The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
The Efficacy and Safety of Selective H1-Antihistamine versus Leukotriene Receptor Antagonist for Seasonal Allergic Rhinitis: A Meta-Analysis
Open accessAbstract
BACKGROUND: Both selective H1-antihistamine (SAH) and leukotriene receptor antagonist (LTRA) have been shown to be effective in treating patients with seasonal allergic rhinitis (SAR), but it is still uncertain which treatment option is optimal. This meta-analysis was aimed to compare the efficacy and safety of SAH and LTRA for SAR. MATERIALS AND METHODS: PubMed, EMBASE and the Cochrane Library were searched for all eligible studies that compared the efficacy and safety of SAH and LTRA for SAR up to September 7, 2014. The pooled mean difference (MD), odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using a fixed- or random-effects model. RESULTS: Nine studies with 5781 SAR patients were included. The results showed that SAH is superior to LTRA in terms of the daytime eye symptoms score (DESS) and composite symptoms score (CSS) for SAR (MD = 0.06, 95% CI, 0.03 to 0.10, P = 0.000, I2 = 99%; MD = 0.03, 95% CI, 0.01 to 0.05, P = 0.010, I2 = 98%), whereas LTRA overmatched SAH with respect to the night-time symptoms score (NSS) (MD = -0.04, 95% CI, -0.05 to -0.02, P = 0.000, I2 = 97%). Additionally, the results of subgroup analysis indicated that the dose, duration and gender of the patients might impact the comparisons of the effects of SAH and LTRA on their efficacy for SAR. CONCLUSION: This meta-analysis suggested that SAH and LTRA have similar effects and safety for SAR, but SAH is more appropriate for daytime nasal symptoms (congestion, rhinorrhea, pruritus and sneezing), while LTRA is better suited for nighttime symptoms (difficulty going to sleep, nighttime awakenings, and nasal congestion on awakening), respectively. Meanwhile, the dose, duration and gender of patients may influence the anti-SAR effects of SAH and LTRA.
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“Antileukotrienes have been shown to be more effective than anti-H 1 against the nocturnal symptoms of AR (including NO) but not against diurnal symptoms [153].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [153]
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Cites
Simons, F. E. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmra033121 · Cited by 697
Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey
Meltzer, E. O., Blaiss, M. S., Derebery, M. J., Mahr, T. A., Gordon, B. R., Sheth, K. K., Simmons, A. L., Wingertzahn, M. A., & Boyle, J. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.013 · Cited by 553
Histamine and H1-antihistamines: Celebrating a century of progress
Simons, F. E. R., & Simons, K. J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.005 · Cited by 541
Regulation of the immune response and inflammation by histamine and histamine receptors
O’Mahony, L., Akdis, M., & Akdis, C. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.051 · Cited by 313
Meltzer, E. O., Malmstrom, K., Lu, S., Prenner, B. M., Wei, L. X., Weinstein, S. F., Wolfe, J. D., & Reiss, T. F. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106040 · Cited by 308
Philip, G., Malmström, K., Hampel, F. C., Weinstein, S. F., LaForce, C., Ratner, P. H., Malice, M., Reiss, T. F., & for the Montelukast Spring Rhinitis Study Group (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2002.01422.x · Cited by 241
Nayak, A. S., Philip, G., Lu, S., Malice, M., & Reiss, T. F. (2002) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61891-1 · Cited by 202
Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Kanaoka, Y., & Boyce, J. A. (2014) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2014.6.4.288 · Cited by 129
Montelukast improves symptoms of seasonal allergic rhinitis over a 4‐week treatment period
van Adelsberg, J., Philip, G., Pedinoff, A., Meltzer, E. O., Ratner, P. H., Menten, J., Reiss, T. F., & for the Montelukast Fall Rhinitis Study Group (2003) · Allergy · doi:10.1046/j.1398-9995.2003.00261.x · Cited by 125
van Adelsberg, J., Philip, G., LaForce, C., Weinstein, S. F., Menten, J., Malice, M., & Reiss, T. F. (2003) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)62144-8 · Cited by 120
Cited by
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C., Roland, L. T., Ebert, C., Levy, J. M., Lin, S., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 507
Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
Cheng, L., Chen, J., Fu, Q., He, S., Li, H., Liu, Z., Tan, G., Tao, Z., Wang, D., Wen, W., et al. (2018) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2018.10.4.300 · Cited by 361
Self-citationThe Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
Jo‐Watanabe, A., Okuno, T., & Yokomizo, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143580 · Cited by 158
Combined allergic rhinitis and asthma syndrome (CARAS)
Ferreira, L. K. D. P., Ferreira, L. A. M. P., Monteiro, T. M., Bezerra, G. C., Bernardo, L. R., & Piuvezam, M. R. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105718 · Cited by 130
IV Brazilian Consensus on Rhinitis – an update on allergic rhinitis
Sakano, E., Sarinho, E. S. C., Cruz, Á. A., Pastorino, A. C., Tamashiro, E., Kuschnir, F. C., Castro, F. F. M., Romano, F. R., Wandalsen, G. F., Chong‐Neto, H. J., et al. (2017) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2017.10.006 · Cited by 86
Metadata
- Authors
- Xu, Y., Zhang, J., & Wang, J.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Xu, Yu
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-11-10
- Volume
- 9
- Issue
- 11
- Pages
- e112815
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4226613
- OpenAlex
- W2058932654
- Cited by
- 30
- References
- 39
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 2
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- allergic rhinitis, leukotriene receptor antagonists, antihistamine efficacy, drug safety, nocturnal symptoms, dose and duration effects, gender differences
- MeSH terms
- Adult, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Rhinitis, Allergic, Seasonal, Histamine H1 Antagonists, Humans, Male, Sex Factors, Databases, Bibliographic, Anti-Allergic Agents, Leukotriene Antagonists
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
