The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Physiology of Hyperuricemia and Urate-Lowering Treatments
Open accessAbstract
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes. Finally, we discuss current therapies and emerging drug discovery efforts aimed at delivering an optimized clinical treatment strategy.
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Cites
Zhu, Y., Pandya, B. J., & Choi, H. K. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30520 · Cited by 1,785
2016 updated EULAR evidence-based recommendations for the management of gout
Richette, P., Doherty, M., Pascual, E., Barskova, V, Becce, F., Castañeda-Sanabria, J., Coyfish, M., Guillo, S., Jansen, T. L., Janssens, H., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209707 · Cited by 1,681
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Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
Enomoto, A., Kimura, H., Chairoungdua, A., Shigeta, Y., Jutabha, P., Ho Cha, S., Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., et al. (2002) · Nature · doi:10.1038/nature742 · Cited by 1,535
Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature
Casagranda, A., Suppa, M., Dehavay, F., & del Marmol, V. (2017) · Case Reports in Dermatology · doi:10.1159/000475802 · Cited by 1,466
Regulation of uric acid metabolism and excretion
Maiuolo, J., Oppedisano, F., Gratteri, S., Muscoli, C., & Mollace, V. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.109 · Cited by 1,375
Febuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout
Becker, M. A., Schumacher, H. R., Wortmann, R. L., MacDonald, P. A., Eustace, D., Palo, W. A., Streit, J., & Joseph-Ridge, N. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050373 · Cited by 1,357
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Huffman, J. E., Albrecht, E., Teumer, A., Mangino, M., Kapur, K., Johnson, T., Kutalik, Z., Pirastu, N., Pistis, G., Lopez, L. M., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0119752 · Cited by 1,227
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Global epidemiology of gout: prevalence, incidence and risk factors
Kuo, C.-F., Grainge, M. J., Zhang, W., & Doherty, M. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.91 · Cited by 1,179
Metadata
- Authors
- Benn, C. L., Dua, P., Gurrell, R., Loudon, P., Pike, A., Storer, R. I., & Vangjeli, C.
- Venue
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Published
- 2018-05-31
- Volume
- 5
- Pages
- 160-160
- ISSN
- 2296-858X (ISSN-L)
- OpenAlex
- W2805641932
- Cited by
- 319
- References
- 230
- FWCI
- 17.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Benn, C. L., Dua, P., Gurrell, R., Loudon, P., Pike, A., Storer, R. I., & Vangjeli, C. (2018). Physiology of Hyperuricemia and Urate-Lowering Treatments. Frontiers in Medicine. https://doi.org/10.3389/fmed.2018.00160
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
