Cited by 536Posttraumatic Stress Disorder ResearchChild Abuse and TraumaMigration, Health and Trauma

A Systematic Review of PTSD Prevalence and Trajectories in DSM-5 Defined Trauma Exposed Populations: Intentional and Non-Intentional Traumatic Events

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Santiago, Patcho N., Ursano, Robert J., Gray, Christine L., Pynoos, Robert S., Spiegel, David, Lewis-Fernandez, Roberto, Friedman, Matthew J., Fullerton, Carol S.·2013·PLoS ONE

Abstract

OBJECTIVE: We conducted a systematic review of the literature to explore the longitudinal course of PTSD in DSM-5-defined trauma exposed populations to identify the course of illness and recovery for individuals and populations experiencing PTSD. METHODS: We reviewed the published literature from January 1, 1998 to December 31, 2010 for longitudinal studies of directly exposed trauma populations in order to: (1) review rates of PTSD in the first year after a traumatic event; (2) examine potential types of proposed DSM-5 direct trauma exposure (intentional and non-intentional); and (3) identify the clinical course of PTSD (early onset, later onset, chronicity, remission, and resilience). Of the 2537 identified articles, 58 articles representing 35 unique subject populations met the proposed DSM-5 criteria for experiencing a traumatic event, and assessed PTSD at two or more time points within 12 months of the traumatic event. RESULTS: The mean prevalence of PTSD across all studies decreases from 28.8% (range =3.1-87.5%) at 1 month to 17.0% (range =0.6-43.8%) at 12 months. However, when traumatic events are classified into intentional and non-intentional, the median prevalences trend down for the non-intentional trauma exposed populations, while the median prevalences in the intentional trauma category steadily increase from 11.8% to 23.3%. Across five studies with sufficient data, 37.1% of those exposed to intentional trauma develop PTSD. Among those with PTSD, about one third (34.8%) remit after 3 months. Nearly 40% of those with PTSD (39.1%) have a chronic course, and only a very small fraction (3.5%) of new PTSD cases appears after three months. CONCLUSIONS: Understanding the trajectories of PTSD over time, and how it may vary by type of traumatic event (intentional vs. non-intentional) will assist public health planning and treatment.

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  • Santiago et al. observed differences in trajectories for different types of trauma: PTSD prevalence decreased over time for non-violent traumas (20.1% at month 1 and 14.0% at month 12), while median prevalence increased from 11.8% at month 1 to 23.3% at month 12 for violent traumas.

    “Differences in trajectories were observed for different types of trauma: whereas PTSD prevalence decreased over time for non-violent traumas (20.1% at month 1 and 14.0% at month 12), the median prevalence increased from 11.8% at month 1 to 23.3% at month 12 for violent traumas.”

    From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013

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  • A past review of mixed traumas indicated that the prevalence of PTSD stabilizes after three months exposure.

    “a past review of mixed traumas which indicated that the prevalence of PTSD stabilizes after three months exposure (Santiago et al., 2013).”

    From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013

  • Santiago et al. (2013) reported decreases in median prevalence of PTSD between 1 month (28.8%) and 3 months (17.8%) post-trauma, followed by stabilization through 12 months (17.0%).

    “they reported decreases in the median prevalence of PTSD between 1 month (28.8%) and 3 months (17.8%) post-trauma, followed by a stabilization in prevalence through 12 months (17.0%; Santiago et al., 2013).”

    From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013

  • Prior reviews have the limitation that neither Santiago nor Hiller statistically determined if there was a time point at which the average rate of recovery slowed.

    “First, although the Santiago and Hiller reviews found that large reductions in PTSD symptomatology occurred between 1 and 3 months post-trauma, neither statistically determined if there was a time point at which the average rate of recovery slowed (Hiller et al., 2016; Santiago et al., 2013).”

    From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013

  • One-month PTSD prevalence was 74.58% following sexual assault in the current analysis, compared to 28.8% following mixed trauma exposure (Santiago et al., 2013) and 21.3% following childhood trauma (Hiller et al., 2016).

    “in the first month post-trauma, PTSD prevalence was 74.58% following sexual assault in the current analysis. In prior meta-analyses, one-month PTSD prevalence was 28.8% following mixed trauma exposure (Santiago et al., 2013) and 21.3% following childhood trauma (Hiller et al., 2016).”

    From PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies (2023) · cites this paper as Santiago et al., 2013

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Research works printed but not linked: 2

  1. [15]Kessler RC (2000) Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry 61 Suppl 5: 4–12; discussion 13–14. 10761674
  2. [19]Matthieu M, Ivanoff A (2006) Treatment of human-caused trauma: attrition in the adult outcomes research. J Interpers Violence 21: 1654– 1664. 17065659

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Authors
Santiago, P. N., Ursano, R. J., Gray, C. L., Pynoos, R. S., Spiegel, D., Lewis-Fernandez, R., Friedman, M. J., & Fullerton, C. S.
Affiliations
  • Uniformed Services University of the Health Sciences (US)
  • University of California, Los Angeles (US)
  • Stanford Medicine (US)
  • United States Department of Veterans Affairs (US)
Corresponding author
Santiago, Patcho N.
Venue
PLoS ONE
Published
2013-04-11
Volume
8
Issue
4
Pages
e59236
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2035901807
Cited by
536
References
35
Citations by year
2026: 34 · 2025: 50 · 2024: 50 · 2023: 41 · 2022: 50 · 2021: 51 · 2020: 53 · 2019: 44 · 2018: 35 · 2017: 43 · 2016: 35 · 2015: 27 · 2014: 15 · 2013: 6 · 2012: 1
FWCI
4.08
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, public-domain)
  • Columbia Academic Commons (Columbia University)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
Keywords
post-traumatic stress disorder, PTSD prevalence, PTSD trajectories, chronic PTSD, PTSD remission, resilience
MeSH terms
Epilepsy, Post-Traumatic, Humans, Longitudinal Studies, Time Factors, Wounds and Injuries, Prevalence, Diagnostic and Statistical Manual of Mental Disorders, PubMed

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