The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats
Abstract
Peptide YY (PYY), an anorectic peptide, is secreted postprandially from the distal gastrointestinal tract. PYY(3-36), the major form of circulating PYY, binds to the hypothalamic neuropeptide Y Y2 receptor (Y2-R) with a high-affinity, reducing food intake in rodents and humans. Additional gastrointestinal hormones involved in feeding, including cholecystokinin, glucagon-like peptide 1, and ghrelin, transmit satiety or hunger signals to the brain via the vagal afferent nerve and/or the blood stream. Here we determined the role of the afferent vagus nerve in PYY function. Abdominal vagotomy abolished the anorectic effect of PYY(3-36) in rats. Peripheral administration of PYY(3-36) induced Fos expression in the arcuate nucleus of sham-operated rats but not vagotomized rats. We showed that Y2-R is synthesized in the rat nodose ganglion and transported to the vagal afferent terminals. PYY(3-36) stimulated firing of the gastric vagal afferent nerve when administered iv. Considering that Y2-R is present in the vagal afferent fibers, PYY(3-36) could directly alter the firing rate of the vagal afferent nerve via Y2-R. We also investigated the effect of ascending fibers from the nucleus of the solitary tract on the transmission of PYY(3-36)-mediated satiety signals. In rats, bilateral midbrain transections rostral to the nucleus of the solitary tract also abolished PYY(3-36)-induced reductions in feeding. This study indicates that peripheral PYY(3-36) may transmit satiety signals to the brain in part via the vagal afferent pathway.
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These gut peptides can activate their cognate receptors located in vagal afferents to signal to the brainstem.
“Moreover, these gut peptides can activate their cognate receptors located in vagal afferents to signal to the brainstem [179,180].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [179]
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- Authors
- Koda, S., Date, Y., Murakami, N., Shimbara, T., Hanada, T., Toshinai, K., Niijima, A., Furuya, M., Inomata, N., Osuye, K., & Nakazato, M.
- Affiliations
- University of Miyazaki (JP)
- Niigata University (JP)
- Suntory (Japan) (JP)
- Corresponding author
- Nakazato, Masamitsu
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2005-05-01
- Volume
- 146
- Issue
- 5
- Pages
- 2369-2375
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2099688918
- Cited by
- 431
- References
- 38
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 15 · 2023: 10 · 2022: 14 · 2021: 25 · 2020: 8 · 2019: 9 · 2018: 21 · 2017: 26 · 2016: 18 · 2015: 15 · 2014: 26 · 2013: 32 · 2012: 32
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peptide YY, PYY3-36, vagal afferent nerves, vagotomy, Y2 receptor, satiety signals, arcuate nucleus, nodose ganglion, nucleus tractus solitarius, anorectic peptides, gastrointestinal hormones
- MeSH terms
- Afferent Pathways, Animals, Arcuate Nucleus of Hypothalamus, Eating, Electrophysiology, Fluorescent Antibody Technique, Male, Nodose Ganglion, Peptide Fragments, Satiation, Vagotomy, Vagus Nerve, Proto-Oncogene Proteins c-fos, Rats, Wistar, Receptors, Neuropeptide Y, Peptide YY, Rats
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