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Gut Dysbiosis in Patients with Anorexia Nervosa
Open accessAbstract
Anorexia nervosa (AN) is a psychological illness with devastating physical consequences; however, its pathophysiological mechanism remains unclear. Because numerous reports have indicated the importance of gut microbiota in the regulation of weight gain, it is reasonable to speculate that AN patients might have a microbial imbalance, i.e. dysbiosis, in their gut. In this study, we compared the fecal microbiota of female patients with AN (n = 25), including restrictive (ANR, n = 14) and binge-eating (ANBP, n = 11) subtypes, with those of age-matched healthy female controls (n = 21) using the Yakult Intestinal Flora-SCAN based on 16S or 23S rRNA-targeted RT-quantitative PCR technology. AN patients had significantly lower amounts of total bacteria and obligate anaerobes including those from the Clostridium coccoides group, Clostridium leptum subgroup, and Bacteroides fragilis group than the age-matched healthy women. Lower numbers of Streptococcus were also found in the AN group than in the control group. In the analysis based on AN subtypes, the counts of the Bacteroides fragilis group in the ANR and ANBP groups and the counts of the Clostridium coccoides group in the ANR group were significantly lower than those in the control group. The detection rate of the Lactobacillus plantarum subgroup was significantly lower in the AN group than in the control group. The AN group had significantly lower acetic and propionic acid concentrations in the feces than the control group. Moreover, the subtype analysis showed that the fecal concentrations of acetic acid were lower in the ANR group than in the control group. Principal component analysis confirmed a clear difference in the bacterial components between the AN patients and healthy women. Collectively, these results clearly indicate the existence of dysbiosis in the gut of AN patients.
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“Nonetheless, decreased fecal SCFA levels have been reported in various disorders where brain physiology and behavior are changed, including anorexia nervosa (Morita et al., 2015) and Parkinson's disease (Unger et al., 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Morita et al., 2015
In the citing paper
“Surprisingly though, literature on this area is scarce, with only a handful of studies measuring gut microbial profile in patients with AN [29,30,31,32] and no data are available on other forms of eating disorders.”
In the citing paper
“Morita et al. [29] found no significant difference between the two subtypes when the abundances of individual species were compared.”
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Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
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“1, a small effect [24, 25].”
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Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
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Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326
Metadata
- Authors
- Morita, C., Tsuji, H., Hata, T., Gondo, M., Takakura, S., Kawai, K., Yoshihara, K., Ogata, K., Nomoto, K., Miyazaki, K., & Sudo, N.
- Affiliations
- Kyushu University (JP)
- Yakult Central Institute (JP)
- Corresponding author
- Sudo, Nobuyuki
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-12-18
- Volume
- 10
- Issue
- 12
- Pages
- e0145274
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4687631
- OpenAlex
- W2205656408
- Cited by
- 238
- References
- 37
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 22 · 2023: 33 · 2022: 28 · 2021: 32 · 2020: 23 · 2019: 31 · 2018: 18 · 2017: 10 · 2016: 10
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- anorexia nervosa, gut dysbiosis, gut microbiota, fecal microbiota, restrictive anorexia nervosa, Bacteroides fragilis group, Lactobacillus plantarum, short-chain fatty acids, acetic acid, propionic acid, Streptococcus, anaerobic bacteria
- MeSH terms
- Gastrointestinal Microbiome, Adult, Anorexia Nervosa, Feces, Female, Humans, Case-Control Studies, Young Adult, Dysbiosis
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