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A Systematic Review of PTSD Prevalence and Trajectories in DSM-5 Defined Trauma Exposed Populations: Intentional and Non-Intentional Traumatic Events
Open accessAbstract
OBJECTIVE: We conducted a systematic review of the literature to explore the longitudinal course of PTSD in DSM-5-defined trauma exposed populations to identify the course of illness and recovery for individuals and populations experiencing PTSD. METHODS: We reviewed the published literature from January 1, 1998 to December 31, 2010 for longitudinal studies of directly exposed trauma populations in order to: (1) review rates of PTSD in the first year after a traumatic event; (2) examine potential types of proposed DSM-5 direct trauma exposure (intentional and non-intentional); and (3) identify the clinical course of PTSD (early onset, later onset, chronicity, remission, and resilience). Of the 2537 identified articles, 58 articles representing 35 unique subject populations met the proposed DSM-5 criteria for experiencing a traumatic event, and assessed PTSD at two or more time points within 12 months of the traumatic event. RESULTS: The mean prevalence of PTSD across all studies decreases from 28.8% (range =3.1-87.5%) at 1 month to 17.0% (range =0.6-43.8%) at 12 months. However, when traumatic events are classified into intentional and non-intentional, the median prevalences trend down for the non-intentional trauma exposed populations, while the median prevalences in the intentional trauma category steadily increase from 11.8% to 23.3%. Across five studies with sufficient data, 37.1% of those exposed to intentional trauma develop PTSD. Among those with PTSD, about one third (34.8%) remit after 3 months. Nearly 40% of those with PTSD (39.1%) have a chronic course, and only a very small fraction (3.5%) of new PTSD cases appears after three months. CONCLUSIONS: Understanding the trajectories of PTSD over time, and how it may vary by type of traumatic event (intentional vs. non-intentional) will assist public health planning and treatment.
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“Differences in trajectories were observed for different types of trauma: whereas PTSD prevalence decreased over time for non-violent traumas (20.1% at month 1 and 14.0% at month 12), the median prevalence increased from 11.8% at month 1 to 23.3% at month 12 for violent traumas.”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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“a past review of mixed traumas which indicated that the prevalence of PTSD stabilizes after three months exposure (Santiago et al., 2013).”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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“they reported decreases in the median prevalence of PTSD between 1 month (28.8%) and 3 months (17.8%) post-trauma, followed by a stabilization in prevalence through 12 months (17.0%; Santiago et al., 2013).”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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“First, although the Santiago and Hiller reviews found that large reductions in PTSD symptomatology occurred between 1 and 3 months post-trauma, neither statistically determined if there was a time point at which the average rate of recovery slowed (Hiller et al., 2016; Santiago et al., 2013).”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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“in the first month post-trauma, PTSD prevalence was 74.58% following sexual assault in the current analysis. In prior meta-analyses, one-month PTSD prevalence was 28.8% following mixed trauma exposure (Santiago et al., 2013) and 21.3% following childhood trauma (Hiller et al., 2016).”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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“PTSD prevalence at the twelfth month post-trauma was 41.5% following sexual assault in this study, as compared to prior meta-analyses, which found 17.0% following mixed trauma exposure (Santiago et al., 2013) and 10.9% following childhood trauma (Hiller et al., 2016).”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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“there is evidence that the course of PTSD differs by trauma type (Santiago et al., 2013).”
From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013
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Citations
Cites
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“These prevalences are similar to previously published rates across different types of traumatic events [14,15,21,22].”
Result60,000 Disaster Victims Speak: Part I. An Empirical Review of the Empirical Literature, 1981–2001
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“Psychiatric epidemiology studies consistently report a lifetime prevalence of PTSD of approximately 8% [15,16,17], however, post-disaster rates of PTSD vary widely [27,28,29], and are similar to those found here.”
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“Psychiatric epidemiology studies consistently report a lifetime prevalence of PTSD of approximately 8% [15,16,17], however, post-disaster rates of PTSD vary widely [27,28,29], and are similar to those found here.”
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“[10,11], again finding substantial variability across different populations, traumatic events and community contexts.”
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Self-citationLooking for resilience: Understanding the longitudinal trajectories of responses to stress
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“Studies using DSM-IV criteria have followed subjects to examine the epidemiology of PTSD after disasters [3,4,5,6], other traumatic events [7,8,9], and military deployment”
MethodThe cross-cultural validity of posttraumatic stress disorder: implications for DSM-5
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“In addition, studies of different disaster types and across cultures may yield different PTSD trajectories [24,25,26].”
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“Studies using DSM-IV criteria have followed subjects to examine the epidemiology of PTSD after disasters [3,4,5,6], other traumatic events [7,8,9], and military deployment”
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- M Matthieu, 2006, Treatment of human-caused trauma: attrition in the adult outcomes research, J Interpers Violence, 21, 1654, 10.1177/0886260506294243 · DOI
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Items 101–200 of 466
Meta-Analysis of Cultural Influences in Trauma Exposure and PTSD Prevalence Rates
Oakley, L., Kuo, W.-C., Kowalkowski, J. A., & Park, W. (2021) · Journal of Transcultural Nursing · doi:10.1177/1043659621993909 · Cited by 32
“For example, the estimated PTSD prevalence rate for intentional (e.g., assault) trauma is 17% (Santiago et al, 2013).”
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“Introduction Malignancy is a substantial societal burden worldwide and can substantially affect the mental health of patients because it is considered a traumatic event that implies a threat of death or severe physical injury and evokes psychological reactions, such as fear, avoidance, and hyperarousal.(1) Notably, th…”
BackgroundBrooks, S. K., & Greenberg, N. L. (2024) · BMC Psychiatry · doi:10.1186/s12888-023-05460-x · Cited by 37
“For example, Santiago et al. [11] note that few studies of PTSD follow participants for more than a year or with more than two assessments.”
BackgroundNijsten, K., van der Minnen, L. M., Dean, C., Bais, J., Ris-Stalpers, C., van Eekelen, R., Bremer, H., van der Ham, D. P., Heidema, W., Huisjes, A., et al. (2022) · Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2022.2089550 · Cited by 31
“Depression, anxiety, and PTSD symptoms may have improved over time, for example by receiving treatment, and therefore have led to an underestimation of symptoms [27,28].”
BackgroundHansen, M. B., Birkeland, M. S., Nissen, A., Blix, I., Solberg, Ø., & Heir, T. (2017) · Psychiatry · doi:10.1080/00332747.2016.1230983 · Cited by 41
“Fluctuations may also reflect substantially different trajectories of PTSD; symptoms can be delayed for some and be characterized by remission and relapse for others (Bryant et al., 2015; Santiago et al., 2013; Solomon & Mikulincer, 2006).”
BackgroundResilience and Recovery Following Disasters: The Meaning Making Model
Park, C. L., & Blake, E. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-32007-2_2 · Cited by 50
Traumas and Their Consequences According to Control-Mastery Theory
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Sullivan, T. P., Weiss, N. H., Price, C. R., Pugh, N. E., & Hansen, N. B. (2017) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000283 · Cited by 46
“…given that (a) most individuals who have been exposed to a trauma experience some PTSD symptoms (Rothbaum, Foa, Riggs, Murdock, & Walsh, 1992; Santiago et al., 2013; Schnurr, 2014), (b) PTSD symptoms can produce clinically significant impairment in functioning, and (c) PTSD symptoms are…”
Resilient Coping Moderates the Effect of Trauma Exposure on Depression
Sinclair, V. G., Wallston, K. A., & Strachan, E. D. (2016) · Research in Nursing & Health · doi:10.1002/nur.21723 · Cited by 31
Kambli, P., Ajbani, K., Sadani, M., Nikam, C., Shetty, A., Udwadia, Z., Georghiou, S. B., Rodwell, T., Catanzaro, A., & Rodrigues, C. (2015) · Diagnostic microbiology and infectious disease · doi:10.1016/j.diagmicrobio.2015.01.009 · Cited by 30
Powell, T. M., Yuma, P. J., Scott, J., Suarez, A., Morales, I., Vinton, M., Marrero, M., & Li, S.-J. (2020) · Traumatology · doi:10.1037/trm0000228 · Cited by 29
Use of mental health supports by civilians exposed to the November 2015 terrorist attacks in Paris
Pirard, P., Baubet, T., Motreff, Y., Rabet, G., Marillier, M., Vandentorren, S., Vuillermoz, C., Stene, L. E., & Messiah, A. (2020) · BMC Health Services Research · doi:10.1186/s12913-020-05785-3 · Cited by 41
Ge, F., Yuan, M., Li, Y., Zhang, J., & Zhang, W. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.065 · Cited by 34
Ge, F., Li, Y., Yuan, M., Zhang, J., & Zhang, W. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.079 · Cited by 35
Brown, M. J., Harrison, S. E., & Li, X. (2019) · AIDS and Behavior · doi:10.1007/s10461-019-02440-9 · Cited by 38
Lipinska, G., & Thomas, K. G. F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01555 · Cited by 31
“…sexual assault because most PTSD studies recruit male war veterans and several authors have highlighted that studies recruiting female participants with trauma etiologies other than war are important to understand the whole spectrum of the disorder (Santiago et al., 2013; Hall Brown et al., 2015).”
BackgroundThormar, S. B., Sijbrandij, M., Gersons, B. P. R., van de Schoot, R., Juen, B. H., Karlsson, Þ., & Olff, M. (2016) · Journal of Traumatic Stress · doi:10.1002/jts.22073 · Cited by 37
Nöthling, J., Abrahams, N., Jewkes, R., Mhlongo, S., Lombard, C., Hemmings, S. M. J., & Seedat, S. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.032 · Cited by 28
Global Posttrauma Symptoms: A Systematic Review of Qualitative Literature
Michalopoulos, L., Meinhart, M., Yung, J., Barton, S. M., Wang, X., Chakrabarti, U., Ritchey, M., Haroz, E. E., Joseph, N., Bass, J., et al. (2018) · Trauma Violence & Abuse · doi:10.1177/1524838018772293 · Cited by 36
“Future research should examine potential differences in posttrauma symptoms according to trauma type, much like previous studies have examined differences in posttrauma symptoms and outcomes comparing interpersonal versus noninterpersonal trauma (Delker & Freyd, 2014; Freyd, DePrince, & Gleaves, 2007; Santiago et al.,…”
BackgroundResultBrunnet, A. E., Bolaséll, L. T., Weber, J. L., & Kristensen, C. H. (2017) · International Journal of Social Psychiatry · doi:10.1177/0020764017737802 · Cited by 36
“The course of PTSD differs in both types of events: PTSD symptoms increase over time in victims of intentional events and decrease in victims of non-intentional events (Santiago et al., 2013).”
BackgroundRelation between lifespan polytrauma typologies and post-trauma mental health
Contractor, A. A., Brown, L. A., & Weiss, N. H. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.10.005 · Cited by 49
Changes of Posttraumatic Stress Responses in Evacuated Residents and Their Related Factors
Oe, M., Takahashi, H., Maeda, M., Harigane, M., Fujii, S., Miura, I., Nagai, M., Yabe, H., Ohira, T., Suzuki, Y., et al. (2017) · Asia Pacific Journal of Public Health · doi:10.1177/1010539516680733 · Cited by 28
Does BDNF Val66Met Polymorphism Confer Risk for Posttraumatic Stress Disorder?
Wang, T. (2015) · Neuropsychobiology · doi:10.1159/000381352 · Cited by 35
The Efficacy of EMDR Early Interventions
Shapiro, E., & Maxfield, L. (2019) · Journal of EMDR Practice and Research · doi:10.1891/1933-3196.13.4.291 · Cited by 34
“Nevertheless, various studies (e.g., Morina, Wicherts, Lobbrecht, & Priebe, 2014; Santiago et al., 2013) have reported that about 40% of those who develop PTSD do not experience spontaneous recovery.”
BackgroundValidation of the PCL-5 in Dutch trauma-exposed adults
Hoeboer, C. M., Karaban, I., Karchoud, J. F., Olff, M., & van Zuiden, M. (2024) · BMC Psychology · doi:10.1186/s40359-024-01951-y · Cited by 33
“More generally, research indicates that the prevalence of PTSD decreases until about 3–6 months following a potentially traumatic event [55].”
BackgroundKim, S.-J., Park, K.-S., & Kim, K. (2022) · Australian Critical Care · doi:10.1016/j.aucc.2022.06.002 · Cited by 31
Trottier, K., Monson, C. M., Kaysen, D. L., Wagner, A. C., Liebman, R. E., & Abbey, S. E. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01965-3 · Cited by 32
Post-traumatic stress disorder moderates the relationship between trauma exposure and chronic pain
Siqveland, J., Ruud, T., & Hauff, E. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1375337 · Cited by 32
“This difference in trauma exposure outcome was previously reported in a review of PTSD trajectories in 35 studies (Santiago et al., 2013).”
ResultCommunity-based randomized controlled trial of psychological first aid with crime victims.
McCart, M. R., Chapman, J. E., Zajac, K., & Rheingold, A. A. (2020) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000588 · Cited by 29
Paintain, E., & Cassidy, S. (2018) · Counselling and Psychotherapy Research · doi:10.1002/capr.12174 · Cited by 25
“…from control groups in longitudinal treatment intervention studies suggests that PTSD has a variable course, dependent on factors including population, traumatic event, and community context, but with a trend towards reduced symptomology, intensity and prevalence over time (Santiago et al., 2013).”
BackgroundGenetic variant in CACNA1C is associated with PTSD in traumatized police officers
Krzyzewska, I. M., Ensink, J. B. M., Nawijn, L., Mul, A. N. P. M., Koch, S. B. J., Venema, A., Shankar, V., Frijling, J. L., Veltman, D. J., Lindauer, R., et al. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-017-0059-1 · Cited by 30
Exposure to Adversity and Trauma Among Students Who Experience School Discipline: A Scoping Review
Sanders, J. E., Joseph, A., Massey, M. D., Swiatek, E., Csiernik, B., & Igor, E. (2023) · Review of Educational Research · doi:10.3102/00346543231203674 · Cited by 32
“Trauma refers to the sequela, symptomology, or impact of a distressing or disturbing experience, such as a car accident or a natural disaster, being harmed by someone, witnessing someone else being harmed, or exposure to violence (Santiago et al., 2013).”
Heesakkers, H., Zegers, M., van Mol, M. V., & van den Boogaard, M. (2022) · Intensive & Critical Care Nursing · doi:10.1016/j.iccn.2022.103313 · Cited by 24
“The shorter amount of time between the surge and the inclusion period could explain the higher prevalence compared to the present study as mental health symptoms tend to decrease over time (Santiago et al., 2013).”
Factors Influencing Mental Health of Medical Workers During the COVID-19 Outbreak
Zhang, Y., Xie, S.-M., Wang, P., Wang, G., Zhang, L., Cao, X., Wu, W.-Z., Bian, Y., Huang, F., Luo, N., et al. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00491 · Cited by 24
El‐Elimat, T., Alzoubi, K. H., AbuAlSamen, M. M., Subeh, Z. Y. A., Graf, T. N., & Oberlies, N. H. (2018) · Planta Medica · doi:10.1055/a-0710-5673 · Cited by 28
“About 17% of people who reported the exposure to traumatic events were diagnosed 12mo later with PTSD using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria [3].”
MethodNygaard, E., Johansen, V. A., Siqveland, J., Hussain, A., & Heir, T. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00913 · Cited by 24
Simon, N. A., Robertson, L., Lewis, C., Roberts, N. P., Bethell, A., Dawson, S., & Bisson, J. I. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011710.pub3 · Cited by 118
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“To determine what medication beliefs and provider ratings were associated with pharmacotherapy retention, we developed a retention model: (1) using backward elimination logistic regression, we entered all potential explanatory factors and covariates into a model to determine which variables were associated with pharma…”
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“This aligns with Santiago et al.’s (2013) systematic review, which observed a consistent rise in PTSD rates at one, three, six-and 12-months post-trauma.”
Jann, P., Netzer, J., & Hecker, T. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2024.2371762 · Cited by 23
“Reviews showed that the prevalence rates are higher following intentional events for both PTSD and PGD (Lobb et al., 2010; Santiago et al., 2013).”
BackgroundImmune system regulation and role of the human leukocyte antigen in posttraumatic stress disorder
Katrinli, Ş., & Smith, A. K. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100366 · Cited by 27
“PTSD is characterized by re-experiencing, avoidance and hyperarousal symptoms that cause negative alterations in cognition, mood, and physiologic health (Santiago et al., 2013; Thomas et al., 2010).”
Prevalence and prognostic factors for psychological distress after trauma.
de Munter, L., Polinder, S., Haagsma, J., Kruithof, N., van de Ree, C. L. P., Steyerberg, E., & de Jongh, M. D. (2019) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2019.10.196 · Cited by 23
Associations Between Existential Concerns and Adverse Experiences: A Systematic Review
Arredondo, A. Y., & Caparrós, B. (2019) · Journal of Humanistic Psychology · doi:10.1177/0022167819846284 · Cited by 28
“In addition, there are some recent systematic reviews that focus on related topics: longitudinal trauma studies (Santiago et al., 2013), measures of existential anxiety (Van Bruggen, Vos, Westerhof, Bohlmeijer, & Glas, 2014), early PTSD interventions efficacy (Roberts, Kitchiner, Kenardy, & Bisson,…”
EMDR therapy for PTSD after motor vehicle accidents: meta-analytic evidence for specific treatment
Boccia, M., Piccardi, L., Cordellieri, P., Guariglia, C., & Giannini, A. M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00213 · Cited by 25
“…traumatic events interact with individual factors (such as personality, gender and genetic factors) and lead to different physical and behavioral outcomes as well as a different prevalence of PTSD (Ditlevsen and Elklit, 2012; Santiago et al., 2013; Husarewycz et al., 2014; Perrin et al., 2014).”
BackgroundBeaudoin, F. L., Kessler, R. C., Hwang, I., Lee, S., Sampson, N. A., An, X., Ressler, K. J., Koenen, K. C., McLean, S. A., & the AURORA Study Group (2021) · European Journal of Pain · doi:10.1002/ejp.1733 · Cited by 28
A novel virtual reality paradigm: Predictors for stress-related intrusions and avoidance behavior
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Tailoring disaster risk reduction for adolescents: Qualitative perspectives from China and Nepal
Newnham, E. A., Tearne, J. E., Gao, X., Guragain, B., Jiao, F., Ghimire, L., Balsari, S., Chan, E., & Leaning, J. (2019) · International Journal of Disaster Risk Reduction · doi:10.1016/j.ijdrr.2018.12.020 · Cited by 22
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“Notably, social phobia is commonly observed in PTSD patients (Santiago et al., 2013); however, SPS&S mice with the current behavioral paradigm did not display abnormal social phobia.”
BackgroundRisk and Resilience Factors of Post-Traumatic Stress Disorder: A Review of Current Research
Lauth, G. (2016) · Clinical and Experimental Psychology · doi:10.4172/2471-2701.1000120 · Cited by 21
Somatic and Posttraumatic Stress Symptoms in Children and Adolescents in France
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Assessing anxiety, depression and insomnia symptoms among Ebola survivors in Africa: A meta-analysis
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“Numerous studies have identified positive or negative changes in PTSD in the wake of traumatic events (Maercker, Gäbler, O’Neil, Schützwohl & Muller, 2013; Solomon & Mikulincer, 2006; Pietrzak et al., 2013; Santiago et al., 2013).”
BackgroundZhu, Z., Lei, D., Qin, K., Suo, X., Li, W., Li, L., DelBello, M. P., Sweeney, J. A., & Gong, Q. (2021) · Diagnostics · doi:10.3390/diagnostics11081416 · Cited by 21
“Many survivors exhibit posttraumatic stress symptoms in the weeks and months after exposure [3], but waiting for individuals to develop PTSD before intervening can delay preventive or early effective treatment.”
BackgroundRosson, S., Monaco, F., Miola, A., Cascino, G., Stubbs, B., Correll, C. U., Firth, J., Ermiş, Ç., Perrotti, A., Marciello, F., et al. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000872 · Cited by 29
Current and future functional imaging techniques for post-traumatic stress disorder
Prasad, A., Chaichi, A., Kelley, D. P., Francis, J., & Gartia, M. R. (2019) · RSC Advances · doi:10.1039/c9ra03562a · Cited by 32
Kapfhammer, H. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.254 · Cited by 21
Coimbra, B. M., Hoeboer, C. M., van Zuiden, M., Williamson, R. E., D'Elia, A. T., Mello, A. F., Mello, M. F., & Olff, M. (2023) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2023.102730 · Cited by 22
Shenk, C. E., O’Donnell, K. J., Pokhvisneva, I., Kobor, M. S., Meaney, M. J., Bensman, H. E., Allen, E. K., & Olson, A. E. (2021) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2020.1864738 · Cited by 24
“This increased prevalence is noteworthy from a public health perspective, as PTSD can have a severe and chronic course (Green et al., 2010; Santiago et al., 2013) that results in significantly higher medical costs (Bonomi et al., 2008) even when compared to more prevalent psychiatric disorders…”
BackgroundSchnabel, A., Hallford, D. J., Stewart, M., McGillivray, J., Forbes, D., & Austin, D. (2020) · Autism Research · doi:10.1002/aur.2301 · Cited by 28
“It is possible to speculate about factors known to be associated with the development of PTSD, such as the severity of the traumatic event, the level of support received after the event, and aspects of individual coping after the event such as rumination or dissociation (Santiago et al., 2013).”
BackgroundMota, N., Cook, J., Smith, N. B., Tsai, J., Harpaz-Rotem, I., Krystal, J., Southwick, S., & Pietrzak, R. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.09.005 · Cited by 18
Chauvelin, L., Gindt, M., Olliac, B., Robert, P., Thümmler, S., & Askenazy, F. (2018) · Disaster Medicine and Public Health Preparedness · doi:10.1017/dmp.2018.51 · Cited by 18
“In addition, this pediatric CUMP had the specificity to be organized in a specific place dedicated to children and their families, and worked in conjunction with (1) the adult CUMP; (2) hospital emergency units; (3) child and adolescent psychiatry; and (4) adult community centers.”
BackgroundInfluentialChoi, K., Kim, D., Jang, E. Y., Bae, H., & Kim, S. H. (2016) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.1.226 · Cited by 39
Hamburger, A. (2016) · Forum der Psychoanalyse · doi:10.1007/s00451-016-0231-1 · Cited by 15
“K Den umgekehrten Weg, von der Abstraktion zur inhaltlichen Spezifizierung oder Trauma-Taxonomie, schlugen nur wenige Studien ein (Amir et al. 1996; Briere et al. 1995; Kira et al. 2008, 2013; cf. Kirmayer et al. 2010; Santiago et al. 2013).”
BackgroundWiesepape, C. N., Smith, E. A., Muth, A. J., & Faith, L. A. (2025) · Behavioral Sciences · doi:10.3390/bs15020150 · Cited by 28
“In fact, it is estimated that approximately 39% of individuals diagnosed with PTSD experience a chronic course (Santiago et al., 2013) and may experience symptoms of PTSD even after 10 years (Kessler et al., 1995).”
Sippel, L. M., Liebman, R. E., Schäfer, S., Ennis, N., Mattern, A. C., Rozek, D. C., & Monson, C. M. (2024) · Behavioral Science · doi:10.3390/bs14040284 · Cited by 17
“Most of these individuals experience some post-traumatic stress symptoms that naturally abate within the first few weeks post trauma [4,5].”
BackgroundJoormann, J., McLean, S. A., Beaudoin, F. L., An, X., Stevens, J. S., Zeng, D., Neylan, T. C., Clifford, G. D., Linnstaedt, S. D., Germine, L. T., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720003773 · Cited by 21
“Introduction Although most individuals experiencing a trauma do not develop adverse post-traumatic neuropsychiatric sequelae (APNS), a substantial number do (Koenen et al., 2017; Santiago et al., 2013).”
BackgroundSpoont, M., Nelson, D., Kehle-Forbes, S., Meis, L., Murdoch, M., Rosen, C., & Sayer, N. (2020) · Psychological services · doi:10.1037/ser0000463 · Cited by 17
“…high rates of mental health comorbidity and chronicity of PTSD among veterans (Marmar et al., 2015; Pietrzak, Goldstein, Southwick, & Grant, 2011; Santiago et al., 2013), patients were not excluded if they had prior mental health diagnoses (including PTSD) before the year prior to the index…”
BackgroundRoberts, N. P., Kitchiner, N., Kenardy, J. A., Robertson, L., Lewis, C., & Bisson, J. I. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006869.pub3 · Cited by 71
Rossi, R., Reda, F., Federico, I., Jannini, T. B., Socci, V., D’Aurizio, G., Pettorruso, M., Pacitti, F., Rossi, A., Martinotti, G., et al. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.10.023 · Cited by 18
Gindt, M., Fernandez, A., Zeghari, R., Ménard, M.-L., Nachon, O., Richez, A., Auby, P., Battista, M., & Askenazy-Gittard, F. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1010957 · Cited by 22
Short, N. A., van Rooij, S. J. H., Murty, V. P., Stevens, J. S., An, X., Ji, Y., McLean, S. A., House, S. L., Beaudoin, F. L., Zeng, D., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.09.027 · Cited by 20
Tai Chi and Qigong for trauma exposed populations: A systematic review
Niles, B. L., Reid, K. F., Whitworth, J. W., Alligood, E. C., Williston, S. K., Grossman, D., McQuade, M., & Mori, D. L. (2022) · Mental health and physical activity · doi:10.1016/j.mhpa.2022.100449 · Cited by 21
Þórarinsdóttir, K., Holmes, E. A., Hardarson, J., Stephenssen, E. S., Jonasdottir, M. H., Kanstrup, M., Singh, L., Hauksdóttir, A., Halldorsdottir, T., Guðmundsdóttir, B., et al. (2022) · JMIR Formative Research · doi:10.2196/37382 · Cited by 17
Germine, L. T., Joormann, J., Passell, E. J., Rutter, L. A., Scheuer, L., Martini, P., Hwang, I. H., Lee, S., Sampson, N. A., Barch, D. M., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.104 · Cited by 17
Davison, K., Hyland, C. E., West, M. L., Lin, S., Tong, H., Kobayashi, K. M., & Fuller‐Thomson, E. (2021) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-02003-7 · Cited by 25
Predictors of moral injury in UK treatment seeking veterans
Williamson, V., Greenberg, N. L., & Murphy, D. (2020) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2020.104889 · Cited by 17
“Nonetheless, just as traumatic events do not always lead to PTSD (Santiago et al., 2013), the mere exposure to adverse event during military service may not always result in moral injury.”
BackgroundAgarwal, T. M., Muneer, M. T., Asim, M., Awad, M., Afzal, Y., Al-Thani, H. A. S., Alhassan, A., Mollazehi, M., & El-Menyar, A. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242849 · Cited by 18
“As reported by a systematic review, the prevalence of PTSD increases over time from in case of intentional trauma [20].”
BackgroundPozza, A., Bossini, L., Ferretti, F., Olivola, M., Matto, L. D., Desantis, S., Fagiolini, A., & Coluccia, A. (2019) · Psychiatric quarterly · doi:10.1007/s11126-019-09650-3 · Cited by 16
Thordardottir, E. B., Guðmundsdóttir, H., Guðmundsdóttir, B., Hrólfsdóttir, A. M., Aspelund, T., & Hauksdóttir, A. (2018) · Scandinavian Journal of Public Health · doi:10.1177/1403494818771444 · Cited by 19
“With regard to the trajectories of PTSD post-disaster, we did not observe a decrease in earthquake-specific PTSD symptoms over a 12-month period, contrary to the majority of previous studies [7,23].”
BackgroundResultPosttraumatic Stress Disorder Among Adults in Communities With Mass Violence Incidents
Moreland, A., Rancher, C., Davies, F., Bottomley, J. S., Galea, S., Abba-Aji, M., Abdalla, S., Schmidt, M. G., Vena, J. E., & Kilpatrick, D. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.23539 · Cited by 15
Siegel, A., Mor, I., & Lahav, Y. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1968597 · Cited by 18
“…although evidence indicates that only a minority of people are vulnerable to longterm distress in the aftermath of trauma exposure (Bonanno, 2004; Santiago et al., 2013), the global scale and ongoing nature of the present pandemic may significantly increase the mental health burden of…”
BackgroundNoor, S. W. B., Sutherland, J. E., Vernon, J. R. G., Adam, B. D., Brennan, D. J., & Hart, T. A. (2020) · Archives of Sexual Behavior · doi:10.1007/s10508-020-01719-6 · Cited by 18
“, assault) and non-intentional events (e.g., motor vehicle accidents; Santiago et al., 2013).”
BackgroundRoepke, A. M., Benson, L., Tsukayama, E., & Yaden, D. B. (2017) · The Journal of Positive Psychology · doi:10.1080/17439760.2017.1365161 · Cited by 20
“We have, however, used the same scales as 3–12 months (Kessler, Sonnega, Bromet, Hughes, & Nelson, 1995; Santiago et al., 2013), and grief is at its most acute in the first six months after a loss (Maciejewski, Zhang, Block, & Prigerson, 2007), trajectories of recovery are diverse (Norris, Tracy, &…”
MethodLies, J., Lau, S. T., Jones, L. E., Jensen, M. P., & Tan, G. (2017) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v46n3p102 · Cited by 14
Morganstein, J. C., West, J. C., & Ursano, R. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-55583-6_2 · Cited by 30
“Events that are the result (Santiago et al.”
BackgroundSelf-citationHaagsma, J., van Beeck, E. F., Toet, H., & Polinder, S. (2013) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.s4-002 · Cited by 15
“published a systematic review of 58 longitudinal studies and a meta-analysis of the trajectories of PTSD [8].”
BackgroundMa, Z., Wang, D., Fu, X., Tao, Y., Zhang, Y., Liu, W., & Fan, F. (2023) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2023.102767 · Cited by 14
Benzakour, L., Braillard, O., Mazzola, V., Gex, D., Nehme, M., Perone, S. A., Agoritsas, T., Kopp, G., Cereghetti, S., Bondolfi, G., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.031 · Cited by 13
Childhood trauma as a predictor of reoffending in a Northern Irish probation sample.
Dalsklev, M., Cunningham, T., Travers, Á., McDonagh, T., Shannon, C., Downes, C., & Hanna, D. (2019) · International Journal of Child Abuse & Neglect · doi:10.1016/j.chiabu.2019.104168 · Cited by 14
Exposure to Traumatic Events and PTSD in a Postconflict and Disaster-Prone Area
Marthoenis, M., Meutia, I., Sofyan, H., & Schouler‐Ocak, M. (2018) · Journal of Loss and Trauma · doi:10.1080/15325024.2018.1423867 · Cited by 22
“Studies have revealed strong relationships between the rate and type of trauma exposure and the occurrence of PTSD (Ghazali et al., 2014; Santiago et al., 2013; Vrana & Lauterbach, 1994).”
BackgroundSchuler, B. R., Bessaha, M. L., & Moon, C. (2016) · Human Services Organizations Management Leadership & Governance · doi:10.1080/23303131.2015.1124060 · Cited by 14
“In addition, a systematic review reported that approximately 30% of adults across all studies, on average, had a diagnosis of posttraumatic stress disorder (PTSD) after experiencing a traumatic event as defined by the DSM-5 (Santiago et al., 2013).”
BackgroundKurapov, A., Schabus, M., Kahveci, S., Wilhelm, F. H., & Blechert, J. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2024.2381371 · Cited by 22
“When it comes to demographics, we found that female gender is positively related to the PTSS and sleep disturbance, which is consistent with a large body of literature (Bre-win et al., 2000; Lukaschek et al., 2013; Santiago et al., 2013).”
ResultDokkedahl, S. B., & Lahav, Y. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2024.2338670 · Cited by 13
“…that individuals vary in post-traumatic distress, with the majority exhibiting spon-taneous recovery within the first six months after the traumatic events ends (Bonanno, 2004; Galea et al., 2003; Santiago et al., 2013), identifying factors that increase susceptibility to PTSD is of importance.”
BackgroundWendlandt, B., Pongracz, L., Lin, F.-C., Toles, M., Gaynes, B. N., Hanson, L. C., & Carson, S. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.7448 · Cited by 13
deMello, R. A. F., Coimbra, B. M., Pedro, B. D. M., Benvenutti, I. M., Yeh, M. S. L., Mello, A. F., Mello, M. F., & Poyares, D. R. (2022) · Journal of Interpersonal Violence · doi:10.1177/08862605221114151 · Cited by 15
“Lifetime prevalence of PTSD is estimated to affect 4% to 12% of individuals (Kessler et al., 1995; Ribeiro et al., 2013) and clinical studies suggest that nearly 40% of patients develop a chronic course of the disorder (Santiago et al., 2013).”
BackgroundPerry, E. W., Culbreth, R. E., Self‐Brown, S., Gilmore, A. K., Kasirye, R., Musuya, T., Ndetei, D. M., & Swahn, M. H. (2022) · International Journal of Mental Health · doi:10.1080/00207411.2022.2073755 · Cited by 16
“Prior research has documented varying effects on mental health diagnoses and trajectories for people exposed to intentional trauma (e.g., assault) and non-intentional trauma (e.g., earthquake, motor vehicle accident; Santiago et al., 2013).”
BackgroundShenk, C. E., Noll, J. G., Griffin, A. M., Allen, E. K., Lee, S. E., Lewkovich, K. L., & Allen, B. (2016) · Child Maltreatment · doi:10.1177/1077559516669253 · Cited by 39
“…adversities (McLaughlin et al., 2010), further increasing the risk for severe and chronic PTSD symptoms (Green et al., 2010) that can extend to different developmental stages (Santiago et al., 2013) and limit the effectiveness of well-established interventions (Hembree, Street, Riggs, & Foa, 2004).”
BackgroundPontelli, R., Nunes, A., & de Oliveira, S. M. B. (2016) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232015213.25212015 · Cited by 13
Metadata
- Authors
- Santiago, P. N., Ursano, R. J., Gray, C. L., Pynoos, R. S., Spiegel, D., Lewis-Fernandez, R., Friedman, M. J., & Fullerton, C. S.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- University of California, Los Angeles (US)
- Stanford Medicine (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Santiago, Patcho N.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-11
- Volume
- 8
- Issue
- 4
- Pages
- e59236
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3623968
- OpenAlex
- W2035901807
- Cited by
- 536
- References
- 35
- Citations by year
- 2026: 34 · 2025: 50 · 2024: 50 · 2023: 41 · 2022: 50 · 2021: 51 · 2020: 53 · 2019: 44 · 2018: 35 · 2017: 43 · 2016: 35 · 2015: 27 · 2014: 15 · 2013: 6
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, public-domain)
- Columbia Academic Commons (Columbia University)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Keywords
- post-traumatic stress disorder, PTSD prevalence, PTSD trajectories, chronic PTSD, PTSD remission, resilience
- MeSH terms
- Epilepsy, Post-Traumatic, Humans, Longitudinal Studies, Time Factors, Wounds and Injuries, Prevalence, Diagnostic and Statistical Manual of Mental Disorders, PubMed
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