The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Open accessAbstract
Cardiomyocytes (CMs) and endothelial cells (ECs) have an intimate anatomical relationship that is essential for maintaining normal development and function in the heart. Little is known about the mechanisms that regulate cardiac and endothelial crosstalk, particularly in situations of acute stress when local active processes are required to regulate endothelial function. We examined whether CM-derived exosomes could modulate endothelial function. Under conditions of glucose deprivation, immortalized H9C2 cardiomyocytes increase their secretion of exosomes. CM-derived exosomes are loaded with a broad repertoire of miRNA and proteins in a glucose availability-dependent manner. Gene Ontology (GO) analysis of exosome cargo molecules identified an enrichment of biological process that could alter EC activity. We observed that addition of CM-derived exosomes to ECs induced changes in transcriptional activity of pro-angiogenic genes. Finally, we demonstrated that incubation of H9C2-derived exosomes with ECs induced proliferation and angiogenesis in the latter. Thus, exosome-mediated communication between CM and EC establishes a functional relationship that could have potential implications for the induction of local neovascularization during acute situations such as cardiac injury.
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Cites
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
Ucar, A., Gupta, S. K., Fiedler, J., Erikci, E., Kardasinski, M., Batkai, S., Dangwal, S., Kumarswamy, R., Bang, C., Holzmann, A., et al. (2012) · Nature Communications · doi:10.1038/ncomms2090 · Cited by 610 · cited 1×
“Culture in-St conditions resulted in exosome loading of several miRNAs, some of which have been associated with exosome microRNA patterns (miRNA-17, 20a, 23b, 30b, 132) [35, 36].”
BackgroundSmall Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia
Agbor, T. A., Cheong, A., Comerford, K. M., Scholz, C. C., Bruning, U., Clarke, A., Cummins, E. P., Cagney, G., & Taylor, C. T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115931 · Cited by 68
Cited by
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
Challenges in Exosome Isolation and Analysis in Health and Disease
Ludwig, N., Whiteside, T. L., & Reichert, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194684 · Cited by 428
Sluijter, J. P. G., Davidson, S. M., Boulanger, C. M., Buzás, E. I., de Kleijn, D. P. V., Engel, F. B., Giricz, Z., Hausenloy, D. J., Kishore, R., Lecour, S., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx211 · Cited by 355
Lopes, D., Lopes, J., Pereira-Silva, M., Peixoto, D., Rabiee, N., Veiga, F., Moradi, O., Guo, Z.-H., Wang, X.-D., Conde, J., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00453-z · Cited by 36
Engineering the cardiac tissue microenvironment
Ronan, G., Bahcecioglu, G., Aliyev, N., & Zorlutuna, P. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad0ea7 · Cited by 4
Metadata
- Authors
- Garcia, N. A., Ontoria-Oviedo, I., González-King, H., Diez-Juan, A., & Sepúlveda, P.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-09-22
- Volume
- 10
- Issue
- 9
- Pages
- e0138849
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2197477527
- Cited by
- 229
- References
- 4
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- gold
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