Cited by 481Gastrointestinal motility and disordersPediatric Pain Management TechniquesInfant Health and Development

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Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis

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Korterink, Judith J., Diederen, Kay, Benninga, Marc A., Tabbers, Merit M.·2015·PLOS ONE

DOI 10.1371/journal.pone.0126982PMC PMC4439136

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Abstract

OBJECTIVE: We aimed to review the literature regarding epidemiology of functional abdominal pain disorders in children and to assess its geographic, gender and age distribution including associated risk factors of developing functional abdominal pain. METHODS: The Cochrane Library, MEDLINE, EMBASE, CINAHL and PsychInfo databases were systematically searched up to February 2014. Study selection criteria included: (1) studies of birth cohort, school based or general population samples (2) containing data concerning epidemiology, prevalence or incidence (3) of children aged 4-18 years (4) suffering from functional abdominal pain. Quality of studies was rated by a self-made assessment tool. A random-effect meta-analysis model was used to estimate the prevalence of functional abdominal pain in childhood. RESULTS: A total of 58 articles, including 196,472 children were included. Worldwide pooled prevalence for functional abdominal pain disorders was 13.5% (95% CI 11.8-15.3), of which irritable bowel syndrome was reported most frequently (8.8%, 95% CI 6.2-11.9). The prevalence across studies ranged widely from 1.6% to 41.2%. Higher pooled prevalence rates were reported in South America (16.8%) and Asia (16.5%) compared to Europe (10.5%). And a higher pooled prevalence was reported when using the Rome III criteria (16.4%, 95% CI 13.5-19.4). Functional abdominal pain disorders are shown to occur significantly more in girls (15.9% vs. 11.5%, pooled OR 1.5) and is associated with the presence of anxiety and depressive disorders, stress and traumatic life events. CONCLUSION: Functional abdominal pain disorders are a common problem worldwide with irritable bowel syndrome as most encountered abdominal pain-related functional gastrointestinal disorder. Female gender, psychological disorders, stress and traumatic life events affect prevalence.

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Fig 1 Flowchart showing results of literature search and study inclusion.CC BY · PubMed Central

Fig 2 Geographic distribution of functional abdominal pain in children, presented in pooled-prevalence rates.CC BY · PubMed Central

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Authors: Korterink, J. J., Diederen, K., Benninga, M. A., & Tabbers, M. M.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Korterink, Judith J.
ORCID: Diederen, Kay
Benninga, Marc A.
Tabbers, Merit M.
Venue: PLOS ONE
Publisher: Public Library of Science (PLoS)
Published: 2015-05-20
Volume: 10
Issue: 5
Pages: e0126982
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0126982
PMC: PMC4439136
OpenAlex: W324818206
Cited by: 481
References: 101
Citations by year: 2026: 30 · 2025: 47 · 2024: 36 · 2023: 48 · 2022: 58 · 2021: 65 · 2020: 53 · 2019: 28 · 2018: 46 · 2017: 29 · 2016: 33 · 2015: 6
FWCI: 6.66
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion, cc-by)
Data Archiving and Networked Services (DANS) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: functional abdominal pain, irritable bowel syndrome, prevalence, incidence, sex differences, anxiety disorders, depressive disorders, stress, traumatic life events, Rome III criteria, functional gastrointestinal disorders, regional variation
MeSH terms: Child, Geography, Humans, Surveys and Questionnaires, Reproducibility of Results, Abdominal Pain, Prevalence

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Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis

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