Cited by 110Flavonoids in Medical ResearchPhytochemistry and Biological ActivitiesBioactive natural compounds

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Genkwanin Inhibits Proinflammatory Mediators Mainly through the Regulation of miR-101/MKP-1/MAPK Pathway in LPS-Activated Macrophages

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Gao, Yuan, Liu, Fen, Fang, Lei, Cai, Runlan, Zong, Chuanjie, Qi, Yun·2014·PLoS ONE

DOI 10.1371/journal.pone.0096741PMC PMC4011752

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Abstract

Genkwanin is one of the major non-glycosylated flavonoids in many herbs with anti-inflammatory activities. Although its anti-inflammatory activity in vivo has been reported, the potential molecular mechanisms remain obscure. In this study, by pharmacological and genetic approaches, we explore the anti-inflammatory effects of genkwanin in LPS-activated RAW264.7 macrophages. Genkwanin potently decreases the proinflammatory mediators, such as iNOS, TNF-α, IL-1β and IL-6, at the transcriptional and translational levels without cytotoxicity, indicating the excellent anti-inflammatory potency of genkwanin in vitro. Mechanism study shows that genkwanin significantly suppresses the p38- and JNK-mediated AP-1 signaling pathway and increases the mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) expression at the posttranscriptional level. We also confirmed that microRNA-101 (miR-101) is a negative regulator of MKP-1 expression. Moreover, regardless of miR-101-deficient cells or miR-101-abundant cells, the suppression effects of genkwanin on supernatant proinflammatory mediators' levels are far less than that in respective negative control cells, suggesting that genkwanin exerts anti-inflammatory effect mainly through reducing miR-101 production. However, genkwanin can't affect the level of phospho-Akt (p-Akt), indicating that the phosphorylation of Akt may be not responsible for the effect of genkwanin on miR-101 production. We conclude that genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-101/MKP-1/MAPK pathway.

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Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
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Baggiolini, M. (1998) · Nature · doi:10.1038/33340 · Cited by 2,711
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MacMicking, J. D., Nathan, C., Hom, G. J., Chartrain, N. A., Fletcher, D. S., Trumbauer, M. E., Stevens, K. A., Xie, Q. W., Sokol, K. A., Hutchinson, N. I., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90085-3 · Cited by 1,445
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Sun, H., Charles, C. H., Lau, L. F., & Tonks, N. K. (1993) · Cell · doi:10.1016/0092-8674(93)90383-2 · Cited by 1,156
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Show all 61 references

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Mahmoud, A. M., Sayed, A. M. M., Ahmed, O. S., Abdel‐Daim, M. M., & Hassanein, E. H. M. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220107105233 · Cited by 16
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Pérez‐Valero, Á., Ye, S., Magadán‐Corpas, P., Villar, C. J., & Lombó, F. (2023) · Microbial Cell Factories · doi:10.1186/s12934-023-02247-3 · Cited by 15
“In different pharmacological studies, this compound showed antibacterial, antiplasmodial, radical scavenging, and chemopreventive activities, among others [35].”
Background
Saccharum Alhagi polysaccharide-1 and -2 promote the immunocompetence of RAW264.7 macrophages inï¿½vitro
Li, G., Xiang, Y., Zhao, J., & Chang, J. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5818 · Cited by 14
“, Nanjing, China) as previously reported (15-17).”
Use of nPSi-βCD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis
Guzmán-Oyarzo, D., Plaza, T., Recio‐Sánchez, G., Abdalla, D. S. P., Salazar, L. A., & Hernández‐Montelongo, J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11060289 · Cited by 15
“These activities are attributed to its polyphenols rich composition, molecules that present different biological properties: relaxing [10], antioxidant [11], antithrombotic [12], antiangiogenic [13], anti-inflammatory [14], anti-carcinogenic [15], among others.”
Wikstroemia: A Review on its Phytochemistry and Pharmacology
Huan, D. Q., Hợp, N. Q., & Son, N. T. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666230606122116 · Cited by 13
LncRNA Riken Attenuated Sevoflurane-Induced Neuroinflammation by Regulating the MicroRNA-101a/MKP-1/JNK Pathway
Hou, Q., Li, S., Zhang, B., Chu, H., Ni, C., Fei, X., & Zheng, H. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00443-w · Cited by 13
Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss
Zamani, S.-S., Hossieni, M., Etebari, M., Salehian, P., & Ebrahimi, S. A. (2016) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-016-0161-x · Cited by 14
Integrated chemical and biological characterization of Hypericum perforatum extract using LC-MS/MS and in vitro functional assays
Güzel, M. A., Kolaç, T., Menevşe, İ. N., Dündar, M., Zengin, R., Güzel, A., & Yılmaz, U. (2026) · Scientific Reports · doi:10.1038/s41598-026-36793-8 · Cited by 12
“The pharmacological relevance of this compound has been well-documented, with studies demonstrating its anti-inflammatory potential 31 , antibacterial activity 32 , chemopreventive properties 33 , and significant anti-tumour effects 34,35 .”
Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-βCD Composites Improves Their Antiangiogenic Activity
Guzmán-Oyarzo, D., Hernández‐Montelongo, J., Rosas, C., Leal, P., Weber, H. L., Marysol Alvear, Z., & Salazar, L. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030484 · Cited by 12
“and morphogenic differentiation [28]; anti-inflammatories [29]; and anticarcinogenics [30].”
Background
RETRACTED: Sinomenine inhibits lipopolysaccharide-induced inflammatory injury by regulation of miR-101/MKP-1/JNK pathway in keratinocyte cells
Liu, S., Man, Y., & Zhao, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.086 · Cited by 11
Retracted
Genkwanin Prevents Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss
Fu, X., Sun, X., Zhang, C., Lv, N., Guo, H., Xing, C., Lv, J., Wu, J., Zhu, X., Liu, M., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.921037 · Cited by 11
Anti-atherosclerosis mechanisms associated with regulation of non-coding RNAs by active monomers of traditional Chinese medicine
Liu, G., Tan, L., Zhao, X., Wang, M., Zhang, Z., Zhang, J., Gao, H., Liu, M., & Qin, W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1283494 · Cited by 10
Traditional Chinese medicine in chronic rhinosinusitis: Mechanisms and postoperative recovery
Zhang, X.-H., Sun, Q., Zhao, L., Chen, L., & Li, W. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156658 · Cited by 11
Therapeutic effects of natural polyphenols on colorectal adenomas: Focus on preclinical studies (Review)
Ma, F., Lin, Y., Ni, Z., Chen, T., & Wang, X. (2023) · Oncology Reports · doi:10.3892/or.2023.8549 · Cited by 10
“GKA has favorable anti‐inflammatory activity in lipopolysaccharide (LPS)‐activated macrophages by regulating miR‐101/MKP‐1/MAPK pathway (45).”
Background
Flavonoid Diversity and Roles in the Lipopolysaccharide-Mediated Inflammatory Response of Monocytes and Macrophages
Rullah, K., Shamsudin, N. F., Koeberle, A., Tham, C. L., Aluwi, M. F. F. M., Leong, S. W., Jantan, I., & Lam, K. W. (2024) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0174 · Cited by 10
Characterization and Structural Analysis of Genkwanin, a Natural Product from Callicarpa americana
Porras, G., Bacsa, J., Tang, H., & Quave, C. L. (2019) · Crystals · doi:10.3390/cryst9100491 · Cited by 10
“Previous pharmacological studies have found that Genkwanin has a variety of pharmacological effects, including anti-tussive, expectorant, anti-bacterial [26,27], anti-plasmodial [28], free radical scavenging activity [29] and especially anti-inflammatory [30] and anti-cancer properties [31,32].”
Background
Protective effect of genkwanin against lipopolysaccharide-induced acute lung injury in mice with p38 mitogen-activated protein kinase and nuclear factor-κB pathway inhibition
Ni, Y., Shen, H., Chen, S., & Kuan, Y. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105271 · Cited by 10
Caragana rosea Turcz Methanol Extract Inhibits Lipopolysaccharide-Induced Inflammatory Responses by Suppressing the TLR4/NF-κB/IRF3 Signaling Pathways
Mitra, A., Ahuja, A., Rahmawati, L., Kim, H. G., Woo, B. Y., Hong, Y. D., Hossain, M. A., Zhang, Z., Kim, S.-Y., Lee, J., et al. (2021) · Molecules · doi:10.3390/molecules26216660 · Cited by 9
“For genkwanin, researchers reported that it possesses anti-inflammatory activity mainly through the regulation of the miR-101/MKP1/MAPK pathway in vitro [50] and has antitumor activity against cancer [51].”
Background
Cytochrome P450s: Blueprints for Potential Applications in Plants
Naveed, A., Li, H., & Liu, X. (2018) · Journal of Plant Biochemistry & Physiology · doi:10.4172/2329-9029.1000204 · Cited by 8
Integration of transcriptome and metabolome provides insights into metabolites and pathways associated with antiproliferative activity of cannabis flower extracts
Liu, Y., Li, S., Shen, M., Guo, F., Li, M., Cai, S., Huang, J., Wu, J., Li, X., Peng, L., et al. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.120239 · Cited by 7
Identification of Molecular Targets and Potential Mechanisms of Yinchen Wuling San Against Head and Neck Squamous Cell Carcinoma by Network Pharmacology and Molecular Docking
Zhang, B., Liu, G., Wang, X., & Hu, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.914646 · Cited by 7
“It exerted an antiinflammatory effect by the regulation of the miR-101/MKP-1/ MAPK signaling pathway and the downregulation of proinflammatory mediators such as TNF-a, IL-1B, and IL-6 (Gao et al., 2014).”
Background
ANTI-AMYLOIDOGENIC EFFECT OF MiR-101 IN EXPERIMENTAL ALZHEIMER’S DISEASE
Sokolik, V. V. (2019) · Biotechnologia Acta · doi:10.15407/biotech12.03.041 · Cited by 7
Canscora lucidissima, a Chinese folk medicine, exerts anti-inflammatory activities by inhibiting the phosphorylation of ERK1/2 in LPS-activated macrophages
Fei, Q., Zhang, X.-Y., Qi, R.-J., Huang, Y., Han, Y., Li, X., Cai, R., Gao, Y., & Qi, Y. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2783-2 · Cited by 7
Uncovering the efficacy and mechanisms of Genkwa flos and bioactive ingredient genkwanin against L. monocytogenes infection
Xu, L., Lu, G., Zhan, B., Wei, L., Deng, X., Zhang, Q., Shen, X., Wang, J., & Feng, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115571 · Cited by 6
Genkwanin improves inflammatory injury in rats with septic lung injury by regulating NF-κB signaling pathway
Qin, G., & Yi, S. (2022) · Quality Assurance and Safety of Crops & Foods · doi:10.15586/qas.v14i2.991 · Cited by 6
Genkwanin Suppresses Mitochondrial Dysfunction to Alleviate IL-1β-elicited Inflammation, Apoptosis, and Degradation of Extracellular Matrix in Chondrocytes Through Upregulating DUSP1
Xu, K., Wang, H., & Wu, Z. (2023) · The Chinese Journal of Physiology · doi:10.4103/cjop.cjop-d-23-00031 · Cited by 5
Metabolic engineering and optimization of Escherichia coli co-culture for the de novo synthesis of genkwanin
Thuấn, N. H., Tatipamula, V. B., Trung, N. T., & Giảng, N. V. (2023) · Journal of Industrial Microbiology & Biotechnology · doi:10.1093/jimb/kuad030 · Cited by 5
The enhancement of bioactive phytochemicals in agarwood leaves by post-harvest application using yeast extract elicitors and evaluation of their bioactivities
Choonong, R., Jabsanthia, J., Waewaram, V., Butdapheng, K., Sritularak, B., & Putalun, W. (2023) · Food and Agricultural Immunology · doi:10.1080/09540105.2023.2265688 · Cited by 4
“Furthermore, an aglycone form of genkwanin has been reported to have a down-regulation e ﬀ ect on the mRNA expression of iNOS , COX-2 , TNF-α , IL-1 β , and IL-6 (Gao et al., 2014; Sun et al., 2020).”
Background
Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia
Zhang, B., Fu, D., Wang, X., & Hu, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1591164 · Cited by 4
Identification and Regioselectivity of a 4'‐O‐Methyltransferase From Chemically Diverse Populations of Chrysanthemum
Yang, D., Yu, Y., Yang, L., Chen, K., Wang, Z., Chen, S., & Zhu, J. (2025) · Food Frontiers · doi:10.1002/fft2.70007 · Cited by 3
COMPONENTS OF ARTEMISIA SOGDIANA
Mukhamatkhanova, R. F., Bobakulov, K. M., Джамильевич, Ш. И., Okmanov, R. Y., Aisa, H. A., Сагдуллаев, Ш. Ш., & Abdullaev, N. D. (2020) · chemistry of plant raw material · doi:10.14258/jcprm.2020015548 · Cited by 3
Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice
Chen, X., Liu, J., An, Z., Li, M., Ji, X.-H., Huang, J., & Yan, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157306 · Cited by 3
Chemical composition and biological propensities of Wikstroemia indica (L.) C. A. Mey (Tie Bush)
Suroowan, S., Llorent-Martínez, E. J., Zengin, G., Khalid, A., Abdalla, A. N., Khogeer, S., Van, B. L., & Mahomoodally, M. F. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.08.020 · Cited by 2
Retracted : Long noncoding RNA MEG3 deteriorates inflammatory damage by downregulating microRNA‐101a
Tang, S., Han, J., Jiao, H., Si, J., Liu, Y., & Wang, J. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29415 · Cited by 2
“miR‐101a is a vertebrate‐ specific negative regulatory gene.(35) A research had reflected miR‐101a was abundant in cardiac fibroblasts and was reduced in pathological cardiac tissue in cardiac fibrosis.”
Background
Retracted
HERBAL NANOSUSPENSION: IN VITRO CANCER STUDY AGAINST DIFFERENT CELL LINES
MM, M., Krishnakumar, K., & Nair, S. K. (2020) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2020.v13i7.37764 · Cited by 3
“antitussive, expectorant, anti-inflammatory [62], anti-bacterial [63], anti-plasmodial [64], radical scavenging [65], chemoprotective [66],”
Study on mechanism of the Hanshi Zufei syndrome formula for COVID-19 based on network pharmacologyPreprint
Zheng, W., Ni, Y., Yan, Q., Huang, Y., Li, J., Liu, X., & Jiang, Y. (2020) · doi:10.21203/rs.3.rs-41445/v1 · Cited by 2
“It mainly inhibits the production of pro-in ammatory mediators by regulating the micro–ribonucleic-acid (miR101), microtubuleassociated protein kinase phosphatase-1 (Mkp-1), and mitogen-activated protein kinase (MAPK) pathways in LPS-activated macrophages [25].”
Background
Metabolic Engineering for Biotechnological Production of Bioactive Methylated Flavonoids and Stilbenes: Progress and Perspectives
Shrestha, S., & Oh, T. (2026) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-026-05658-1 · Cited by 1
Chemistry of Coleus forskohlii Briq.
Pullaiah, T. (2022) · Springer eBooks · doi:10.1007/978-981-19-6521-0_4 · Cited by 1
Polyphenols and Antioxidants
Hossen, M. S., & Ali, M. Y. (2023) · doi:10.1002/9781119113324.ch9 · Cited by 1
Analysis of amino acid in albumen and circular RNAs in ovaries of laying hens by chromatographic analysis and RNA-seq
Duan, X., Liu, Y., Luo, Q., & Han, R. (2021) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2021.2023022
Faculty Opinions recommendation of Origin and Function of Stress-Induced IL-6 in Murine Models.
Lynch, L. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738227474.793583818
The role of RNA in synapse physiology and neurodegeneration in models of Parkinson´s disease
Xylaki, M. (2021) · doi:10.53846/goediss-9275
Modulating effect of liposomal miR-101 on the processes of amyloidogenesis, smell, sleep and neuroinflammation in experimental Alzheimer's disease
Sokolik, V. V., Левічева, Н. О., Geiko, V. V., Берченко, О. Г., & Shulga, S. (2021) · The Journal of V N Karazin Kharkiv National University Series Biology · doi:10.26565/2075-5457-2021-36-2
Potential therapeutic targets of Aquilaria malaccensis leaf extract: A network pharmacology approach
Hashim, Y. Z. H.-Y., Eissa, M., Abbas, P., Samsudin, N., & Warif, N. M. A. (2025) · Asia-Pacific Journal of Molecular Biology and Biotechnology · doi:10.35118/apjmbb.2025.033.4.14
Additional file 10 of Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
Pérez‐Valero, Á., Ye, S., Magadán‐Corpas, P., Villar, C. J., & Lombó, F. (2024) · Figshare · doi:10.6084/m9.figshare.26640097
Additional file 12 of Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
Pérez‐Valero, Á., Ye, S., Magadán‐Corpas, P., Villar, C. J., & Lombó, F. (2024) · Figshare · doi:10.6084/m9.figshare.26640103
Additional file 2 of Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
Pérez‐Valero, Á., Ye, S., Magadán‐Corpas, P., Villar, C. J., & Lombó, F. (2024) · Figshare · doi:10.6084/m9.figshare.24564273
Additional file 6 of Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
Pérez‐Valero, Á., Ye, S., Magadán‐Corpas, P., Villar, C. J., & Lombó, F. (2024) · Figshare · doi:10.6084/m9.figshare.26640079

Authors: Gao, Y., Liu, F., Fang, L., Cai, R., Zong, C., & Qi, Y.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Qi, Yun
ORCID: Gao, Yuan
Liu, Fen
Fang, Lei
Qi, Yun
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2014-05-06
Volume: 9
Issue: 5
Pages: e96741
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0096741
PMC: PMC4011752
OpenAlex: W2035643839
Cited by: 110
References: 61
Citations by year: 2026: 4 · 2025: 5 · 2024: 15 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 4
FWCI: 4.13
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: National Natural Science Foundation of China (81173645, 2014ZX09201022-006, 81274163, 2012ZX09301002-001)
Ministry of Science and Technology of the People's Republic of China (81274163, 2012ZX09301-002, 2014ZX09201022-006, 2012ZX09301-002-001)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: genkwanin, anti-inflammatory activity, macrophages, lipopolysaccharide stimulation, miR-101, MKP-1, MAPK signaling, AP-1 signaling, p38 MAPK, JNK, inflammatory cytokines, inducible nitric oxide synthase, post-transcriptional regulation, Akt
MeSH terms: Animals, Anti-Inflammatory Agents, Cell Line, Lipopolysaccharides, Macrophages, Nitric Oxide, Phosphorylation, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Up-Regulation, Oligonucleotides, Antisense, Inflammation Mediators, Mitogen-Activated Protein Kinases, MicroRNAs, Flavones, Mice, Nitric Oxide Synthase Type II, Interleukin-1beta, Dual Specificity Phosphatase 1

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Genkwanin Inhibits Proinflammatory Mediators Mainly through the Regulation of miR-101/MKP-1/MAPK Pathway in LPS-Activated Macrophages

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