Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin
Open accessAbstract
Secretin (SCT) is a classical peptide hormone that is synthesized and released from the gastrointestinal tract after a meal. We have previously shown that it acts both as a central and peripheral anorectic peptide, and that its central effect is mediated via melanocortin system. As peripheral satiety signals from the gastrointestinal tract can be sent to the brain via the vagal afferent or by crossing the blood-brain barrier (BBB), we therefore sought to investigate the pathway by which peripheral SCT reduces appetite in this study. It is found that bilateral subdiaphragmatic vagotomy and treatment of capsaicin, an excitotoxin for primary afferent neurons, could both block the anorectic effect of peripherally injected SCT. These treatments are found to be capable of blunting i.p. SCT-induced Fos activation in pro-opiomelanocortin (POMC) neurons within the hypothalamic Arcuate Nucleus (Arc). Moreover, we have also found that bilateral midbrain transaction could block feeding reduction by peripheral SCT. Taken together, we conclude that the satiety signals of peripheral SCT released from the gastrointestinal tract are sent via the vagus nerves to the brainstem and subsequently Arc, where it controls central expression of other regulatory peptides to regulate food intake.
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Secretin can inhibit food intake via activation of secretin receptor in vagal sensory nerves and melanocortin signaling in the brain.
“Moreover, secretin can also inhibit food intake via the activation of secretin receptor (SctR) in vagal sensory nerves and melanocortin signaling in the brain 22, 23.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [23]
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- Authors
- Chu, J. Y. S., Cheng, C. Y. Y., Sekar, R., & Chow, B. K. C.
- Affiliations
- University of Hong Kong (HK)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-30
- Volume
- 8
- Issue
- 5
- Pages
- e64859
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3667839
- OpenAlex
- W2075248627
- Cited by
- 28
- References
- 34
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 2 · 2014: 2 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- Hong Kong Government
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- secretin, anorectic effect, vagal afferent neurons, vagotomy, capsaicin, proopiomelanocortin neurons, arcuate nucleus, hypothalamus, satiety signals, food intake regulation, melanocortin system, brainstem
- MeSH terms
- Animals, Appetite Depressants, Brain Stem, Eating, Male, Neurons, Afferent, Pro-Opiomelanocortin, Secretin, Vagus Nerve, Mice
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