Distal gut microbiota of adolescent children is different from that of adults: Gut microbiota of adolescents differs from that of adults
Open accessAbstract
Human intestinal microbiota plays a number of important roles in human health and is also implicated in several gastrointestinal disorders. Although the diversity of human gut microbiota in adults and in young children has been examined, few reports of microbiota composition are available for adolescents. In this work, we used Microbiota Array for high-throughput analysis of distal gut microbiota in adolescent children 11-18 years of age. Samples obtained from healthy adults were used for comparison. Adolescent and adult groups could be separated in the principal components analysis space based on the relative species abundance of their distal gut microbiota. All samples were dominated by class Clostridia. A core microbiome of 46 species that were detected in all examined samples was established; members of genera Ruminococcus, Faecalibacterium, and Roseburia were well represented among core species. Comparison of intestinal microbiota composition between adolescents and adults revealed a statistically significantly higher abundance of genera Bifidobacterium and Clostridium among adolescent samples. The number of detected species was similar between sample groups, indicating that it was the relative abundances of the genera and not the presence or absence of a specific genus that differentiated adolescent and adult samples. In summary, contrary to the current belief, this study suggests that the gut microbiome of adolescent children is different from that of adults.
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The gut microbiota may undergo a more prolonged development than previously suspected, continuing past early childhood.
“The gut microbiota, however, may undergo a more prolonged development than previously suspected, with other evidence to indicate that it continues to develop past early childhood [82,83].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [83]
At genus level, adolescents had higher relative abundances of Bifidobacterium and Clostridium, but lower relative abundances of Prevotella and Sutterella.
“At the genus level, adolescents had higher relative abundances of Bifidobacterium and Clostridium, but lower relative abundances of Prevotella and Sutterella.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Agans et al., 2011
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- Authors
- Agans, R., Rigsbee, L., Kenche, H., Michail, S., Khamis, H. J., & Paliy, O.
- Affiliations
- Wright State University (US)
- Corresponding author
- Paliy, Oleg
- Venue
- FEMS Microbiology Ecology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-01
- Volume
- 77
- Issue
- 2
- Pages
- 404-412
- ISSN
- 0168-6496 (ISSN-L)
- PMC
- PMC4502954
- OpenAlex
- W1921871707
- Cited by
- 343
- References
- 41
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 34 · 2023: 18 · 2022: 35 · 2021: 26 · 2020: 51 · 2019: 24 · 2018: 16 · 2017: 16 · 2016: 17 · 2015: 19 · 2014: 13 · 2013: 13 · 2012: 12
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FEMS Microbiology Ecology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Journal of Bioresource Management (submittedVersion)
- Funders
- National Institutes of Health
- National Center for Complementary and Integrative Health (R21AT003423, AT003423)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD065575, R03HD065575)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, adolescents, age differences, core microbiome, Clostridia, Bifidobacterium, Clostridium, Ruminococcus, Faecalibacterium, Roseburia, species abundance, healthy adults
- MeSH terms
- Adolescent, Adult, Bacteria, Child, DNA, Bacterial, Female, Humans, Intestines, Male, Middle Aged, Polymerase Chain Reaction, Genome, Bacterial, Oligonucleotide Array Sequence Analysis, Principal Component Analysis, Metagenome, Young Adult
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