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Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults
Open accessAbstract
To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. Each age cohort was divided into two groups: the endurance-training group (14 young, 14 middle-aged/older) and the control group. Subjects in the training groups completed an 8-week endurance-training program (cycling at 60-70% peak oxygen uptake [V̇O2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated serum irisin level, V̇O2peak, and body composition. The increase in V̇O2peak in the young and middle-aged/older training groups after the intervention period was significantly greater than those in the young and middle-aged/older control groups (P < 0.05). Serum irisin level was significantly increased in the middle-aged/older training group after the intervention period (P < 0.01), but not in the young training group. Furthermore, in the middle-aged/older training group, the endurance training-induced reduction in visceral adipose tissue area was negatively correlated with the change in serum irisin level (r = -0.54, P < 0.05). These results suggest a possible role for secreted irisin in the exercise-induced alteration of abdominal visceral fat in middle-aged and older adults.
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“After an 8-week endurance training in healthy adults, increased circulating irisin levels were positively correlated with the amount of visceral fat loss measured by DEXA scan [121].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [121]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The main results indicated an increase in serum irisin levels in the elderly group compared to the young group (age 21 ± 1 years)”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
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In the citing paper
“accompanied by a reduction in visceral adiposity which was negatively correlated with irisin levels (r = −0.54, P < 0.05; Miyamoto-Mikami et al., 2015).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
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Citations
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
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The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
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FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · cited 1×
“FNDC5mRNA is expressed at higher levels in skeletal muscle than in other organs [9], and FNDC5 expression in skeletal muscle contributes significantly to circulating irisin levels [5, 9, 22].”
BackgroundEffect of Exercise Training Intensity on Abdominal Visceral Fat and Body Composition
Irving, B. A., Davis, C. K., Brock, D. W., Weltman, J. Y., Swift, D. L., Barrett, E. J., Gaesser, G. A., & WELTMAN, A. L. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181801d40 · Cited by 407
Is irisin a human exercise gene?
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 393
Cited by
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Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Liu, T., Shi, C., Gao, R., Sun, H., Xiong, X., Ding, L., Chen, Q., Li, Y., Wang, J., Kang, Y., et al. (2015) · Clinical Science · doi:10.1042/cs20150009 · Cited by 378
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 271
Metadata
- Authors
- Miyamoto-Mikami, E., Sato, K., Kurihara, T., Hasegawa, N., Fujie, S., Fujita, S., Sanada, K., Hamaoka, T., Tabata, I., & Iemitsu, M.
- Affiliations
- Ritsumeikan University (JP)
- Corresponding author
- Iemitsu, Motoyuki
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-20
- Volume
- 10
- Issue
- 3
- Pages
- e0120354
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4368602
- OpenAlex
- W1969017622
- Cited by
- 143
- References
- 25
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 13 · 2023: 14 · 2022: 23 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 10 · 2017: 13 · 2016: 3 · 2015: 3
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (25560378)
- Japan Society for the Promotion of Science (26282199, 25560378, 26350825, 24300235, 24300239)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- irisin, endurance training, visceral fat, middle-aged and older adults, peak oxygen uptake, body composition, aging, cycling training
- MeSH terms
- Aged, Body Composition, Body Weight, Female, Fibronectins, Humans, Male, Middle Aged, Physical Endurance, Case-Control Studies, Intra-Abdominal Fat, Young Adult
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