušević, A., Semiz, S., Macić-Džanković, A., Cico, B., Dujić, T., Malenica, M., & Bego, T. (2010) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2010.2736 · Cited by 43 · see citing works
The role of uric acid for predicting future metabolic syndrome and type 2 diabetes in older people
Chang, J.-L., Chen, Y.-L., Hung, Y.-J., Hsieh, C., Lee, C.-H., Pei, D., Lin, J., Wu, C., Liang, Y., & Lin, C. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0749-3 · Cited by 41 · see citing works
Serum uric acid, plasma glucose and diabetes
Nan, H., Pang, Z., Wang, S., Gao, W., Zhang, L., Ren, J., Ning, F., Tuomilehto, J. O., & Qiao, Q. (2009) · Diabetes and Vascular Disease Research · doi:10.1177/1479164109347408 · Cited by 41 · see citing works
Oda, E. (2013) · Heart and Vessels · doi:10.1007/s00380-013-0386-2 · Cited by 40 · see citing works
Kong, A. P. S., Choi, K. C., Ho, C. S., Chan, M. H. M., Ozaki, R., Chan, C. W., & Chan, J. C. N. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00115.x · Cited by 40 · see citing works
McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.09.058 · Cited by 38 · see citing works
Yang, F., Liu, M., Qin, N., Li, S., Yu, M., Wang, C., & Ma, Q. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1054-z · Cited by 38 · see citing works
Robles‐Cervantes, J. A., Ramos-Zavala, M. G., González-Ortı́z, M., Martínez‐Abundis, E., Valencia-Sandoval, C., Torres-Chávez, A., Espinel-Bermúdez, C., Santiago-Hernández, N. J., & Hernández‐González, S. O. (2011) · International Journal of Endocrinology · doi:10.1155/2011/107904 · Cited by 36 · see citing works
Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis
Thakkinstian, A., Anothaisintawee, T., Chailurkit, L., Ratanachaiwong, W., Yamwong, S., Sritara, P., & Ongphiphadhanakul, B. (2015) · Scientific Reports · doi:10.1038/srep14528 · Cited by 36 · see citing works
Tsai, Y.-T., Liu, J., Tu, Y., Lee, M., Chen, P.-R., Hsu, H., Chen, M.-F., & Chien, K. (2012) · PubMed · Cited by 34 · see citing works
Self-citationFu, S., Luo, L., Ye, P., & Xiao, W. (2015) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0116-z · Cited by 34 · see citing works
Shin, J. Y., Lee, H. R., & Shim, J. (2012) · Vascular Medicine · doi:10.1177/1358863x11434197 · Cited by 33 · see citing works
Zhang, S., Zhuang, J., Yue, G., Wang, Y., Liu, M., Zhang, B., Du, Z., & Ma, Q. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.06.037 · Cited by 32 · see citing works
Zhang, L., Li, J., Guo, L., Li, H., Li, D., & Xu, G. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01468-3 · Cited by 31 · see citing works
Yang, W.-S., Chen, Y., Chen, P., Hsu, H., Su, T., Lin, H., Chen, M.-F., Lee, Y., & Chien, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55686-7 · Cited by 31 · see citing works
Self-citationSports activity and risk of type 2 diabetes in Chinese
Chien, K., Chen, M.-F., Hsu, H., Su, T., & Lee, Y. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.03.006 · Cited by 31 · see citing works
Self-citationLee, K. W., & Shin, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-15176-9 · Cited by 29 · see citing works
Liu, W., Hung, C., Chen, S., Lin, M., Chen, L.-I., Hwang, D., Chang, J., Tsai, J., Chen, H., & Hwang, S.-J. (2011) · Experimental Diabetes Research · doi:10.1155/2011/527520 · Cited by 28 · see citing works
Wang, L., Hu, W., Miao, D., Zhang, Q., Wang, C., Pan, E., & Wu, M. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.03.023 · Cited by 27 · see citing works
Hao, Z., Huang, X. D., Shao, H., & Tian, F. (2018) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s186347 · Cited by 27 · see citing works
Serum uric acid and metabolic risk
Richette, P., & Pérez-Ruiz, F. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.790801 · Cited by 26 · see citing works
Major Dietary Patterns and Risk of Asymptomatic Hyperuricemia in Chinese Adults
Zhang, M., Chang, H., Gao, Y., Wang, X., Xu, W., Liu, D., Li, G., & Huang, G. (2012) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.58.339 · Cited by 26 · see citing works
Wang, S., Shu, L., Wang, S., Wang, X., Mu, M., Hu, C., Liu, K., Zhao, Q.-H., Hu, A., Bo, Q., et al. (2014) · Blood Pressure · doi:10.3109/08037051.2014.906131 · Cited by 25 · see citing works
Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan
Wu, W.-C., Lai, Y.-W., Chou, Y., Liao, Y.-C., You, S., Bai, C., & Sun, C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072277 · Cited by 24 · see citing works
Zhang, H., Li, Y., Mao, Z., Liu, X., Zhang, X., Yang, K., Liu, R., Qian, X., Zhang, H., Jiang, J., et al. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.02.003 · Cited by 23 · see citing works
Vučak, J., Katić, M., Bielen, I., Vrdoljak, D., Lalić, D. I., Kranjčević, K., & Marković, B. B. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-117 · Cited by 22 · see citing works
Alatalo, P., Koivisto, H., Hietala, J., Bloigu, R., & Niemelä, O. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.002 · Cited by 22 · see citing works
Association of Hyperuricemia With Conventional Cardiovascular Risk Factors in Elderly Patients
Marotta, T., Liccardo, M., Schettini, F., Verde, F., & Ferrara, A. L. (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12434 · Cited by 21 · see citing works
Lin, J., Chen, S., Li, S., Lü, M., Li, Y., & Su, Y. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2146204 · Cited by 21 · see citing works
Interaction between gender and uric acid on hemoglobin A1c in community-dwelling persons
Kawamoto, R., Ninomiya, D., Kasai, Y., Senzaki, K., Kusunoki, T., Ohtsuka, N., & Kumagi, T. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0760-5 · Cited by 20 · see citing works
Study of Microalbuminuria and Uric Acid in Type 2 Diabetes Mellitus
Warjukar, P., Jain, P., Kute, P. K., Anjankar, A. P., & Ghangale, S. (2020) · International Journal of Current Research and Review · doi:10.31782/ijcrr.2020.5665 · Cited by 20 · see citing works
Du, T., Sun, X., Lu, H., Lin, X., Liu, Q., Huo, R., & Yu, X. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.03.004 · Cited by 20 · see citing works
Sudhindra, R. M., & Sahayo, B. J. (2012) · Journal of Health and Allied Sciences NU · doi:10.1055/s-0040-1703565 · Cited by 20 · see citing works
Serum uric acid as prognostic marker of coronary heart disease (CHD)
Purnima, S., & El-Aal, B. G. A. (2016) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2016.05.006 · Cited by 19 · see citing works
Navin, S. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/6106.3332 · Cited by 19 · see citing works
Santos, R. D. (2012) · Endocrine · doi:10.1007/s12020-012-9657-4 · Cited by 19 · see citing works
Hsieh, C.-T., Chien, K., Hsu, H., Lin, H., Su, T., Chen, M.-F., & Lee, Y. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-054638 · Cited by 18 · see citing works
Self-citationDiabetes and Its Chronic Complications in the She Ethnic Minority Group of China
Lin, Y., Xu, Y., Chen, G., Lai, X., Huang, B., Chen, Z., Yao, L.-T., Zhu, S., Yao, J. Y., Wen, J., et al. (2012) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0244 · Cited by 18 · see citing works
Wang, H., Xu, Y., Xu, B., Lu, J., Xia, J., Shen, T. H., Ji, F., & Lei, T. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s430235 · Cited by 16 · see citing works
Mortality Predictive Role of Serum Uric Acid in Diabetic Hemodialysis Patients
Jeon, J. S., Chung, S. H., Han, D. C., Noh, H., Kwon, S. H., Lindholm, B., & Lee, H. B. (2014) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2014.05.005 · Cited by 16 · see citing works
Huang, K., Tai, C., Tsai, Y., Kuan, Y., & Lee, C. (2019) · Europe PMC (PubMed Central) · doi:10.6515/acs.201911_35(6).20190403b · Cited by 16 · see citing works
Oda, E., & Kawai, R. (2009) · Diabetes Care · doi:10.2337/dc09-1244 · Cited by 14 · see citing works
Li, N. F., Wang, H., Yang, J., Zhou, L., Yao, X. G., & Hong, J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-101 · Cited by 13 · see citing works
Vinuthinee-Naidu, M.-N., Zunaina, E., Anuar, A.-R., & Naing, N.-N. (2017) · BMC Ophthalmology · doi:10.1186/s12886-017-0486-3 · Cited by 12 · see citing works
Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus
Leng, J., Wang, L., Wang, J., Li, W., Liu, H., Zhang, S., Li, L., Tian, H., Xun, P., Yang, X., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.09.015 · Cited by 12 · see citing works
Chien, K., Lee, M., Tsai, Y.-T., Chen, P., Lin, H., Hsu, H., Lee, Y.-T., & Chen, M.-F. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-23 · Cited by 12 · see citing works
Self-citationKuo, K.-T., Chang, Y., Wu, I.-H., Lu, F.-H., Yang, Y., Wu, J., & Chang, C. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.05.004 · Cited by 11 · see citing works
The Management of Diabetes with Hyperuricemia: Can We Hit Two Birds with One Stone?
Wang, Y., & Lü, J. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s433438 · Cited by 10 · see citing works
Chen, R., Nie, S., Zhou, S., Su, L., Li, Y., Zhang, X., Luo, F., Xu, R., Gao, Q., Lin, Y., et al. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103043 · Cited by 10 · see citing works
Chien, K. (2017) · Europe PMC (PubMed Central) · doi:10.6515/acs20161021a · Cited by 10 · see citing works
Self-citationSimental‐Mendía, L. E., Simental-Mendía, E., Rodríguez‐Morán, M., & Guerrero‐Romero, F. (2016) · Endocrine Research · doi:10.3109/07435800.2016.1155597 · Cited by 10 · see citing works
- Authors
- Chien, K.-L., Chen, M.-F., Hsu, H.-C., Chang, W.-T., Su, T.-C., Lee, Y.-T., & Hu, F. B.
- Affiliations
- Harvard University (US)
- National Taiwan University Hospital (TW)
- Corresponding author
- Lee, Yuan-Teh
- Hu, Frank B
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-01
- Volume
- 54
- Issue
- 2
- Pages
- 310-316
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2149640217
- Cited by
- 172
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 6 · 2014: 11 · 2013: 14 · 2012: 13
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- American Heart Association
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- plasma uric acid, hyperuricemia, type 2 diabetes, diabetes incidence, metabolic syndrome, Chinese population, prospective cohort
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Taiwan, Uric Acid, Biomarkers, Multivariate Analysis, Asian People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review