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Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival
Open accessAbstract
The use of small antimicrobial peptides or bacteriocins, like nisin, to treat cancer is a new approach that holds great promise. Nisin exemplifies this new approach because it has been used safely in humans for many years as a food preservative, and recent laboratory studies support its anti-tumor potential in head and neck cancer. Previously, we showed that nisin (2.5%, low content) has antitumor potential in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. The current studies explored a naturally occurring variant of nisin (nisin ZP; 95%, high content) for its antitumor effects in vitro and in vivo. Nisin ZP induced the greatest level of apoptosis in HNSCC cells compared to low content nisin. HNSCC cells treated with increasing concentrations of nisin ZP exhibited increasing levels of apoptosis and decreasing levels of cell proliferation, clonogenic capacity, and sphere formation. Nisin ZP induced apoptosis through a calpain-dependent pathway in HNSCC cells but not in human oral keratinocytes. Nisin ZP also induced apoptosis dose-dependently in human umbilical vein endothelial cells (HUVEC) with concomitant decreases in vascular sprout formation in vitro and reduced intratumoral microvessel density in vivo. Nisin ZP reduced tumorigenesis in vivo and long-term treatment with nisin ZP extended survival. In addition, nisin treated mice exhibited normal organ histology with no evidence of inflammation, fibrosis or necrosis. In summary, nisin ZP exhibits greater antitumor effects than low content nisin, and thus has the potential to serve as a novel therapeutic for HNSCC.
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“Lactococcus lactis, a commensal of the oral microbiota, produces nisin, a bacteriocin that has been shown to reduce oral tumorigenesis and extend the life span of mice with tumors.165, 166”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [166]
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Siegel, R., Naishadham, D., & Jemal, A. (2012) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20138 · Cited by 10,679
Bacteriocins: safe, natural antimicrobials for food preservation.
Cleveland, J., Montville, T. J., Nes, I. F., & Chikindas, M. L. (2001) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00560-8 · Cited by 1,835
Studies on anticancer activities of antimicrobial peptides
Hoskin, D. W., & Ramamoorthy, A. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.11.008 · Cited by 1,297
Self-citationA simple technique for quantifying apoptosis in 96-well plates
Ribble, D., Goldstein, N. B., Norris, D. A., & Shellman, Y. G. (2005) · BMC Biotechnology · doi:10.1186/1472-6750-5-12 · Cited by 854
Wiedemann, I., Breukink, E. J., van Kraaij, C., Kuipers, O. P., Bierbaum, G., KRUIJFF, B. D., & Sahl, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006770200 · Cited by 793
Identification and characterization of the lantibiotic nisin Z, a natural nisin variant
Mulders, J. W. M., Boerrigter, I. J., Rollema, H. S., Siezen, R. J., & de Vos, W. M. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16317.x · Cited by 429
Mungrue, I. N., Pagnon, J. C., Omid Kohannim, A., Gargalovic, P. S., & Lusis, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.466 · Cited by 332
Ihle, N. T., Williams, R. R., Chow, S., Chew, W. M., Berggren, M. I., Paine-Murrieta, G. D., Minion, D. J., Halter, R. J., Wipf, P., Abraham, R. T., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.763.3.7 · Cited by 317
Koczulla, A. R., & Bals, R. (2003) · Drugs · doi:10.2165/00003495-200363040-00005 · Cited by 309
Genotyping of 73 UM‐SCC head and neck squamous cell carcinoma cell lines
Brenner, J. C., Graham, M. P., Kumar, B., Saunders, L. M., Kupfer, R., Lyons, R. H., Bradford, C. R., & Carey, T. E. (2010) · Head & Neck · doi:10.1002/hed.21198 · Cited by 304
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Items 101–200 of 214
Sørensen, H. M., Rochfort, K. D., Maye, S., Macleod, G. H. B., Loscher, C. E., Brabazon, D., & Freeland, B. H. (2023) · Nutrients · doi:10.3390/nu15224754 · Cited by 17
Identification of Key Residues in the NisK Sensor Region for Nisin Biosynthesis Regulation
Ge, X., Teng, K., Wang, J., Zhao, F., Zhang, J., & Zhong, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00106 · Cited by 16
Bacteriocin, Antimicrobial as A New Natural Food Preservative: Its Potential and Challenges
Surati, S. (2021) · Eruditio Indonesia Journal of Food and Drug Safety · doi:10.54384/eruditio.v1i1.34 · Cited by 15
Nisin variants: What makes them different and unique?
Oliveira, W. D. S., Teixeira, C. R. V., Mantovani, H. C., Dolabella, S. S., Jain, S. A., & Barbosa, A. A. T. (2024) · Peptides · doi:10.1016/j.peptides.2024.171220 · Cited by 15
Zhao, J., Zhou, Z., Bai, X., Zhang, D., Zhang, L., Wang, J., Wu, B., Zhu, J., & Yang, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.943232 · Cited by 15
Patil, S. M., Barji, D. S., Aziz, S., McChesney, D. A., Bagde, S., Muttil, P., & Kunda, N. K. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122641 · Cited by 15
Preet, S., Kaur, J., & Raza, K. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12909 · Cited by 13
Eftekhari, E., Ghollasi, M., Halabian, R., Soltanyzadeh, M., & Enderami, S. E. (2021) · Human Cell · doi:10.1007/s13577-021-00537-9 · Cited by 13
Al-Khazaleh, A. K., Chang, D., Münch, G. W., & Bhuyan, D. J. (2024) · Cancers · doi:10.3390/cancers16081464 · Cited by 12
Genome database mining for the discovery of novel lantibiotics
Sandiford, S. K. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1303475 · Cited by 12
AFM Study of Nanoscale Membrane Perturbation Induced by Antimicrobial Lipopeptide C14 KYR
Nasompag, S., Siritongsuk, P., Thammawithan, S., Srichaiyapol, O., Prangkio, P., Camesano, T. A., Sinthuvanich, C., & Patramanon, R. (2021) · Membranes · doi:10.3390/membranes11070495 · Cited by 12
Ligand determinants of nisin for its induction activity
Ge, X., Teng, K., Wang, J., Zhao, F., Wang, F., Zhang, J., & Zhong, J. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10809 · Cited by 12
Engineered microorganism-based delivery systems for targeted cancer therapy: a narrative review.
Huang, X., Guo, H., Wang, L., & Shao, Z. (2022) · PubMed Central · doi:10.12336/biomatertransl.2022.03.004 · Cited by 11
Synthesis, high yield strategy and application of nisin: A review
Wang, R., Yu, S., Huang, Y., & Liu, Y. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16418 · Cited by 11
Self-citationBastarrachea, L. J., Britt, D. W., & Demırcı, A. (2022) · Food and Bioprocess Technology · doi:10.1007/s11947-021-02743-7 · Cited by 11
Glycated nisin enhances nisin's cytotoxic effects on breast cancer cells
Mohammadi, A., Kazemipour, N., Ghorbankhani, G. A., Morovati, S., & Sadeghian, M. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-68765-1 · Cited by 11
An Insight into Bacteriocins for Combating Microbial Infections and Ensuring Food Safety
Howlader, M., Das, S. C., Gupta, S. D., Barman, D. N., Islam, M. M., Mia, M. E., Salahuddin, M., & Hossain, M. M. (2025) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-025-10691-5 · Cited by 10
Selvan, S. A., Ghalsasi, V. V., Bandyopadhyay, A., & Pal, T. (2025) · Future Microbiology · doi:10.1080/17460913.2025.2520693 · Cited by 10
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC
Xiang, Y., Fen, L., Wang, L., Zheng, A., Zuo, J., Li, M., Wang, Y., Xu, Y. J., Chen, C., Chen, S., et al. (2017) · Oncology Letters · doi:10.3892/ol.2017.5687 · Cited by 12
Travers, W., & Kelleher, F. (2021) · Biophysical Chemistry · doi:10.1016/j.bpc.2021.106603 · Cited by 10
Mohanty, S., Panda, S., Devadharshini, U., & Paul, S. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188862 · Cited by 10
Garg, V. K., Joshi, H., Sharma, A. K., Yadav, K., & Yadav, V. K. (2024) · Peptides · doi:10.1016/j.peptides.2024.171320 · Cited by 9
Soans, S. H., Chonche, M. J., Sharan, K., Srinivasan, A., & Archer, A. C. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141747 · Cited by 9
Bacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review)
Guo, Y. H., Dong, W., Sun, D., Zhao, X., Huang, Z., Liu, C., & Sheng, Y. (2025) · Oncology Letters · doi:10.3892/ol.2025.14956 · Cited by 10
Bacteriocins as natural weapon against cancer: in vitro, in vivo, and in silico perspectives
Assega, B. G., Tsegaye, K. N., Mitiku, T., & Andualem, B. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-06929-y · Cited by 9
Poorinmohammad, N., Hamedi, J., & Masoudi‐Nejad, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-59731-8 · Cited by 9
Mohammadi, P., Zangeneh, M., Mohammadi‐Motlagh, H., & Khademi, F. (2020) · Reports of Biochemistry and Molecular Biology · doi:10.29252/rbmb.9.3.250 · Cited by 9
Nisin: Prerequisites and Prospects for Application in the Medical Field
Knysh, O. V., & Martynov, A. (2023) · Galician Medical Journal · doi:10.21802/gmj.2023.1.6 · Cited by 8
Raudenská, M., Bugajová, M., Kalfeřt, D., Plzák, J., Šubrt, A., Tesařová, P., & Masařík, M. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189216 · Cited by 8
Yousefy, Z., Esmaeili, D., & Goudarzi, H. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100751 · Cited by 8
Bacteriocins: New Potential Therapeutic Candidates in Cancer Therapy
Fathizadeh, H., Saffari, M., Esmaeili, D., Moniri, R., & Kafil, H. S. (2020) · Current Molecular Medicine · doi:10.2174/1566524020999200817113730 · Cited by 8
Bacteriocins of Probiotics as Potent Anticancer Agents
Sharma, P., & Tiwari, S. K. (2020) · Springer eBooks · doi:10.1007/978-981-15-8214-1_11 · Cited by 8
Mechanism of action of the lantibiotics on the multidrug-resistant organisms
Chattopadhyay, A., Das, N., & Banerjee, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99141-4.00010-2 · Cited by 9
The Anti-Adhesion Effect of Nisin as a Robust Lantibiotic on the Colorectal Cancer Cells
Soleimanifar, H., Hosseini, H. M., Tehrani, S. S., & Mirhosseini, S. A. (2023) · Advanced Biomedical Research · doi:10.4103/abr.abr_267_21 · Cited by 8
Apoptotic activity of Newcastle disease virus in comparison with nisin A in MDA-MB-231 cell line.
Ghorbankhani, G. A., Mohammadi, A., Kazemipur, N., Morovati, S., Gharesi‐Fard, B., آبادی, د. س. ن. ح., & Sadeghian, M. H. (2023) · PubMed Central · doi:10.30466/vrf.2022.542258.3297 · Cited by 7
Soares, R. S., Santos, R., Cunha, E. S., Tavares, L. M., Trindade, A., & Oliveira, M. (2020) · Antibiotics · doi:10.3390/antibiotics9110781 · Cited by 7
Bacteriocins: Novel Applications in Food, and Human and Animal Health
Mbandlwa, P., Doyle, N., Hill, C., Stanton, C., & Ross, R. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.23030-8 · Cited by 7
Improving the attrition rate of Lanthipeptide discovery for commercial applications
Geng, M., & Smith, L. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1410137 · Cited by 6
Microbiome and Gastroesophageal Disease: Pathogenesis and Implications for Therapy
D’Souza, S. M., Cundra, L. B., Yoo, B. S., Parekh Parth, J., & Johnson, D. A. (2020) · Annals of Clinical Gastroenterology and Hepatology · doi:10.29328/journal.acgh.1001018 · Cited by 7
Raman, S. R., Liu, C., Herremans, K. M., Riner, A. N., Vudatha, V., Freudenberger, D. C., McKinley, K. L., Triplett, E. W., & Trevino, J. (2022) · Microorganisms · doi:10.3390/microorganisms10112291 · Cited by 6
Flow Cytometry as a Tool to Study the Effects of Bacteriocins on Prokaryotic and Eukaryotic Cells
Mathur, H., & Rea, M. C. (2016) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.s8-013 · Cited by 6
Sequence-based analysis and prediction of lantibiotics: A machine learning approach
Poorinmohammad, N., Hamedi, J., & Moghaddam, M. H. A. M. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.10.004 · Cited by 5
Lactobacillus in cancer therapy: A critical mechanistic review
Baker, D. H. A. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.102256 · Cited by 5
Polymersome-based nanomedicine for combined cancer therapy
Zonouz, A. M., Ebrahimpour, M., Zibaei, K., Ramezani, M., Taghavi, S., Abnous, K., Taghdisi, S. M., & Alibolandi, M. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2577137 · Cited by 5
Salehi, S., Boddohi, S., Ghiass, M. A., & Behmanesh, M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124371 · Cited by 5
Inferring diet, disease and antibiotic resistance from ancient human oral microbiomes
Dahlquist-Axe, G., Standeven, F. J., Speller, C., Tedder, A., & Meehan, C. J. (2024) · Microbial Genomics · doi:10.1099/mgen.0.001251 · Cited by 6
Bacterial Peptides and Bacteriocins as a Promising Therapy for Solid Tumor
Yaghoubi, A., Ghazvini, K., Hasanian, S. M., Avan, A., Soleimanpour, S., & Khazaei, M. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220921150037 · Cited by 5
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Dicks, L. M. T., Staden, A. D. P. V., & Klumperman, B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-41625-2.00007-7 · Cited by 5
Periodontitis and respiratory infections – exploring the oral–systemic link
Beniwal, S. S., Caroicar, Y. S., Patil, K., Rawat, A., Said, A. S., Manickavelan, H. V., Desai, A., Jani, H. T., da Costa, R. E. A. R., Cacas, A. C., et al. (2026) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000004374 · Cited by 5
Geda, A. M., Tumebo, A. W., Abey, S. L., Kasse, G. E., Temesgen, A. B., & Wassie, Z. G. (2026) · BioMed Research International · doi:10.1155/bmri/1527677 · Cited by 4
Pneumolysin-responsive liposomal platform for selective treatment of Streptococcus pneumoniae
Watt, E., Andriescu, I., & Ho, E. A. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01708-5 · Cited by 4
Önder, F. C., & Ay, M. (2022) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91250-1.00009-4 · Cited by 4
Bacteriocin producing lactic acid bacteria from camel milk and its fermented products: A review
Singhal, R., Meena, K. K., Meghwal, D., Gupta, L., Panwar, N. L., & Meena, S. K. (2023) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2023.12.2.23 · Cited by 4
Role of Bacteriocins in Modulation of Microbiome in Human Diseases
Rani, P., & Tiwari, S. K. (2023) · Springer eBooks · doi:10.1007/978-981-99-3126-2_17 · Cited by 4
Nia, L. H., Alqudah, S., Markley, R. L., DeLucia, B., Bobba, V., Elmallah, J., Nemet, I., Sangwan, N., & Claesen, J. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01557-25 · Cited by 3
Application of nisin as a potential drug candidate for electrochemotherapy
Michel, O., Lekešytė, B., Malyško-Ptašinskė, V., Morozas, A., Malakauskaitė, P., Mickevičiūtė, E., Želvys, A., Ivaška, J., Kulbacka, J., & Novickij, V. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1689261 · Cited by 3
Costa, S. S., Leticia, A. B. L., Silva, A., das Graças, D. A., Lameira, J., & Baraúna, R. A. (2022) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2021-0204 · Cited by 3
Tymoszewska, A., & Aleksandrzak‐Piekarczyk, T. (2024) · Postępy Biochemii · doi:10.18388/pb.2021_517 · Cited by 3
Loiseau, C., Augenstreich, J., Marchand, A., Harté, E., Garcia, M., Verdon, J., Mesnil, M., Lecomte, S., & Berjeaud, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162007 · Cited by 3
Anticancer activity of cloned Nisin as an alternative therapy for MCF-7 brest cancer cell line
Ahmed, S. S. T. S., Abdulrahman, Z. F. A., & Othman, R. T. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.9.22 · Cited by 3
Pyla, M., Kankipati, S., Sumithra, B., Mishra, P. K., Mishra, B., Mandal, S. K., Panda, J., Chopra, H., Avula, S. K., Attia, M. S., et al. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673253414231127162817 · Cited by 3
Al-Khazaleh, A. K., Alsherbiny, M. A., Chang, D., Münch, G. W., & Bhuyan, D. J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1664468 · Cited by 2
Duramycin: Exploring the therapeutic frontier of a unique lantibiotic
Yuan, M., Bao, S., Wu, K., Deng, Z., & Gao, J. (2025) · Peptides · doi:10.1016/j.peptides.2025.171447 · Cited by 2
Chen, Y.-F., Fan, C.-S., Hung, Y.-C., Chien, P., Tsai, W.-H., Yeh, Y., Jhong, J.-H., Hsieh, Y.-N., Huang, Y.-H., Jan, M., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149033 · Cited by 2
Heidari, S., Hamedi, J., Olad, G., Amani, J., Panahi, M. R. S., & Najafi, A. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2735-5 · Cited by 2
Antibiotic properties of nisin in the context of its use as a food additive
Bagryantseva, O. V., Sa, K., Petrenko, A. S., Sa, S., Arnautov, O. V., & Викторовна, Е. Е. (2020) · Hygiene and Sanitation · doi:10.47470/0016-9900-2020-99-7-704-711 · Cited by 3
Anti-Microbial Peptides: The Importance of Structure-Function Analysis in the Design of New AMPs
Ouertani, A., Mosbah, A., & Cherif, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.99801 · Cited by 2
Lantibiotics production—optimization and scale-up research: cutting edge and challenges
Sahithi, S. T. A., Gundupalli, M. P., Shanmugam, V., & Sriariyanun, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99141-4.00020-5 · Cited by 2
Mousavi, S. M., Archangi, B., & Zamani, I. (2023) · PubMed Central · doi:10.32592/ari.2023.78.6.2694 · Cited by 2
Bacteriocins and Antimicrobial Peptides
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_27 · Cited by 2
Fidan, A., & Uğraş, S. (2022) · Türk Mikrobiyoloji Cemiyeti Dergisi · doi:10.54453/tmcd.2022.24855 · Cited by 2
Mousavi, S. M., Archangi, B., & Zamani, I. (2023) · Archives of Razi Institute · doi:10.32592/ari.2023.78.6.1738 · Cited by 1
Biomedical Applications of Antimicrobial Peptides Produced by Lactic Acid Bacteria
Gutiérrez-Carrillo, A.-E., Garrido-Escárcega, M. S., Rodríguez‐Hernández, A., Castrejón-Jiménez, N. S., López-Cuellar, M. D. R., & Chavarría‐Hernández, N. (2024) · Springer eBooks · doi:10.1007/978-981-97-3413-9_11 · Cited by 1
Shalibeik, S., Ghandehari, F., Ahadi, A. M., Rastegari, A., & Ghiasian, M. (2024) · Peptide Science · doi:10.1002/pep2.24378 · Cited by 1
Wang, M., Zhang, W., & Zhang, J. (2025) · Food Biotechnology · doi:10.1080/08905436.2025.2502105 · Cited by 2
Data-Driven Visualization of the Dynamics of Antimicrobial Peptides in Cell Death
Hou, D., Zhao, J., Guo, M., Zhang, X., Yu, S., Li, J., Forouzanfar, T., Zhang, Q., & Pathak, J. L. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10578-3 · Cited by 1
The antimicrobial peptide nisin promotes host cell survival during SARS-CoV-2 infection
English, B. C., Radaic, A., Barrios-Medina, R., Lin, K., Kamarajan, P., Sil, A., & Kapila, Y. L. (2025) · Virology Journal · doi:10.1186/s12985-025-02921-5 · Cited by 1
Self-citationChitosan glutamate nanoparticles loaded with Nisin for antibacterial and anticancer studies
Shafieisabet, S., Komijani, S., Sharifian, G., Hosseini, F., & Mohajer, F. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148400 · Cited by 1
Of mice and men—The emerging oral–gut–brain axis of health and disease
Kapila, Y. L., & Weisenberger, D. J. (2026) · Periodontology 2000 · doi:10.1111/prd.70064 · Cited by 1
Self-citationMicrobes used as anticancer agents and their potential application in biomedicine
Bhardwaj, S., & Bhatia, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90113-0.00010-9 · Cited by 1
Isakova, M. N. (2023) · Bulletin of NSAU (Novosibirsk State Agrarian University) · doi:10.31677/2072-6724-2023-68-3-185-203 · Cited by 1
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Wang, G. (2024) · Springer eBooks · doi:10.1007/978-981-97-3413-9_4 · Cited by 1
Erdoğmuş, S. F., İşitez, N., & Hazman, Ö. (2025) · Microscopy Research and Technique · doi:10.1002/jemt.70076 · Cited by 1
Yousefy, Z., Esmaeili, D., & Goudarzi, H. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101088 · Cited by 1
Azmi, M. F., Khateeb, A. A., Rahim, S. A., Froemming, G. R. A., & Omar, E. (2022) · Asia-Pacific Journal of Molecular Biology and Biotechnology · doi:10.35118/apjmbb.2022.030.4.05 · Cited by 1
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Sharma, P., Kaur, S., Chadha, B. S., Kaur, R., Kaur, M., & Kaur, S. (2021) · Figshare · doi:10.6084/m9.figshare.13719036
Metadata
- Authors
- Kamarajan, P., Hayami, T., Matte, B., Liu, Y., Danciu, T., Ramamoorthy, A., Worden, F., Kapila, S., & Kapila, Y.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Kapila, Yvonne
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-07-01
- Volume
- 10
- Issue
- 7
- Pages
- e0131008
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4489501
- OpenAlex
- W1871229721
- Cited by
- 214
- References
- 63
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 26 · 2023: 27 · 2022: 31 · 2021: 33 · 2020: 24 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 5 · 2015: 3
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Michigan
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Peking University
- Ciência sem Fronteiras
- Division of Graduate Education
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- bacteriocins, antimicrobial peptides, head and neck squamous cell carcinoma, anticancer activity, apoptosis, calpain, tumor angiogenesis, microvessel density, carcinogenesis, survival, food preservatives, oral keratinocytes, endothelial cells
- MeSH terms
- Animals, Carcinoma, Squamous Cell, Dose-Response Relationship, Drug, Flow Cytometry, Head and Neck Neoplasms, Humans, Mice, Nude, Mouth Neoplasms, Neoplasms, Experimental, Neovascularization, Pathologic, Nisin, Blotting, Western, Apoptosis, Cell Line, Tumor, Cell Proliferation, Mice, Microvessels, Carcinogenesis
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