The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Open accessAbstract
We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10-8), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10-8), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10-4). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H., Klemm, A., Flicek, P., Manolio, T., Hindorff, L., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1229 · Cited by 2,707
GenABEL: an R library for genome-wide association analysis
Aulchenko, Y. S., Ripke, S., Isaacs, A., & van Duijn, C. M. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm108 · Cited by 1,836 · cited 1×
“g a score test mmscore [18] implemented in the GenABEL package [19]).”
MethodHamza, T. H., Chen, H., Hill-Burns, E. M., Rhodes, S. L., Montimurro, J., Kay, D. M., Tenesa, A., Kusel, V. I., Sheehan, P., Eaaswarkhanth, M., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002237 · Cited by 218
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Rodriguez-Ayllon, M., Cadenas-Sánchez, C., Estévez-López, F., Muñoz, N. E., Mora-Gonzalez, J., Migueles, J. H., Molina-García, P., Henriksson, H., Mena-Molina, A., Martínez-Vizcaíno, V., et al. (2019) · Sports Medicine · doi:10.1007/s40279-019-01099-5 · Cited by 1,360
Zheng, J., Erzurumluoglu, A. M., Elsworth, B. L., Kemp, J. P., Howe, L., Haycock, P. C., Hemani, G., Tansey, K., Laurin, C., Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw613 · Cited by 869
The global burden of sepsis: barriers and potential solutions
Rudd, K. E., Kissoon, N., Limmathurotsakul, D., Bory, S., Mutahunga, B., Seymour, C. W., Angus, D. C., & West, T. E. (2018) · Critical Care · doi:10.1186/s13054-018-2157-z · Cited by 416
Physiology of Hyperuricemia and Urate-Lowering Treatments
Benn, C. L., Dua, P., Gurrell, R., Loudon, P., Pike, A., Storer, R. I., & Vangjeli, C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00160 · Cited by 319
Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., Karsdal, M. A., Grove, J. I., Neil Guha, I., Kawaguchi, T., et al. (2019) · Hepatology · doi:10.1002/hep.30163 · Cited by 273
Metadata
- Authors
- Huffman, J. E., Albrecht, E., Teumer, A., Mangino, M., Kapur, K., Johnson, T., Kutalik, Z., Pirastu, N., Pistis, G., Lopez, L. M., Haller, T., Salo, P., Goel, A., Li, M., Tanaka, T., Dehghan, A., Ruggiero, D., Malerba, G., Smith, A. V., Nolte, I. M., Portas, L., Phipps-Green, A., Boteva, L., Navarro, P., Johansson, A., Hicks, A. A., Polasek, O., Esko, T., Peden, J. F., Harris, S. E., Murgia, F., Wild, S. H., Tenesa, A., Tin, A., Mihailov, E., Grotevendt, A., Gislason, G. K., Coresh, J., D'Adamo, P., Ulivi, S., Vollenweider, P., Waeber, G., Campbell, S., Kolcic, I., Fisher, K., Viigimaa, M., Metter, J. E., Masciullo, C., Trabetti, E., Bombieri, C., Sorice, R., Döring, A., Reischl, E., Strauch, K., Hofman, A., Uitterlinden, A. G., Waldenberger, M., Wichmann, H.-E., Davies, G., Gow, A. J., Dalbeth, N., Stamp, L., Smit, J. H., Kirin, M., Nagaraja, R., Nauck, M., Schurmann, C., Budde, K., Farrington, S. M., Theodoratou, E., Jula, A., Salomaa, V., Sala, C., Hengstenberg, C., Burnier, M., Mägi, R., Klopp, N., Kloiber, S., Schipf, S., Ripatti, S., Cabras, S., Soranzo, N., Homuth, G., Nutile, T., Munroe, P. B., Hastie, N., Campbell, H., Rudan, I., Cabrera, C., Haley, C., Franco, O. H., Merriman, T. R., Gudnason, V., Pirastu, M., Penninx, B. W., Snieder, H., Metspalu, A., Ciullo, M., Pramstaller, P. P., van Duijn, C. M., Ferrucci, L., Gambaro, G., Deary, I. J., Dunlop, M. G., Wilson, J. F., Gasparini, P., Gyllensten, U., Spector, T. D., Wright, A. F., Hayward, C., Watkins, H., Perola, M., Bochud, M., Kao, W. H. L., Caulfield, M., Toniolo, D., Völzke, H., Gieger, C., Köttgen, A., & Vitart, V.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-26
- Volume
- 10
- Issue
- 3
- Pages
- e0119752
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2095845810
- Cited by
- 1,227
- References
- 3
- FWCI
- 124.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Huffman, J. E., Albrecht, E., Teumer, A., Mangino, M., Kapur, K., Johnson, T., Kutalik, Z., Pirastu, N., Pistis, G., Lopez, L. M., Haller, T., Salo, P., Goel, A., Li, M., Tanaka, T., Dehghan, A., Ruggiero, D., Malerba, G., Smith, A. V., . . . Vitart, V. (2015). Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans. PLOS ONE. https://doi.org/10.1371/journal.pone.0119752
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