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DIC score in pregnant women–a population based modification of the International Society on Thrombosis and Hemostasis score
Open accessAbstract
OBJECTIVES: The objectives of this study were: 1) To determine the component needed to generate a validated DIC score during pregnancy. 2) To validate such scoring system in the identification of patients with clinical diagnosis of DIC. MATERIAL AND METHODS: This is a population based retrospective study, including all women who gave birth at the 'Soroka University Medical Center' during the study period, and have had blood coagulation tests including complete blood cell count, prothrombin time (PT)(seconds), partial thromboplastin time (aPTT), fibrinogen, and D-dimers. Nomograms for pregnancy were established, and DIC score was constructed based on ROC curve analyses. RESULTS: 1) maternal plasma fibrinogen concentrations increased during pregnancy; 2) maternal platelet count decreased gradually during gestation; 3) the PT and PTT values did not change with advancing gestation; 4) PT difference had an area under the curve (AUC) of 0.96 (p<0.001), and a PT difference ≥1.55 had an 87% sensitivity and 90% specificity for the diagnosis of DIC; 5) the platelet count had an AUC of 0.87 (p<0.001), an 86% sensitivity and 71% specificity for the diagnosis of DIC; 6) fibrinogen concentrations had an AUC of 0.95 (p<0.001) and a cutoff point ≤3.9 g/L had a sensitivity of 87% and a specificity of 92% for the development of DIC; and 7) The pregnancy adjusted DIC score had an AUC of 0.975 (p<0.001) and at a cutoff point of ≥26 had a sensitivity of 88%, a specificity of 96%, a LR(+) of 22 and a LR(-) of 0.125 for the diagnosis of DIC. CONCLUSION: We could establish a sensitive and specific pregnancy adjusted DIC score. The positive likelihood ratio of this score suggests that a patient with a score of ≥26 has a high probability to have DIC.
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“Abruption is the most common cause of DIC in pregnancy (93, 94).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [93]
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“Scoring systems such as the International Society of Thrombosis and Hemostasis DIC Score (101) was modified for pregnancy (93)(TABLE 6).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [93]
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Erez, O., Mastrolia, S. A., & Thachil, J. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.03.054 · Cited by 170
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Erez, O., Othman, M., Rabinovich, A., Leron, E., Gotsch, F., & Thachil, J. V. (2022) · Journal of Blood Medicine · doi:10.2147/jbm.s273047 · Cited by 124
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Cunningham, F. G., & Nelson, D. B. (2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000001110 · Cited by 113
DIC in Pregnancy – Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments
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Disseminated intravascular coagulation in pregnancy – Clinical phenotypes and diagnostic scores
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Iba, T., Levi, M. M., Thachil, J. V., & Levy, J. H. (2022) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0042-1756300 · Cited by 69
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Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know?
Haram, K., Mortensen, J. H. S., Mastrolia, S. A., & Erez, O. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2016.1189897 · Cited by 54
Rabinovich, A., Kadir, R. A., Thachil, J. V., Iba, T., Othman, M., & Erez, O. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14523 · Cited by 44
Squizzato, A., Gallo, A., Levi, M. M., Iba, T., Levy, J. H., Erez, O., Cate, H. T., Solh, Z., Gando, S., Vicente, V., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14946 · Cited by 43
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Alhousseini, A., Romero, R. J., Benshalom-Tirosh, N., Gudicha, D. W., Pacora, P., Tirosh, D., Kabiri, D., Yeo, L., Thachil, J. V., Hsu, C., et al. (2020) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1716330 · Cited by 26
Oda, T., Tamura, N., Ide, R., Itoh, T., Horikoshi, Y., Matsumoto, M., Narumi, M., Kohmura‐Kobayashi, Y., Furuta‐Isomura, N., Yaguchi, C., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004665 · Cited by 25
Amniotic fluid embolism-associated coagulopathy: a single-center observational study
Schröder, L., Hellmund, A., Gembruch, U., & Merz, W. M. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05466-w · Cited by 25
“Table 4 DIC scores currently applied in obstetric hemorrhage [1, 2, 4, 5]”
MethodPlacental abruption as a trigger of DIC in women with HELLP syndrome: a population-based study
Gomez-Tolub, R., Rabinovich, A., Kachko, E., Benshalom-Tirosh, N., Tirosh, D., Thachil, J. V., Besser, L., Than, N. G., & Erez, O. (2020) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1818200 · Cited by 25
“35% [5] and has been associated with obstetrical complications such as placental abruption, amniotic fluid embolism, acute fatty liver of pregnancy, and Hemolysis, Elevated Liver enzymes and Low Platelets (HELLP) syndrome [6].”
BackgroundResultTsai, Y.-C., Chang, H.-C., Chiou, M., Luo, S., & Kuo, C. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059203 · Cited by 24
Coagulopathy in surgical management of placenta accreta spectrum
Shamshirsaz, A. A., Fox, K. A., Erfani, H., Clark, S. L., Hui, S. R., Shamshirsaz, A. A., Rezaei, A., Nassr, A. A., Lake, Y. N., Teruya, J., et al. (2019) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2019.04.026 · Cited by 23
Ponzio-Klijanienko, A., Vincent-Rohfritsch, A., Girault, A., Ray, C. L., Goffinet, F., & Bonnet, M. (2020) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2020.101821 · Cited by 21
Su, J., Yang, Y., Cao, Y., & Yin, Z. (2020) · Placenta · doi:10.1016/j.placenta.2020.10.006 · Cited by 21
The role of fibrinogen in postpartum hemorrhage
Vermeulen, T., & de Velde, M. V. (2022) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2022.10.002 · Cited by 21
Miyagi, Y., Tada, K., Yasuhi, I., Maekawa, Y., Okura, N., Kawakami, K., Yamaguchi, K. D., Ogawa, M., Kodama, T. S., Nomiyama, M., et al. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14166 · Cited by 20
“…with datasets that include DIC; other markers of coagulation such as D-dimer, plasmin-α 2 plasmin inhibitor complex (PIC), 49,50 and thrombin – antithrombin complex (TAT) 49,50 ; prothrombin time 64 ; and pathological fi ndings to determine the existence of pathological thrombi and organ failure.”
BackgroundEchocardiography findings in amniotic fluid embolism: a systematic review of the literature
Wiseman, D., Simard, C., Yang, S. S., Koolian, M., Abenhaim, H. A., & Lipes, J. (2022) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-022-02343-9 · Cited by 20
“Disseminated intravascular coagulation was defined as C 26 points on the International Society of Thrombosis and Hemostasis DIC score modified for pregnancy.(17) Rotational thromboelastometry was accepted if used as a surrogate for other markers of coagulation.”
MethodMuin, D. A., Haslacher, H., Koller, V., Kiss, H., Scharrer, A., & Farr, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-30687-0 · Cited by 20
Vaginal Bleeding in Late Pregnancy
Young, J. S., & White, L. M. (2019) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2019.01.006 · Cited by 20
Disseminated intravascular coagulation
Hossain, N., & Paidas, M. J. (2013) · Seminars in Perinatology · doi:10.1053/j.semperi.2013.04.008 · Cited by 20
Hizkiyahu, R., Rabinovich, A., Thachil, J. V., Sheiner, E., Shaked, G., Sebbag, G., Maymon, E., & Erez, O. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1439469 · Cited by 19
“Modified ISTH DIC score [20] was calculated for each patient.”
BackgroundMethodInfluentialYoon, J. G., Heo, J., Kim, M., Park, Y. J., Choi, M. H., Song, J., Wyi, K., Kim, H., Duchenne, O., Eom, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195861 · Cited by 18
“Those criteria have respective advantages and limitations depending on the underlying conditions, and numbers of refinements have been made [10, 13, 15].”
BackgroundOthman, M., Santamaría, A., Cerda, M. A., Erez, O., Minford, A., Obeng‐Tuudah, D., Blondon, M., Bistervels, I. M., Middeldorp, S., & Kadir, R. A. (2019) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12243 · Cited by 19
Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies
Erez, O. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.04.009 · Cited by 18
“In 2014 my colleagues and I presented evidence that a pregnancy-specific DIC score could improve diagnosis; this was based on a cohort of 24,693 patients of whom 87 had DIC.3 The score was based on pregnancy-specific reference ranges for fibrinogen, prothrombin difference (test-control), and platelet count.”
MethodMorikawa, M., Takeda, Y., Matsunaga, S., Makino, S., Eto, E., Serizawa, M., Nii, M., Takeda, J., Masuyama, H., & Itakura, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-68298-7 · Cited by 16
“Erez et. al. published the pregnancy-specific modified ISTH DIC score in 2014 15 , which excluded underlying disease and clinical symptoms as factors to diagnose obstetrical DIC (see Supplementary Table S3 online).”
BackgroundMorikawa, M., Matsunaga, S., Makino, S., Takeda, Y., Hyoudo, H., Nii, M., Serizawa, M., Itakura, A., Adachi, T., & Kobayashi, T. (2021) · International Journal of Hematology · doi:10.1007/s12185-021-03119-5 · Cited by 16
Hayakawa, M., Seki, Y., Ikezoe, T., Yamakawa, K., Okamoto, K., Kushimoto, S., Sakamoto, Y., Itagaki, Y., Takahashi, Y., Ishikura, H., et al. (2025) · International Journal of Hematology · doi:10.1007/s12185-025-03918-0 · Cited by 15
“In 2014, a modified DIC score for pregnant women was introduced based on Prothrombin Time (PT) differences, platelet counts, and fibrinogen levels [72].”
When does obstetric coagulopathy occur and how do I manage it?
Collis, R. E., Kenyon, C. R., Roberts, T. C. D., & McNamara, H. (2021) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2021.102979 · Cited by 15
Ide, R., Oda, T., Todo, Y., Kawai, K., Matsumoto, M., Narumi, M., Kohmura‐Kobayashi, Y., Furuta‐Isomura, N., Yaguchi, C., Uchida, T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-50911-w · Cited by 14
“In the present study, we used the modified-International Society on Thrombosis and Haemostasis score proposed by Erez 30 to diagnose DIC in our AFE and PA cohorts; thereby we showed that AFE and sPA complicated with DIC had marked activation of coagulation and fibrinolysis and that AFE patients…”
MethodPoint-of-care viscoelastic tests in the management of obstetric hemorrhage
Nelson, D. B., Ogunkua, O., & Cunningham, F. G. (2022) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000004686 · Cited by 13
Prenatal Plasma Fibrinogen Level Predicts Postpartum Hemorrhage of Patients With HELLP Syndrome
Cui, C., Ma, S., & Qiao, R. (2020) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029619894057 · Cited by 13
“When the level of FIB is below 3 g/L, coagulation abnormalities are usually present.(18) In this present study, the level of FIB in postpartum hemorrhage group was lower than that in nonpostpartum hemorrhage group (P < .”
BackgroundSohn, C. H., Kim, S. R., Kim, Y., Seo, D. W., Ahn, S. Y., Lee, Y., Lee, J., Oh, B. J., Won, H., Shim, J., et al. (2017) · Shock · doi:10.1097/shk.0000000000000852 · Cited by 13
“Common causes of disseminated intravascular coagulation associated with PPH are uterine atony, retained placenta or membranes, uterine rupture, placenta accreta, and severe cervical, or vaginal lacerations (14).”
BackgroundThromboprophylaxis in Pregnant Women with COVID-19: An Unsolved Issue
Varlas, V. N., Roxana Georgiana, B. O. R. S., Plotogea, M., Iordache, M. D., Mehedințu, C., & Cîrstoiu, M. M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031949 · Cited by 14
“A marked increase in D-dimers above the normal pregnancy level (median in third trimester 1.24 µg/mL) [103] indicates possible COVID-19 coagulopathy or DIC [39].”
MethodInfluentialSkalska-Świstek, M., Huras, H. K., Jaworowski, A. P., Świstek, R., & Kolak, M. L. (2022) · Diagnostics · doi:10.3390/diagnostics12030655 · Cited by 10
Disseminated intravascular coagulation in pregnancy: New insights
Erez, O. (2021) · Thrombosis Update · doi:10.1016/j.tru.2021.100083 · Cited by 9
Potential predictors for prognosis and postpartum recovery time of acute fatty liver of pregnancy
Chen, J., Huang, Z., Fan, X., Hu, X., Qi, M., Liao, C.-J., Long, L., & Huang, Y. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-03287-y · Cited by 8
“The diagnosis of disseminated intravascular coagulation (DIC) was based on the DIC score in pregnancy [14].”
MethodDisseminated intravascular coagulation complicating mild or asymptomatic maternal COVID-19
Carpenter, J., Combs, C. A., Kahn, B. F., Maurel, K. A., & Clark, R. H. (2022) · AJOG Global Reports · doi:10.1016/j.xagr.2022.100110 · Cited by 8
“DIC, disseminated intravascular coagulation; ISTH, International Society on Thrombosis and Haemostasis, score from Erez et al.(33) Statistical test not applicable because groups are defined by laboratory values.”
Potter, L. A., Ly, S. H., Pei, X., Ponzini, M. D., Wilson, M., & Hou, M. Y. (2023) · Contraception · doi:10.1016/j.contraception.2023.110118 · Cited by 7
Goals for Collaborative Management of Obstetric Hemorrhage
Baird, S. M., Martin, S., & Kennedy, M. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2020.11.001 · Cited by 7
Okoye, H. C., Nwagha, T. U., Ugwu, A. O., Menuba, I. E., Duru, A. N., Ugwu, E. O., Ezebialu, I. U., Eze, S. C., & Ugwu, A. O. (2022) · African Health Sciences · doi:10.4314/ahs.v22i1.24 · Cited by 7
Zorlu, U., Altınsoy, H. B., Okutucu, G., Orhan, N., Tanaçan, A., & Şahin, D. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70609 · Cited by 6
Investigating gastrointestinal disorders in pregnancy
Morton, A. (2023) · Obstetric Medicine · doi:10.1177/1753495x231206211 · Cited by 6
Morton, A., & Teasdale, S. (2018) · Emergency Medicine Australasia · doi:10.1111/1742-6723.12957 · Cited by 6
“%) compared with mean levels of 60–85% in PET, and 62–80% in HELLP.118–124 An ATIII level of less than 65% is suggestive of the diagnosis of AFLP.124–126 Fibrinogen levels rise significantly during pregnancy and the use of non-pregnant reference intervals may underestimate the prevalence of DIC.127,128 A fibrinogen le…”
BackgroundInfluentialMorikawa, M., Kamiya, A., Yoshida, A., Nishibata, S., & Okada, H. (2024) · International Journal of Hematology · doi:10.1007/s12185-023-03702-y · Cited by 5
Othman, M., Nemeti, G. I., Solow, M., Cruciat, G., Mureșan, D., Sulaiman, M., Thaker, S., Kadir, R. A., & Malinowski, A. K. (2024) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2024.102339 · Cited by 5
“Conversely, using the pregnancy-speci fi c DIC score [17], 9% of patients met the criteria for DIC without a signi fi cant difference according to the severity of illness.”
MethodMiyagi, Y., Tada, K., Yasuhi, I., Tsumura, K., Maegawa, Y., Tanaka, N., Mizunoe, T., Emoto, I., Maeda, K., & Kawakami, K. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061826 · Cited by 6
“DIC during pregnancy is one of the chief causes of maternal mortality worldwide [3,4], with a frequency of 0.03% [5] to 0.35% [6].”
BackgroundMethodInfluentialHaury, J., Seco, A., Goffinet, F., & Lepercq, J. A. (2023) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2023.102626 · Cited by 5
Disseminated Intravascular Coagulation
Padrnos, L. J., & Athale, J. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197628638.003.0053 · Cited by 5
Özkavak, O. O., Tanaçan, A., Haksever, M., Şahin, R., Ersak, D. T., Iskefiyeli, E., & Şahın, D. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07355-4 · Cited by 5
“The diagnosis of DIC was made using the modified International Society on Thrombosis Hemostasis score system which is based on platelet count, prothrombin time and fibrinogen level [9, 12].”
Walker, J. W., & Bonavia, A. S. (2020) · Case Reports in Anesthesiology · doi:10.1155/2020/9642438 · Cited by 4
“(ese are platelet count, fibrinogen concentration, and PT difference (defined as the difference between the patient’s value and the laboratory normal value) [6, 17].”
BackgroundMethodYang, Y., Hu, Y., Wu, M., & Xiang, Z. (2022) · PubMed Central · doi:10.11817/j.issn.1672-7347.2022.210536 · Cited by 4
Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG)
Kazi, S., Othman, M., Khoury, R. S., Bernstein, P. S., Thachil, J. V., Ciantar, E., Ferrara, L., Netto, M., Kadir, R. A., & Malinowski, A. K. (2023) · Obstetric Medicine · doi:10.1177/1753495x231206931 · Cited by 4
Gerinnungsstörungen in der Geburtshilfe
Rath, W. H., Bergmann, F., & Korte, W. C. (2024) · Springer Reference Medizin · doi:10.1007/978-3-662-44369-9_41-2 · Cited by 4
Linström, M. A., Musekwa, E., Nell, E., de Waard, L., & Chapanduka, Z. C. (2024) · Transfusion · doi:10.1111/trf.17849 · Cited by 3
Miranda, H. G. (2022) · Oxford University Press eBooks · doi:10.1093/med/9780190885939.003.0021 · Cited by 3
Lieng, C., Fischer, C., & Girault, A. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70713 · Cited by 2
“The ISTH scoring system, while widely used for diagnosing DIC, has not been validated specifically for pregnant populations. to DIC in pregnancy, 5 and underscore the importance of maintaining a targeted but flexible approach to coagulation testing, guided by clinical judgment rather than strict…”
Kulikov, A. V., Shifman, E. M., Николаевич, П. Д., Zabolotskikh, I. B., Ovezov, A. M., Ройтман, Е. В., Артымук, Н. В., Астахов, А. А., Belokrinitskaya, T. E., Ronenson, A. M., et al. (2022) · Russian Journal of Anesthesiology and Reanimatology · doi:10.17116/anaesthesiology20220215 · Cited by 2
Crucial new insights into the understanding and treatment of acute obstetric coagulopathy
Bouthors, A. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2022.12.010 · Cited by 2
Transfusion and hematologic indices in cases of stillbirth due to placental abruption
White, A. M., Pruszynski, J. E., Williams, R., & Duryea, E. L. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.06.042 · Cited by 2
Krsman, A., Kupresanin, M., Baturan, B., Bulatovic, S., Petrović, D., & Ilić, D. (2023) · Medicinski pregled · doi:10.2298/mpns2302052k · Cited by 2
Errors in the diagnosis for DIC due to a statistical misunderstanding
Wada, H., Shiraki, K., & Shimaoka, M. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14833 · Cited by 2
Disseminated Intravascular Coagulation
Hossain, N., & Paidas, M. J. (2018) · doi:10.1002/9781119129400.ch31 · Cited by 2
Spontaneous Abortion Complications
Tsur, A., Malvası, A., Vergari, U., & Carp, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-31377-1_2 · Cited by 1
Disseminated intravascular coagulation in obstetric patients: maternal and fetal results
Ceylan, Ö., & Çağlar, A. T. (2022) · Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi · doi:10.38136/jgon.1179018 · Cited by 1
Babaei, M. E., Kabiri, A., Movahedi, M., Ghahiri, A., Hajhashemi, M., & Dehghan, M. (2024) · Advanced Biomedical Research · doi:10.4103/abr.abr_257_23 · Cited by 1
Fang, Y., Liao, G., Li, X., Fang, Y., & Gao, Y. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1574686 · Cited by 1
Wolfovitz, A., Brenner, B., & Solt, I. (2025) · Seminars in Thrombosis and Hemostasis · doi:10.1055/a-2645-2845 · Cited by 1
“36,37 The modi fi ed score for the diagnosis of DIC during pregnancy developed by Erez et al 17,38 and the new Japanese obstetric DIC criteria 39 aim to account for these changes.”
Tada, K., Miyagi, Y., Yasuhi, I., Tsumura, K., Emoto, I., Sagawa, M., Tanaka, N., Yamaguchi, K., Maeda, K., & Kawakami, K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14155179 · Cited by 1
“Two clinical diagnostic criteria were recently discovered for diagnosing obstetrical DIC: the pregnancy-modified ISTH DIC score [14] and new Japanese diagnostic criteria for obstetrical DIC [15].”
Cui, J., Liu, Z., He, W., Su, R., Ma, R., Tao, H., Yang, Z., Sun, L., Chen, S., Li, Y., et al. (2025) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000313 · Cited by 1
Ii, K., Hisamune, R., Ushio, N., Nii, M., Nishioka, D., Oda, T., Umemura, Y., Okamoto, K., Matsuoka, T., Mochizuki, K., et al. (2026) · Thrombosis Research · doi:10.1016/j.thromres.2026.109686 · Cited by 1
Olaya, S., Hernandez, J. D., Murillo-Garcia, D. R., & Garay-Fernández, M. (2021) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2021.114037 · Cited by 1
A rare case of visceral leishmaniasis misdiagnosed as systemic lupus erythematosus
Zheng, M., Liu, S., Wang, X., Li, X., Wang, N., Guo, Y., Yang, J., Upreti, B., Cui, R., & Xu, J. (2021) · Rheumatology & autoimmunity · doi:10.1002/rai2.12008 · Cited by 1
Tada, K., Miyagi, Y., Kumazawa, K., 塚原, 紗., Okimoto, N., Yoshida, M., & Ooka, N. (2022) · European Journal of Clinical and Biomedical Sciences · doi:10.11648/j.ejcbs.20220802.14 · Cited by 1
Paluch, Z., Krawczyk, M., Duda, P., Rypulak, E., & Wichowska, O. (2023) · Journal of Pre-Clinical and Clinical Research · doi:10.26444/jpccr/168416 · Cited by 1
Usage of blood components in obstetric practice
Ghosh, K., & Mandal, P. K. (2024) · Journal of Hematology and Allied Sciences · doi:10.25259/jhas_51_2023 · Cited by 1
Tamara, T., Allam, I. F. S. E., & El-Ghazaly, T. E.-S. M. (2016) · The Egyptian Journal of Hospital Medicine · doi:10.12816/0033775 · Cited by 1
Disseminated intravascular coagulation in perinatal medicine
Mingalimov, M. A., Grigoreva, K. N., Tretyakova, M. V., Elalamy, I., Sultangadzhieva, K. G., Bitsadze, V. O., Khizroeva, J. K., & Makatsariya, A. D. (2020) · Obstetrics Gynecology and Reproduction · doi:10.17749/2313-7347.2020.14.1.56-68 · Cited by 1
Disseminated intravascular coagulation in obstetrics: Diagnosis and up-to-date management strategies
KAWASAKI, K. (2022) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.33.544 · Cited by 1
Reply to “Errors in the diagnosis for DIC due to a statistical misunderstanding”
Rabinovich, A., Kadir, R. A., Thachil, J. V., Iba, T., Othman, M., & Erez, O. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14831 · Cited by 1
Disseminated Intravascular Coagulation
Burn, M. S., Hosier, H., Hossain, N., & Paidas, M. J. (2024) · doi:10.1002/9781119820260.ch31 · Cited by 1
Fox, K. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-30726-8_9
Prognostic indicators of Disseminated Intravascular Coagulation in pregnancy
Gupta, D. N., Nagori, D. S., Kumar, D. J., & Nagori, D. G. (2016) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-1509109093
Shih, A. W. Y., & Heddle, N. M. (2017) · doi:10.1002/9781119129431.ch47
Transfusion Medicine in Obstetrics and Prenatal Patients
Reeves, H. M., & Hong, H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54458-0.00011-8
Metadata
- Authors
- Erez, O., Novack, L., Beer-Weisel, R., Dukler, D., Press, F., Zlotnik, A., Than, N. G., Tomer, A., & Mazor, M.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Erez, Offer
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-04-11
- Volume
- 9
- Issue
- 4
- Pages
- e93240
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3984105
- OpenAlex
- W1975061570
- Cited by
- 146
- References
- 92
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 20 · 2023: 11 · 2022: 19 · 2021: 12 · 2020: 19 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 1
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- disseminated intravascular coagulation, pregnancy, fibrinogen, platelet count, prothrombin time, activated partial thromboplastin time, D-dimer
- MeSH terms
- Disseminated Intravascular Coagulation, Female, Fibrinogen, Hemostasis, Humans, Pregnancy, Prothrombin Time, Retrospective Studies, Thrombosis
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