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Cited by 60Obstructive Sleep Apnea ResearchParkinson's Disease Mechanisms and TreatmentsSleep and related disorders

Risk of Obstructive Sleep Apnea in Parkinson’s Disease: A Meta-Analysis

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Zeng, Jun, Wei, Min, Li, Taoping, Chen, Wei, Feng, Yuan, Shi, Rong, Song, Yanbin, Zheng, Wenling +1 more·2013·PLoS ONE
DOI 10.1371/journal.pone.0082091PMC PMC3857239
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Abstract

STUDY OBJECTIVES: Sleep disorders are a common symptom of Parkinson's disease (PD) and they significantly impair the sleep quality of the PD patients. However, there is no conclusive evidence to support the relation between PD and the prevalence of obstructive sleep apnea (OSA). The purpose of this meta-analysis review is to evaluate the association between PD and the prevalence of OSA. METHODS: A comprehensive literature search was conducted on PubMed and Embase through July 2013. Only studies that referred to PD and the prevalence of OSA and that met the selection criteria were included in the analysis. The odds ratios (ORs) were used to evaluate the relationship of PD and the prevalence of OSA by the fixed-effect model. RESULTS: Five eligible studies were analyzed in this study including 322 cases and 6,361 controls. The pooled-analysis showed the OR to be 0.60 (95% confidence interval (CI): 0.44 to 0.81, P = 0.001) and I(2) = 0.0% (χ(2) = 3.90, P = 0.420) in the fixed-effect model. CONCLUSIONS: Although we only included five small sample studies that indicated high homogeneity in the heterogeneity test, the results suggest that there is a significant negative association between PD and the prevalence of OSA; PD patients generally have a reduced prevalence of OSA. According to our analysis, these results are primarily due to the lower BMI of PD patients when compared with the general population controls.

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  • Not all studies have shown increased prevalence of obstructive sleep apnoea among Parkinson's disease patients.

    “Although obstructive sleep apnoea, where breathing stops intermittently during sleep, is well known in PD (Monderer and Thorpy 2008), not all studies have shown increased prevalence among patients (Zeng et al. 2013).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Zeng et al. 2013

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References 43 · Cited by 60

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Authors
Zeng, J., Wei, M., Li, T., Chen, W., Feng, Y., Shi, R., Song, Y., Zheng, W., & Ma, W.
Affiliations
  • Southern Medical University (CN)
  • Nanfang Hospital (CN)
Corresponding author
Ma, Wenli
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-12-09
Volume
8
Issue
12
Pages
e82091
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0082091
PMC
PMC3857239
OpenAlex
W2086090341
Cited by
60
References
43
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (30901721)
  • Natural Science Foundation of Guangdong Province (S2012010009537)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
Parkinson's disease, obstructive sleep apnea, sleep disorders, prevalence, body mass index, sleep quality
MeSH terms
Humans, Parkinson Disease, Quality Assurance, Health Care, Risk Factors, Prevalence, Case-Control Studies, Sleep Apnea, Obstructive

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