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Characteristics of Effective Collaborative Care for Treatment of Depression: A Systematic Review and Meta-Regression of 74 Randomised Controlled Trials
Open accessAbstract
BACKGROUND: Collaborative care is a complex intervention based on chronic disease management models and is effective in the management of depression. However, there is still uncertainty about which components of collaborative care are effective. We used meta-regression to identify factors in collaborative care associated with improvement in patient outcomes (depressive symptoms) and the process of care (use of anti-depressant medication). METHODS AND FINDINGS: Systematic review with meta-regression. The Cochrane Collaboration Depression, Anxiety and Neurosis Group trials registers were searched from inception to 9th February 2012. An update was run in the CENTRAL trials database on 29th December 2013. Inclusion criteria were: randomised controlled trials of collaborative care for adults ≥18 years with a primary diagnosis of depression or mixed anxiety and depressive disorder. Random effects meta-regression was used to estimate regression coefficients with 95% confidence intervals (CIs) between study level covariates and depressive symptoms and relative risk (95% CI) and anti-depressant use. The association between anti-depressant use and improvement in depression was also explored. Seventy four trials were identified (85 comparisons, across 21,345 participants). Collaborative care that included psychological interventions predicted improvement in depression (β coefficient -0.11, 95% CI -0.20 to -0.01, p = 0.03). Systematic identification of patients (relative risk 1.43, 95% CI 1.12 to 1.81, p = 0.004) and the presence of a chronic physical condition (relative risk 1.32, 95% CI 1.05 to 1.65, p = 0.02) predicted use of anti-depressant medication. CONCLUSION: Trials of collaborative care that included psychological treatment, with or without anti-depressant medication, appeared to improve depression more than those without psychological treatment. Trials that used systematic methods to identify patients with depression and also trials that included patients with a chronic physical condition reported improved use of anti-depressant medication. However, these findings are limited by the observational nature of meta-regression, incomplete data reporting, and the use of study aggregates.
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“Previous reviews have supported collaborative care for depression and anxiety,32,73”
From Task-sharing approaches to improve mental health care in rural and other low-resource settings: a systematic review (2018) · cites this paper as [73]
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“a systematic review published in 2014 showed that trials of collaborative care that include psychological treatment, with or without anti-depressant medication, appear to improve depression more than those without psychological treatment.”
From Integrated care for people with long-term mental and physical health conditions in low-income and middle-income countries (2019) · cites this paper as [38]
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“Interventions that used systematic methods to identify patients with depression, and also trials that included patients with a chronic physical condition reported improved use of anti-depressant medication 38 .”
From Integrated care for people with long-term mental and physical health conditions in low-income and middle-income countries (2019) · cites this paper as [38]
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Citations
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349
A simulation study of the number of events per variable in logistic regression analysis
Peduzzi, P., Concato, J., Kemper, E., Holford, T. R., & Feinstein, A. R. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00236-3 · Cited by 9,655
(2000) · Cited by 9,198
Michie, S., Richardson, M., Johnston, M., Abraham, C., Francis, J., Hardeman, W., Eccles, M. P., Cane, J., & Wood, C. E. (2013) · Annals of Behavioral Medicine · doi:10.1007/s12160-013-9486-6 · Cited by 7,629
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., Vos, T., & Whiteford, H. A. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001547 · Cited by 3,115
How should meta‐regression analyses be undertaken and interpreted?
Thompson, S. G., & Higgins, J. P. T. (2002) · Statistics in Medicine · doi:10.1002/sim.1187 · Cited by 3,026
Improving Primary Care for Patients With Chronic Illness
Bodenheimer, T. (2002) · JAMA · doi:10.1001/jama.288.14.1775 · Cited by 2,961
Organizing Care for Patients with Chronic Illness
Wagner, E. H., Austin, B. T., & Korff, M. V. (1996) · The Milbank Quarterly · doi:10.2307/3350391 · Cited by 2,877
Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442
Meta-analysis of individual participant data: rationale, conduct, and reporting
Riley, R. D., Lambert, P. C., & Abo-Zaid, G. (2010) · BMJ · doi:10.1136/bmj.c221 · Cited by 1,701
Collaborative care for patients with depression and chronic illnesses
Katon, W. J., Lin, E. H. B., Von Korff, M., Ciechanowski, P., Ludman, E. J., Young, B., Peterson, D., Rutter, C. M., McGregor, M., & McCulloch, D. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003955 · Cited by 1,697
Collaborative care for depression and anxiety problems
Archer, J., Bower, P., Gilbody, S., Lovell, K., Richards, D., Gask, L., Dickens, C., & Coventry, P. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006525.pub2 · Cited by 1,126
Self-citationBarriers to improvement of mental health services in low-income and middle-income countries
Saraceno, B., van Ommeren, M., Batniji, R., Cohen, A., Gureje, O., Mahoney, J., Sridhar, D., & Underhill, C. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61263-x · Cited by 1,088
Metan: fixed- and random-effects meta-analysis
Harris, R. J., Deeks, J. J., Altman, D. G., Bradburn, M. J., Harbord, R. M., & Sterne, J. A. C. (2008) · The Stata Journal: Promoting communications on statistics and Stata · doi:10.1177/1536867x0800800102 · Cited by 1,027
Harbord, R. M., & Higgins, J. P. T. (2008) · The Stata Journal: Promoting communications on statistics and Stata · doi:10.1177/1536867x0800800403 · Cited by 897
Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study
Salisbury, C., Johnson, L., Purdy, S., Valderas, J. M., & Montgomery, A. A. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x548929 · Cited by 883
McHugh, R. K., Whitton, S. W., Peckham, A. D., Welge, J. A., & Otto, M. W. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07757 · Cited by 800
Gilbody, S., Whitty, P., Grimshaw, J., & Thomas, R. (2003) · JAMA · doi:10.1001/jama.289.23.3145 · Cited by 749
Self-citationWe need minimally disruptive medicine
May, C. R., Montori, V. M., & Mair, F. S. (2009) · BMJ · doi:10.1136/bmj.b2803 · Cited by 739
Weingarten, S. R. (2002) · BMJ · doi:10.1136/bmj.325.7370.925 · Cited by 735
Issues in the meta-analysis of cluster randomized trials
Donner, A., & Klar, N. (2002) · Statistics in Medicine · doi:10.1002/sim.1301 · Cited by 734
Patterns of intra-cluster correlation from primary care research to inform study design and analysis
Adams, G., Gulliford, M. C., Ukoumunne, O. C., Eldridge, S., Chinn, S., & Campbell, M. J. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2003.12.013 · Cited by 602
A comparison of statistical methods for meta‐analysis
Brockwell, S. E., & Gordon, I. R. (2001) · Statistics in Medicine · doi:10.1002/sim.650 · Cited by 573
A Re-Analysis of the Cochrane Library Data: The Dangers of Unobserved Heterogeneity in Meta-Analyses
Kontopantelis, E., Springate, D. A., & Reeves, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069930 · Cited by 525
Self-citationA meta-analysis of interventions to improve care for chronic illnesses.
Tsai, A. C., Morton, S. C., Mangione, C. M., & Keeler, E. B. (2005) · PubMed · Cited by 482
Bower, P., Gilbody, S., Richards, D., Fletcher, J., & Sutton, A. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.023655 · Cited by 429
Self-citationBambling, M., King, R., Raue, P., Schweitzer, R., & Lambert, W. (2006) · Psychotherapy Research · doi:10.1080/10503300500268524 · Cited by 280
Kontopantelis, E., & Reeves, D. (2010) · Statistical Methods in Medical Research · doi:10.1177/0962280210392008 · Cited by 264
Self-citationEmpirical Evaluation of Very Large Treatment Effects of Medical Interventions
Pereira, T. V., Horwitz, R. I., & Ioannidis, J. P. A. (2012) · JAMA · doi:10.1001/jama.2012.13444 · Cited by 257
Kendrick, T., Dowrick, C., McBride, A., Howe, A., Clarke, P., Maisey, S., Moore, M., & Smith, P. W. (2009) · BMJ · doi:10.1136/bmj.b750 · Cited by 231 · cited 2×
“Inadequate antidepressant treatment of depression is more pronounced in people with chronic physical conditions [46].”
BackgroundImproving outcomes in depression
Korff, M. V., & Goldberg, D. P. (2001) · BMJ · doi:10.1136/bmj.323.7319.948 · Cited by 227
Collaborative care for depression and anxiety problems
Young, C. F., & Skorga, P. (2013) · International Journal of Evidence-Based Healthcare · doi:10.1111/1744-1609.12043 · Cited by 222
Gunn, J. M., Diggens, J., Hegarty, K. L., & Blashki, G. A. (2006) · BMC Health Services Research · doi:10.1186/1472-6963-6-88 · Cited by 219
Driessen, E., Cuijpers, P., Hollon, S. D., & Dekker, J. J. M. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0020570 · Cited by 208
Bower, P., Macdonald, W., Harkness, E. F., Gask, L. L., Kendrick, T., Valderas, J. M., Dickens, C. M., Blakeman, T., & Sibbald, B. (2011) · Family Practice · doi:10.1093/fampra/cmr018 · Cited by 191
Self-citationHewitt, C., Hahn, S., Torgerson, D. J., Watson, J., & Bland, J. M. (2005) · BMJ · doi:10.1136/bmj.38413.576713.ae · Cited by 176
Costs and consequences of enhanced primary care for depression
Gilbody, S. M., Bower, P., & Whitty, P. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.016006 · Cited by 175
Self-citationCollaborative Care Models for Depression
Katon, W. J. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.21.2304 · Cited by 134
A systematic review of effective cognitive‐behavioural supervision
Milne, D., & James, I. (2000) · British Journal of Clinical Psychology · doi:10.1348/014466500163149 · Cited by 130
Ekers, D., Murphy, R., Archer, J., Ebenezer, C., Kemp, D., & Gilbody, S. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.032 · Cited by 110
Self-citationCardiovascular multimorbidity: the effect of ethnicity on prevalence and risk factor management
Mathur, R., Hull, S., Badrick, E., & Robson, J. P. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x572454 · Cited by 91
Deshauer, D., Moher, D., Fergusson, D., Moher, E., Sampson, M., & Grimshaw, J. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.071068 · Cited by 78
Dickens, C. M., Katon, W. J., Blakemore, A., Khara, A., McGowan, L., Tomenson, B., Jackson, J., Walker, L., & Guthrie, E. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.08.018 · Cited by 64
Self-citationMetaEasy: A Meta-Analysis Add-In for MicrosoftExcel
Kontopantelis, E., & Reeves, D. (2009) · Journal of Statistical Software · doi:10.18637/jss.v030.i07 · Cited by 57
Self-citationRoyle, P., & Waugh, N. R. (2005) · BMC Medical Research Methodology · doi:10.1186/1471-2288-5-23 · Cited by 55
Boerma, W. G. W., & Verhaak, P. F. M. (1999) · Psychological Medicine · doi:10.1017/s003329179900851x · Cited by 40
Studies of Long-Term Use of Antidepressants: How Should the Data from Them be Interpreted?
El-Mallakh, R. S., & Briscoe, B. (2012) · CNS Drugs · doi:10.2165/11599450-000000000-00000 · Cited by 36
Negassa, A., & Hanley, J. A. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2006.08.007 · Cited by 24
How many well vs. unwell days can you expect over 10 years, once you become depressed?
Furukawa, T. A., Yoshimura, R., Harai, H., Imaizumi, T., Takeuchi, H., Kitamura, T., & Takahashi, K. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01288.x · Cited by 12
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Self-citationHoeft, T. J., Fortney, J. C., Patel, V., & Unützer, J. (2018) · The Journal of Rural Health · doi:10.1111/jrh.12229 · Cited by 619
Cuijpers, P., Noma, H., Karyotaki, E., Vinkers, C. H., Cipriani, A., & Furukawa, T. A. (2020) · World Psychiatry · doi:10.1002/wps.20701 · Cited by 540
Coventry, P., Lovell, K., Dickens, C., Bower, P., Chew-Graham, C., McElvenny, D., Hann, M., Cherrington, A., Garrett, C., Gibbons, C. J., et al. (2015) · BMJ · doi:10.1136/bmj.h638 · Cited by 325
Self-citationCheung, A. H., Zuckerbrot, R. A., Jensen, P. S., Laraque, D., Stein, R. E. K., GLAD-PC STEERING GROUP, Levitt, A., Birmaher, B., Campo, J., Clarke, G., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-4082 · Cited by 299
Metadata
- Authors
- Coventry, P. A., Hudson, J. L., Kontopantelis, E., Archer, J., Richards, D. A., Gilbody, S., Lovell, K., Dickens, C., Gask, L., Waheed, W., & Bower, P.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- King's College London (GB)
- University of Manchester (GB)
- University of Exeter (GB)
- University of York (GB)
- Lancashire Care NHS Foundation Trust (GB)
- Corresponding author
- Coventry, Peter A.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-09-29
- Volume
- 9
- Issue
- 9
- Pages
- e108114
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4180075
- OpenAlex
- W2096684104
- Cited by
- 221
- References
- 56
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 22 · 2023: 15 · 2022: 20 · 2021: 30 · 2020: 25 · 2019: 17 · 2018: 18 · 2017: 23 · 2016: 23 · 2015: 9
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Research Exeter (University of Exeter) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by)
- Funders
- National Institute for Health and Care Research (NF-SI-0611-10203, 08/19/04, 10/57/43, RCF_R10_PC)
- Medical Research Council (MR/K006665/1, MC_PC_13042)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- collaborative care, depression, mixed anxiety-depressive disorder, psychological intervention, antidepressant use, chronic physical illness, patient identification, depressive symptoms, complex interventions
- MeSH terms
- Antidepressive Agents, Cooperative Behavior, Depression, Humans, Randomized Controlled Trials as Topic
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