The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome
Open accessAbstract
BACKGROUND: Particulate matter (PM) is a key pollutant in ambient air that has been associated with negative health conditions in urban environments. The aim of this study was to examine the effects of orally administered PM on the gut microbiome and immune function under normal and inflammatory conditions. METHODS: Wild-type 129/SvEv mice were gavaged with Ottawa urban PM10 (EHC-93) for 7-14 days and mucosal gene expression analyzed using Ingenuity Pathways software. Intestinal permeability was measured by lactulose/mannitol excretion in urine. At sacrifice, segments of small and large intestine were cultured and cytokine secretion measured. Splenocytes were isolated and incubated with PM10 for measurement of proliferation. Long-term effects of exposure (35 days) on intestinal cytokine expression were measured in wild-type and IL-10 deficient (IL-10(-/-)) mice. Microbial composition of stool samples was assessed using terminal restriction fragment length polymorphism. Short chain fatty acids were measured in caecum. RESULTS: Short-term treatment of wild-type mice with PM10 altered immune gene expression, enhanced pro-inflammatory cytokine secretion in the small intestine, increased gut permeability, and induced hyporesponsiveness in splenocytes. Long-term treatment of wild-type and IL-10(-/-) mice increased pro-inflammatory cytokine expression in the colon and altered short chain fatty acid concentrations and microbial composition. IL-10(-/-) mice had increased disease as evidenced by enhanced histological damage. CONCLUSIONS: Ingestion of airborne particulate matter alters the gut microbiome and induces acute and chronic inflammatory responses in the intestine.
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Environmental triggers in IBD: a review of progress and evidence
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Air pollution and its effects on the immune system
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Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch, A. M., Arcidiacono, S. M., Pearce, S. C., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 530
Metadata
- Authors
- Kish, L., Hotte, N., Kaplan, G. G., Vincent, R., Tso, R., Gänzle, M., Rioux, K. P., Thiesen, A., Barkema, H. W., Wine, E., & Madsen, K. L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-24
- Volume
- 8
- Issue
- 4
- Pages
- e62220
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2038064966
- Cited by
- 306
- References
- 70
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kish, L., Hotte, N., Kaplan, G. G., Vincent, R., Tso, R., Gänzle, M., Rioux, K. P., Thiesen, A., Barkema, H. W., Wine, E., & Madsen, K. L. (2013). Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome. PLoS ONE. https://doi.org/10.1371/journal.pone.0062220
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