The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Quantitative Proteomic Analysis of Gingival Crevicular Fluid in Different Periodontal Conditions
Open accessAbstract
AIM: To quantify the proteome composition of the GCF in periodontal health (HH) and in sites with different clinical conditions in chronic periodontitis (CP) subjects. MATERIAL AND METHODS: 5 subjects with HH and 5 with CP were submitted to full-mouth periodontal examination, and GCF sampling. Sites in the CP group were classified and sampled as periodontitis (P, probing depth, PD>4 mm), gingivitis (G, PD≤3 mm with bleeding on probing, BOP), and healthy sites (H, PD≤3 mm without BOP). GCF proteins were subjected to liquid chromatography electrospray ionization mass spectrometry for identification, characterization and quantification. RESULTS: 230 proteins were identified; 145 proteins were detected in HH, 214 in P, 154 in G, and 133 in H. Four proteins were exclusively detected at HH, 43 proteins at P, 7 proteins at G, and 1 protein at H. Compared to HH group, 35 and 6 proteins were more abundant in P and G (p<0.001), respectively; and 4, 15 and 37 proteins were less abundant in P, G and H (p≤0.01), respectively. CONCLUSIONS: There are marked differences in the GCF proteome according to disease profile. Comprehension of the role of the identified proteins in the etiopathogenesis of periodontal disease may lead to biomarkers definition.
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“Culture‐independent methods have improved our understanding of microbial diversity in the oral cavity.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [70]
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“Proteomic applications have been applied to understand changes in the proteome that diverge states of periodontal health from disease and to further characterize various periodontal disease states, including gingivitis, mild, moderate, chronic, and aggressive periodontitis.70, 101, 102, 103, 104”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [70]
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Armitage, G. C. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.1 · Cited by 5,110
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Research works printed but not linked: 1
- WL Siqueira, 2012, Quantitative proteomic analysis of the effect of fluoride on the acquired enamel pellicle, PLOS ONE, 7, e42204, 10.1371/journal.pone.0042204 · DOI
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Items 101–103 of 103
Souza, L. D. P. S. S., Dias, D. R., Cesar, G. P. S., Bianco, D. D. A., Araújo, M., & Matarazzo, F. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c01217
Yang, C. X., Norouzi, M., Abovsky, M., Jurišica, I., & McCulloch, C. A. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112807
Li, R., Du, F., He, J., Luo, Z., Yang, R., Liu, J., Wang, Y., Zhou, C., Huang, M., & He, L. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1875551
Metadata
- Authors
- Silva-Boghossian, C. M., Colombo, A. P. V., Tanaka, M., Rayo, C., Xiao, Y., & Siqueira, W. L.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Western University (CA)
- Corresponding author
- Siqueira, Walter L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-10-01
- Volume
- 8
- Issue
- 10
- Pages
- e75898
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3787961
- OpenAlex
- W1965316932
- Cited by
- 104
- References
- 31
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 16 · 2020: 22 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Canadian Institutes of Health Research (25116, 113166, 106657, 97577)
- Natural Sciences and Engineering Research Council of Canada (#371813, 113166)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Periodontics › Oral and gingival health research
- Keywords
- gingival crevicular fluid, proteome, chronic periodontitis, gingivitis, periodontal health, periodontal biomarkers, protein abundance
- MeSH terms
- Female, Gingival Crevicular Fluid, Humans, Male, Middle Aged, Case-Control Studies, Proteomics, Chronic Periodontitis, Young Adult
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