Cited by 208Neuroinflammation and Neurodegeneration MechanismsNF-κB Signaling Pathwaysinterferon and immune responses

Human TBK1: A Gatekeeper of Neuroinflammation

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Ahmad, Liyana, Zhang, Shen-Ying, Casanova, Jean-Laurent, Sancho-Shimizu, Vanessa·2016·Trends in Molecular Medicine

Abstract

The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that modulates inflammation and autophagy, in human health has been highlighted for the first time by the recent discoveries of mutations in TBK1 that underlie amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE). Gain-of-function of TBK1 are associated with NTG, whereas loss-of-function mutations result in ALS/FTD or in HSE. In light of these new findings, we review the role of TBK1 in these seemingly unrelated, yet allelic diseases, and discuss the role of TBK1 in neuroinflammatory diseases. This discovery has the potential to significantly increase our understanding of the molecular basis of these poorly understood diseases.

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Crossref · 10.1016/j.molmed.2016.04.006

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  1. [82]Quigley HA 2011 Glaucoma Lancet (London, England) 377 1367 1377 21453963

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Authors
Ahmad, L., Zhang, S.-Y., Casanova, J.-L., & Sancho-Shimizu, V.
Affiliations
  • Imperial College London (GB)
  • Inserm (FR)
  • Hôpital Necker-Enfants Malades (FR)
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2016-06
Volume
22
Issue
6
Pages
511-527
ISSN
1471-4914 (ISSN-L)
OpenAlex
W2398211621
Cited by
208
References
122
Citations by year
2026: 18 · 2025: 26 · 2024: 23 · 2023: 22 · 2022: 21 · 2021: 27 · 2020: 25 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 4
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Trends in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
Funders
  • Agence Nationale de la Recherche (ANR-14-CE14-0008)
  • National Institute of Allergy and Infectious Diseases (R01AI088364)
  • National Institute of Neurological Disorders and Stroke (R01NS072381)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
TBK1, neuroinflammation, amyotrophic lateral sclerosis, frontotemporal dementia, normal-tension glaucoma, gain-of-function mutations, loss-of-function mutations, autophagy, inflammation
MeSH terms
Amyotrophic Lateral Sclerosis, Autophagy, Central Nervous System, Humans, Inflammation, Interferons, Mutation, Gene Expression, Protein Serine-Threonine Kinases, Disease Progression, Encephalitis, Herpes Simplex, Low Tension Glaucoma, Frontotemporal Dementia

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