Cited by 230Gut microbiota and healthInfant Nutrition and HealthOral microbiology and periodontitis research

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Intestinal Microbiota in Healthy U.S. Young Children and Adults—A High Throughput Microarray Analysis

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Ringel-Kulka, Tamar, Cheng, Jing, Ringel, Yehuda, Salojärvi, Jarkko, Carroll, Ian, Palva, Airi, de Vos, Willem M., Satokari, Reetta·2013·PLoS ONE

DOI 10.1371/journal.pone.0064315PMC PMC3662718

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Abstract

UNLABELLED: It is generally believed that the infant's microbiota is established during the first 1-2 years of life. However, there is scarce data on its characterization and its comparison to the adult-like microbiota in consecutive years. AIM: To characterize and compare the intestinal microbiota in healthy young children (1-4 years) and healthy adults from the North Carolina region in the U.S. using high-throughput bacterial phylogenetic microarray analysis. METHODS: Detailed characterization and comparison of the intestinal microbiota of healthy children aged 1-4 years old (n = 28) and healthy adults of 21-60 years (n = 23) was carried out using the Human Intestinal Tract Chip (HITChip) phylogenetic microarray targeting the V1 and V6 regions of 16S rRNA and quantitative PCR. RESULTS: The HITChip microarray data indicate that Actinobacteria, Bacilli, Clostridium cluster IV and Bacteroidetes are the predominant phylum-like groups that exhibit differences between young children and adults. The phylum-like group Clostridium cluster XIVa was equally predominant in young children and adults and is thus considered to be established at an early age. The genus-like level show significant 3.6 fold (higher or lower) differences in the abundance of 26 genera between young children and adults. Young U.S. children have a significantly 3.5-fold higher abundance of Bifidobacterium species than the adults from the same location. However, the microbiota of young children is less diverse than that of adults. CONCLUSIONS: We show that the establishment of an adult-like intestinal microbiota occurs at a later age than previously reported. Characterizing the microbiota and its development in the early years of life may help identify 'windows of opportunity' for interventional strategies that may promote health and prevent or mitigate disease processes.

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Authors: Ringel-Kulka, T., Cheng, J., Ringel, Y., Salojärvi, J., Carroll, I., Palva, A., de Vos, W. M., & Satokari, R.
Affiliations: University of Helsinki (FI)
University of North Carolina at Chapel Hill (US)
ORCID: Cheng, Jing
Salojärvi, Jarkko
Carroll, Ian
Satokari, Reetta
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2013-05-23
Volume: 8
Issue: 5
Pages: e64315
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0064315
PMC: PMC3662718
OpenAlex: W1987296519
Cited by: 230
References: 62
Citations by year: 2026: 4 · 2025: 15 · 2024: 13 · 2023: 18 · 2022: 23 · 2021: 25 · 2020: 50 · 2019: 15 · 2018: 14 · 2017: 8 · 2016: 13 · 2015: 18 · 2014: 12 · 2013: 2
FWCI: 6.71
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Työväentutkimus Vuosikirja (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Academy of Finland
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK075621, K23DK075621)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, gut microbiota development, children versus adults, Bifidobacterium, Clostridium cluster XIVa, Clostridium cluster IV, Bacteroidetes, actinobacteria, bacilli, microbial diversity, 16S rRNA, healthy adults
MeSH terms: Adult, Bifidobacterium, Child, Preschool, Clostridium, Feces, Female, Genes, Bacterial, Health, Humans, Infant, Intestines, Male, Middle Aged, Phylogeny, RNA, Ribosomal, 16S, Oligonucleotide Array Sequence Analysis, Principal Component Analysis, Actinobacteria, Bacteroidetes, Young Adult, Molecular Typing, Microbiota

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Intestinal Microbiota in Healthy U.S. Young Children and Adults—A High Throughput Microarray Analysis

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