The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults
Open accessAbstract
To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. Each age cohort was divided into two groups: the endurance-training group (14 young, 14 middle-aged/older) and the control group. Subjects in the training groups completed an 8-week endurance-training program (cycling at 60-70% peak oxygen uptake [V̇O2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated serum irisin level, V̇O2peak, and body composition. The increase in V̇O2peak in the young and middle-aged/older training groups after the intervention period was significantly greater than those in the young and middle-aged/older control groups (P < 0.05). Serum irisin level was significantly increased in the middle-aged/older training group after the intervention period (P < 0.01), but not in the young training group. Furthermore, in the middle-aged/older training group, the endurance training-induced reduction in visceral adipose tissue area was negatively correlated with the change in serum irisin level (r = -0.54, P < 0.05). These results suggest a possible role for secreted irisin in the exercise-induced alteration of abdominal visceral fat in middle-aged and older adults.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“After an 8-week endurance training in healthy adults, increased circulating irisin levels were positively correlated with the amount of visceral fat loss measured by DEXA scan [121].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [121]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The main results indicated an increase in serum irisin levels in the elderly group compared to the young group (age 21 ± 1 years)”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“accompanied by a reduction in visceral adiposity which was negatively correlated with irisin levels (r = −0.54, P < 0.05; Miyamoto-Mikami et al., 2015).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Age-predicted maximal heart rate revisited
Tanaka, H., Monahan, K. D., & Seals, D. R. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01054-8 · Cited by 3,775 · cited 1×
“7 × age) [11], and (IV) RPE 18.”
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
Subcutaneous and visceral adipose tissue: Structural and functional differences
Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040
Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631
FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · cited 1×
“FNDC5mRNA is expressed at higher levels in skeletal muscle than in other organs [9], and FNDC5 expression in skeletal muscle contributes significantly to circulating irisin levels [5, 9, 22].”
BackgroundEffect of Exercise Training Intensity on Abdominal Visceral Fat and Body Composition
Irving, B. A., Davis, C. K., Brock, D. W., Weltman, J. Y., Swift, D. L., Barrett, E. J., Gaesser, G. A., & WELTMAN, A. L. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181801d40 · Cited by 407
Is irisin a human exercise gene?
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 393
Cited by
Sorted by citations
Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Liu, T., Shi, C., Gao, R., Sun, H., Xiong, X., Ding, L., Chen, Q., Li, Y., Wang, J., Kang, Y., et al. (2015) · Clinical Science · doi:10.1042/cs20150009 · Cited by 378
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 271
Xiong, X.-Q., Chen, D., Sun, H.-J., Ding, L., Wang, J.-J., Chen, Q., Li, Y.-H., Zhou, Y.-B., Han, Y., Zhang, F., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.017 · Cited by 242
Zhang, H., Tong, T. K., Qiu, W., Zhang, X., Zhou, S., Liu, Y., & He, Y. (2017) · Journal of Diabetes Research · doi:10.1155/2017/5071740 · Cited by 220
Burtscher, J., Millet, G. P., Place, N., Kayser, B., & Zanou, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126479 · Cited by 164
Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling
Tang, H. W., Yu, R., Liu, S., Huwatibieke, B., Li, Z., & Zhang, W. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.041 · Cited by 152
Exercise-induced myokines and their effect on prostate cancer
Kim, J., Galvao, D. A., Newton, R. U., Gray, E. S., & Taaffe, D. R. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00476-y · Cited by 131
Küster, O. C., Laptinskaya, D., Fissler, P., Schnack, C., Zügel, M., Nold, V., Thurm, F., Pleiner, S., Karabatsiakis, A., von Einem, B., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170447 · Cited by 122
Extracellular Vesicles: Delivery Vehicles of Myokines
Trovato, E., Felice, V. D., & Barone, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00522 · Cited by 115
Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
Vints, W. A. J., Levin, O., Fujiyama, H., Verbunt, J., & Masiulis, N. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100993 · Cited by 119
An update on the role of irisin in the regulation of endocrine and metabolic functions
Mahgoub, M., D’Souza, C. M., Darmaki, R. S. A., Baniyas, M. M. Y. H., & Adeghate, E. A. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.018 · Cited by 110
Is irisin the new player in exercise-induced adaptations or not? A 2017 update
Fatouros, I. G. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0674 · Cited by 95
Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process
Zhang, H., Wu, X., Liang, J., Kirberger, M., & Chen, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101680 · Cited by 88
Jo, D., Yoon, G., Kim, O. Y., & Song, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112636 · Cited by 86
Lombardi, G., Ziemann, E., & Banfi, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00060 · Cited by 92
Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults
Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00171 · Cited by 83
The serum level of irisin, but not asprosin, is abnormal in polycystic ovary syndrome patients
Chang, C. L., Huang, S. Y., Hsu, Y. C., Chin, T. H., & Soong, Y. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-42061-9 · Cited by 80
Ma, C., Ding, H., Deng, Y., Liu, H., Xiong, X., & Yang, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.620608 · Cited by 76
Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines
Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis
Jandova, T., Buendía‐Romero, Á., Polanská, H., Hola, V., Říhova, M., Větrovský, T., Courel‐Ibáñez, J., & Šteffl, M. (2021) · Healthcare · doi:10.3390/healthcare9111438 · Cited by 65
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases
Marques‐Aleixo, I., Beleza, J., Sampaio, A., Stevanović, J., Coxito, P. M., Gonçalves, I. O., Ascensão, A. A. M. R., & Magalhães, J. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8075 · Cited by 68
The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity
Li, H., Wang, F., Mu, Y., Sun, J., Zhao, Y. C., & Tang, D. (2021) · International Journal of Endocrinology · doi:10.1155/2021/6572342 · Cited by 67
Babaei, P., & Azari, H. B. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.771553 · Cited by 64
Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
Trettel, C. D. S., Pelozin, B. R. D. A., Barros, M. P., Bachi, A. L. L., Braga, P. G. S., Momesso, C. M., Furtado, G. E., Valente, P. A., de Oliveira, E. M., Hogervorst, E., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1106529 · Cited by 56
Dinas, P. C., Lahart, I. M., Timmons, J. A., Svensson, P.-A., Koutedakis, Y., Flouris, A. D., & Metsios, G. S. (2017) · F1000Research · doi:10.12688/f1000research.11107.2 · Cited by 51
Li, J., Wang, Z., Li, C., Song, Y., Wang, Y., Hai, B., & Zhang, Y. (2022) · Cells · doi:10.3390/cells11132086 · Cited by 56
Lee, T. H.-Y., Formolo, D. A., Kong, T., Lau, S. W.-Y., Ho, C. S.-L., Leung, R. Y. H., Hung, F. H.-Y., & Yau, S. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.06.002 · Cited by 49
Inoue, K., Fujie, S. J., Hasegawa, N., Horii, N., Uchida, M., Iemitsu, K., Sanada, K., Hamaoka, T., & Iemitsu, M. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0602 · Cited by 76
Dünnwald, T., Melmer, A., Gatterer, H., Salzmann, K., Ebenbichler, C. F., Burtscher, M., Schobersberger, W., & Grander, W. (2019) · International Journal of Sports Medicine · doi:10.1055/a-0828-8047 · Cited by 47
Buscemi, S., Corleo, D., Vasto, S., Buscemi, C., Massenti, M. F., Nuzzo, D., Lucisano, G., Barile, A. M., Rosafio, G., Maniaci, V., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.255 · Cited by 49
Han, C., Lu, P., & Yan, S.-Z. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111648 · Cited by 44
Colpitts, B. H., Rioux, B. V., Eadie, A. L., Brunt, K. R., & Sénéchal, M. (2022) · Physiological Reports · doi:10.14814/phy2.15198 · Cited by 44
Kazeminasab, F., Sadeghi, E., & Afshari-Safavi, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8235809 · Cited by 43
Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Miyoshi, N., Morita, A., & Miura, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40643-1 · Cited by 44
Exercise-induced myokines: a brief review of controversial issues of this decade
Son, J. S., Chae, S. A., Testroet, E. D., Du, ., & Jun, H.-P. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1416290 · Cited by 38
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review
Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 41
Ghanbari–Niaki, A., Saeidi, A., Ahmadian, M., Gharahcholo, L., Naghavi, N., Fazelzadeh, M., Mahjoub, S., Myers, S., & Williams, A. D. (2018) · Integrative Medicine Research · doi:10.1016/j.imr.2018.01.007 · Cited by 36
Safarimosavi, S., Mohebbi, H., & Rohani, H. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002709 · Cited by 35
Bertheau, R. C., Lorbeer, R., Nattenmüller, J., Wintermeyer, E., Machann, J., Linkohr, B., Peters, A., Bamberg, F., & Schlett, C. L. (2020) · European Radiology · doi:10.1007/s00330-019-06612-y · Cited by 33
Exercise hormone irisin prevents physical inactivity-induced cognitive decline in mice
Park, J.-H., Kim, J., & Mikami, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114008 · Cited by 35
Biniaminov, N., Bandt, S., Röth, A., Haertel, S., Neumann, R., & Bub, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0189254 · Cited by 29
Irisin: circulating levels in serum and its relation to gonadal axis
Luo, Y., Qiao, X., Xu, L., & Huang, G. (2022) · Endocrine · doi:10.1007/s12020-022-02981-5 · Cited by 30
Dagpo, T., Nolan, C. J., & Delghingaro‐Augusto, V. (2020) · Cells · doi:10.3390/cells9071596 · Cited by 32
From Exercise to Cognitive Performance: Role of Irisin
Pesce, M., Fratta, I. L., Paolucci, T., Grilli, A., Patruno, A., Agostini, F., Bernetti, A., Mangone, M., Paoloni, M., Invernizzi, M., et al. (2021) · Applied Sciences · doi:10.3390/app11157120 · Cited by 29
Rahimi, G. R. M., Hejazi, K., & Hofmeister, M. (2022) · EXCLI journal · doi:10.17179/excli2022-4703 · Cited by 36
Rajabi, A., Khajehlandi, M., Siahkuhian, M., Akbarnejad, A., Khoramipour, K., & Suzuki, K. (2022) · Sports · doi:10.3390/sports10110167 · Cited by 31
Hola, V., Polanská, H., Jandova, T., Dytrtová, J. J., Weinerová, J., Šteffl, M., Kramperová, V., Daďová, K., Durkalec‐Michalski, K., & Bartoš, A. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s482479 · Cited by 28
Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats
Seo, D. Y., Bae, J. H., Kim, T. N., Kwak, H., Kha, P. T., & Han, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113863 · Cited by 26
Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice
Kang, J. S., Kim, J. H., Kim, M. J., Min, B., Lee, S.-M., Go, G.-Y., Kim, J., Kim, S., Kwak, J. Y., Chun, S.-W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59959-w · Cited by 24
Kaneda, H., Nakajima, T., Haruyama, A., Shibasaki, I., Hasegawa, T., Sawaguchi, T., Kuwata, T., Obi, S., Arikawa, T., Sakuma, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201499 · Cited by 26
A Bibliometric Analysis of the Literature on Irisin from 2012–2021
Liu, J., Qi, B., Gan, L., Shen, Y., & Zou, Y. F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19106153 · Cited by 25
Adipokines in Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets
Bilski, J., Schramm‐Luc, A., Szczepanik, M., Mazur-Biały, A. I., Bonior, J., Luc, K., Zawojska, K., & Szklarczyk, J. (2023) · Biomedicines · doi:10.3390/biomedicines11112998 · Cited by 28
Does iris(in) bring bad news or good news?
Buscemi, S., Corleo, D., Buscemi, C., & Giordano, C. S. D. S. (2017) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-017-0431-8 · Cited by 24
Parada-Sánchez, S., Macías-Cervantes, M. H., Pérez‐Vázquez, V., & Vargas‐Ortiz, K. (2022) · Physiological Research · doi:10.33549/physiolres.934896 · Cited by 22
Tavassoli, H., Heidarianpour, A., & Hedayati, M. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1673432 · Cited by 20
Li, N., Wang, B., Wang, Y., Tian, X., Lin, J., Sun, X., Sun, Y., Zhang, X., Xu, H., Li, M., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04801-z · Cited by 21
Gheit, R. E. A. E., Younis, R. L., El‐Saka, M. H., Emam, M. N., Soliman, N. A., El‐Sayed, R. M., Hafez, Y. M., AbuoHashish, N. A., Radwan, D. A., Khaled, H. E., et al. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00915-3 · Cited by 20
Sánchez, M., Sánchez, E., Hernández, M., González, J., Purroy, F. F., Rius, F., Pamplona, R., Farràs-Sallés, C., Gutiérrez-Carrasquilla, L., Fernández, E., et al. (2019) · Nutrients · doi:10.3390/nu11061359 · Cited by 19
Vasyukova, O. V., Kasyanova, Y. V., Okorokov, P. L., & Bezlepkina, O. B. (2021) · Problems of Endocrinology · doi:10.14341/probl12779 · Cited by 18
New insights into the roles of Irisin in diabetic cardiomyopathy and vascular diseases
Zhang, T., Qian, Y., Huang, W., Feng, J., & Liu, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116631 · Cited by 22
Fernández-del-Valle, M., Short, M. J., Chung, E., McComb, J. J. R., Kloiber, S. D., Naclerio, F., & Larumbe‐Zabala, E. (2018) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.13025 · Cited by 17
Modification of Muscle-Related Hormones in Women with Obesity: Potential Impact on Bone Metabolism
Maı̈moun, L., Mura, T., Attalin, V., Dupuy, A., Cristol, J., Avignon, A., Mariano‐Goulart, D., & Sultan, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041150 · Cited by 17
Timofte, D. V., Tudor, R. C., Mocanu, V., & Labusca, L. S. (2024) · Nutrients · doi:10.3390/nu16234231 · Cited by 16
Terada, T., Boulé, N. G., Forhan, M. A., Prado, C. M. M., Kenny, G. P., Prud’homme, D., Ito, E., & Sigal, R. J. (2017) · Obesity · doi:10.1002/oby.21808 · Cited by 16
Weber‐Rajek, M., Radzimińska, A., Strączyńska, A., Strojek, K., Piekorz, Z., Kozakiewicz, M., & Styczyńska, H. (2019) · BioMed Research International · doi:10.1155/2019/7356187 · Cited by 15
Gaowa, A., Leangpanich, S., Park, E. J., Kawamoto, E., & Shimaoka, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-76658-6 · Cited by 14
Lin, H., Yuan, Y., Tian, S., Han, J., Huang, R., Guo, D., Wang, J., An, K., & Wang, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00634 · Cited by 14
Zhao, R., Zhou, Y., Li, J., Lin, J., Cui, W., Peng, Y., & Bu, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.639066 · Cited by 14
Parkin, R., & Murray, A. J. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1355922 · Cited by 12
Tai chi effects on balance in older adults: the role of sustained attention and myokines
Solianik, R., Brazaitis, M., & ČEKANAUSKAITĖ-KRUŠNAUSKIENĖ, A. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.21.12990-1 · Cited by 14
Serum Irisin Concentrations in Severely Inflamed Patients
Buscemi, S., Corleo, D., Vasto, S., Buscemi, C., Barile, A. M., Rosafio, G., Randazzo, C., Currenti, W., & Galvano, F. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1111-9249 · Cited by 11
Moreira, V. C., Silva, C. M. S., Welker, A. F., & da Silva, I. C. R. (2022) · Journal of Aging Research · doi:10.1155/2022/8350527 · Cited by 13
Özçelik, O., Algül, Ş., & Yılmaz, B. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.10.21 · Cited by 11
Impacts of rat hindlimb Fndc5/irisin overexpression on muscle and adipose tissue metabolism
Farrash, W. F., Brook, M. S., Crossland, H., Phillips, B. E., Cegielski, J., Wilkinson, D. J., Constantin‐Teodosiu, D., Greenhaff, P. L., Smith, K., Cleasby, M. E., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00034.2020 · Cited by 13
Rashidlamir, A., Hoseinzadeh, M., & Dashtkhaki, L. Z. (2017) · Annals of Applied Sport Science · doi:10.18869/acadpub.aassjournal.5.2.51 · Cited by 10
Effects of running a marathon on irisin concentration in men aged over 50
Jóźków, P., Koźlenia, D., Zawadzka, K., Konefał, M., Chmura, P., Młynarska, K., Kosowski, M., Mędraś, M., Chmura, J., Ponikowski, P. P., et al. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0619-3 · Cited by 10
Davies, M. D., Sandoo, A., & Macdonald, J. H. (2022) · Kidney and Dialysis · doi:10.3390/kidneydial2020026 · Cited by 12
Irisin and the muscle–brain axis: Mechanisms and translational potential
Arosio, B., & Picca, A. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113028 · Cited by 11
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging
Wang, Y., Wang, M., & Wang, Y. (2023) · Aging and Disease · doi:10.14336/ad.2023.1112 · Cited by 10
Lázničková, P., Bendíčková, K., Kepák, T., & Frič, J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.708788 · Cited by 10
Rodrigues, A. C., Ferreira, E., Carneiro‐Júnior, M. A., Natali, A. J., & Bressan, J. (2016) · Science & Sports · doi:10.1016/j.scispo.2016.07.005 · Cited by 10
Role of irisin in metabolic and cardiovascular disorders and its therapeutic potential
Khalil, R. G., Atia, T. A., Yousef, A. I., Sakr, H. I., & Ahmed, O. M. (2025) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-025-00643-9 · Cited by 8
Boudehri, M. E. A., Adel, B., Oumri, D., & Ahmed, A. (2023) · Quality in Sport · doi:10.12775/qs.2023.11.01.002 · Cited by 8
Deep phenotyping of patients with MASLD upon high-intensity interval training
Houttu, V., Boulund, U., Troelstra, M., Csader, S., Stols‐Gonçalves, D., Mak, A. L., van Dijk, A., Bouts, J., Winkelmeijer, M., Verdoes, X., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101289 · Cited by 8
Cordingley, D. M., Anderson, J. E., & Cornish, S. M. (2024) · Muscles · doi:10.3390/muscles3030018 · Cited by 8
Skeletal Muscle as Endocrine Organ
Ma, M., Zhang, Z., Hai, B., & Zhang, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_22 · Cited by 9
Myokines: A central point in managing redox homeostasis and quality of life
Rathor, R., & Suryakumar, G. (2024) · BioFactors · doi:10.1002/biof.2054 · Cited by 6
Rádiková, Ž., Mosna, L., Eckerstorfer, C., Bajer, B., Havranová, A., Imrich, R., Vlček, M., & Penesová, A. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0013 · Cited by 6
Understanding the Role of Irisin in Longevity and Aging: A Narrative Review
Plácido, A. I., Azevedo, D., Herdeiro, M. T., Morgado, M., & Roque, F. (2025) · Epidemiologia · doi:10.3390/epidemiologia6010001 · Cited by 5
Jürimäe, J., Purge, P., Remmel, L., Ereline, J., Kums, T., Kamandulis, S., Brazaitis, M., Venckūnas, T., & Pääsuke, M. (2022) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.22.13949-6 · Cited by 5
Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle
O’Reilly, C. L., Lin, L., Wang, H., Fluckey, J. D., & Sun, Y. (2022) · Genes · doi:10.3390/genes13081368 · Cited by 5
Boycott, C., Kilańczyk, E., Zhang, H. A., Zhang, J., Abolhassani, A., Kubiak, M., Celichowski, J., Kryściak, K., Gruszka, D. T., Sliwowska, J. H., et al. (2025) · Epigenetics · doi:10.1080/15592294.2025.2590237 · Cited by 4
Chen, M., Zhang, Y. C., Yu, X., & Qun, Z. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003627 · Cited by 5
Rahimi, M. R., Mahmazi, S., Abbaspoor, M., Rahnema, M., Saifalddin, D. L., Ghanbari, N., Kolahdouzi, S., & Golpasandi, H. (2025) · Economy of Tajikistan · doi:10.61882/phypha.29.2.171 · Cited by 4
Lee, S., Kim, T.-W., Park, T.-H., Lee, I.-H., Jang, E.-C., Kwon, S.-C., Lee, H.-J., Choi, J.-H., & Lee, J. (2022) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2022.26.6.501 · Cited by 4
Irisin is weakly associated with usual physical activity in young overweight women
Tenorio, B., Jiménez, T., Barrera, G., Hirsch, S., de la Maza, M. P., Troncoso, R., Farias, M. B., Rodríguez, J. M., & Bunout, D. C. (2017) · Nutrición Hospitalaria · doi:10.20960/nh.463 · Cited by 4
Latihan Sirkuit Signifikan Menurunkan Berat Badan dan BMI
Ramdhanni, D., Pitriani, P., & Mulyana, M. (2020) · JUARA Jurnal Olahraga · doi:10.33222/juara.v5i2.759 · Cited by 8
Metadata
- Authors
- Miyamoto-Mikami, E., Sato, K., Kurihara, T., Hasegawa, N., Fujie, S., Fujita, S., Sanada, K., Hamaoka, T., Tabata, I., & Iemitsu, M.
- Affiliations
- Ritsumeikan University (JP)
- Corresponding author
- Iemitsu, Motoyuki
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-20
- Volume
- 10
- Issue
- 3
- Pages
- e0120354
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4368602
- OpenAlex
- W1969017622
- Cited by
- 143
- References
- 25
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 13 · 2023: 14 · 2022: 23 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 10 · 2017: 13 · 2016: 3 · 2015: 3
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (25560378)
- Japan Society for the Promotion of Science (26282199, 25560378, 26350825, 24300235, 24300239)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- irisin, endurance training, visceral fat, middle-aged and older adults, peak oxygen uptake, body composition, aging, cycling training
- MeSH terms
- Aged, Body Composition, Body Weight, Female, Fibronectins, Humans, Male, Middle Aged, Physical Endurance, Case-Control Studies, Intra-Abdominal Fat, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
