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Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012

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Looker, Katharine J., Magaret, Amalia S., May, Margaret T., Turner, Katherine M. E., Vickerman, Peter, Gottlieb, Sami L., Newman, Lori M.·2015·PLOS ONE
DOI 10.1371/journal.pone.0140765
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Abstract

BACKGROUND: Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. METHODS: We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. FINDINGS: We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. CONCLUSIONS: The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.

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Metadata

Authors
Looker, K. J., Magaret, A. S., May, M. T., Turner, K. M. E., Vickerman, P., Gottlieb, S. L., & Newman, L. M.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2015-10-28
Volume
10
Issue
10
Pages
e0140765
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0140765
OpenAlex
W2137186878
Cited by
644
References
0
FWCI
32.11
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/publicdomain/zero/1.0/ (vor)

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CoChat. (2026). Citation check: Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012. https://app.cochat.ai/papers/10.1371/journal.pone.0140765
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Looker, K. J., Magaret, A. S., May, M. T., Turner, K. M. E., Vickerman, P., Gottlieb, S. L., & Newman, L. M. (2015). Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012. PLOS ONE. https://doi.org/10.1371/journal.pone.0140765

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