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Cited by 110Diabetes Management and EducationCardiac Health and Mental HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Depression as a Risk Factor for Mortality in Individuals with Diabetes: A Meta-Analysis of Prospective Studies

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Hofmann, Mareike, Köhler, Birgit, Leichsenring, Falk, Kruse, Johannes·2013·PLoS ONE
DOI 10.1371/journal.pone.0079809PMC PMC3836777
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Abstract

OBJECTIVE: To quantify the impact of depression measured by self-reports and depression measured by clinical interview on all-cause mortality in individuals with diabetes and to analyze the strength of both associations, the influence of covariates, and possible differences between studies assessing self-rated depressive symptoms and those using a clinical interview to measure depression as predictors of mortality. RESEARCH DESIGN AND METHODS: PUBMED and PsycINFO were searched up to July 2013 for prospective studies assessing depression, diabetes and mortality. The pooled hazard ratios were calculated using random-effects models. RESULTS: Sixteen studies met the inclusion criteria. After adjustment for demographic variables depression measured by self-reports was associated with an increased all-cause mortality risk (pooled HR = 2.56, 95% CI 1.89-3.47), and the mortality risk remained high after additional adjustment for diabetes complications (HR = 1.76, 95% CI 1.45-2.14,). Six studies reporting adjusted HRs for depression measured by clinical interviews supported the results of the other models (HR = 1.49, 95% CI 1.15-1.93). CONCLUSIONS: Both depression measured by self-report and depression measured by clinical interview have an unfavorable impact on mortality in individuals with diabetes. The results, however, are limited by the heterogeneity of the primary studies. It remains unclear whether self-reports or clinical interviews for depression are the more precise predictor.

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  • In 16 prospective studies (nine studies on T2DM; 6-year follow-up; n=107,944 with diabetes mellitus; n=19,589 with diabetes mellitus and depression), self-reported depression was associated with increased risk of all-cause mortality HR 1.76 (95% CI 1.45-2.14).

    “16 prospective studies (nine studies on T2DM); 6 year follow- up ( n = 107,944 with diabetes mellitus; n = 19,589 with diabetes mellitus and depression). | Depression by self-report and by clinical interview | *Self-reported depression: increased risk of all-cause mortality HR 1.76 (95% CI 1.45-2.14).”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Hofmann (2013) 124

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Authors
Hofmann, M., Köhler, B., Leichsenring, F., & Kruse, J.
Affiliations
  • Justus-Liebig-Universität Gießen (DE)
  • Philipps University of Marburg (DE)
Corresponding author
Hofmann, Mareike
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-11-21
Volume
8
Issue
11
Pages
e79809
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0079809
PMC
PMC3836777
OpenAlex
W2069342062
Cited by
110
References
7
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 15 · 2016: 12 · 2015: 12 · 2014: 6
FWCI
1.48
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
University of Bern
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
depression, diabetes mellitus, all-cause mortality, risk factors, diabetes complications
MeSH terms
Depression, Diabetes Mellitus, Humans, Risk Factors

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