The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis
Open accessAbstract
OBJECTIVE: We aimed to review the literature regarding epidemiology of functional abdominal pain disorders in children and to assess its geographic, gender and age distribution including associated risk factors of developing functional abdominal pain. METHODS: The Cochrane Library, MEDLINE, EMBASE, CINAHL and PsychInfo databases were systematically searched up to February 2014. Study selection criteria included: (1) studies of birth cohort, school based or general population samples (2) containing data concerning epidemiology, prevalence or incidence (3) of children aged 4-18 years (4) suffering from functional abdominal pain. Quality of studies was rated by a self-made assessment tool. A random-effect meta-analysis model was used to estimate the prevalence of functional abdominal pain in childhood. RESULTS: A total of 58 articles, including 196,472 children were included. Worldwide pooled prevalence for functional abdominal pain disorders was 13.5% (95% CI 11.8-15.3), of which irritable bowel syndrome was reported most frequently (8.8%, 95% CI 6.2-11.9). The prevalence across studies ranged widely from 1.6% to 41.2%. Higher pooled prevalence rates were reported in South America (16.8%) and Asia (16.5%) compared to Europe (10.5%). And a higher pooled prevalence was reported when using the Rome III criteria (16.4%, 95% CI 13.5-19.4). Functional abdominal pain disorders are shown to occur significantly more in girls (15.9% vs. 11.5%, pooled OR 1.5) and is associated with the presence of anxiety and depressive disorders, stress and traumatic life events. CONCLUSION: Functional abdominal pain disorders are a common problem worldwide with irritable bowel syndrome as most encountered abdominal pain-related functional gastrointestinal disorder. Female gender, psychological disorders, stress and traumatic life events affect prevalence.
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“Prevalence rates vary considerably due to differences in case definitions, assessment instruments and study populations.1–3”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [1]
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Cites
Bias in meta-analysis detected by a simple, graphical test
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“[5] Children with AP-FGIDs report significantly lower quality of life (QoL) scores compared to healthy peers and AP-FGIDs are ranked as second in causing school absence[6,7] In 29.”
BackgroundChildhood Functional Gastrointestinal Disorders: Child/Adolescent
Rasquin, A., Lorenzo, C. D., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., & Walker, L. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.063 · Cited by 1,785
Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields
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Pain in children and adolescents: a common experience
Perquin, C. W., Hazebroek-Kampschreur, A. A. J. M., Hunfeld, J. A. M., Bohnen, A. M., van Suijlekom-Smit, L. W. A., Passchier, J., & van der Wouden, J. C. (2000) · Pain · doi:10.1016/s0304-3959(00)00269-4 · Cited by 1,114
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Epidemiology of constipation in children and adults: A systematic review
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1 of the 101 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- FG Demirceken, 2010, Functional dyspepsia in children: A Turkish prospective survey in kirikkale province, Journal of Pediatric Gastroenterology and Nutrition, E122
- Y Wang, 2008, The prevalence investigation of IBS in Qinhuandao area, Shandong Med, 48, 107
- H-Q Zhou, 2009, Epidemiologic study of irritable bowel syndrome among adolescents in Western China, Journal of Shanghai Jiaotong University (Medical Science). China, 29, 581
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Sorted by citations
Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis
Koppen, I. J. N., Vriesman, M. H., Saps, M., Rajindrajith, S., Shi, X., van Etten‐Jamaludin, F. S., Lorenzo, C. D., Benninga, M. A., & Tabbers, M. M. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.02.029 · Cited by 362
Self-citationChambers, C. T., Dol, J., Tutelman, P. R., Langley, C., Parker, J. A., Cormier, B., Macfarlane, G. J., Jones, G. T., Chapman, D., Proudfoot, N. A., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003267 · Cited by 311
Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents
Lewis, M. L., Palsson, O. S., Whitehead, W. E., & van Tilburg, M. A. L. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.04.008 · Cited by 290
Pediatric Chronic Pain: Biopsychosocial Assessment and Formulation
Liossi, C., & Howard, R. F. (2016) · PEDIATRICS · doi:10.1542/peds.2016-0331 · Cited by 269
Family therapy and systemic interventions for child‐focused problems: the current evidence base
Carr, A. (2018) · Journal of Family Therapy · doi:10.1111/1467-6427.12226 · Cited by 312
Metadata
- Authors
- Korterink, J. J., Diederen, K., Benninga, M. A., & Tabbers, M. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Korterink, Judith J.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-05-20
- Volume
- 10
- Issue
- 5
- Pages
- e0126982
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4439136
- OpenAlex
- W324818206
- Cited by
- 481
- References
- 101
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 36 · 2023: 48 · 2022: 58 · 2021: 65 · 2020: 53 · 2019: 28 · 2018: 46 · 2017: 29 · 2016: 33 · 2015: 6
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- functional abdominal pain, irritable bowel syndrome, prevalence, incidence, sex differences, anxiety disorders, depressive disorders, stress, traumatic life events, Rome III criteria, functional gastrointestinal disorders, regional variation
- MeSH terms
- Child, Geography, Humans, Surveys and Questionnaires, Reproducibility of Results, Abdominal Pain, Prevalence
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