Whey Protein Reduces Early Life Weight Gain in Mice Fed a High-Fat Diet
Open accessAbstract
An increasing number of studies indicate that dairy products, including whey protein, alleviate several disorders of the metabolic syndrome. Here, we investigated the effects of whey protein isolate (whey) in mice fed a high-fat diet hypothesising that the metabolic effects of whey would be associated with changes in the gut microbiota composition. Five-week-old male C57BL/6 mice were fed a high-fat diet ad libitum for 14 weeks with the protein source being either whey or casein. Faeces were collected at week 0, 7, and 13 and the fecal microbiota was analysed by denaturing gradient gel electrophoresis analyses of PCR-derived 16S rRNA gene (V3-region) amplicons. At the end of the study, plasma samples were collected and assayed for glucose, insulin and lipids. Whey significantly reduced body weight gain during the first four weeks of the study compared with casein (P<0.001-0.05). Hereafter weight gain was similar resulting in a 15% lower final body weight in the whey group relative to casein (34.0±1.0 g vs. 40.2±1.3 g, P<0.001). Food intake was unaffected by protein source throughout the study period. Fasting insulin was lower in the whey group (P<0.01) and glucose clearance was improved after an oral glucose challenge (P<0.05). Plasma cholesterol was lowered by whey compared to casein (P<0.001). The composition of the fecal microbiota differed between high- and low-fat groups at 13 weeks (P<0.05) whereas no difference was seen between whey and casein. In conclusion, whey initially reduced weight gain in young C57BL/6 mice fed a high-fat diet compared to casein. Although the effect on weight gain ceased, whey alleviated glucose intolerance, improved insulin sensitivity and reduced plasma cholesterol. These findings could not be explained by changes in food intake or gut microbiota composition. Further studies are needed to clarify the mechanisms behind the metabolic effects of whey.
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Feeding whey protein to mice attenuated some negative effects on gut microbiota composition, including increasing Lactobacillaceae/Lactobacillus and decreasing Clostridiaceae/Clostridium.
“feeding of whey protein to mice attenuated some negative effects on the composition of the gut microbiota composition including increasing Lactobacillaceae/Lactobacillus and decreasing Clostridiaceae/Clostridium [184, 185].”
From The athletic gut microbiota (2020) · cites this paper as [185]
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- Authors
- Tranberg, B., Hellgren, L. I., Lykkesfeldt, J., Sejrsen, K., Jeamet, A., Rune, I., Ellekilde, M., Nielsen, D. S., & Hansen, A. K.
- Affiliations
- University of Copenhagen (DK)
- Technical University of Denmark (DK)
- Corresponding author
- Tranberg, Britt
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-08-06
- Volume
- 8
- Issue
- 8
- Pages
- e71439
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3735523
- OpenAlex
- W2058692930
- Cited by
- 46
- References
- 42
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 9
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
- Funders
- Forsknings- og Innovationsstyrelsen
- Danish Agency for Science and Higher Education (2101-07-0094)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- whey protein isolate, casein, high-fat diet, gut microbiota, impaired glucose tolerance, insulin sensitivity, serum cholesterol, metabolic syndrome, milk protein, C57BL/6 mice
- MeSH terms
- Whey Proteins, Animals, Animals, Newborn, Body Weight, Insulin Resistance, Lipids, Male, Mice, Inbred C57BL, Milk Proteins, Organ Size, Weight Gain, Glucose Intolerance, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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